LOCUS       NP_001361670             623 aa            linear   ROD 07-DEC-2024
DEFINITION  glucokinase regulatory protein isoform 1 [Mus musculus].
ACCESSION   NP_001361670 XP_006503944
VERSION     NP_001361670.1
DBSOURCE    REFSEQ: accession NM_001374741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 623)
  AUTHORS   Ford,B.E., Chachra,S.S., Alshawi,A., Oakley,F., Fairclough,R.J.,
            Smith,D.M., Tiniakos,D. and Agius,L.
  TITLE     Compromised chronic efficacy of a glucokinase activator AZD1656 in
            mouse models for common human GCKR variants
  JOURNAL   Biochem Pharmacol 229, 116499 (2024)
   PUBMED   39173844
REFERENCE   2  (residues 1 to 623)
  AUTHORS   Buziau,A.M., Oosterveer,M.H., Wouters,K., Bos,T., Tolan,D.R.,
            Agius,L., Ford,B.E., Cassiman,D., Stehouwer,C.D.A., Schalkwijk,C.G.
            and Brouwers,M.C.G.J.
  TITLE     Hepatic glucokinase regulatory protein and carbohydrate response
            element binding protein attenuation reduce de novo lipogenesis but
            do not mitigate intrahepatic triglyceride accumulation in Aldob
            deficiency
  JOURNAL   Mol Metab 87, 101984 (2024)
   PUBMED   38972375
  REMARK    GeneRIF: Hepatic glucokinase regulatory protein and carbohydrate
            response element binding protein attenuation reduce de novo
            lipogenesis but do not mitigate intrahepatic triglyceride
            accumulation in Aldob deficiency.
REFERENCE   3  (residues 1 to 623)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 623)
  AUTHORS   Ford,B.E., Chachra,S.S., Rodgers,K., Moonira,T., Al-Oanzi,Z.H.,
            Anstee,Q.M., Reeves,H.L., Schattenberg,J.M., Fairclough,R.J.,
            Smith,D.M., Tiniakos,D. and Agius,L.
  TITLE     The GCKR-P446L gene variant predisposes to raised blood cholesterol
            and lower blood glucose in the P446L mouse-a model for GCKR
            rs1260326
  JOURNAL   Mol Metab 72, 101722 (2023)
   PUBMED   37031802
  REMARK    GeneRIF: The GCKR-P446L gene variant predisposes to raised blood
            cholesterol and lower blood glucose in the P446L mouse-a model for
            GCKR rs1260326.
REFERENCE   5  (residues 1 to 623)
  AUTHORS   Codner,G.F., Mianne,J., Caulder,A., Loeffler,J., Fell,R., King,R.,
            Allan,A.J., Mackenzie,M., Pike,F.J., McCabe,C.V., Christou,S.,
            Joynson,S., Hutchison,M., Stewart,M.E., Kumar,S., Simon,M.M.,
            Agius,L., Anstee,Q.M., Volynski,K.E., Kullmann,D.M., Wells,S. and
            Teboul,L.
  TITLE     Application of long single-stranded DNA donors in genome editing:
            generation and validation of mouse mutants
  JOURNAL   BMC Biol 16 (1), 70 (2018)
   PUBMED   29925374
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 623)
  AUTHORS   Kaminski,M.T., Schultz,J., Waterstradt,R., Tiedge,M., Lenzen,S. and
            Baltrusch,S.
  TITLE     Glucose-induced dissociation of glucokinase from its regulatory
            protein in the nucleus of hepatocytes prior to nuclear export
  JOURNAL   Biochim Biophys Acta 1843 (3), 554-564 (2014)
   PUBMED   24333860
REFERENCE   7  (residues 1 to 623)
  AUTHORS   Grimsby,J., Coffey,J.W., Dvorozniak,M.T., Magram,J., Li,G.,
            Matschinsky,F.M., Shiota,C., Kaur,S., Magnuson,M.A. and Grippo,J.F.
  TITLE     Characterization of glucokinase regulatory protein-deficient mice
  JOURNAL   J Biol Chem 275 (11), 7826-7831 (2000)
   PUBMED   10713097
REFERENCE   8  (residues 1 to 623)
  AUTHORS   Weninger,S.C., Peters,L.L. and Majzoub,J.A.
