LOCUS       NM_145523               3288 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus grancalcin (Gca), mRNA.
ACCESSION   NM_145523
VERSION     NM_145523.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3288)
  AUTHORS   Su,T., He,Y., Wang,M., Zhou,H., Huang,Y., Ye,M., Guo,Q., Xiao,Y.,
            Cai,G., Zhao,M., Wang,J. and Luo,X.
  TITLE     Macrophage-Hepatocyte Circuits Mediated by Grancalcin Aggravate the
            Progression of Metabolic Dysfunction Associated Steatohepatitis
  JOURNAL   Adv Sci (Weinh) 11 (42), e2406500 (2024)
   PUBMED   39279458
REFERENCE   2  (bases 1 to 3288)
  AUTHORS   Xiang,P., Jiang,M., Chen,X., Chen,L., Cheng,Y., Luo,X., Zhou,H. and
            Zheng,Y.
  TITLE     Targeting Grancalcin Accelerates Wound Healing by Improving
            Angiogenesis in Diabetes
  JOURNAL   Adv Sci (Weinh) 11 (14), e2305856 (2024)
   PUBMED   38308197
REFERENCE   3  (bases 1 to 3288)
  AUTHORS   Su,T., He,Y., Huang,Y., Ye,M., Guo,Q., Xiao,Y., Cai,G., Chen,L.,
            Li,C., Zhou,H. and Luo,X.
  TITLE     Myeloid-derived grancalcin instigates obesity-induced insulin
            resistance and metabolic inflammation in male mice
  JOURNAL   Nat Commun 15 (1), 97 (2024)
   PUBMED   38167327
  REMARK    GeneRIF: Myeloid-derived grancalcin instigates obesity-induced
            insulin resistance and metabolic inflammation in male mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3288)
  AUTHORS   Li,C.J., Xiao,Y., Sun,Y.C., He,W.Z., Liu,L., Huang,M., He,C.,
            Huang,M., Chen,K.X., Hou,J., Feng,X., Su,T., Guo,Q., Huang,Y.,
            Peng,H., Yang,M., Liu,G.H. and Luo,X.H.
  TITLE     Senescent immune cells release grancalcin to promote skeletal aging
  JOURNAL   Cell Metab 33 (10), 1957-1973 (2021)
   PUBMED   34614408
  REMARK    Erratum:[Cell Metab. 2022 Jan 4;34(1):184-185. doi:
            10.1016/j.cmet.2021.12.003.. PMID: 34986333]
REFERENCE   5  (bases 1 to 3288)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3288)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 3288)
  AUTHORS   Liu,F., Shinomiya,H., Kirikae,T., Hirata,H. and Asano,Y.
  TITLE     Characterization of murine grancalcin specifically expressed in
            leukocytes and its possible role in host defense against bacterial
            infection
  JOURNAL   Biosci Biotechnol Biochem 68 (4), 894-902 (2004)
   PUBMED   15118320
  REMARK    GeneRIF: findings suggest that grancalcin plays a key role in
            leukocyte-specific functions that are responsible for host defense
REFERENCE   8  (bases 1 to 3288)
  AUTHORS   Roes,J., Choi,B.K., Power,D., Xu,P. and Segal,A.W.
  TITLE     Granulocyte function in grancalcin-deficient mice
  JOURNAL   Mol Cell Biol 23 (3), 826-830 (2003)
   PUBMED   12529388
  REMARK    GeneRIF: Homozygous Gca mutants appeared healthy and reproduced
            normally. Leukocyte recruitment into the peritoneal cavity upon
            induction of inflammation was not significantly affected by the
            absence of grancalcin.
REFERENCE   9  (bases 1 to 3288)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3288)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK078915.1.
            
            On Apr 6, 2007 this sequence version replaced NM_145523.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078915.1, SRR1660811.58418.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3288              AK078915.1         2-3289
FEATURES             Location/Qualifiers
     source          1..3288
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 36.47 cM"
     gene            1..3288
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /note="grancalcin"
                     /db_xref="GeneID:227960"
                     /db_xref="MGI:MGI:1918521"
     exon            1..133
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..769
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /codon_start=1
                     /product="grancalcin"
                     /protein_id="NP_663498.1"
                     /db_xref="CCDS:CCDS16069.1"
                     /db_xref="GeneID:227960"
                     /db_xref="MGI:MGI:1918521"
                     /translation="MAYPGYGGAFGNFSGQIPGMQMQMGQPMPGAGPNMFSGGYPGYL
                     GYSDSYSPADDSMWTYFTAVAGQDGEVDAEELQRCLTQSGISGTYAPFSLETCRIMIA
                     MLDRDYTGKMGFNEFKELWAALNAWKQNFMTIDQDQSGTVEHHELSQAIALMGYRLSP
                     QTLAAIVRRYSKNGRIFFDDYVACCVKLRALTDFFRRRDHLQQGIVNFMYEDFLQGTM
                     TI"
     exon            134..307
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            308..377
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            378..421
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            422..569
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            570..683
