LOCUS       NM_008102               2775 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus GTP cyclohydrolase 1 (Gch1), mRNA.
ACCESSION   NM_008102
VERSION     NM_008102.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2775)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2775)
  AUTHORS   Chuaiphichai,S., Chu,S.M., Carnicer,R., Kelly,M., Bendall,J.K.,
            Simon,J.N., Douglas,G., Crabtree,M.J., Casadei,B. and Channon,K.M.
  TITLE     Endothelial cell-specific roles for tetrahydrobiopterin in
            myocardial function, cardiac hypertrophy, and response to
            myocardial ischemia-reperfusion injury
  JOURNAL   Am J Physiol Heart Circ Physiol 324 (4), H430-H442 (2023)
   PUBMED   36735402
REFERENCE   3  (bases 1 to 2775)
  AUTHORS   Wang,D., Liang,W., Huo,D., Wang,H., Wang,Y., Cong,C., Zhang,C.,
            Yan,S., Gao,M., Su,X., Tan,X., Zhang,W., Han,L., Zhang,D. and
            Feng,H.
  TITLE     SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis
            by reducing lipid peroxidation through regulation of GCH1 and TFR1
  JOURNAL   Cell Death Differ 30 (2), 369-382 (2023)
   PUBMED   36443440
  REMARK    GeneRIF: SPY1 inhibits neuronal ferroptosis in amyotrophic lateral
            sclerosis by reducing lipid peroxidation through regulation of GCH1
            and TFR1.
REFERENCE   4  (bases 1 to 2775)
  AUTHORS   Yin,Y.L., Chen,Y., Ren,F., Wang,L., Zhu,M.L., Lu,J.X., Wang,Q.Q.,
            Lu,C.B., Liu,C., Bai,Y.P., Wang,S.X., Wang,J.Z. and Li,P.
  TITLE     Nitrosative stress induced by homocysteine thiolactone drives
            vascular cognitive impairments via GTP cyclohydrolase 1
            S-nitrosylation in vivo
  JOURNAL   Redox Biol 58, 102540 (2022)
   PUBMED   36399957
  REMARK    GeneRIF: Nitrosative stress induced by homocysteine thiolactone
            drives vascular cognitive impairments via GTP cyclohydrolase 1
            S-nitrosylation in vivo.
REFERENCE   5  (bases 1 to 2775)
  AUTHORS   Chuaiphichai,S., Yu,G.Z., Tan,C.M.J., Whiteman,C., Douglas,G.,
            Dickinson,Y., Drydale,E.N., Appari,M., Zhang,W., Crabtree,M.J.,
            McNeill,E., Hale,A.B., Lewandowski,A.J., Alp,N.J., Vatish,M.,
            Leeson,P. and Channon,K.M.
  TITLE     Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin
            Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and
            Fetal Growth
  JOURNAL   Hypertension 78 (6), 1871-1884 (2021)
   PUBMED   34689592
  REMARK    GeneRIF: Endothelial GTPCH (GTP Cyclohydrolase 1) and
            Tetrahydrobiopterin Regulate Gestational Blood Pressure,
            Uteroplacental Remodeling, and Fetal Growth.
REFERENCE   6  (bases 1 to 2775)
  AUTHORS   Ichinose,H., Ohye,T., Matsuda,Y., Hori,T., Blau,N., Burlina,A.,
            Rouse,B., Matalon,R., Fujita,K. and Nagatsu,T.
  TITLE     Characterization of mouse and human GTP cyclohydrolase I genes.
            Mutations in patients with GTP cyclohydrolase I deficiency
  JOURNAL   J Biol Chem 270 (17), 10062-10071 (1995)
   PUBMED   7730309
REFERENCE   7  (bases 1 to 2775)
  AUTHORS   Ichinose,H., Ohye,T., Takahashi,E., Seki,N., Hori,T., Segawa,M.,
            Nomura,Y., Endo,K., Tanaka,H., Tsuji,S. et al.
  TITLE     Hereditary progressive dystonia with marked diurnal fluctuation
            caused by mutations in the GTP cyclohydrolase I gene
  JOURNAL   Nat Genet 8 (3), 236-242 (1994)
   PUBMED   7874165
REFERENCE   8  (bases 1 to 2775)
  AUTHORS   Gutlich,M., Ziegler,I., Witter,K., Hemmens,B., Hultner,L.,
            McDonald,J.D., Werner,T., Rodl,W. and Bacher,A.
