LOCUS       NM_001083312            5604 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus guanylate binding protein 7 (Gbp7), transcript variant
            2, mRNA.
ACCESSION   NM_001083312
VERSION     NM_001083312.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5604)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5604)
  AUTHORS   Feng,S., Enosi Tuipulotu,D., Pandey,A., Jing,W., Shen,C., Ngo,C.,
            Tessema,M.B., Li,F.J., Fox,D., Mathur,A., Zhao,A., Wang,R.,
            Pfeffer,K., Degrandi,D., Yamamoto,M., Reading,P.C., Burgio,G. and
            Man,S.M.
  TITLE     Pathogen-selective killing by guanylate-binding proteins as a
            molecular mechanism leading to inflammasome signaling
  JOURNAL   Nat Commun 13 (1), 4395 (2022)
   PUBMED   35906252
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5604)
  AUTHORS   Feng,M., Zhang,Q., Wu,W., Chen,L., Gu,S., Ye,Y., Zhong,Y., Huang,Q.
            and Liu,S.
  TITLE     Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus
            Replication by Suppressing Innate Immunity via NF-kappaB and
            JAK-STAT Signaling Pathways
  JOURNAL   J Virol 95 (6), e02038-20 (2021)
   PUBMED   33408175
  REMARK    GeneRIF: Inducible Guanylate-Binding Protein 7 Facilitates
            Influenza A Virus Replication by Suppressing Innate Immunity via
            NF-kappaB and JAK-STAT Signaling Pathways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5604)
  AUTHORS   Steffens,N., Beuter-Gunia,C., Kravets,E., Reich,A., Legewie,L.,
            Pfeffer,K. and Degrandi,D.
  TITLE     Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection
  JOURNAL   mBio 11 (1), e02993-19 (2020)
   PUBMED   31964735
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5604)
  AUTHORS   Legewie,L., Loschwitz,J., Steffens,N., Prescher,M., Wang,X.,
            Smits,S.H.J., Schmitt,L., Strodel,B., Degrandi,D. and Pfeffer,K.
  TITLE     Biochemical and structural characterization of murine GBP7, a
            guanylate binding protein with an elongated C-terminal tail
  JOURNAL   Biochem J 476 (21), 3161-3182 (2019)
   PUBMED   31689351
  REMARK    GeneRIF: GBP7 exhibits a concentration-dependent GTPase activity
            and an apparent GTP turnover number of 20 min-1.
REFERENCE   6  (bases 1 to 5604)
  AUTHORS   Meunier,E., Dick,M.S., Dreier,R.F., Schurmann,N., Kenzelmann
            Broz,D., Warming,S., Roose-Girma,M., Bumann,D., Kayagaki,N.,
            Takeda,K., Yamamoto,M. and Broz,P.
  TITLE     Caspase-11 activation requires lysis of pathogen-containing
            vacuoles by IFN-induced GTPases
  JOURNAL   Nature 509 (7500), 366-370 (2014)
   PUBMED   24739961
REFERENCE   7  (bases 1 to 5604)
  AUTHORS   Kim,B.H., Shenoy,A.R., Kumar,P., Das,R., Tiwari,S. and
            MacMicking,J.D.
  TITLE     A family of IFN-gamma-inducible 65-kD GTPases protects against
            bacterial infection
  JOURNAL   Science 332 (6030), 717-721 (2011)
   PUBMED   21551061
  REMARK    GeneRIF: findings show that at least 4 IFN-gamma-inducible
            Gbps--Gbp1, Gbp6, Gbp7, and Gbp10--conferred cell-autonomous
            immunity to listerial or mycobacterial infection within macrophages
            and gene-deficient animals
REFERENCE   8  (bases 1 to 5604)
  AUTHORS   Degrandi,D., Konermann,C., Beuter-Gunia,C., Kresse,A., Wurthner,J.,
            Kurig,S., Beer,S. and Pfeffer,K.
  TITLE     Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10
            involved in host defense
  JOURNAL   J Immunol 179 (11), 7729-7740 (2007)
   PUBMED   18025219
REFERENCE   9  (bases 1 to 5604)
  AUTHORS   Olszewski,M.A., Gray,J. and Vestal,D.J.
  TITLE     In silico genomic analysis of the human and murine
            guanylate-binding protein (GBP) gene clusters
  JOURNAL   J Interferon Cytokine Res 26 (5), 328-352 (2006)
   PUBMED   16689661
REFERENCE   10 (bases 1 to 5604)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102108.12 and AK087751.1.
