LOCUS       NM_008099               3298 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus germinal center associated, signaling and motility
            (Gcsam), transcript variant 2, mRNA.
ACCESSION   NM_008099
VERSION     NM_008099.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3298)
  AUTHORS   Schenten,D., Egert,A., Pasparakis,M. and Rajewsky,K.
  TITLE     M17, a gene specific for germinal center (GC) B cells and a
            prognostic marker for GC B-cell lymphomas, is dispensable for the
            GC reaction in mice
  JOURNAL   Blood 107 (12), 4849-4856 (2006)
   PUBMED   16493007
REFERENCE   2  (bases 1 to 3298)
  AUTHORS   Steinke,J.W., Hodsdon,W., Parenti,S., Ostraat,R., Lutz,R.,
            Borish,L. and Hagman,J.
  TITLE     Identification of an Sp factor-dependent promoter in GCET, a gene
            expressed at high levels in germinal center B cells
  JOURNAL   Mol Immunol 41 (12), 1145-1153 (2004)
   PUBMED   15482850
  REMARK    GeneRIF: Assays identified a non-consensus binding site for Sp
            factors near sites of transcriptional initiation. The site binds
            Spl and Sp3 in nuclear extracts.
REFERENCE   3  (bases 1 to 3298)
  AUTHORS   Eriksson,A. and Nordqvist,K.
  TITLE     Protocol for using signal peptide differential display and
            representational difference analysis to isolate differentially
            expressed cDNAs from fetal mouse brain
  JOURNAL   Brain Res Brain Res Protoc 6 (3), 119-128 (2001)
   PUBMED   11223410
REFERENCE   4  (bases 1 to 3298)
  AUTHORS   Christoph,T., Rickert,R. and Rajewsky,K.
  TITLE     M17: a novel gene expressed in germinal centers
  JOURNAL   Int Immunol 6 (8), 1203-1211 (1994)
   PUBMED   7981148
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U13263.1 and AK036553.1.
            
            On Apr 11, 2009 this sequence version replaced NM_008099.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. This
            difference results in a protein (isoform 2) with a shorter
            N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036553.1, U13263.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1099              U13263.1           2-1100
            1100-3298           AK036553.1         1118-3316
FEATURES             Location/Qualifiers
     source          1..3298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 29.72 cM"
     gene            1..3298
                     /gene="Gcsam"
                     /gene_synonym="Gcet; Gcet2; M17; M17-L"
                     /note="germinal center associated, signaling and motility"
                     /db_xref="GeneID:14525"
                     /db_xref="MGI:MGI:102969"
     exon            1..121
                     /gene="Gcsam"
                     /gene_synonym="Gcet; Gcet2; M17; M17-L"
                     /inference="alignment:Splign:2.1.0"
     exon            122..178
                     /gene="Gcsam"
                     /gene_synonym="Gcet; Gcet2; M17; M17-L"
                     /inference="alignment:Splign:2.1.0"
     exon            179..225
                     /gene="Gcsam"
                     /gene_synonym="Gcet; Gcet2; M17; M17-L"
                     /inference="alignment:Splign:2.1.0"
     exon            226..254
                     /gene="Gcsam"
                     /gene_synonym="Gcet; Gcet2; M17; M17-L"
                     /inference="alignment:Splign:2.1.0"
     exon            255..3298
                     /gene="Gcsam"
                     /gene_synonym="Gcet; Gcet2; M17; M17-L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1643..1648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gcsam"
                     /gene_synonym="Gcet; Gcet2; M17; M17-L"
                     /note="hexamer: GATAAA"
     polyA_site      1664
                     /gene="Gcsam"
                     /gene_synonym="Gcet; Gcet2; M17; M17-L"
                     /note="major polyA site"
ORIGIN      
        1 gccagttaca gagcacagtg ccagaccaag gtgcaagccg gctgagaagg aagtggagac
