LOCUS       NM_177157                629 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus GTP cyclohydrolase I feedback regulator (Gchfr), mRNA.
ACCESSION   NM_177157
VERSION     NM_177157.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 629)
  AUTHORS   Wyler,S.C., Donovan,L.J., Yeager,M. and Deneris,E.
  TITLE     Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter
            Genes in Serotonin Neurons
  JOURNAL   ACS Chem Neurosci 6 (7), 1198-1205 (2015)
   PUBMED   25642596
REFERENCE   2  (bases 1 to 629)
  AUTHORS   Pathak,R., Pawar,S.A., Fu,Q., Gupta,P.K., Berbee,M., Garg,S.,
            Sridharan,V., Wang,W., Biju,P.G., Krager,K.J., Boerma,M.,
            Ghosh,S.P., Cheema,A.K., Hendrickson,H.P., Aykin-Burns,N. and
            Hauer-Jensen,M.
  TITLE     Characterization of transgenic Gfrp knock-in mice: implications for
            tetrahydrobiopterin in modulation of normal tissue radiation
            responses
  JOURNAL   Antioxid Redox Signal 20 (9), 1436-1446 (2014)
   PUBMED   23521531
REFERENCE   3  (bases 1 to 629)
  AUTHORS   Li,L., Rezvan,A., Salerno,J.C., Husain,A., Kwon,K., Jo,H.,
            Harrison,D.G. and Chen,W.
  TITLE     GTP cyclohydrolase I phosphorylation and interaction with GTP
            cyclohydrolase feedback regulatory protein provide novel regulation
            of endothelial tetrahydrobiopterin and nitric oxide
  JOURNAL   Circ Res 106 (2), 328-336 (2010)
   PUBMED   19926872
  REMARK    GeneRIF: Studies provide a new mechanism for regulation of
            endothelial GTPCH-1 by its phosphorylation and interplay with GFRP.
REFERENCE   4  (bases 1 to 629)
  AUTHORS   Tatham,A.L., Crabtree,M.J., Warrick,N., Cai,S., Alp,N.J. and
            Channon,K.M.
  TITLE     GTP cyclohydrolase I expression, protein, and activity determine
            intracellular tetrahydrobiopterin levels, independent of GTP
            cyclohydrolase feedback regulatory protein expression
  JOURNAL   J Biol Chem 284 (20), 13660-13668 (2009)
   PUBMED   19286659
  REMARK    GeneRIF: GTPCH expression is the primary regulator of BH4 levels,
            and changes in GTPCH or BH4 are not necessarily accompanied by
            changes in GFRP expression.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK028116.1.
            
            On Apr 5, 2007 this sequence version replaced NM_177157.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028116.1, AK028122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-629               AK028116.1         2-630
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.97 cM"
     gene            1..629
                     /gene="Gchfr"
                     /gene_synonym="2010323F13Rik; GFRP; P35"
                     /note="GTP cyclohydrolase I feedback regulator"
                     /db_xref="GeneID:320415"
                     /db_xref="MGI:MGI:2443977"
     exon            1..86
                     /gene="Gchfr"
                     /gene_synonym="2010323F13Rik; GFRP; P35"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..305
                     /gene="Gchfr"
                     /gene_synonym="2010323F13Rik; GFRP; P35"
                     /note="GTP cyclohydrolase I feedback regulatory protein"
                     /codon_start=1
                     /product="GTP cyclohydrolase 1 feedback regulatory
                     protein"
                     /protein_id="NP_796131.1"
                     /db_xref="CCDS:CCDS38204.1"
                     /db_xref="GeneID:320415"
                     /db_xref="MGI:MGI:2443977"
                     /translation="MPYLLISTQIRMEVGPTMVGDEHSDPELMQHLGASKRSVLGNNF
                     YEYYVNDPPRIVLDKLECKGFRVLSMTGVGQTLVWCLHKE"
     exon            87..181
                     /gene="Gchfr"
                     /gene_synonym="2010323F13Rik; GFRP; P35"
                     /inference="alignment:Splign:2.1.0"
     exon            182..629
                     /gene="Gchfr"
                     /gene_synonym="2010323F13Rik; GFRP; P35"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      611
                     /gene="Gchfr"
                     /gene_synonym="2010323F13Rik; GFRP; P35"
ORIGIN      
        1 agagcaggga gtaacgggac tgtggtcgcg ggcagcccca gccacgcacc atgccctatc
       61 tgctcatcag cactcagatc cgtatggagg tgggccccac catggtgggt gatgaacact
      121 cggatccgga gctgatgcag cacctggggg cctccaagag aagtgtcttg ggaaacaact
      181 tttacgaata ctacgtcaac gaccctcctc gcatagtcct ggacaagctg gaatgcaagg
      241 gcttccgagt gctgagcatg acaggggtgg gccagacgct ggtgtggtgt ctgcacaagg
      301 aatgagctgc ttgagctgac ctgttcagag accgccatgt gccctgccca catccttgca
      361 tcactgtttg ccctgcctat ctctttccaa attgtcaact cccttgccca atactggtgg
      421 gctgtgaaca gcctaaggga cctcgctcca gctggttggg cacagcaggc tcctgccctg
      481 gtgctttcag cttcccccag ctaggcctga ccctggctct tgctgtaggc cacatgctga
      541 aggcaagcca acccgaggac gaggacagtc cctggatcct acacagctaa tccaagccaa
      601 taaagggctc tcacaagtgg ttgttcctc
//