  TITLE     Molecular characterization of HPH-1: a mouse mutant deficient in
            GTP cyclohydrolase I activity
  JOURNAL   Biochem Biophys Res Commun 203 (3), 1675-1681 (1994)
   PUBMED   7524491
REFERENCE   9  (bases 1 to 2775)
  AUTHORS   Nomura,T., Ichinose,H., Sumi-Ichinose,C., Nomura,H., Hagino,Y.,
            Fujita,K. and Nagatsu,T.
  TITLE     Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase I
  JOURNAL   Biochem Biophys Res Commun 191 (2), 523-527 (1993)
   PUBMED   8461009
REFERENCE   10 (bases 1 to 2775)
  AUTHORS   Gutlich,M., Schott,K., Werner,T., Bacher,A. and Ziegler,I.
  TITLE     Detection and quantification of GTP cyclohydrolase I mRNA
  JOURNAL   Adv Exp Med Biol 338, 167-170 (1993)
   PUBMED   8304101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154589.3 and AC159006.2.
            
            On Apr 14, 2018 this sequence version replaced NM_008102.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152571.1, AK150657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               AC154589.3         149265-149726       c
            463-572             AC159006.2         228596-228705       c
            573-628             AC159006.2         225860-225915       c
            629-660             AC159006.2         218247-218278       c
            661-745             AC159006.2         216793-216877       c
            746-2775            AC159006.2         213279-215308       c
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 24.6 cM"
     gene            1..2775
                     /gene="Gch1"
                     /gene_synonym="Gch; GTP-CH; GTP-CH-I; GTPCH"
                     /note="GTP cyclohydrolase 1"
                     /db_xref="GeneID:14528"
                     /db_xref="MGI:MGI:95675"
     exon            1..462
                     /gene="Gch1"
                     /gene_synonym="Gch; GTP-CH; GTP-CH-I; GTPCH"
                     /inference="alignment:Splign:2.1.0"
     exon            463..572
                     /gene="Gch1"
                     /gene_synonym="Gch; GTP-CH; GTP-CH-I; GTPCH"
                     /inference="alignment:Splign:2.1.0"
     exon            573..628
                     /gene="Gch1"
                     /gene_synonym="Gch; GTP-CH; GTP-CH-I; GTPCH"
                     /inference="alignment:Splign:2.1.0"
     exon            629..660
                     /gene="Gch1"
                     /gene_synonym="Gch; GTP-CH; GTP-CH-I; GTPCH"
                     /inference="alignment:Splign:2.1.0"
     exon            661..745
                     /gene="Gch1"
                     /gene_synonym="Gch; GTP-CH; GTP-CH-I; GTPCH"
                     /inference="alignment:Splign:2.1.0"
     exon            746..2775
                     /gene="Gch1"
                     /gene_synonym="Gch; GTP-CH; GTP-CH-I; GTPCH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1024..1029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gch1"
                     /gene_synonym="Gch; GTP-CH; GTP-CH-I; GTPCH"
                     /note="hexamer: AATAAA"
     polyA_site      1043
                     /gene="Gch1"
                     /gene_synonym="Gch; GTP-CH; GTP-CH-I; GTPCH"
                     /note="major polyA site"
     regulatory      2755..2760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gch1"
                     /gene_synonym="Gch; GTP-CH; GTP-CH-I; GTPCH"
                     /note="hexamer: ATTAAA"
     polyA_site      2775
                     /gene="Gch1"
                     /gene_synonym="Gch; GTP-CH; GTP-CH-I; GTPCH"