  TITLE     Urocortin expression in the Edinger-Westphal nucleus is
            up-regulated by stress and corticotropin-releasing hormone
            deficiency
  JOURNAL   Endocrinology 141 (1), 256-263 (2000)
   PUBMED   10614646
REFERENCE   9  (residues 1 to 623)
  AUTHORS   Farrelly,D., Brown,K.S., Tieman,A., Ren,J., Lira,S.A., Hagan,D.,
            Gregg,R., Mookhtiar,K.A. and Hariharan,N.
  TITLE     Mice mutant for glucokinase regulatory protein exhibit decreased
            liver glucokinase: a sequestration mechanism in metabolic
            regulation
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14511-14516 (1999)
   PUBMED   10588736
REFERENCE   10 (residues 1 to 623)
  AUTHORS   Wightman,P.J., Hayward,B.E. and Bonthron,D.T.
  TITLE     The genes encoding glucokinase regulatory protein and
            ketohexokinase co-localize to mouse chromosome 5
  JOURNAL   Mamm Genome 8 (9), 700-701 (1997)
   PUBMED   9271679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114619.9.
            
            On Oct 10, 2019 this sequence version replaced XP_006503944.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.763218.1,
                                           SRR17784649.1178994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.27 cM"
     Protein         1..623
                     /product="glucokinase regulatory protein isoform 1"
                     /note="glucokinase regulator"
                     /calculated_mol_wt=68590
     Region          30..>277
                     /region_name="PRK12570"
                     /note="N-acetylmuramic acid-6-phosphate etherase;
                     Reviewed"
                     /db_xref="CDD:237142"
     Region          199..200
                     /region_name="Important for interaction with GCK.
                     /evidence=ECO:0000250|UniProtKB:Q07071"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91X44.4)"
     Region          293..555
                     /region_name="SIS"
                     /note="SIS domain. SIS (Sugar ISomerase) domains are found
                     in many phosphosugar isomerases and phosphosugar binding
                     proteins. SIS domains are also found in proteins that
                     regulate the expression of genes involved in synthesis of
                     phosphosugars; cl00389"
                     /db_xref="CDD:444881"
     Region          463..465
                     /region_name="Essential for interaction with GCK.
                     /evidence=ECO:0000250|UniProtKB:Q14397"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91X44.4)"
     Region          <482..606
                     /region_name="MurQ"
                     /note="N-acetylmuramic acid 6-phosphate (MurNAc-6-P)
                     etherase [Cell wall/membrane/envelope biogenesis];
                     COG2103"
                     /db_xref="CDD:441706"
     CDS             1..623
                     /gene="Gckr"
                     /gene_synonym="GKRP"
                     /coded_by="NM_001374741.1:58..1929"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS89900.1"
                     /db_xref="GeneID:231103"
                     /db_xref="MGI:MGI:1096345"
ORIGIN      
        1 mpstkryqhv ietpepgewe lsgyeaavpi teksnpltrn ldkadaekiv qllgqcdaei
       61 fqeegqimpt yqrlysesvl ttmlqvagkv qevlkepdgg lvvlsgggts grmaflmsvs
      121 fnqlmkglgq kplytyliag gdrsvvasre rtedsalhgi eelkkvaagk krvvvigisv
      181 glsapfvagq mdycmdntav flpvlvgfnp vsmarndpie dwrstfrqva ermqkmqekq
      241 eafvlnpaig peglsgssrm kggsatkill etlllaahkt vdqgvvssqr clleilrtfe
      301 rahqvtysqs skiatltkqv gislekkghv hlvgwqtlgi iaimdgveci htfgadfrdi
      361 rgfligdhnd mfnqkdelsn qgpqftfsqd dfltsvlpsl teidtvvfif tlddnlaevq
      421 alaervreks wniqalvhst vgqslpaplk klfpslisit wpllffdyeg syvqkfqrel
      481 stkwvlntvs tgahvllgki lqnhmldlri ansklfwral amlqrfsgqs karciesllq
      541 vihfpqplsn dvraapisch vqvahekekv iptallslll rcsiteaker laaassvcev
      601 vrsalsgpgq krsiqafgdp vvp
//
