LOCUS       NM_145545               5622 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus guanylate binding protein 7 (Gbp7), transcript variant
            1, mRNA.
ACCESSION   NM_145545
VERSION     NM_145545.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5622)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5622)
  AUTHORS   Feng,S., Enosi Tuipulotu,D., Pandey,A., Jing,W., Shen,C., Ngo,C.,
            Tessema,M.B., Li,F.J., Fox,D., Mathur,A., Zhao,A., Wang,R.,
            Pfeffer,K., Degrandi,D., Yamamoto,M., Reading,P.C., Burgio,G. and
            Man,S.M.
  TITLE     Pathogen-selective killing by guanylate-binding proteins as a
            molecular mechanism leading to inflammasome signaling
  JOURNAL   Nat Commun 13 (1), 4395 (2022)
   PUBMED   35906252
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5622)
  AUTHORS   Feng,M., Zhang,Q., Wu,W., Chen,L., Gu,S., Ye,Y., Zhong,Y., Huang,Q.
            and Liu,S.
  TITLE     Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus
            Replication by Suppressing Innate Immunity via NF-kappaB and
            JAK-STAT Signaling Pathways
  JOURNAL   J Virol 95 (6), e02038-20 (2021)
   PUBMED   33408175
  REMARK    GeneRIF: Inducible Guanylate-Binding Protein 7 Facilitates
            Influenza A Virus Replication by Suppressing Innate Immunity via
            NF-kappaB and JAK-STAT Signaling Pathways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5622)
  AUTHORS   Steffens,N., Beuter-Gunia,C., Kravets,E., Reich,A., Legewie,L.,
            Pfeffer,K. and Degrandi,D.
  TITLE     Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection
  JOURNAL   mBio 11 (1), e02993-19 (2020)
   PUBMED   31964735
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5622)
  AUTHORS   Legewie,L., Loschwitz,J., Steffens,N., Prescher,M., Wang,X.,
            Smits,S.H.J., Schmitt,L., Strodel,B., Degrandi,D. and Pfeffer,K.
  TITLE     Biochemical and structural characterization of murine GBP7, a
            guanylate binding protein with an elongated C-terminal tail
  JOURNAL   Biochem J 476 (21), 3161-3182 (2019)
   PUBMED   31689351
  REMARK    GeneRIF: GBP7 exhibits a concentration-dependent GTPase activity
            and an apparent GTP turnover number of 20 min-1.
REFERENCE   6  (bases 1 to 5622)
  AUTHORS   Meunier,E., Dick,M.S., Dreier,R.F., Schurmann,N., Kenzelmann
            Broz,D., Warming,S., Roose-Girma,M., Bumann,D., Kayagaki,N.,
            Takeda,K., Yamamoto,M. and Broz,P.
  TITLE     Caspase-11 activation requires lysis of pathogen-containing
            vacuoles by IFN-induced GTPases
  JOURNAL   Nature 509 (7500), 366-370 (2014)
   PUBMED   24739961
REFERENCE   7  (bases 1 to 5622)
  AUTHORS   Kim,B.H., Shenoy,A.R., Kumar,P., Das,R., Tiwari,S. and
            MacMicking,J.D.
  TITLE     A family of IFN-gamma-inducible 65-kD GTPases protects against
            bacterial infection
  JOURNAL   Science 332 (6030), 717-721 (2011)
   PUBMED   21551061
  REMARK    GeneRIF: findings show that at least 4 IFN-gamma-inducible
            Gbps--Gbp1, Gbp6, Gbp7, and Gbp10--conferred cell-autonomous
            immunity to listerial or mycobacterial infection within macrophages
            and gene-deficient animals
REFERENCE   8  (bases 1 to 5622)
  AUTHORS   Degrandi,D., Konermann,C., Beuter-Gunia,C., Kresse,A., Wurthner,J.,
            Kurig,S., Beer,S. and Pfeffer,K.
  TITLE     Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10
            involved in host defense
  JOURNAL   J Immunol 179 (11), 7729-7740 (2007)
   PUBMED   18025219
REFERENCE   9  (bases 1 to 5622)
  AUTHORS   Olszewski,M.A., Gray,J. and Vestal,D.J.
  TITLE     In silico genomic analysis of the human and murine
            guanylate-binding protein (GBP) gene clusters
  JOURNAL   J Interferon Cytokine Res 26 (5), 328-352 (2006)
   PUBMED   16689661
REFERENCE   10 (bases 1 to 5622)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102108.12 and AK036666.1.
