LOCUS       NM_001044744            2140 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus glutaryl-Coenzyme A dehydrogenase (Gcdh), transcript
            variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001044744
VERSION     NM_001044744.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2140)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2140)
  AUTHORS   Barzi,M., Johnson,C.G., Chen,T., Rodriguiz,R.M., Hemmingsen,M.,
            Gonzalez,T.J., Rosales,A., Beasley,J., Peck,C.K., Ma,Y.,
            Stiles,A.R., Wood,T.C., Maeso-Diaz,R., Diehl,A.M., Young,S.P.,
            Everitt,J.I., Wetsel,W.C., Lagor,W.R., Bissig-Choisat,B.,
            Asokan,A., El-Gharbawy,A. and Bissig,K.D.
  TITLE     Rescue of glutaric aciduria type I in mice by liver-directed
            therapies
  JOURNAL   Sci Transl Med 15 (692), eadf4086 (2023)
   PUBMED   37075130
REFERENCE   3  (bases 1 to 2140)
  AUTHORS   Seminotti,B., Brondani,M., Ribeiro,R.T., Leipnitz,G. and Wajner,M.
  TITLE     Disturbance of Mitochondrial Dynamics, Endoplasmic
            Reticulum-Mitochondria Crosstalk, Redox Homeostasis, and
            Inflammatory Response in the Brain of Glutaryl-CoA
            Dehydrogenase-Deficient Mice: Neuroprotective Effects of
            Bezafibrate
  JOURNAL   Mol Neurobiol 59 (8), 4839-4853 (2022)
   PUBMED   35639256
  REMARK    GeneRIF: Disturbance of Mitochondrial Dynamics, Endoplasmic
            Reticulum-Mitochondria Crosstalk, Redox Homeostasis, and
            Inflammatory Response in the Brain of Glutaryl-CoA
            Dehydrogenase-Deficient Mice: Neuroprotective Effects of
            Bezafibrate.
REFERENCE   4  (bases 1 to 2140)
  AUTHORS   Bhatt,D.P., Mills,C.A., Anderson,K.A., Henriques,B.J., Lucas,T.G.,
            Francisco,S., Liu,J., Ilkayeva,O.R., Adams,A.E., Kulkarni,S.R.,
            Backos,D.S., Major,M.B., Grimsrud,P.A., Gomes,C.M. and
            Hirschey,M.D.
  TITLE     Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme
            SIRT5 promotes lysine oxidation in mice
  JOURNAL   J Biol Chem 298 (4), 101723 (2022)
   PUBMED   35157847
REFERENCE   5  (bases 1 to 2140)
  AUTHORS   Leandro,J., Bender,A., Dodatko,T., Argmann,C., Yu,C. and
            Houten,S.M.
  TITLE     Glutaric aciduria type 3 is a naturally occurring biochemical trait
            in inbred mice of 129 substrains
  JOURNAL   Mol Genet Metab 132 (2), 139-145 (2021)
   PUBMED   33483254
REFERENCE   6  (bases 1 to 2140)
  AUTHORS   Kawamoto,S., Matsumoto,Y., Mizuno,K., Okubo,K. and Matsubara,K.
  TITLE     Expression profiles of active genes in human and mouse livers
  JOURNAL   Gene 174 (1), 151-158 (1996)
   PUBMED   8863742
REFERENCE   7  (bases 1 to 2140)
  AUTHORS   Beccari,T., Appolloni,M.G., Stirling,J.L. and Orlacchio,A.
  TITLE     Assignment of lysosomal alpha-D-mannosidase to mouse chromosome 8
  JOURNAL   Mamm Genome 7 (9), 707-708 (1996)
   PUBMED   8829553
REFERENCE   8  (bases 1 to 2140)
  AUTHORS   Swartz,D.A., Park,E.I., Visek,W.J. and Kaput,J.