ORIGIN      
        1 agccggcgac tgccctagac tccgagagtg tccctaggtg ctgagcccca gtccgggtga
       61 cggccacagg ttacggccgc cggctaagct gagccgcagc gcttgttagc accctagggt
      121 gtctcgggag cggtcgcgcc gggtccatgg agaagccgcg gggagtcagg tgcaccaatg
      181 ggttctccga gcgggagctg ccgcggcccg gggccagccc gcctgccgag aagtcccggc
      241 cgcccgaggc caagggcgca cagccggccg acgcctggaa ggcagggcgg caccgcagcg
      301 aggaggaaaa ccaggtgaac ctccccaaac tggcggccgc ttactcgtcc attctgctct
      361 cgctgggcga ggacccccag cggcaggggc tgctcaagac gccctggagg gcggccaccg
      421 ccatgcagta cttcaccaag ggataccagg agaccatctc agatgtcctg aatgatgcta
      481 tatttgatga agatcatgac gagatggtga ttgtgaagga catagatatg ttctccatgt
      541 gtgagcatca ccttgttcca tttgtaggaa gggtccatat tggctatctt cctaacaagc
      601 aagtccttgg tctcagtaaa cttgccagga ttgtagaaat ctacagtaga cgactacaag
      661 ttcaagagcg cctcaccaaa cagattgcgg tggccatcac agaagccttg cagcctgctg
      721 gcgttggagt agtgattgaa gcgacacaca tgtgcatggt aatgcgaggc gtgcagaaaa
      781 tgaacagcaa gactgtcact agcaccatgc tgggcgtgtt ccgggaagac cccaagactc
      841 gggaggagtt cctcacacta atcaggagct gagctgagct tccgtgctcg agccctggtt
      901 tgcagacccc gctgctgcgg ctgttatctg tctcagtcgt acattccagt ttcagttggt
      961 acacttgtga actttatgtc tcatcatgaa ttgtatttaa taattattta tatagatacg
     1021 tcaaataaag gtgatcaact aagggtgagc ttccgctttc ttctcgccac cgtcttagtg
     1081 gcaatgttaa agtgaactgc caggagtata ggctatccac agcgactgct gccattcaga
     1141 gcccccaggg atgctgggag gagggggaac gcatgcattt ggttgacata atcactgact
     1201 cattagcaga gggcactggg cattcaagga gccatggcca ctatgctgtt tgctgcctcc
     1261 agtgggcata gtctaacgtt ggagtgctgg agatggtgag gggttcagag agcattgccc
     1321 tctgtgttca gaggcccaca gacaccactc tgttttgatc atgtatgtga agctaccagg
     1381 gacattttct tctttatatt aactgtccag ctataacact agtctctgag ggaaggtggt
     1441 gggatatctg cctttaattt tgctgtgagt taaaaagaca aaattttcac cttctatatt
     1501 ttgaaatttt gagaagggag aatcgctttc tgcagtagtt tattctcatg tcagctacgt
     1561 gcatttaggg ggttgactcg gtgccttggt gagaatatca caccatttgg agagcaggta
     1621 cttccgccat cctttcggac agccgttact tctcaagttt ataagtactg actcggcaca
     1681 tggctgatct cctgtaagaa gttcttggga gtttactttg tctattccat ggagatgctt
     1741 caaaggattt tcaaaaactc gtatgaggta ttttttgcaa ttatttccag gatcttttgg
     1801 aactgccgct cagtcagctc tgtgggttcc cagctcctca caactgccga gagcatagga
     1861 tgatgaggga ggccagggag ctgtgcccac tgctctggac aggccatgct gtggccgttg
     1921 gtgcacagag gacttcggtc tagttctttt cttgttggtg tgtgccttgt cttcagtaca
     1981 agtgtgtcca gaggtgtagc tgtccgagaa gtgtggctac gtaccagtta ccatgtcctc
     2041 cactggggca gtgagggcca aatcaaatcg cagcattctt gctcccctgc aaaaacacaa
     2101 tcatcatagc tgttacaatg aagagttctc cctctggctg acatagtgct ctttaaatga
     2161 attcctgtgg tcttatctac cacttagaca ctcaacagct tatgataaga caagagctgg
     2221 tttttaattt tatttttttt ttcacttcta ctttttccta gcagtttcta tatttagagt
     2281 caggttgatt ttgagtttcc tttgaaatct aacctgatag cagtgttaac ctgctttgct
     2341 atttagacat ttctaggtag aatgctaagt acgtagcctg tgcttggtat tttaaagtta
     2401 acaaaaccag tgtgacttga cttagaggac caaagagatt gttagctata cctttatctt
     2461 tctggggggt tggtcacttg tatcccttct gaacgaccct gttgggtcat tctctagaag
     2521 tgttcttaac aaatgcctga catctccagg ctgtgttctc atcagcgtct gtgtaggggt
     2581 agcctcgtct gtctcaggct cgtctgaagt gtttcaaagt gaccttctca catccatgac
     2641 accgagtaca tttggggaat tcttaggaat ttgatgtaat taaatatact gttcaattac
     2701 actgtgtgga tttactgtat gtatatgtat gttactgaag gttctattta aatgattaaa
     2761 gtgtttttaa ttttg
//
