LOCUS       NP_083785                525 aa            linear   ROD 04-AUG-2023
DEFINITION  guanylate binding protein 8 [Mus musculus].
ACCESSION   NP_083785
VERSION     NP_083785.3
DBSOURCE    REFSEQ: accession NM_029509.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 525)
  AUTHORS   Simpson DS, Pang J, Weir A, Kong IY, Fritsch M, Rashidi M, Cooney
            JP, Davidson KC, Speir M, Djajawi TM, Hughes S, Mackiewicz L,
            Dayton M, Anderton H, Doerflinger M, Deng Y, Huang AS, Conos SA,
            Tye H, Chow SH, Rahman A, Norton RS, Naderer T, Nicholson SE,
            Burgio G, Man SM, Groom JR, Herold MJ, Hawkins ED, Lawlor KE,
            Strasser A, Silke J, Pellegrini M, Kashkar H, Feltham R and Vince
            JE.
  TITLE     Interferon-gamma primes macrophages for pathogen ligand-induced
            killing via a caspase-8 and mitochondrial cell death pathway
  JOURNAL   Immunity 55 (3), 423-441 (2022)
   PUBMED   35139355
REFERENCE   2  (residues 1 to 525)
  AUTHORS   Kim BH, Shenoy AR, Kumar P, Das R, Tiwari S and MacMicking JD.
  TITLE     A family of IFN-gamma-inducible 65-kD GTPases protects against
            bacterial infection
  JOURNAL   Science 332 (6030), 717-721 (2011)
   PUBMED   21551061
REFERENCE   3  (residues 1 to 525)
  AUTHORS   Degrandi D, Konermann C, Beuter-Gunia C, Kresse A, Wurthner J,
            Kurig S, Beer S and Pfeffer K.
  TITLE     Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10
            involved in host defense
  JOURNAL   J Immunol 179 (11), 7729-7740 (2007)
   PUBMED   18025219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144914.18, BY089370.1 and DQ295175.1.
            
            On Dec 21, 2005 this sequence version replaced NP_083785.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: DQ295175.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.68 cM"
     Protein         1..525
                     /product="guanylate binding protein 8"
                     /calculated_mol_wt=60546
     Region          16..>207
                     /region_name="GBP"
                     /note="Guanylate-binding protein, N-terminal domain;
                     pfam02263"
                     /db_xref="CDD:460516"
     Region          206..493
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     pfam02841"
                     /db_xref="CDD:460721"
     CDS             1..525
                     /gene="Gbp8"
                     /gene_synonym="5830443L24Rik; mGBP8"
                     /coded_by="NM_029509.4:86..1663"
                     /db_xref="CCDS:CCDS19490.1"
                     /db_xref="GeneID:76074"
                     /db_xref="MGI:MGI:1923324"
ORIGIN      
        1 mtqpqmapic lvenhnehls vnheaieile kisqpvvvva ivglyrtgks ylmnrlagqn
       61 hgfplgstvq sqtkgiwmwc mphptkpeht lvlldteglg dvekgdpknd lwifalsvll
      121 sstfiynsmn tishdslekl hyvtelteli raksspnpdg iknstefvsf fpdfvwtvrd
      181 fmlelklnge ditsdeylen alklipglgi lvttyvdain sgavpcvdda vttlaqrens
      241 vavqraadhy seqmvqrlsl ptdtlqelld vhaacekeam avfmehsfkd enqqflkklv
      301 eligeakvlf llkneeasdk ycqeeldrls kdlmdnistf svpgghrlym dmrekiehdy
      361 wqvprkgvka revfqsflqs qaiiessilq adtaltagqk aiaeertkke aaekeqdllr
      421 qkqkeqqeym eaqekrnken ieqlrrkleq ereqlikdhn mmvekklkeq kalleegfkk
      481 kaeemdgeiq qlkhniedmk kkqwfhfryy ykrscfiyff shfnd
//
