LOCUS       NM_172777               5561 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus guanylate-binding protein 9 (Gbp9), transcript variant
            1, mRNA.
ACCESSION   NM_172777 XM_001006543
VERSION     NM_172777.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5561)
  AUTHORS   Simpson DS, Pang J, Weir A, Kong IY, Fritsch M, Rashidi M, Cooney
            JP, Davidson KC, Speir M, Djajawi TM, Hughes S, Mackiewicz L,
            Dayton M, Anderton H, Doerflinger M, Deng Y, Huang AS, Conos SA,
            Tye H, Chow SH, Rahman A, Norton RS, Naderer T, Nicholson SE,
            Burgio G, Man SM, Groom JR, Herold MJ, Hawkins ED, Lawlor KE,
            Strasser A, Silke J, Pellegrini M, Kashkar H, Feltham R and Vince
            JE.
  TITLE     Interferon-gamma primes macrophages for pathogen ligand-induced
            killing via a caspase-8 and mitochondrial cell death pathway
  JOURNAL   Immunity 55 (3), 423-441 (2022)
   PUBMED   35139355
REFERENCE   2  (bases 1 to 5561)
  AUTHORS   Kim BH, Shenoy AR, Kumar P, Das R, Tiwari S and MacMicking JD.
  TITLE     A family of IFN-gamma-inducible 65-kD GTPases protects against
            bacterial infection
  JOURNAL   Science 332 (6030), 717-721 (2011)
   PUBMED   21551061
REFERENCE   3  (bases 1 to 5561)
  AUTHORS   Kresse A, Konermann C, Degrandi D, Beuter-Gunia C, Wuerthner J,
            Pfeffer K and Beer S.
  TITLE     Analyses of murine GBP homology clusters based on in silico, in
            vitro and in vivo studies
  JOURNAL   BMC Genomics 9, 158 (2008)
   PUBMED   18402675
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5561)
  AUTHORS   Degrandi D, Konermann C, Beuter-Gunia C, Kresse A, Wurthner J,
            Kurig S, Beer S and Pfeffer K.
  TITLE     Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10
            involved in host defense
  JOURNAL   J Immunol 179 (11), 7729-7740 (2007)
   PUBMED   18025219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144914.18 and DQ985742.1.
            
            [WARNING] On Oct 2, 2023 this sequence was replaced by NM_172777.5.
            
            On Jan 21, 2018 this sequence version replaced NM_172777.3.
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.5980.1, DQ985742.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC144914.18        27859-27874
            17-1830             DQ985742.1         1-1814
            1831-1831           AC144914.18        57955-57955
            1832-3633           DQ985742.1         1816-3617
            3634-5561           AC144914.18        59758-61685
FEATURES             Location/Qualifiers
     source          1..5561
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.68 cM"
     gene            1..5561
                     /gene="Gbp9"
                     /note="guanylate-binding protein 9"
                     /db_xref="GeneID:236573"
                     /db_xref="MGI:MGI:3605620"
     exon            1..88
                     /gene="Gbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            89..296
                     /gene="Gbp9"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1972
                     /gene="Gbp9"
                     /codon_start=1
                     /product="guanylate binding protein family, member 9"
                     /protein_id="NP_766365.1"
                     /db_xref="CCDS:CCDS39191.1"
                     /db_xref="GeneID:236573"
                     /db_xref="MGI:MGI:3605620"
                     /translation="MTQPQMAPICLVENHNEQLLVNQEAIEILEKISQPVVVVAIVGL
                     YRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDV
                     EKSNPKNDSWIFALSVLLSSTFVYNSMSTINHQALEQLHYVTELTELIRSKSSRNPHG
                     IKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGYNPRVQASNSA
                     RECIRCFFPNRKCFVFDRPTHDRELLQKLETISEDQLDLKFREGTKAFVSYVFTYAKI
                     KTLREGIKVTGNRLGTLVTTYVDAINSGAVPCLDDAMTSVARRENSVAVQKAADHYSE
                     QMAQRLRLPTDTLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVEIISEKIAFF
