LOCUS       NM_008101               1929 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glucagon receptor (Gcgr), mRNA.
ACCESSION   NM_008101
VERSION     NM_008101.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1929)
  AUTHORS   Wang,M.Y., Zhang,Z., Zhao,S., Onodera,T., Sun,X.N., Zhu,Q., Li,C.,
            Li,N., Chen,S., Paredes,M., Gautron,L., Charron,M.J.,
            Marciano,D.K., Gordillo,R., Drucker,D.J. and Scherer,P.E.
  TITLE     Downregulation of the kidney glucagon receptor, essential for renal
            function and systemic homeostasis, contributes to chronic kidney
            disease
  JOURNAL   Cell Metab 36 (3), 575-597 (2024)
   PUBMED   38237602
  REMARK    GeneRIF: Downregulation of the kidney glucagon receptor, essential
            for renal function and systemic homeostasis, contributes to chronic
            kidney disease.
REFERENCE   2  (bases 1 to 1929)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1929)
  AUTHORS   Srivastava,S.P. and Goodwin,J.E.
  TITLE     Loss of endothelial glucocorticoid receptor accelerates organ
            fibrosis in db/db mice
  JOURNAL   Am J Physiol Renal Physiol 325 (4), F519-F526 (2023)
   PUBMED   37589053
  REMARK    GeneRIF: Loss of endothelial glucocorticoid receptor accelerates
            organ fibrosis in db/db mice.
REFERENCE   4  (bases 1 to 1929)
  AUTHORS   Yuan,H., Kang,Q., Li,Z., Bai,X., Jia,J., Han,D., Wu,X. and Li,M.
  TITLE     Crispr-Cas9 mediated complete deletion of glucagon receptor in mice
            display hyperglucagonemia and alpha-cell hyperplasia
  JOURNAL   Biochem Biophys Res Commun 643, 121-128 (2023)
   PUBMED   36596263
REFERENCE   5  (bases 1 to 1929)
  AUTHORS   Galsgaard,K.D., Elmelund,E., Johansen,C.D., Bomholt,A.B.,
            Kizilkaya,H.S., Ceutz,F., Hunt,J.E., Kissow,H.,
            Winther-Sorensen,M., Sorensen,C.M., Kruse,T., Lau,J.F.,
            Rosenkilde,M.M., Orskov,C., Christoffersen,C., Holst,J.J. and Wewer
            Albrechtsen,N.J.
  TITLE     Glucagon receptor antagonism impairs and glucagon receptor agonism
            enhances triglycerides metabolism in mice
  JOURNAL   Mol Metab 66, 101639 (2022)
   PUBMED   36400402
  REMARK    GeneRIF: Glucagon receptor antagonism impairs and glucagon receptor
            agonism enhances triglycerides metabolism in mice.
REFERENCE   6  (bases 1 to 1929)
  AUTHORS   Burcelin,R., Mrejen,C., Decaux,J.F., De Mouzon,S.H., Girard,J. and
            Charron,M.J.
  TITLE     In vivo and in vitro regulation of hepatic glucagon receptor mRNA
            concentration by glucose metabolism
  JOURNAL   J Biol Chem 273 (14), 8088-8093 (1998)
   PUBMED   9525910
REFERENCE   7  (bases 1 to 1929)
  AUTHORS   Yamato,E., Ikegami,H., Takekawa,K., Fujisawa,T., Nakagawa,Y.,
            Hamada,Y., Ueda,H. and Ogihara,T.
  TITLE     Tissue-specific and glucose-dependent expression of receptor genes
            for glucagon and glucagon-like peptide-1 (GLP-1)
  JOURNAL   Horm Metab Res 29 (2), 56-59 (1997)
   PUBMED   9105899
REFERENCE   8  (bases 1 to 1929)
  AUTHORS   Burcelin,R., Li,J. and Charron,M.J.
  TITLE     Cloning and sequence analysis of the murine glucagon
            receptor-encoding gene
  JOURNAL   Gene 164 (2), 305-310 (1995)
   PUBMED   7590348
REFERENCE   9  (bases 1 to 1929)
  AUTHORS   Kershaw,E.E., Chua,S.C. Jr. and Leibel,R.L.
  TITLE     Localization of a (CA)n repeat in glucagon-like peptide-1 receptor
            gene (Glp1r) to proximal mouse chromosome 17 and its linkage to
            other markers
  JOURNAL   Mamm Genome 6 (4), 301-303 (1995)
   PUBMED   7613039
REFERENCE   10 (bases 1 to 1929)
  AUTHORS   Campos,R.V., Lee,Y.C. and Drucker,D.J.
  TITLE     Divergent tissue-specific and developmental expression of receptors
            for glucagon and glucagon-like peptide-1 in the mouse
  JOURNAL   Endocrinology 134 (5), 2156-2164 (1994)
   PUBMED   8156917
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB869050.1, AK144393.1, AK004890.1 and AV354937.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_008101.3.