            
            On Nov 14, 2013 this sequence version replaced NM_001083312.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087751.1, BC010229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC102108.12        129505-129510       c
            7-2503              AK087751.1         1-2497
            2504-5604           AC102108.12        109695-112795       c
FEATURES             Location/Qualifiers
     source          1..5604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 66.69 cM"
     gene            1..5604
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /note="guanylate binding protein 7"
                     /db_xref="GeneID:229900"
                     /db_xref="MGI:MGI:2444421"
     exon            1..104
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            105..300
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..2027
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /note="GTP-binding protein 7; guanylate-binding protein
                     4-like; guanine nucleotide-binding protein 7"
                     /codon_start=1
                     /product="guanylate-binding protein 7"
                     /protein_id="NP_001076781.1"
                     /db_xref="CCDS:CCDS38657.1"
                     /db_xref="GeneID:229900"
                     /db_xref="MGI:MGI:2444421"
                     /translation="MASGPNMEAPVCLVENENEELRVNSKAINILERITQPVVVVAIV
                     GLYRTGKSYLMNRLAGQNHGFNLGTTVRSETKGIWMWCVPHPSKPKFTLVLLDTEGLG
                     DVEKGDPKNDSWIFALAVLLSSTFVYNSMSTINHQALEQLHYVTELTERIRAKSTSRS
                     EEVDDSDEFVSFFPDFIWTVRDFVLELKLEGRVITADEYLENALKLIPGMSIKAQKAN
                     LPRECIRHFFPRRKCFVFDRPTKDKELLVHVEEMPEDQLDHSFQVQSKEFCSYIFSNS
                     KAKTLKEGIVVNGNRLATLVTTYVDAINSGDVPCLENAVTTLAQRENSIAVQKAADHY
                     SEQMAQRMRLPTDTLQELLTVHTACEKEAIAVFMEHSFKDENQQFQKNLVVTIEEKKE
                     DFLRQNEAASLSHCQAELDKLSESLRESISRGVFSVPGGHRLYLEARKKVEQDYERVP
                     RKGVKANHVLQSFLQSQISIEDSIMQSDKALTDGQKAMEAERAQKEAAEKEQELLRQK
                     QKELQQVMEAQERSYKENVAQLHEKMETERKNILREQEVKLEHKLKIQKDMLNEGFKR
                     KCEAMDLEISQLQKEIQLNKEKNSSLGAKILDGFGDVLISVVPGSGKYFGLGLKILSS
                     QMNQTQNSDKVRKL"
     exon            301..428
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            429..538
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            539..735
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            736..981
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1262
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1475
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1578
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1772
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..5604
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5575..5580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /note="hexamer: AATAAA"
     polyA_site      5599
                     /gene="Gbp7"
                     /gene_synonym="9830147J24Rik; GBP-7"
                     /note="major polyA site"
ORIGIN      
        1 actctggagt ttaagaatag agagctttca ggaggaatcg gggcgggcgc agcagcaagc
       61 ctaaaggtgc tgaatccagg tagcagagaa tccggtgcag gctggttacc atggcatctg
      121 gtcccaacat ggaggctcct gtgtgcctag tggaaaatga gaatgaagaa ctgagggtga