  TITLE     The e subunit gene of murine F1F0-ATP synthase. Genomic sequence,
            chromosomal mapping, and diet regulation
  JOURNAL   J Biol Chem 271 (34), 20942-20948 (1996)
   PUBMED   8702853
REFERENCE   9  (bases 1 to 2140)
  AUTHORS   Hwang,S., Benjamin,L.E., Oh,B., Rothstein,J.L., Ackerman,S.L.,
            Beddington,R.S., Solter,D. and Knowles,B.B.
  TITLE     Genetic mapping and embryonic expression of a novel, maternally
            transcribed gene Mem3
  JOURNAL   Mamm Genome 7 (8), 586-590 (1996)
   PUBMED   8678978
REFERENCE   10 (bases 1 to 2140)
  AUTHORS   Koeller,D.M., DiGiulio,K.A., Angeloni,S.V., Dowler,L.L.,
            Frerman,F.E., White,R.A. and Goodman,S.I.
  TITLE     Cloning, structure, and chromosome localization of the mouse
            glutaryl-CoA dehydrogenase gene
  JOURNAL   Genomics 28 (3), 508-512 (1995)
   PUBMED   7490088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161765.5, AU080952.1, AK078866.1 and AI181022.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.5071062.1,
                                           SRR1660813.254625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC161765.5         161145-161287       c
            144-705             AU080952.1         1-562
            706-2114            AK078866.1         316-1724
            2115-2140           AI181022.1         21-46               c
FEATURES             Location/Qualifiers
     source          1..2140
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.28 cM"
     gene            1..2140
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /note="glutaryl-Coenzyme A dehydrogenase"
                     /db_xref="GeneID:270076"
                     /db_xref="MGI:MGI:104541"
     exon            1..180
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /inference="alignment:Splign:2.1.0"
     exon            181..310
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1527
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /EC_number="1.3.8.6"
                     /codon_start=1
                     /product="glutaryl-CoA dehydrogenase, mitochondrial"
                     /protein_id="NP_001038209.2"
                     /db_xref="CCDS:CCDS22482.2"
                     /db_xref="GeneID:270076"
                     /db_xref="MGI:MGI:104541"
                     /translation="MVPAMLTGYMSLRGVSARLLSRRSGLRFPRFPRTWSSAAAHTEK
                     TQIRPAKSSRPVFDWKDPLILEEQLTADEKLIRDTFRNYCQERLMSRILLANRNEVFH
                     RDIVYEMGELGVLGPTIKGYGCAGVSSVAYGLLTRELERVDSGYRSMMSVQSSLVMHP
                     IYTYGSEEQRQKYLPGLAKGELLGCFGLTEPNHGSDPGGMETRARHNPSNQSYTLSGT
                     KTWITNSPVADLFIVWARCEDNCIRGFILEKGMRGLSAPRIEGKFSLRASATGMIIMD
                     SVEVPEENVLPNVSSLAGPFGCLNTARYGITWGVLGAAEFCLHTARQYALDRIQFGVP
                     LARNQLVQKKLADMLTEITLGLHACLQLGRLKDQDKATPEMVSMLKRNNCGKALDIAR
                     QARDILGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTVGK"
     exon            311..337
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /inference="alignment:Splign:2.1.0"
     exon            338..481
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /inference="alignment:Splign:2.1.0"
     exon            482..544
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /inference="alignment:Splign:2.1.0"
     exon            545..715
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /inference="alignment:Splign:2.1.0"
     exon            716..845