            
            On Nov 14, 2013 this sequence version replaced NM_145545.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK005760.1, AK036666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC102108.12        129505-129510       c
            7-34                AK036666.1         3-30
            35-35               AC102108.12        129476-129476       c
            36-967              AK036666.1         32-963
            968-968             AC102108.12        118276-118276       c
            969-2990            AK036666.1         965-2986
            2991-5622           AC102108.12        109695-112326       c
FEATURES             Location/Qualifiers
     source          1..5622
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 66.69 cM"
     gene            1..5622
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /note="guanylate binding protein 7"
                     /db_xref="GeneID:229900"
                     /db_xref="MGI:MGI:2444421"
     exon            1..104
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            105..318
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2045
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /note="GTP-binding protein 7; guanylate-binding protein
                     4-like; guanine nucleotide-binding protein 7"
                     /codon_start=1
                     /product="guanylate-binding protein 7"
                     /protein_id="NP_663520.2"
                     /db_xref="CCDS:CCDS38657.1"
                     /db_xref="GeneID:229900"
                     /db_xref="MGI:MGI:2444421"
                     /translation="MASGPNMEAPVCLVENENEELRVNSKAINILERITQPVVVVAIV
                     GLYRTGKSYLMNRLAGQNHGFNLGTTVRSETKGIWMWCVPHPSKPKFTLVLLDTEGLG
                     DVEKGDPKNDSWIFALAVLLSSTFVYNSMSTINHQALEQLHYVTELTERIRAKSTSRS
                     EEVDDSDEFVSFFPDFIWTVRDFVLELKLEGRVITADEYLENALKLIPGMSIKAQKAN
                     LPRECIRHFFPRRKCFVFDRPTKDKELLVHVEEMPEDQLDHSFQVQSKEFCSYIFSNS
                     KAKTLKEGIVVNGNRLATLVTTYVDAINSGDVPCLENAVTTLAQRENSIAVQKAADHY
                     SEQMAQRMRLPTDTLQELLTVHTACEKEAIAVFMEHSFKDENQQFQKNLVVTIEEKKE
                     DFLRQNEAASLSHCQAELDKLSESLRESISRGVFSVPGGHRLYLEARKKVEQDYERVP
                     RKGVKANHVLQSFLQSQISIEDSIMQSDKALTDGQKAMEAERAQKEAAEKEQELLRQK
                     QKELQQVMEAQERSYKENVAQLHEKMETERKNILREQEVKLEHKLKIQKDMLNEGFKR
                     KCEAMDLEISQLQKEIQLNKEKNSSLGAKILDGFGDVLISVVPGSGKYFGLGLKILSS
                     QMNQTQNSDKVRKL"
     exon            319..446
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            447..556
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            557..753
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            754..999
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1280
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1493
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1596
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1790
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..5622
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5593..5598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /note="hexamer: AATAAA"
     polyA_site      5617
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /note="major polyA site"
ORIGIN      
        1 actctggagt ttaagaatag agagctttca ggaggaatcg gggcgggcgc agcagcaagc
       61 ctaaaggtgc tgaatccagg tagcagagaa tccggtgcag gctgactttt tggggtttgc
