LOCUS       NM_015739               1452 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus gastrulation brain homeobox 1 (Gbx1), mRNA.
ACCESSION   NM_015739 XM_981631
VERSION     NM_015739.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1452)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1452)
  AUTHORS   Su-Feher,L., Rubin,A.N., Silberberg,S.N., Catta-Preta,R., Lim,K.J.,
            Ypsilanti,A.R., Zdilar,I., McGinnis,C.S., McKinsey,G.L.,
            Rubino,T.E. Jr., Hawrylycz,M.J., Thompson,C., Gartner,Z.J.,
            Puelles,L., Zeng,H., Rubenstein,J.L.R. and Nord,A.S.
  TITLE     Single cell enhancer activity distinguishes GABAergic and
            cholinergic lineages in embryonic mouse basal ganglia
  JOURNAL   Proc Natl Acad Sci U S A 119 (15), e2108760119 (2022)
   PUBMED   35377797
REFERENCE   3  (bases 1 to 1452)
  AUTHORS   Wen,Y., Su,Z., Wang,Z., Yang,L., Liu,G., Shang,Z., Duan,Y., Du,H.,
            Li,Z., You,Y., Li,X., Yang,Z. and Zhang,Z.
  TITLE     Transcription Factor VAX1 Regulates the Regional Specification of
            the Subpallium Through Repressing Gsx2
  JOURNAL   Mol Neurobiol 58 (8), 3729-3744 (2021)
   PUBMED   33821423
REFERENCE   4  (bases 1 to 1452)
  AUTHORS   Monteiro,F.A., Miranda,R.M., Samina,M.C., Dias,A.F.,
            Raposo,A.A.S.F., Oliveira,P., Reguenga,C., Castro,D.S. and Lima,D.
  TITLE     Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory
            Neurons in the Dorsal Spinal Cord
  JOURNAL   Front Cell Dev Biol 9, 642697 (2021)
   PUBMED   33996801
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1452)
  AUTHORS   Buckley,D.M., Burroughs-Garcia,J., Kriks,S., Lewandoski,M. and
            Waters,S.T.
  TITLE     Gbx1 and Gbx2 Are Essential for Normal Patterning and Development
            of Interneurons and Motor Neurons in the Embryonic Spinal Cord
  JOURNAL   J Dev Biol 8 (2), 9 (2020)
   PUBMED   32244588
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1452)
  AUTHORS   Asbreuk,C.H., van Schaick,H.S., Cox,J.J., Kromkamp,M., Smidt,M.P.
            and Burbach,J.P.
  TITLE     The homeobox genes Lhx7 and Gbx1 are expressed in the basal
            forebrain cholinergic system
  JOURNAL   Neuroscience 109 (2), 287-298 (2002)
   PUBMED   11801365
  REMARK    GeneRIF: Combined expression of Lhx7 and Gbx1 plays a role in the
            development of the cholinergic system of the basal forebrain.
REFERENCE   7  (bases 1 to 1452)
  AUTHORS   Wightman,P.J., Hayward,B.E. and Bonthron,D.T.
  TITLE     The genes encoding glucokinase regulatory protein and
            ketohexokinase co-localize to mouse chromosome 5
  JOURNAL   Mamm Genome 8 (9), 700-701 (1997)
   PUBMED   9271679
REFERENCE   8  (bases 1 to 1452)
  AUTHORS   Montgomery,J.C., Guarnieri,M.H., Tartaglia,K.E. and Flaherty,L.A.
  TITLE     High-resolution genetic map and YAC contig around the mouse
            neurological locus reeler
  JOURNAL   Mamm Genome 5 (12), 756-761 (1994)
   PUBMED   7894155
REFERENCE   9  (bases 1 to 1452)
  AUTHORS   Bulfone,A., Puelles,L., Porteus,M.H., Frohman,M.A., Martin,G.R. and
            Rubenstein,J.L.
  TITLE     Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and
            Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential
            transverse and longitudinal segmental boundaries
  JOURNAL   J Neurosci 13 (7), 3155-3172 (1993)
   PUBMED   7687285
REFERENCE   10 (bases 1 to 1452)
  AUTHORS   Murtha,M.T., Leckman,J.F. and Ruddle,F.H.
  TITLE     Detection of homeobox genes in development and evolution
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10711-10715 (1991)
   PUBMED   1720547
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC120353.9.