      181 actccaaagc aataaacatt cttgagagga tcactcagcc tgtagtggtg gtggccattg
      241 taggactata ccgtacggga aaatcctact tgatgaaccg cttggcagga cagaaccatg
      301 gcttcaatct gggcaccaca gttaggtctg aaactaaggg catctggatg tggtgtgtgc
      361 ctcaccccag caagcccaag ttcacactcg tgcttctgga cacggagggc ttaggagatg
      421 tggaaaaggg tgaccctaag aatgactcgt ggatcttcgc cctggctgtg cttctgagca
      481 gcacctttgt ctacaacagc atgagcacca tcaaccacca ggccctggag cagctgcact
      541 atgtcacaga actgacagag cggatcaggg caaagtccac ttcacggtct gaagaagtgg
      601 atgactctga tgagtttgta agtttctttc cagattttat ctggactgtt cgagatttcg
      661 ttctggagct gaagttagag ggacgtgtca tcacagcaga cgagtaccta gaaaatgccc
      721 tgaagctgat cccaggcatg agtatcaaag cccagaaagc taacttgcct agggaatgca
      781 tcaggcactt ctttccaaga cggaagtgct ttgtctttga tcgacctaca aaagacaaag
      841 aacttttagt gcatgttgag gaaatgccag aggaccagtt ggatcacagt ttccaagtgc
      901 agtcaaaaga attctgttcc tacatcttct ccaattcgaa ggccaagacc ttgaaagagg
      961 gaatcgttgt caatggaaac cgactggcga ctctggtgac gacctacgtg gatgctatca
     1021 atagtggaga cgtgccgtgt ttagagaacg cagtaacaac cctggcccag cgtgagaact
     1081 ccatagctgt gcagaaggca gctgaccact acagtgagca gatggcccag cgaatgaggc
     1141 tccccacaga cacgctccag gagctgctga ctgtgcatac agcctgtgag aaggaagcca
     1201 ttgctgtctt catggagcac tccttcaagg atgagaatca gcaattccag aagaacttgg
     1261 tggtcaccat agaggaaaaa aaggaagatt tcctgcgaca gaatgaagca gcgtctctca
     1321 gtcactgcca ggctgagctg gacaagctct cagagtccct gagggagagc atctcacgtg
     1381 gagttttctc tgttcctggg ggtcacaggc tctacttaga ggccaggaag aaggttgaac
     1441 aggactatga gcgagtgccc aggaagggag tgaaggcaaa tcatgtcctt cagagcttcc
     1501 tacagtcaca gatttccatt gaggactcca ttatgcagtc agacaaagcc ctcactgatg
     1561 gccagaaggc catggaagct gagcgagctc agaaggaggc agctgagaag gagcaggagc
     1621 tactaagaca gaaacagaag gagctgcagc aggtgatgga agctcaagag agaagctaca
     1681 aggaaaatgt ggcccagctg cacgagaaga tggagacaga aaggaagaac atcctgagag
     1741 agcaagaggt gaagctggaa cacaagttga agattcaaaa agacatgctt aatgagggat
     1801 ttaaaaggaa atgtgaagca atggatttgg agataagtca actacaaaaa gagattcaac
     1861 taaataagga gaagaatagc tcattgggtg caaaaatcct tgatgggttt ggagatgtat
     1921 taatttcagt agtgcctggt tctggtaagt actttggtct agggttgaaa atattaagca
     1981 gccaaatgaa tcagacacag aattcagaca aagttagaaa actctaagta tagctttccc
     2041 ccacctccct gagacttact tttgaagtcc atctcacttt aatttcattt atcaaatttc
     2101 aaaaaccaag aatataggtc actctctata aattaatggc aagaccccat tgctgaaaac
     2161 aaatgtatac aactcattga ttgatggaga actcaagctg gtgcccatag atccttctcc
     2221 ttatatgcgg acatctttgg cacagaatga cactctgcat gctaccaaag gaaaaacaca
     2281 aatgccagcc cagccacaag ccctttgatc tacaatggca tcctgcctgc aaaatatgca
     2341 aatgcagtgg tggcacaaac tgtgggagta actaaccaat atctgatttg atttaaggcc
     2401 aacttcacgg gatgaaaccc atgcctacac tgcctgggtg atccagaacc tagatcagat
     2461 agcccagcga accttgagta aaaccaaata ctattgttgt attaaaaaaa aaaaagtagc
     2521 aatataatga ctcttcctga cattctgcag tactcattaa tcagtgcctt gctcagccat
     2581 catcacagaa gcttccccct gccacagatg ggaacaaatg cagagaggcc cacagccaga
     2641 cactgtacag agagagaatg agagtcttgg gaacactcaa ccttaagtag ggtgtcttta
     2701 tcaaacccct cccctcgggg ctcaggaaca ctgtgaaaga ggaaacagaa aaactataac
     2761 agccagagag gacagagggc accaagaaaa acacccacct cgcgggggct ggagagatgg
     2821 ctcagaggtc aagagcactg gctgctcttc tggaggtccc tggttcagtt tccagaatcc
