LOCUS       NM_010262               2126 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus gastrulation brain homeobox 2 (Gbx2), mRNA.
ACCESSION   NM_010262
VERSION     NM_010262.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2126)
  AUTHORS   Assali,A., Chenaux,G., Cho,J.Y., Berto,S., Ehrlich,N.A. and
            Cowan,C.W.
  TITLE     EphB1 controls long-range cortical axon guidance through a cell
            non-autonomous role in GABAergic cells
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38345254
REFERENCE   2  (bases 1 to 2126)
  AUTHORS   de Lope,C., Garcia-Lucena,R., Magarinos,M., Leon,Y.,
            Casa-Rodriguez,N., Contreras,N., Escudero-Iriarte,C.,
            Varela-Nieto,I., Maire,P. and Palmero,I.
  TITLE     Dysfunction of programmed embryo senescence is linked to genetic
            developmental defects
  JOURNAL   Development 150 (9) (2023)
   PUBMED   37017267
REFERENCE   3  (bases 1 to 2126)
  AUTHORS   Ahmed,N.Y., Knowles,R., Liu,L., Yan,Y., Li,X., Schumann,U.,
            Wang,Y., Sontani,Y., Reynolds,N., Natoli,R., Wen,J., Del Pino,I.,
            Mi,D. and Dehorter,N.
  TITLE     Developmental deficits of MGE-derived interneurons in the Cntnap2
            knockout mouse model of autism spectrum disorder
  JOURNAL   Front Cell Dev Biol 11, 1112062 (2023)
   PUBMED   36819097
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2126)
  AUTHORS   Govek,K.W., Chen,S., Sgourdou,P., Yao,Y., Woodhouse,S., Chen,T.,
            Fuccillo,M.V., Epstein,D.J. and Camara,P.G.
  TITLE     Developmental trajectories of thalamic progenitors revealed by
            single-cell transcriptome profiling and Shh perturbation
  JOURNAL   Cell Rep 41 (10), 111768 (2022)
   PUBMED   36476860
REFERENCE   5  (bases 1 to 2126)
  AUTHORS   van de Haar,L.L., Riga,D., Boer,J.E., Garritsen,O., Adolfs,Y.,
            Sieburgh,T.E., van Dijk,R.E., Watanabe,K., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Posthuma,D., Meye,F.J., Basak,O. and
            Pasterkamp,R.J.
  TITLE     Molecular signatures and cellular diversity during mouse habenula
            development
  JOURNAL   Cell Rep 40 (1), 111029 (2022)
   PUBMED   35793630
REFERENCE   6  (bases 1 to 2126)
  AUTHORS   Bouillet,P., Chazaud,C., Oulad-Abdelghani,M., Dolle,P. and
            Chambon,P.
  TITLE     Sequence and expression pattern of the Stra7 (Gbx-2)
            homeobox-containing gene induced by retinoic acid in P19 embryonal
            carcinoma cells
  JOURNAL   Dev Dyn 204 (4), 372-382 (1995)
   PUBMED   8601031
REFERENCE   7  (bases 1 to 2126)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
REFERENCE   8  (bases 1 to 2126)
  AUTHORS   Chapman,G. and Rathjen,P.D.
  TITLE     Sequence and evolutionary conservation of the murine Gbx-2 homeobox
            gene
  JOURNAL   FEBS Lett 364 (3), 289-292 (1995)
   PUBMED   7758585
REFERENCE   9  (bases 1 to 2126)
  AUTHORS   Bulfone,A., Puelles,L., Porteus,M.H., Frohman,M.A., Martin,G.R. and
            Rubenstein,J.L.
  TITLE     Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and
            Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential
            transverse and longitudinal segmental boundaries
  JOURNAL   J Neurosci 13 (7), 3155-3172 (1993)
   PUBMED   7687285
REFERENCE   10 (bases 1 to 2126)
  AUTHORS   Murtha,M.T., Leckman,J.F. and Ruddle,F.H.
  TITLE     Detection of homeobox genes in development and evolution
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10711-10715 (1991)
   PUBMED   1720547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124227.21.
