LOCUS       NM_029509               2459 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus guanylate-binding protein 8 (Gbp8), mRNA.
ACCESSION   NM_029509
VERSION     NM_029509.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2459)
  AUTHORS   Simpson DS, Pang J, Weir A, Kong IY, Fritsch M, Rashidi M, Cooney
            JP, Davidson KC, Speir M, Djajawi TM, Hughes S, Mackiewicz L,
            Dayton M, Anderton H, Doerflinger M, Deng Y, Huang AS, Conos SA,
            Tye H, Chow SH, Rahman A, Norton RS, Naderer T, Nicholson SE,
            Burgio G, Man SM, Groom JR, Herold MJ, Hawkins ED, Lawlor KE,
            Strasser A, Silke J, Pellegrini M, Kashkar H, Feltham R and Vince
            JE.
  TITLE     Interferon-gamma primes macrophages for pathogen ligand-induced
            killing via a caspase-8 and mitochondrial cell death pathway
  JOURNAL   Immunity 55 (3), 423-441 (2022)
   PUBMED   35139355
REFERENCE   2  (bases 1 to 2459)
  AUTHORS   Kim BH, Shenoy AR, Kumar P, Das R, Tiwari S and MacMicking JD.
  TITLE     A family of IFN-gamma-inducible 65-kD GTPases protects against
            bacterial infection
  JOURNAL   Science 332 (6030), 717-721 (2011)
   PUBMED   21551061
REFERENCE   3  (bases 1 to 2459)
  AUTHORS   Degrandi D, Konermann C, Beuter-Gunia C, Kresse A, Wurthner J,
            Kurig S, Beer S and Pfeffer K.
  TITLE     Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10
            involved in host defense
  JOURNAL   J Immunol 179 (11), 7729-7740 (2007)
   PUBMED   18025219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144914.18, BY089370.1 and DQ295175.1.
            
            On Sep 22, 2006 this sequence version replaced NM_029509.3.
            
            ##Evidence-Data-START##
            CDS exon combination :: DQ295175.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC144914.18        84590-84617
            29-85               BY089370.1         3-59
            86-1685             DQ295175.1         1-1600
            1686-2459           AC144914.18        123225-123998
FEATURES             Location/Qualifiers
     source          1..2459
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.68 cM"
     gene            1..2459
                     /gene="Gbp8"
                     /gene_synonym="5830443L24Rik; mGBP8"
                     /note="guanylate-binding protein 8"
                     /db_xref="GeneID:76074"
                     /db_xref="MGI:MGI:1923324"
     exon            1..61
                     /gene="Gbp8"
                     /gene_synonym="5830443L24Rik; mGBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            62..269
                     /gene="Gbp8"
                     /gene_synonym="5830443L24Rik; mGBP8"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1663
                     /gene="Gbp8"
                     /gene_synonym="5830443L24Rik; mGBP8"
                     /codon_start=1
                     /product="guanylate binding protein 8"
                     /protein_id="NP_083785.3"
                     /db_xref="CCDS:CCDS19490.1"
                     /db_xref="GeneID:76074"
                     /db_xref="MGI:MGI:1923324"
                     /translation="MTQPQMAPICLVENHNEHLSVNHEAIEILEKISQPVVVVAIVGL
                     YRTGKSYLMNRLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDV
                     EKGDPKNDLWIFALSVLLSSTFIYNSMNTISHDSLEKLHYVTELTELIRAKSSPNPDG
                     IKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGLGILVTTYVDA
                     INSGAVPCVDDAVTTLAQRENSVAVQRAADHYSEQMVQRLSLPTDTLQELLDVHAACE
                     KEAMAVFMEHSFKDENQQFLKKLVELIGEAKVLFLLKNEEASDKYCQEELDRLSKDLM
                     DNISTFSVPGGHRLYMDMREKIEHDYWQVPRKGVKAREVFQSFLQSQAIIESSILQAD
                     TALTAGQKAIAEERTKKEAAEKEQDLLRQKQKEQQEYMEAQEKRNKENIEQLRRKLEQ
                     EREQLIKDHNMMVEKKLKEQKALLEEGFKKKAEEMDGEIQQLKHNIEDMKKKQWFHFR
                     YYYKRSCFIYFFSHFND"
     exon            270..397
                     /gene="Gbp8"
                     /gene_synonym="5830443L24Rik; mGBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            398..507