            
            On Nov 17, 2006 this sequence version replaced NM_015739.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF547996.1, AY319256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-738               AC120353.9         11193-11930
            739-1452            AC120353.9         32902-33615
FEATURES             Location/Qualifiers
     source          1..1452
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 11.93 cM"
     gene            1..1452
                     /gene="Gbx1"
                     /gene_synonym="Gbx-1"
                     /note="gastrulation brain homeobox 1"
                     /db_xref="GeneID:231044"
                     /db_xref="MGI:MGI:95667"
     exon            1..738
                     /gene="Gbx1"
                     /gene_synonym="Gbx-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1289
                     /gene="Gbx1"
                     /gene_synonym="Gbx-1"
                     /note="gastrulation and brain-specific homeobox protein 1"
                     /codon_start=1
                     /product="homeobox protein GBX-1"
                     /protein_id="NP_056554.1"
                     /db_xref="CCDS:CCDS19123.1"
                     /db_xref="GeneID:231044"
                     /db_xref="MGI:MGI:95667"
                     /translation="MSPEGDTPNPPARPLPPYERESAAPEPHCAEPAPRRHLGPRARS
                     EPCVSARGARRGPGSAMQRAAGGGAPGGSGGSSGGPGAAFSIDSLIGPPPPRSGHLLY
                     TGYPMFMPYRPLVLPQALAPAPLPAGLPPLAPLASFAGRLSNTFCAGLGQAVPSMVAL
                     TTALPSFAEPPDAYYGPPELAAAAASTASRSNPEPAARRTDGALDAEELLPAREKVTE
                     PPPPPPPHFSETFPSLPAEGKVYSSDEEKLEPPAGDPAGSEQEEEGSGGDSEDSFLDS
                     SAGGPGALLGPKPKLKGSPGTGAEEGTPVATGVTTPGGKSRRRRTAFTSEQLLELEKE
                     FHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAGNVSSRSGEPVRNPKI
                     VVPIPVHVNRFAVRSQHQQMEQGARP"
     exon            739..1452
                     /gene="Gbx1"
                     /gene_synonym="Gbx-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcaagtg aagcgtaatt tgaggaagat ggatgagtcc ggagggcgac acccccaacc
       61 cgcccgcccg ccccctccct ccttatgagc gagagagcgc ggcgccggag ccacactgcg
      121 ccgagcccgc gccccgccgc cacctcggcc cgcgcgcccg cagcgagccc tgcgtgtccg
      181 cgcggggcgc acggcggggc ccgggcagcg ccatgcagag agcggcaggc ggcggcgccc
      241 ccgggggcag cggcgggagc agcggcggcc ccggcgccgc cttctccatc gactcgctca
      301 tcgggccgcc gccgccgcgc tcgggccacc tgctctacac cggctacccc atgttcatgc
      361 cctaccggcc gctcgtgttg ccgcaggcgc tggcccccgc gccgctgccc gccggcctgc
      421 cgccgctcgc cccgctcgcc tcgttcgccg gccgcctgag caataccttc tgcgcggggc
      481 tgggccaggc ggtgccctcg atggtggcgc tgaccactgc gctgcccagc ttcgcagagc
      541 ccccggacgc ctactacggg cccccggagc tcgccgccgc cgccgcctcc accgcctcgc
      601 gaagcaaccc ggagcccgcg gcccggcgca ctgacggagc gctggacgct gaggagctgc
      661 tgcccgcgcg cgagaaagtg actgaacctc cgccgccccc gcctccgcac ttctctgaga
      721 ctttcccgag tctaccggca gaggggaagg tgtacagctc agatgaagag aagctagagc
      781 ccccagcagg agacccagca ggcagcgagc aggaggaaga gggctcaggc ggtgacagcg
      841 aggacagctt cctggacagt tctgcagggg gcccaggggc tcttctggga cctaaaccga
      901 agctaaaggg aagcccgggg actggcgctg aggaggggac accagtggcc acaggggtca
      961 ccacgcctgg ggggaaaagc cgaaggcggc gcacagcctt caccagcgag cagcttttgg
     1021 agctggagaa ggagtttcac tgcaagaaat acctgagtct gacagagcgc tcccagatcg
     1081 cccacgccct caagctcagt gaggtgcagg tgaagatctg gtttcagaac cgccgggcca
     1141 agtggaagcg catcaaggct ggcaatgtga gcagtcgttc tggggagccg gtgagaaacc
     1201 ccaagattgt agtgcccata cctgtgcacg tcaacaggtt tgctgtgcgc agccagcacc
     1261 aacagatgga gcaaggagcc cggccctgac cgagctcccc ggaccggaag tcacaggatc
     1321 tgaacctgtg gccgcccaag actcactggg tactgcagcc tagaggggcc tgttgaaccc
     1381 tgctccggga gaggccagcg tattcccggg acacaagact atttggcctg agactgttct
     1441 agagacctca gg
//