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1062
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1166
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1292
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1453
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..2120
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1901..1906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /note="hexamer: AATAAA"
     polyA_site      1926
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /note="major polyA site"
     regulatory      2101..2106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
                     /note="hexamer: AATAAA"
     polyA_site      2120
                     /gene="Gcdh"
                     /gene_synonym="9030411L18; GCD"
ORIGIN      
        1 aaaggagaga cctgcctggg catggaagaa cccgcttgca aaaccaggca gctgccttgg
       61 ctcttttaaa aggcagagcc acagaggagg cggtgttctg ggaggaacca aggaggaacc
      121 aatgagcaac ccctattagg cctagtgtgc tggtcccgga gcacagcccg caagcaccag
      181 gttatggttc ctgcaatgct caccggctac atgtccctga gaggagtctc cgcgcggttg
      241 ctgagccgca ggtccggcct gcgcttcccg cgttttccac gtacctggag ctcggcggcc
      301 gcccacaccg agaagacaca gatccgaccg gccaaatcct ctcgccccgt gtttgactgg
      361 aaggacccac tcatactgga ggagcagctg actgccgatg agaaactgat cagggacacc
      421 ttccgtaact actgccagga gcggcttatg tctcgaattc tgctggctaa tcgaaatgaa
      481 gtttttcaca gggacattgt gtatgagatg ggggagctgg gcgtgttggg acccaccatt
      541 aaagggtatg gctgtgctgg tgtgtcgtcg gtggcctatg ggctcctgac ccgagagctt
      601 gagagggtgg acagtggcta caggtcgatg atgagtgttc agtcctccct tgtcatgcac
      661 cccatctata cctatgggag cgaggaacag cgacagaaat atctgcccgg actggccaag
      721 ggtgaacttc tgggctgctt tggacttaca gagcccaacc atgggagtga cccaggtggc
      781 atggagacca gagctcgcca caatccatca aaccagagct acactctcag tgggaccaag
      841 acctggatca ccaactcccc tgtggctgac ctatttatag tgtgggctcg gtgtgaggat
      901 aactgtattc ggggcttcat actggagaag ggtatgcggg gcctctcagc ccctaggatt
      961 gaaggaaagt tctccttgcg ggcctcggct accggtatga tcatcatgga cagtgtggaa
     1021 gtgcctgagg agaatgtgct gcctaatgta tccagcctgg cgggcccttt tggctgcctt
     1081 aacactgccc gctatggcat cacatggggt gtgttgggag ctgctgagtt ctgtttgcac
     1141 acagcccggc agtatgccct agacaggatc cagtttggag tccccttggc caggaaccag
     1201 ctggttcaga agaagttggc agacatgctc actgagatca cactgggact ccatgcttgt
     1261 ttgcaacttg gccgtttaaa ggatcaggac aaggctaccc cagagatggt ctccatgttg
     1321 aagagaaaca actgtggaaa agccctggat attgcccgcc aggcacgaga catcctggga
     1381 ggaaatggga tttctgatga gtaccatgtc atccggcatg ctatgaatct ggaggcagtg
     1441 aacacttatg aaggtacaca tgacattcat gctctgatcc ttgggagagc aattactggg
     1501 attcaggcat tcacggttgg caagtgaaac tacttcaaca gagaaatact ttgccctgag
     1561 tctgctcaag aagaaatgta tggacacaac ttttatggtg gaaagtgaga cactgatttg
     1621 agattcagga catttctttc tggaagacat tcagatatgc tctatagaaa gaagatgaaa
     1681 ttaattctct gtatggccct cagccctttt taactggatg aaatcagcct ccacctaccc
     1741 tgttttaagt tttttggaac tgggtgagac aaaggggagt aacacaggag ccactgagat
     1801 ggagcagacc ttgtgagaag gtgcaatgga ctttacagtt taccttgcct ctatcccagg
     1861 ggcagtgcct tctatgtgca ctgaacagat aagagatgaa aataaagagc ctgtgcctta
     1921 ctcctaggac tggactaggt ctactggtaa ccatggagag gtggtttggg gaatttctca
     1981 taggagggat aaacatgcct gggggttgtg ccatgctgga atagcacaca gagtttgagc
     2041 tagacattct gactggcagg ggacactttg tcctttccct catgacacag ctaactacac
     2101 aataaacaac atggacaata aaaaaaaaaa aaaaaaaaaa
//
