LOCUS       NP_032155                274 aa            linear   ROD 06-NOV-2024
DEFINITION  glutamate--cysteine ligase regulatory subunit [Mus musculus].
ACCESSION   NP_032155
VERSION     NP_032155.1
DBSOURCE    REFSEQ: accession NM_008129.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 274)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 274)
  AUTHORS   Xue,Z., Nuerrula,Y., Sitiwaerdi,Y. and Eli,M.
  TITLE     Nuclear factor erythroid 2-related factor 2 promotes
            radioresistance by regulating glutamate-cysteine ligase modifier
            subunit and its unique immunoinvasive pattern
  JOURNAL   Biomol Biomed 24 (3), 545-559 (2024)
   PUBMED   38340316
  REMARK    GeneRIF: Nuclear factor erythroid 2-related factor 2 promotes
            radioresistance by regulating glutamate-cysteine ligase modifier
            subunit and its unique immunoinvasive pattern.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 274)
  AUTHORS   Skupienski,R., Steullet,P., Do,K.Q. and Xin,L.
  TITLE     Developmental changes in cerebral NAD and neuroenergetics of an
            antioxidant compromised mouse model of schizophrenia
  JOURNAL   Transl Psychiatry 13 (1), 275 (2023)
   PUBMED   37543592
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 274)
  AUTHORS   Lim,J., Shioda,T., Malott,K.F., Shioda,K., Odajima,J., Leon
            Parada,K.N., Nguyen,J., Getze,S., Lee,M., Nguyen,J., Reshel
            Blakeley,S., Trinh,V., Truong,H.A. and Luderer,U.
  TITLE     Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and
            masculinizes embryonic ovarian germ cell transcriptome
            transgenerationally
  JOURNAL   Sci Rep 13 (1), 8671 (2023)
   PUBMED   37248279
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 274)
  AUTHORS   Chen,Y., Holland,K.D., Shertzer,H.G., Nebert,D.W. and Dalton,T.P.
  TITLE     Fatal Epileptic Seizures in Mice Having Compromised Glutathione and
            Ascorbic Acid Biosynthesis
  JOURNAL   Antioxidants (Basel) 12 (2), 448 (2023)
   PUBMED   36830006
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 274)
  AUTHORS   Thompson,S.A., White,C.C., Krejsa,C.M., Eaton,D.L. and
            Kavanagh,T.J.
  TITLE     Modulation of glutathione and glutamate-L-cysteine ligase by
            methylmercury during mouse development
  JOURNAL   Toxicol Sci 57 (1), 141-146 (2000)
   PUBMED   10966520
REFERENCE   7  (residues 1 to 274)
  AUTHORS   Hudson,F.N. and Kavanagh,T.J.
  TITLE     Cloning and characterization of the proximal promoter region of the
            mouse glutamate-L-cysteine ligase regulatory subunit gene
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 447-451 (2000)
   PUBMED   10899580
REFERENCE   8  (residues 1 to 274)
  AUTHORS   Reid,L.L., Botta,D., Shao,J., Hudson,F.N. and Kavanagh,T.J.
  TITLE     Molecular cloning and sequencing of the cDNA encoding mouse
            glutamate-cysteine ligase regulatory subunit
  JOURNAL   Biochim Biophys Acta 1353 (2), 107-110 (1997)
   PUBMED   9294003
REFERENCE   9  (residues 1 to 274)
  AUTHORS   Gage,P.J. and Camper,S.A.
  TITLE     Pituitary homeobox 2, a novel member of the bicoid-related family
            of homeobox genes, is a potential regulator of anterior structure
            formation
  JOURNAL   Hum Mol Genet 6 (3), 457-464 (1997)
   PUBMED   9147650
REFERENCE   10 (residues 1 to 274)
  AUTHORS   Tsuchiya,K., Mulcahy,R.T., Reid,L.L., Disteche,C.M. and
            Kavanagh,T.J.
  TITLE     Mapping of the glutamate-cysteine ligase catalytic subunit gene
            (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of
            the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22
            and mouse chromosome 3H1-3
  JOURNAL   Genomics 30 (3), 630-632 (1995)
   PUBMED   8825659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB615104.1, AK028236.1 and DV659479.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172387.1, AK028236.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..274
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 52.94 cM"
     Protein         1..274
                     /product="glutamate--cysteine ligase regulatory subunit"
                     /EC_number="6.3.2.2"
                     /note="GCS light chain; gamma-ECS regulatory subunit;
                     gamma-glutamylcysteine synthetase regulatory subunit"
                     /calculated_mol_wt=30404
     Site            59
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O09172.1)"
     Region          <109..>211
                     /region_name="AKR_SF"
                     /note="Aldo-keto reductase (AKR) superfamily; cl00470"
                     /db_xref="CDD:444925"
     Site            263
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P48507; propagated from
                     UniProtKB/Swiss-Prot (O09172.1)"
     CDS             1..274
                     /gene="Gclm"
                     /gene_synonym="Gcmc; Glclr"
                     /coded_by="NM_008129.4:430..1254"
                     /db_xref="CCDS:CCDS17808.1"
                     /db_xref="GeneID:14630"
                     /db_xref="MGI:MGI:104995"
ORIGIN      
        1 mgtdsraaga llarastlhl qtgnllnwgr lrkkcpsths eelrdciqkt lnewssqisp
       61 dlvrefpdvl ectmshavek inpdereemk vsaklfivgs nsssstrsav dmacsvlgva
      121 qldsvimasp piedgvnlsl ehlqpyweel enlvqskkiv aigtsdldkt qleqlyqwaq
      181 vkpnsnqvnl asccvmppdl tafakqfdiq llthndpkel lseasfqeal qesipdieaq
      241 dwvplwllry svivksrgii kskgyilqak rrgs
//