       61 taccagaggg aaggtgctga ggggcctgcc tcatggggaa ctgtttgcag aggacaacca
      121 gatacttcag gggctggagt tgttgtcaca gcgttgaagg atgctcctgc cttccttgga
      181 aaaacatacg cacatttaaa gccagacaag agtctccaaa gcaaaatgaa gggatgactt
      241 cagctcccgt tcaggacaat gctaatgaga cctacacaga agagttgtgc tacatccttg
      301 ttgatcacga agctgtcagg ggaaggccat cagtgaaccc tgctgagggg ttctacgaga
      361 acatctctaa caaggctgag agacacaaag agtcttcaag aggaacagag actgagtatt
      421 cggttctccg tttcccttct ccccctcagc ccctaccttc cacagatgat gaatatgaac
      481 ttcttatgcc cagcagattc tcctcacatg cctttcaaca gccacggccg cttacaaccc
      541 cctacgagac acacttttct tatccacaat gaagtgacta gggtggagtt tgtttagcac
      601 tgacagataa aagtaggagt tagggactct agctgaggca gccataggtc agggagatcc
      661 tttgtttatt tcttctagag gcccttcgta gggcagactc tgcaagcctc tcagagtcta
      721 acaatagtca aatactcaaa aattagacaa ctgtcttgca tattgcattg aaaaaaggag
      781 tgaccacctt tgtttctgag tggtgttaaa aataatctgt ggcaggaagg gctcctggta
      841 tctccactgg ggtgtaccac aaaaggctct gctcttctca gtaagttctt acaaattgtc
      901 cccacaactt tactctgcag tcaggggaag cttactcatt gtgatccagg accccgagag
      961 aattcctcat cactgttaaa ttccagctta gtaccacttg ctatggaaac tggcaatatt
     1021 ccttttattc catgggtcta acattcgtcc tttacacagt gtccttggct tcatggtccc
     1081 catgacttgg aatttcctgt atagtcatta atataatttt aaactatata tttaaacttt
     1141 gagtttctca tcagaattgt ctttctccta tggtacagga aaacattctc agaacgtctt
     1201 ccacggtagg caagggatca tccatgaaga gacagctcaa atgctgccac ataaatctca
     1261 gtagaaccac cacaatgtca ggaactgaca aagtggaaag tttctggaaa gattttaacc
     1321 ccattatctt cttttttact gagagaaaac tgtttgcccc atgttacagt atcagcatta
     1381 gtggcagaac tttattttgg cttccaagtc agtgttgctg ctgagtgtgc tatctgatag
     1441 agtaaatggt ccagcatgca tgcaatgtcc acatgagaga actaacacat accttttctc
     1501 tgtgagcatc cctctctgac ttgagtcttt attttccacc actgttttct tttgaatttc
     1561 tggaatcatt tctatgctaa gttagccaat gatgcacaac ctactgactg gcccaatcta
     1621 gcccatcacc tgtatttttg tagataaacg tttattgaaa cacagctgca ctgatttgtc
     1681 tacatactat ctatggttgc tcaaccatgg taaaattgat ttgtgacaca gaccggaggc
     1741 tttacaaagc taaaaatatc tgtaatttaa cctattctag ataataattt tgtagacctc
     1801 tgctttaaac agtcacggtt tgagataaac tggagaggat tacatttggt tattgacaca
     1861 ctcattagga gcagagaaca atgagctggc gggaaaatat taaaccacaa aggagataag
     1921 caagactaaa acaattacta gcaaatgaga ctatttgtac attcacacct gcatccgcaa
     1981 ggtgttgttt tatttacctc atggccactg tcctaatttt agggatgcta agatgtcaag
     2041 atgttcgttg aggtgagctt gggagggact atgtatttaa tttctatttt gttatcaaag
     2101 acgaataact ttctacttaa aatgccccac agaggtagct cagtagtagg gtccttgcct
     2161 agcatgtaca agacagacag acagagagag acagagacag agacagacgg agacagagag
     2221 agacagagag agacagagaa aatacaaaac aggccaagtg cccactaaga gtaagtgcag
     2281 tggcttaagg tccgttgggt gactttgctg agacataaag cagttgatca ctttcagcta
     2341 aagagccaac aagatctcag tacctcggtc tccattaact tcctttcttt acagatatct
     2401 ttcatttaga agcctaagtg tagtgtttgg ccagaagtca cttgggtcca aaggatgtgt
     2461 cattgaagat aagaaatgct gtacaaaatg taacatgtgg cttgtggggg gaaaagtggg
     2521 ggccagagat agatttaaat ctttgtttcc ttttgccctc ctttcagccc aatccacaaa
     2581 cttataagct caatctactg cgtccataca ttggatggct gcatctgata tgtaatcatc
     2641 cattctagtt tgctttagga tgctgggata aaacactgac caaaagctaa ttggagaaga
     2701 aagggtttac ttgacttata gtccatcata gcaggagctt gaggtaggtt ctgaagtgga
     2761 ggtaatggag aaatgctact tagtctccat gactctctta gttttctttc ttatacaacc
     2821 gagggtcatc agatcaaggg gtggcaacgc aggggagtgg ccctcccacg tcaatcataa
     2881 atcaagacga agccccaaag aaacacccac aggtcaagcc aatggagtag attgctaaac
     2941 tggtgttcct tcttcccagg taactcaatt ttgtgttgtt gataaaaaca aaacaaaaca
     3001 aaacaaccct cgccattata tcatctatca tagaccctga ggataaatga tagcaaagaa
     3061 tagagagaaa cagacgcctt ttaaagcata tggaaaaaga catgctgctg caacaagtgg
     3121 ttagagtccc caagttccct ccagcaagac agacatcaaa cagatggctc tatgttagaa
     3181 ctctgtgcta aacctttgtg gcagaaaggc agtggaaata ttcccagtac gatacaatga
     3241 gctgtatttg tttgcaattc attaataaag tattacctga ccccgaaagc aaatgctt
//