      121 aggttaccat ggcatctggt cccaacatgg aggctcctgt gtgcctagtg gaaaatgaga
      181 atgaagaact gagggtgaac tccaaagcaa taaacattct tgagaggatc actcagcctg
      241 tagtggtggt ggccattgta ggactatacc gtacgggaaa atcctacttg atgaaccgct
      301 tggcaggaca gaaccatggc ttcaatctgg gcaccacagt taggtctgaa actaagggca
      361 tctggatgtg gtgtgtgcct caccccagca agcccaagtt cacactcgtg cttctggaca
      421 cggagggctt aggagatgtg gaaaagggtg accctaagaa tgactcgtgg atcttcgccc
      481 tggctgtgct tctgagcagc acctttgtct acaacagcat gagcaccatc aaccaccagg
      541 ccctggagca gctgcactat gtcacagaac tgacagagcg gatcagggca aagtccactt
      601 cacggtctga agaagtggat gactctgatg agtttgtaag tttctttcca gattttatct
      661 ggactgttcg agatttcgtt ctggagctga agttagaggg acgtgtcatc acagcagacg
      721 agtacctaga aaatgccctg aagctgatcc caggcatgag tatcaaagcc cagaaagcta
      781 acttgcctag ggaatgcatc aggcacttct ttccaagacg gaagtgcttt gtctttgatc
      841 gacctacaaa agacaaagaa cttttagtgc atgttgagga aatgccagag gaccagttgg
      901 atcacagttt ccaagtgcag tcaaaagaat tctgttccta catcttctcc aattcgaagg
      961 ccaagacctt gaaagaggga atcgttgtca atggaaaccg actggcgact ctggtgacga
     1021 cctacgtgga tgctatcaat agtggagacg tgccgtgttt agagaacgca gtaacaaccc
     1081 tggcccagcg tgagaactcc atagctgtgc agaaggcagc tgaccactac agtgagcaga
     1141 tggcccagcg aatgaggctc cccacagaca cgctccagga gctgctgact gtgcatacag
     1201 cctgtgagaa ggaagccatt gctgtcttca tggagcactc cttcaaggat gagaatcagc
     1261 aattccagaa gaacttggtg gtcaccatag aggaaaaaaa ggaagatttc ctgcgacaga
     1321 atgaagcagc gtctctcagt cactgccagg ctgagctgga caagctctca gagtccctga
     1381 gggagagcat ctcacgtgga gttttctctg ttcctggggg tcacaggctc tacttagagg
     1441 ccaggaagaa ggttgaacag gactatgagc gagtgcccag gaagggagtg aaggcaaatc
     1501 atgtccttca gagcttccta cagtcacaga tttccattga ggactccatt atgcagtcag
     1561 acaaagccct cactgatggc cagaaggcca tggaagctga gcgagctcag aaggaggcag
     1621 ctgagaagga gcaggagcta ctaagacaga aacagaagga gctgcagcag gtgatggaag
     1681 ctcaagagag aagctacaag gaaaatgtgg cccagctgca cgagaagatg gagacagaaa
     1741 ggaagaacat cctgagagag caagaggtga agctggaaca caagttgaag attcaaaaag
     1801 acatgcttaa tgagggattt aaaaggaaat gtgaagcaat ggatttggag ataagtcaac
     1861 tacaaaaaga gattcaacta aataaggaga agaatagctc attgggtgca aaaatccttg
     1921 atgggtttgg agatgtatta atttcagtag tgcctggttc tggtaagtac tttggtctag
     1981 ggttgaaaat attaagcagc caaatgaatc agacacagaa ttcagacaaa gttagaaaac
     2041 tctaagtata gctttccccc acctccctga gacttacttt tgaagtccat ctcactttaa
     2101 tttcatttat caaatttcaa aaaccaagaa tataggtcac tctctataaa ttaatggcaa
     2161 gaccccattg ctgaaaacaa atgtatacaa ctcattgatt gatggagaac tcaagctggt
     2221 gcccatagat ccttctcctt atatgcggac atctttggca cagaatgaca ctctgcatgc
     2281 taccaaagga aaaacacaaa tgccagccca gccacaagcc ctttgatcta caatggcatc
     2341 ctgcctgcaa aatatgcaaa tgcagtggtg gcacaaactg tgggagtaac taaccaatat
     2401 ctgatttgat ttaaggccaa cttcacggga tgaaacccat gcctacactg cctgggtgat
     2461 ccagaaccta gatcagatag cccagcgaac cttgagtaaa accaaatact attgttgtat
     2521 taaaaaaaaa aaagtagcaa tataatgact cttcctgaca ttctgcagta ctcattaatc
     2581 agtgccttgc tcagccatca tcacagaagc ttccccctgc cacagatggg aacaaatgca
     2641 gagaggccca cagccagaca ctgtacagag agagaatgag agtcttggga acactcaacc
     2701 ttaagtaggg tgtctttatc aaacccctcc cctcggggct caggaacact gtgaaagagg
     2761 aaacagaaaa actataacag ccagagagga cagagggcac caagaaaaac acccacctcg
     2821 cgggggctgg agagatggct cagaggtcaa gagcactggc tgctcttctg gaggtccctg