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            684..742
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            743..3288
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2652..2657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2679
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /note="major polyA site"
     regulatory      3144..3149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3165
                     /gene="Gca"
                     /gene_synonym="5133401E04Rik"
                     /note="major polyA site"
ORIGIN      
        1 actgcgctcg gaccttccgc acctgtcgca cgcacttgcg ctttccccgc tctaagccgc
       61 gctgacgctg acttactggt gacgcgttac tttcgatcgc ctggtcatgg cctacccggg
      121 atacggaggg gcgtttggaa acttcagtgg tcagattcca ggcatgcaaa tgcagatggg
      181 ccagccaatg ccaggggcag gtcccaatat gttctctggt ggctaccctg gatacctggg
      241 ttattctgac agctactccc ctgccgacga ctccatgtgg acttatttca cagctgttgc
      301 tggtcaggat ggtgaggtgg atgctgagga actgcagaga tgcttgaccc agtctggaat
      361 tagtggaact tacgcacctt tcagtttgga aacctgcaga attatgattg ccatgttgga
      421 tagagactac acaggaaaaa tggggttcaa cgaattcaag gagctttggg ccgctcttaa
      481 tgcctggaag cagaacttca tgaccattga ccaagatcaa agtggcacgg tagaacatca
      541 tgagctgagt caagccatcg ctcttatggg ctacaggttg agtccacaga cattagctgc
      601 aattgtcaga cgctacagca agaatggccg gattttcttt gatgactatg ttgcctgctg
      661 tgtgaagctg cgcgccctga cagatttctt taggcgaaga gaccacttgc aacaagggat
      721 tgtgaatttc atgtatgaag attttttgca gggcactatg acaatttgaa agcctagcat
      781 tccaaaggcg gagacagact gcgaatcctt ctgcttcatt gaaacagact ggactaccta
      841 aaattgaaag ctcgcggaac tgttttgtat accttcctgt gaaagctccc cgccctttct
      901 gttatttaac cttaaagcac agttcaatgc aataactttt ttatttggaa tatattattt
      961 ttggaaaagt tatgacattg cagatatatg cacgctctct tgaaatgttg ctaatggtat
     1021 gtagctaact gatcccagca tacctgagcc ttagttctta acaataaagc atagcagaat
     1081 gtagtcacat gacagattgt ctactaagcc aaataacgaa agtctagata aaacttttat
     1141 attatctaaa ggctacaagt tatacttgtg atgttgtttg tgtctgtggg tgtttctagg
     1201 agtgagtcag aggggacagc tgcactttgt gctgtctttt gggttttgat taaaccatca
     1261 gaggacatag cacatgttcg tggccagtga actgtagttc ctaagacttt atcgttcttt
     1321 gggtctgtca gcctagagta gtagtaggta ttgtttcacc tattttttat tgcattattt
     1381 ttgtacaata tgttttattg tcttcccaca attgtttttg ttttcaactt ctctgttttc
     1441 atttagctgt gttttgtgag acagggtctt tctacatagc ccagtgtgac acaaattcat
     1501 ggtcttcctt tcttgtccct cattgtttgt agaaattcaa gacttgcaca cccttgccca
     1561 tactaaaaat tccaatgaag atgcttttct ctttcattag tgaaggccca ggtaacctaa
     1621 aatgtcaacc gtccctgaat cccgcagctc agaggagcag cacacattag tgctgggtca
     1681 gcattcattc acgtttgttc agttaaagcc aggttctgct cctagttaat ggcaacagtt
     1741 tataaagcaa accaagtgat ctgcctctgt taactgttca gaaattctgt gttggattgg
     1801 tagtatggac taatttatgt gtgcctgttt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     1861 gtgtgtgtgt gccaagtagt gttttgactt ttttcttttt ttttttataa aattataaaa
     1921 ttatcctcct cctcccattc gtccacttcc ctttcctcct cttcttcctt ttccccctct
     1981 ttttcctcct cttcttcctc ttcctcctcc tcctccttct tgttccatag gcagtgtttt
     2041 tggtgaaatt ttctatagag atttcagtgg ttaccgggtt ctttgcatta agttgtctga
     2101 tctaagatgt cagagttaat ttggtttctg aattttcgta tattttaact gaatatattc
     2161 tagctgaatt ctgatgcaaa tagatataat tttagtgtag ctggtgacca aattaaatat
     2221 ttaagaaaga actccatgat ttttaaaaat atttttaaaa gaaaactcca caaaagtgca
     2281 agctcttttt ataaatacag aaaacttaaa atcagctttt acttcaaaag atcctgaaaa
     2341 ggaaatgatg tctaatcatt ttgatattga ttactatgta acttgccatc aatctggata
     2401 cttggttatt gtgtaagaat agatcaatga ataatgcata cacattgtcc tctgacaatt
     2461 tgttcatgac cacatagtca gtagcctgaa ggaatattaa gggaaccatt gaaggtacag
     2521 aatctgaagc tgtcatagaa aacagaagcc acaccatgat gttgtaagtc attgagcagt
     2581 gtacactctt aatgtataag tgcttttatt tatacagtaa acatgtttcc atgtcatttt
     2641 gagaattttt taataaacat tcaaatagct tgctgtaaag ttttgtatca tacaaaattt
     2701 gttacatata tactgcaatg agatgcctca gttcaaacaa cggtgcatta attcagctat
     2761 tatctaaaag attgccaaat ggttaaatgc caggtattgc acttctagtg tgagtggcag
     2821 tttacacact ttaaattaca tcaagggaaa atcaatacta tgagaatctt gatttggtcc
     2881 actttaaatg tatttttaag gactgtgctc attaacctat tttaggcatg cattcagaaa
     2941 aaagaaagtt aacaaatata tattcaagtt atatatttat ttccagaaaa agcatttagc
     3001 ctggaagaaa gtagaattta tcaaggtagt ttaaactctg tgcaattaaa aaaataagaa
     3061 aatcaatttg tgatagttct ttaattaaaa tatacaaatc aagtccactt gtaatcttat
     3121 gatagtactg attgaacaaa caaaataaat actattcgtg agaaatgtgc ttttttaaat
     3181 gttcttttct gtttgacaaa ctaaagtgga tatgttttgt cttgtttcat taacaacttc
     3241 ctgtaaattt gataggaata tgttttttaa agtttgtaaa ttgaaccc
//