            
            On Nov 14, 2007 this sequence version replaced NM_008101.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144393.1, BC057988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BB869050.1         2-8
            8-53                BB869050.1         9-54
            54-1445             AK144393.1         1-1392
            1446-1928           AK004890.1         2021-2503
            1929-1929           AV354937.1         226-226
FEATURES             Location/Qualifiers
     source          1..1929
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.24 cM"
     gene            1..1929
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /note="glucagon receptor"
                     /db_xref="GeneID:14527"
                     /db_xref="MGI:MGI:99572"
     exon            1..107
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     exon            108..247
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1642
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /note="GL-R"
                     /codon_start=1
                     /product="glucagon receptor precursor"
                     /protein_id="NP_032127.2"
                     /db_xref="CCDS:CCDS25739.1"
                     /db_xref="GeneID:14527"
                     /db_xref="MGI:MGI:99572"
                     /translation="MPLTQLHCPHLLLLLLVLSCLPEAPSAQVMDFLFEKWKLYSDQC
                     HHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCG
                     PDGQWVRGPRGQPWRNASQCQLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLA
                     LVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLS
                     DGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAP
                     LLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVFLALLINFFIFVHIIHLLVAKL
                     RAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFLSSF
                     QGLLVAVLYCFLNKEVQAELMRRWRQWQEGKALQEERLASSHGSHMAPAGPCHGDPCE
                     KLQLMSAGSSSGTGCVPSMETSLASSLPRLADSPT"
     exon            248..350
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     exon            351..458
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     exon            459..580
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     exon            581..687
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     exon            688..844
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1004
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1065
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1135
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1224
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1363
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1405
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1929
                     /gene="Gcgr"
                     /gene_synonym="GR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1929
                     /gene="Gcgr"
                     /gene_synonym="GR"
ORIGIN      
        1 gccgaccccg atcacagcgc ggccgaggcg agcagtcgcc ggcgcccaga tccgagtacg
       61 ctcgaggacc gcgaggagcg cagccctagc cccggcgact gagcacacct gaggagaggt
      121 gcacacactc tgaggaccta ggtgtgcaac ctctgccaga tgtggggcgt ggctacccag
      181 aggcatgccc ctcacccagc tccactgtcc ccacctgctg ctgctgctgt tggtgctgtc
      241 atgtctgcca gaggcaccct ctgcccaggt aatggacttt ttgtttgaga agtggaagct
      301 ctatagtgac caatgccacc acaacctaag cctgctgccc ccacctactg agctggtctg
      361 taacagaacc ttcgacaagt actcctgctg gcctgacacc cctcccaaca ccactgccaa
      421 catttcctgc ccctggtacc taccttggta ccacaaagtg cagcaccgcc tagtgttcaa
      481 gaggtgtggg cccgatgggc agtgggttcg agggccacgg gggcagccgt ggcgcaacgc
      541 ctcccaatgt cagttggatg atgaagagat cgaggtccag aagggggtgg ccaagatgta
      601 tagcagccag caggtgatgt acaccgtggg ctacagtctg tccctggggg ccttgctcct
      661 tgcgctggtc atcctgctgg gcctcaggaa gctgcactgc acccgaaact acatccatgg
      721 gaacctgttt gcgtcctttg tgctcaaggc tggctctgtg ttggtcatcg attggctgct
      781 gaagacacgg tacagccaga agattggcga tgacctcagt gtgagcgtct ggctcagtga
      841 cggggcgatg gccggctgca gagtggccac agtgatcatg cagtacggca tcatagccaa
      901 ctattgctgg ttgctggtag agggcgtgta cctgtacagc ctgctgagcc ttgccacctt
      961 ctctgagagg agcttctttt ccctctacct gggcattggc tggggtgcgc ccctgctgtt
     1021 tgtcatcccc tgggtggtgg tcaagtgtct gtttgagaat gttcagtgct ggaccagcaa
     1081 tgacaacatg ggattctggt ggatcctgcg tattcctgtc ttcctggcct tactgatcaa
     1141 ttttttcatc tttgtccaca tcattcacct tcttgtggcc aagctgcgtg cccatcagat
     1201 gcactatgct gactataagt tccggctggc caggtccacg ctgaccctca tccctctgct
     1261 gggggtccac gaggtggtct ttgcctttgt gactgacgag catgcccaag gcaccctgcg
     1321 ctccaccaag ctcttttttg acctgttcct cagctccttc cagggtctgc tggtggctgt
     1381 tctctactgt ttcctcaaca aggaggtgca ggcagagctg atgcggcgtt ggaggcaatg
     1441 gcaagaaggc aaagctcttc aggaggaaag gttggccagc agccatggca gccacatggc
     1501 cccagcaggg ccttgtcatg gtgatccctg tgagaaactt cagcttatga gtgcaggcag
     1561 cagcagtggg actggctgtg tgccctctat ggagacctcg ctggccagta gtctcccaag
     1621 gttggctgac agccccacct gaatctccac tggagcctag ccaggctgcg ttcagaaagg
     1681 gcctcagagg acaacccaga gccagatgcc cggccaaggc tgaagagaca aagcagcaag
     1741 acagcagctt gtactgtgca cactccccta acctgtccta gcctggcaca ggccacagtg
     1801 acagagtagg ggttggatat gatggagaag ccatgttatc tatgaactct gagtgttccc
     1861 atgtgtgttg acatggtccc tgtacccaga tatgtccttc agtaaaaagc tcgagtggga
     1921 gctgctgca
//