            
            On Mar 21, 2007 this sequence version replaced NM_010262.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z48800.1, L39770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-944               AC124227.21        119595-120538
            945-2126            AC124227.21        121628-122809
FEATURES             Location/Qualifiers
     source          1..2126
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 45.06 cM"
     gene            1..2126
                     /gene="Gbx2"
                     /gene_synonym="D130058E05Rik; Gbx-2; MMoxA; Stra7"
                     /note="gastrulation brain homeobox 2"
                     /db_xref="GeneID:14472"
                     /db_xref="MGI:MGI:95668"
     exon            1..944
                     /gene="Gbx2"
                     /gene_synonym="D130058E05Rik; Gbx-2; MMoxA; Stra7"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..1468
                     /gene="Gbx2"
                     /gene_synonym="D130058E05Rik; Gbx-2; MMoxA; Stra7"
                     /note="stimulated by retinoic acid gene 7 protein;
                     gastrulation and brain-specific homeobox protein 2"
                     /codon_start=1
                     /product="homeobox protein GBX-2"
                     /protein_id="NP_034392.1"
                     /db_xref="CCDS:CCDS15150.1"
                     /db_xref="GeneID:14472"
                     /db_xref="MGI:MGI:95668"
                     /translation="MSAAFPPSLMMMQRPLGSSTAFSIDSLIGSPPQPSPGHFVYTGY
                     PMFMPYRPVVLPPPPPPPPALPQAALQPALPPAHPHHQIPSLPTGFCSSLAQGMALTS
                     TLMATLPGGFSASPQHQEAAAARKFAPQPLPGGGNFDKAEALQADAEDGKAFLAKEGS
                     LLAFSAAEAVQASLVGAVRGQGKDESKVEDDPKGKEESFSLESDVDYSSDDNLPGQTA
                     HKEEDPGHALEETPQSGGAAGSTTSTGKNRRRRTAFTSEQLLELEKEFHCKKYLSLTE
                     RSQIAHALKLSEVQVKIWFQNRRAKWKRVKAGNANSKTGEPSRNPKIVVPIPVHVSRF
                     AIRSQHQQLEQARP"
     exon            945..2126
                     /gene="Gbx2"
                     /gene_synonym="D130058E05Rik; Gbx-2; MMoxA; Stra7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcccgcc agagacaagt gcgccggctt cgcgcgctcc ccagccgccc gtgggagacg
       61 acggactgca ggacggacag acggacggac gcacgcactg ctggtagctg ggccgagacc
      121 tgcagacgcg aagcgcgcgc gttccgacgg gctagcagcc gggagcggtt ccggcgaacg
      181 cgaggtcccc ggcgccctct ccatcccggg cgcacggcct catcgcgctc ggtggctgca
      241 cccgtgcagg ccgggtatgc tgcgggtcct gcactgaggg gcggcggcgg cgtctgcgct
      301 ctgggcaccg ctcagcccct gcccggagtt cccggtggta ctcccagcgt ccggagggct
      361 tccaggcggc ggcgggacac ggggactttt cgtctctccc tggcttctcc cgaacgcgtc
      421 tatgagcgca gcgttcccgc cgtcgctgat gatgatgcag cgcccgctgg ggagtagtac
      481 cgccttcagc atagactcgc tgatcggcag cccgccgcag cccagtcccg gccatttcgt
      541 ctacaccggc taccccatgt tcatgcccta ccggccggtg gtgctgccgc caccgccgcc
      601 accgcctccc gcgctgcccc aggcagcgct gcagcccgct ctgccgcccg cgcaccctca
      661 ccaccagatc cccagcctgc ccaccggctt ctgctccagc ctggcgcagg gcatggcgct
      721 cacctccacg ctcatggcca ctctgcccgg cggcttctct gcgtcgcccc agcaccaaga
      781 ggcggcggct gcccgcaagt tcgctccaca gccactgccc ggaggcggca acttcgacaa
      841 agccgaggcg ctccaagcgg atgcggaaga cggcaaagcc ttcttggcca aggagggctc
      901 gctgctcgct ttctctgcgg ccgaagcggt gcaggcgtcg ctcgtcgggg ctgtccgagg
      961 gcaagggaaa gacgagtcaa aggtggaaga tgacccgaag ggcaaggagg agagcttctc
     1021 tctggagagc gatgtggatt acagctcaga tgacaatttg cctggtcaga ctgctcataa
     1081 ggaagaagac cccggccacg cactggagga gaccccgcag agcggcggtg cagcaggcag
     1141 caccacgtcc acaggcaaga accggcggcg gcggactgcc ttcaccagcg aacagctgct
     1201 ggagctggag aaagaattcc actgcaaaaa gtacctctcc ctgaccgagc gctcacagat
     1261 cgcccacgcc ctcaaactca gcgaggtgca agtaaaaatc tggttccaga accgccgggc
     1321 caagtggaaa cgtgtcaagg caggcaacgc caattccaag acgggggagc cctctcggaa
     1381 ccccaagatt gtcgtcccca tccctgttca cgttagcagg ttcgctattc gaagtcaaca
     1441 ccagcagctg gagcaggccc gaccctgagg gcccagccag ggtggacacc accatggaga
     1501 ggccctaaca cctgaaggaa cccgtgtcag actccactgt ttaaagcaga actcagaggc
     1561 acctcctaga tgtggacatc caagcaaatt gagagtatat tcattagacg ggcttaaagg
     1621 gggctacagc cacaccagaa gatacactaa atatttatta tacaacccta ctttgtacat
     1681 agatctctat ctagactgga tctcagctgc agtgttttga aagggatagg atcaaatctc
     1741 tctccttaca ctttccagat gaaacaaaac caccactgta ctctgtcgcc ttcagcgacc
     1801 accttcccat acgtgcccaa aggtaaacag gagacacaag gacaaacact gcggtttaac
     1861 cttcttattg ttattttttg tttgtttgtt tctattttgg ctttttgagt tgagtgcaga
     1921 gcagtcggtt gattttggag caatctagaa ctctgctctg ctcgtttgct ttgcctggct
     1981 gtctttcctg gccttgtata tcctatctga gccatgtcgg aagcacgtct ccgttgtgtt
     2041 taatttattt caatgtagct tattttcata taagttatga catttaaaca atctcagtct
     2101 tgtgaataat aaaaaaaaag gcaagg
//