                     WLKNEEASNKYCQEELDRLSKDFMDNISTFSVPGGHRIYTDMRKKIERDYWQVPRKGV
                     KACEVFQNFLQSQYIIESSILQADRALTAGEKAIAEERAQKEVAEKEQELLRQKQKEQ
                     QEYMEAQEKRNKENLEQLRRKLMQEREQDIKDHDMMLEKQLKDQKAFLEEGFTNKAEE
                     INAEIERLEHNIKDKKENIGPILELIEKAFCAGVFSSLIMVALLTHNPSLLRK"
     exon            297..424
                     /gene="Gbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            425..534
                     /gene="Gbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            535..731
                     /gene="Gbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            732..977
                     /gene="Gbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1258
                     /gene="Gbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1465
                     /gene="Gbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1568
                     /gene="Gbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1762
                     /gene="Gbp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..5561
                     /gene="Gbp9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagagagca ggagggagga gagcagaagt gagcctgagg aggcagcagc agctgagaac
       61 tgcacttgga cctgtgctgt gggaccagat ttgtgtatgt tggcagattg ctatgaccca
      121 accacaaatg gctcccattt gtcttgtgga aaaccacaat gaacagctgt tggtgaacca
      181 ggaagccata gagattctgg agaagatttc tcagccagtg gtagtcgtgg ctattgttgg
      241 attgtaccgt acagggaagt cctatttgat gaactgtctg gcgggacaga atcatggttt
      301 ccctctgggc tccactgtgc agtctcagac caagggcatc tggatgtggt gcatgcccca
      361 ccccaccaag ccagagcaca ccctggtcct cctggacacc gagggcctgg gggatgtgga
      421 aaagagtaat cctaaaaacg actcatggat cttcgcccta agtgtgcttc tgagcagcac
      481 cttcgtctac aacagcatga gcaccatcaa ccaccaggcc ctggagcagc tgcattatgt
      541 cacagaactc actgagctga tcagatcaaa gtcttcccga aatccccacg gaataaagaa
      601 ttccacagag tttgtgagtt tctttccaga ctttgtctgg actgttcggg atttcatgct
      661 ggagctgaag ttaaatgggg aagacatcac aagtgatgag tacctggaga atgccctgaa
      721 gctgatccca ggttacaatc ccagagtgca agcatccaat tcagccaggg aatgcatcag
      781 atgtttcttt cctaaccgga agtgttttgt ctttgaccgg ccaactcatg acagagaact
      841 cttacaaaaa cttgagacta tctcagaaga ccaactggat cttaagttcc gggaaggaac
      901 aaaggctttt gtttcttatg tcttcactta tgccaagatc aagaccctca gagagggaat
      961 taaggtcacc gggaatagac tgggtactct ggtgacaact tacgtggatg ccatcaacag
     1021 tggagcagtg ccttgtctgg atgatgctat gacaagtgtg gcccggcgtg agaactcagt
     1081 agctgtgcag aaggcagccg accactacag tgagcagatg gcccagcgac tgaggcttcc
     1141 cacagacact ctccaggagt tgctggatgt gcatgctgcc tgcgagaagg aagccatggc
     1201 tgtcttcatg gagcattcct tcaaggatga aaatcagcaa ttcctgaaga aactggtgga
     1261 aataatcagt gagaagatag cttttttctg gttgaagaat gaagaggcat cgaataaata
     1321 ctgccaggaa gaactggatc gactttcaaa ggattttatg gacaatatct caacattctc
     1381 tgttcctggg ggacacagga tttacacgga catgaggaag aagattgaac gtgactactg
     1441 gcaggttccc aggaaagggg tgaaggcatg tgaagtcttc caaaactttc tccagtcaca
     1501 gtacatcatt gagagttcca tcctgcaggc agatagagcc ctcactgctg gggagaaggc
     1561 cattgcagag gagcgtgccc aaaaggaggt agccgagaag gagcaggagc tactaagaca
     1621 gaagcagaag gagcagcagg agtatatgga ggctcaagag aaaaggaaca aggaaaacct
     1681 agagcaactg aggagaaagc tgatgcagga gagagagcag gacatcaaag accatgatat
     1741 gatgctggag aagcaactga aggatcaaaa ggctttcctt gaggaaggat ttacgaacaa
     1801 agctgaagaa ataaatgcag agatagagag actggaacat aacatcaagg ataagaaaga
     1861 aaacattggt cccattctgg aacttatcga aaaagcattt tgtgcagggg tttttagttc
     1921 ccttatcatg gttgcattgt taacacacaa tccttcactt ttaaggaaat gatagactgt
     1981 gacataagca ttgttttatt tcaaagctgc ctgttttcta ttttcactca gcgaaggtta
     2041 aatataaaag tgctgatttg agggtggctg tgtcctgcac acatgaacag aacagctcat
     2101 gcatggctgt acagacaatg cttgccttta gaggacacat ttttttttaa atgagtccaa
     2161 tagaagatat gcaattagtc attacatgcc attactgttg actgcatata gagtcagcta
     2221 tgagacaagg ctttccatac tcctttgagg aatatgtagc ccaagtttgc ttgtggggga
     2281 gtatctcaga ttaatacagt agggaaccca tcctatgtgt ggacgggacc attcctgtgg