     2881 gttcagtttc cagaatccac atggcagttc acaaatgtct gtaactgtgg tgccaggtga
     2941 tctgacaccc tcatacagac atacatgcaa aacaaaaaca aaaacaaaaa gcaaaaaaaa
     3001 aatcaaacaa accccaaata atcaacaaca acaacaacaa caaaaccaat caagcaagca
     3061 agcaagcaaa caaacaaaaa caacaccaaa caaaaccagc taaccaagga atcatttaaa
     3121 aaaaaaaatg cccactgaac caatatgatc aatgtacata ggaactcaca gagacagagg
     3181 caaggatgca caggcctgca caggtctgca ctagttgggg ttctagggct gaaaggaaaa
     3241 gtggacacaa gccctcatct ctgacacaga agcaatcttc aattcataac cacttacaaa
     3301 tggaaattaa tcttactcca agagagtttc tccatctcat ggaatgggct gcctgacgcc
     3361 acagttattt tccttcatgg actgggagac actgggcaag gatgggcagg agctgttggt
     3421 tgcaggcggc agaacatccc acatcaggca cacctgtcca catgacaccc gatatgccta
     3481 ttacagtcaa catgaatatg accaggcctt cttggtttga tattggactt tctgcagatt
     3541 tccaggagga cgaatctgga attaaacagg tggcagggaa tgtaagagct ttgtgataga
     3601 tcgagaggtg aaggatggca tcgcttctaa cagcattatt tggggaggat tttctcaggg
     3661 aggcaattga tttttttttt tttttttaaa tcatgctctt aagacacagc aaaaactgca
     3721 ggacaccaat gggctcagtt gctggcttcc acttccggct tcttctccac agggtcccat
     3781 caataccact aacagagata ttttttgttc tccagtgcca tggagattgt gactctttag
     3841 ttcccctaac atcggttctc ttcctgctga aaaactaaca gcattggtta atccagccaa
     3901 tgtaaccttc aaagctttgg tgcacagctg ttgtctgcag gaaatgatgg atggcaggca
     3961 attcattgat aaacttctac ctccagtgat tgacatcact aagagccttg tgtagacgct
     4021 ggctggcatc actgtagtag agtacctgat gggaaaactt ctaatgttgc agtgttaaaa
     4081 tgatttacaa atacatacca gtgagacaga ctaaatgatg tcttcctcat gggaaatgta
     4141 tgatccttta catttctaca acatatttca gtattataca atccagaata tctaagtgtt
     4201 aaagaaggaa aagtaggcag ctagcttttt ttttttctta aattaatcca tcagtcttaa
     4261 tacatcattt gaaaagtgac tagtaagctc actgaaaaat atttcagggc taaacaagcc
     4321 gttaggatgt aaatgatttc ttaattttgt gaattagact ataattttac tccacaattt
     4381 tatggtctct atgcagtgtc tatattttca tatgtgtatt cacatataca tgatgaatta
     4441 gatggtatta taatatcctt aatactaggg ataatgcttt tagagcatca aagaaaaaat
     4501 aatactgctc tcttcagtta atggcccttt tagtgtggaa accaggcctt tctttttctg
     4561 ctatttcatt ttttcttctc ttgagaaaca aaaaaatagt tggtttcttt ctatcttgat
     4621 tttctataga agtccaatat tgcctctttg ccataaaacc taccaatata tactataatt
     4681 ttacagtttg aaacatagac attgtatttc aaatctaggg gtaatgtgaa aaaacaaaca
     4741 ttactaagat tacatattaa ctaattgcac ctcagtccag ctttagactg cagagttatc
     4801 agaatcttca gccctggtga taattctatg gtttttttgt ttagtaaaga actgaaagag
     4861 taaataaaac cttattatgt taagaaataa atacttaaga tcagttttga agtctaattc
     4921 taagacagtt acaacttaca gaagagtttg agtttacatt ttctgtacct atgctatgtt
     4981 taaatgcaaa tactgttcaa catgagcaat tcaaaagttt tattttcatc tggtcatgaa
     5041 ctaattagaa aatttcattt taggtaaaaa aaagtttttt gagaataagt ctccagtgtg
     5101 tacattaaaa taacaataaa ttgagtttaa atagtgccca gaatattgat gaaaattatt
     5161 taaattaatt tacgagtaat aaagactgat tagaacacac tcataaactc acatacacac
     5221 acacactata cataaaacag ctgaatacat acaaaactgt ggttattgat gagctgttgc
     5281 ttttgttgcc tttcttgctg tttattaact gacaaagacc atgctaacaa tcatctttat
     5341 gaatgggtgc tagctgatgg gcagatcatt tgtatgggct agataaaaat gttaataatg
     5401 aagccatgtg ctcaggtttg aattgaaaac aattaaaaaa aatcacttgc tattttgttt
     5461 tcctttgaag aatataaagt tatttcagtt agatcatcag taaagtttta tctgggctaa
     5521 gaaaatttcc cttgagttct tgtgctgtaa tgtgggaaaa tatcatgttt ttcacagttt
     5581 ccatcaatgt gaaataaaat ttaattctgg caaaaaagtc ta
//