                     /gene="Gbp8"
                     /gene_synonym="5830443L24Rik; mGBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            508..704
                     /gene="Gbp8"
                     /gene_synonym="5830443L24Rik; mGBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            705..985
                     /gene="Gbp8"
                     /gene_synonym="5830443L24Rik; mGBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1192
                     /gene="Gbp8"
                     /gene_synonym="5830443L24Rik; mGBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1295
                     /gene="Gbp8"
                     /gene_synonym="5830443L24Rik; mGBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1489
                     /gene="Gbp8"
                     /gene_synonym="5830443L24Rik; mGBP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..2459
                     /gene="Gbp8"
                     /gene_synonym="5830443L24Rik; mGBP8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgagcctg aggaggcagc agcagctgag aactgcactt ggacctgtgc tgtgggacca
       61 gattcatcta cgttggcagg ttgctatgac ccaaccacaa atggctccca tttgtcttgt
      121 ggaaaaccac aatgaacatc tgtccgtgaa ccatgaagcc atagagattc tggagaagat
      181 ttctcagcca gtggtagtcg tggctattgt tggattgtac cgtacaggga agtcctattt
      241 gatgaaccgt ctggcaggac agaatcacgg tttccctctg ggctccactg tgcagtctca
      301 gaccaagggc atctggatgt ggtgcatgcc acaccccact aaaccagagc acaccctggt
      361 cctcctggac accgagggcc tgggggatgt ggaaaagggt gatcctaaga acgacttgtg
      421 gatctttgcc ctcagtgtgc ttctgagcag caccttcatc tacaacagca tgaacaccat
      481 cagccatgat tccctggaga aactacatta tgtcacagaa ctcactgagc tgatcagagc
      541 aaagtcttca ccaaatcctg atggaataaa gaattccaca gagtttgtga gtttctttcc
      601 agactttgtc tggactgttc gggatttcat gctagagctg aagttaaatg gggaagacat
      661 cacaagtgat gagtacctgg agaatgccct gaagctgatc ccaggattgg ggattctagt
      721 gacaacctat gtagatgcca tcaacagtgg agcagtgcct tgtgtggatg atgctgtgac
      781 aactctggcc cagcgtgaga actcagtagc tgtgcagagg gcagctgacc actacagtga
      841 gcagatggtc cagcgactga gccttcccac agacacgctc caggagctgc tggatgtgca
      901 tgcagcctgc gagaaggaag ccatggctgt cttcatggag cattccttca aggacgaaaa
      961 tcagcaattc ctgaagaagc tggtggaatt aataggtgag gcgaaagtgc ttttcctgtt
     1021 gaagaatgaa gaggcatctg ataaatactg ccaggaagaa ctggatcgac tttcaaagga
     1081 tttgatggac aatatctcaa cattttctgt tcctggggga cacaggctct acatggacat
     1141 gagagagaag attgagcatg attactggca agttcccagg aaaggggtga aggcaagaga
     1201 agtcttccag agctttcttc agtcgcaggc catcattgag agttccatcc tgcaggcaga
     1261 cacagccctc actgctgggc agaaggccat tgcagaggag cgcaccaaga aggaggcagc
     1321 tgagaaggag caggatctgc taagacagaa gcagaaggag cagcaggagt atatggaggc
     1381 tcaagagaaa aggaacaagg aaaacataga gcaactgaga aggaagctgg agcaggagag
     1441 agagcagctc atcaaagacc ataacatgat ggtggagaag aagctgaagg aacaaaaggc
     1501 tttgcttgag gaaggattta agaagaaagc tgaagaaatg gacggagaga tacagcaact
     1561 gaaacataac atcgaggata tgaaaaaaaa acagtggttc cattttcgat actattataa
     1621 gagaagttgc ttcatttatt ttttctccca tttcaatgat tgaaaagggt ataaggtccc
     1681 ttttttagta aaaatgatag actgtgatat acactttgtg ttactttgac gctgcctgtt
     1741 ttccattttc actccgcaga gaagtttaaa cataaaaagt gctgattaga gggcatctgt
     1801 gccccacaca gaagacatag aacagctcct acatgtctgc acagacaatg cttgccttta
     1861 gagaacatat tttgaaacca ttcctatgaa agctatgcat ttagtcatca gatgtgatca
     1921 ctgctggcca atttaactac atatagaatc tgcatataga atctgtactc ctatgaggac
     1981 catgtagccc aggataggtt gtacgggatt ctctcaggtt aatatggtag gaaacccatc
     2041 ctaagtgtgg gcagcaccat tcctgtggac tgaagacaca gtagaaagat gaaagcaatc
     2101 tccctaccac ttgtggcttc aactgtggat gccatacaac aagccagcct tgacttctct
     2161 cagaatgcat tatccagcct tgaccgaatg tatcatcatg atacatggag ctcaacaaac
     2221 cattcattaa gttggttttg tgagggtatt tcatcacagc aagaggaaaa gtcactgata
     2281 tcataatagt gataatcctg gaaactactt aatcatccct gagttagatt ggcaataaat
     2341 tttaatatga cttgttcttg gagtactgta tagtcaagaa acaaatgtca gtcaaactat
     2401 ctgtatagtg atctaaattg agctaaaata tatcttaaaa ataaagtcaa aacactata
//