     2341 actgaagaca cagtagaaag atgaaagcaa tcttcctacc acttgtggct tcctgactgt
     2401 ggatgcaata caacaagcca gcctcgactt ctctcagaat gcattatcca gccttgacag
     2461 aatgtattat catgattcat ggaccacaac aaatcctttc ttaagttggt tttgtgaggg
     2521 tatttcatct cagcaagagg aaaagtcatt gatatcataa tcgtgataat cctggaatct
     2581 acttaaacat cactttttag attggcaatg aattttagta tgacttgatc ttggagtact
     2641 atatagtcaa gaaacaaata acagtcaagc tatctgtata atgatctaaa ttgagctaaa
     2701 atatatctta aaagtaaagt caaaacacca taaaactgtg cgattattat tagaaatgct
     2761 actattccat gcaaacatac aagaacacaa atgaaatgcc ctctggaaga ttagtaaaaa
     2821 ccttggtcta ctggcttcat ctagagagaa taagttggag tcaaaagttg aagtgatgcc
     2881 tgcattccat gactttttca atcttacaca tttaatgaag agtgctggga aagggaattt
     2941 acatttttag atagtcacaa taagttaaaa ctcaccactg catgatgaag tctctgcttc
     3001 tagaaatggc aaaagccacc gcagaccaag acttgagtac caggaagtat aacttttgtg
     3061 gcttaatgat gttttccttt gtggctttgc ttttttaaaa ataatttaaa taacacattt
     3121 tatgtaaacc aatatatcaa aatattattt ccacaggcag gcaatacaat ttatgcatgc
     3181 cacatttaca tcacatttat ttatttgcaa agtaactggg aaactgtatt aagaaacata
     3241 tgataatata gagtataaga gaatctatgg ggcacaaggg aggtggacag ctcagagatg
     3301 gctcagttgt caagagtgca caatgttcat cctgggtagc tcagttcctg gggcaggtaa
     3361 caaggaacgg taaatctaac tccaagggaa ctcacttcct tttctgaccc ccaaggactc
     3421 ctggtatttc cattacatat ccccaggtta tacatataca tatttacaag taagatgtaa
     3481 aggaatgtac tgttaacatt gataatgggc catataggta aagagaccca aggaccctta
     3541 ttagtgcatt aatgaatata atgtatttag aatgtacccg ccgcagctcc tctaagacat
     3601 cctgcaatac ccctacaaac ttcatgtctt cttctcttcc tccaccactt cctctttcct
     3661 catactctga ataaattaat gctggcctca tgtccctggg cattagacac catctatcag
     3721 accatgaaca atttatcatg aagcacaccc ccatagaaaa cacacgctcc cagtgaccac
     3781 atatcaaatg ctagtagttc ttcagctagg ggtggggtct catgagctca ctgcctctcc
     3841 acactggatg ttgactggct tgatagtgtg tattttgtgc caacaatcat aactattgtc
     3901 aagcccccat catatccaga aaatattatt ttaaaacagt gtgatcttat ttataaaata
     3961 gttagcttta ttatttcaaa attatattgt agacattcct atgattactg gaatcttgga
     4021 gtagcttact tcctctgtct tcatgtcttg taagatgtca tgttcaaaag aatgaacagt
     4081 gaaaaggaga gttcttggtg ctgttttatt gggagccatt ttgtttgctt ctgcctgcca
     4141 ggcagagtca aggcaggtca gcatctactg gcagattttc tggcctactg actcatgtca
     4201 caataagagg aaattcactt gaggctcaag gcaaggggat gaacattcta tgaatctcgg
     4261 tggaaggaac agggaagcct ctggatgggt actgatatcc tgtgtgtaca tcagccattg
     4321 tttctgatac cttgtgactt tgtttcccat ggtactgagg aatataagga gacaaataaa
     4381 taaatacata aacttgaggc tgatatgcta ttcccctgca tccttcccca ttctaatgtt
     4441 tgtctttgag tcttctttct gtctttccta taattatcct cactccccct tcagagtctg
     4501 gtctaacttg tgttgattgg actggcatac tctttcattt aggtagtgac ttcactgaag
     4561 tggcgagaat caggtctttt cagaactaga tcccttgatg gggaattgcc acacccactc
     4621 cagtggagtc tcagtgacaa gtccaaaaac atggccagag tcctgaggca acaagtttca
     4681 ctgaaactgg tccttggtat gccttaacat ggatgtggtc tagattttcc cttgagatag
     4741 ttggtaaagg gatttctttc agtattgttt attataggag tccccaagga atatttgaca
     4801 aataaccaag gtagatttga cattttcctg gtctctaccc gtgttccaac atcctagtta
     4861 agcgttgagc caaccctcaa ctttgaattt cataagaatg ttacttattc agacgaaatg
     4921 tctcaagttt tgatagagag atagtgaaag aaatcaggca ttgcagttta ctggatagag
     4981 ttagaaattt cagggtaagt tcaacaaagt aagcttagaa ttctcattgc agtcatgtat
     5041 ggcacactac atttcataat agaatgaaat agagtaaaat cttagaagaa cagctgagtc
     5101 actcccatat gcaggaattt ataatggtcc aggaagaagg tgtgttgtgg tttaaggaag
     5161 aacaatagta ttgtatgatt catgaaaaag ttagccagaa cagatccccc cttatgcatg
     5221 ttttatgccc cagaggcata gcataattgg gtgtttacta agggatccct ggtggtgggt
     5281 tacacaatag actggaatta tggctagggt aggaagccca tgcaactggc tcctaagaat
     5341 agctgacttt tgatagggct ggttattttt atctcagttg caaacactgc ctggttcctg
     5401 ctagttttta tgtatgcatt tctctgtttt ctatacagag tcattattct ttggatgact
     5461 tcaatgtatc ttggctgatg tattacctaa cttccctgtt ttcttctgta atgactatat
     5521 aatcctggtg tttgctttga ggaattacag tcagattcag t
//