     2881 acatggcagt tcacaaatgt ctgtaactgt ggtgccaggt gatctgacac cctcatacag
     2941 acatacatgc aaaacaaaaa caaaaacaaa aagcaaaaaa aaaatcaaac aaaccccaaa
     3001 taatcaacaa caacaacaac aacaaaacca atcaagcaag caagcaagca aacaaacaaa
     3061 aacaacacca aacaaaacca gctaaccaag gaatcattta aaaaaaaaaa tgcccactga
     3121 accaatatga tcaatgtaca taggaactca cagagacaga ggcaaggatg cacaggcctg
     3181 cacaggtctg cactagttgg ggttctaggg ctgaaaggaa aagtggacac aagccctcat
     3241 ctctgacaca gaagcaatct tcaattcata accacttaca aatggaaatt aatcttactc
     3301 caagagagtt tctccatctc atggaatggg ctgcctgacg ccacagttat tttccttcat
     3361 ggactgggag acactgggca aggatgggca ggagctgttg gttgcaggcg gcagaacatc
     3421 ccacatcagg cacacctgtc cacatgacac ccgatatgcc tattacagtc aacatgaata
     3481 tgaccaggcc ttcttggttt gatattggac tttctgcaga tttccaggag gacgaatctg
     3541 gaattaaaca ggtggcaggg aatgtaagag ctttgtgata gatcgagagg tgaaggatgg
     3601 catcgcttct aacagcatta tttggggagg attttctcag ggaggcaatt gatttttttt
     3661 ttttttttta aatcatgctc ttaagacaca gcaaaaactg caggacacca atgggctcag
     3721 ttgctggctt ccacttccgg cttcttctcc acagggtccc atcaatacca ctaacagaga
     3781 tattttttgt tctccagtgc catggagatt gtgactcttt agttccccta acatcggttc
     3841 tcttcctgct gaaaaactaa cagcattggt taatccagcc aatgtaacct tcaaagcttt
     3901 ggtgcacagc tgttgtctgc aggaaatgat ggatggcagg caattcattg ataaacttct
     3961 acctccagtg attgacatca ctaagagcct tgtgtagacg ctggctggca tcactgtagt
     4021 agagtacctg atgggaaaac ttctaatgtt gcagtgttaa aatgatttac aaatacatac
     4081 cagtgagaca gactaaatga tgtcttcctc atgggaaatg tatgatcctt tacatttcta
     4141 caacatattt cagtattata caatccagaa tatctaagtg ttaaagaagg aaaagtaggc
     4201 agctagcttt ttttttttct taaattaatc catcagtctt aatacatcat ttgaaaagtg
     4261 actagtaagc tcactgaaaa atatttcagg gctaaacaag ccgttaggat gtaaatgatt
     4321 tcttaatttt gtgaattaga ctataatttt actccacaat tttatggtct ctatgcagtg
     4381 tctatatttt catatgtgta ttcacatata catgatgaat tagatggtat tataatatcc
     4441 ttaatactag ggataatgct tttagagcat caaagaaaaa ataatactgc tctcttcagt
     4501 taatggccct tttagtgtgg aaaccaggcc tttctttttc tgctatttca ttttttcttc
     4561 tcttgagaaa caaaaaaata gttggtttct ttctatcttg attttctata gaagtccaat
     4621 attgcctctt tgccataaaa cctaccaata tatactataa ttttacagtt tgaaacatag
     4681 acattgtatt tcaaatctag gggtaatgtg aaaaaacaaa cattactaag attacatatt
     4741 aactaattgc acctcagtcc agctttagac tgcagagtta tcagaatctt cagccctggt
     4801 gataattcta tggttttttt gtttagtaaa gaactgaaag agtaaataaa accttattat
     4861 gttaagaaat aaatacttaa gatcagtttt gaagtctaat tctaagacag ttacaactta
     4921 cagaagagtt tgagtttaca ttttctgtac ctatgctatg tttaaatgca aatactgttc
     4981 aacatgagca attcaaaagt tttattttca tctggtcatg aactaattag aaaatttcat
     5041 tttaggtaaa aaaaagtttt ttgagaataa gtctccagtg tgtacattaa aataacaata
     5101 aattgagttt aaatagtgcc cagaatattg atgaaaatta tttaaattaa tttacgagta
     5161 ataaagactg attagaacac actcataaac tcacatacac acacacacta tacataaaac
     5221 agctgaatac atacaaaact gtggttattg atgagctgtt gcttttgttg cctttcttgc
     5281 tgtttattaa ctgacaaaga ccatgctaac aatcatcttt atgaatgggt gctagctgat
     5341 gggcagatca tttgtatggg ctagataaaa atgttaataa tgaagccatg tgctcaggtt
     5401 tgaattgaaa acaattaaaa aaaatcactt gctattttgt tttcctttga agaatataaa
     5461 gttatttcag ttagatcatc agtaaagttt tatctgggct aagaaaattt cccttgagtt
     5521 cttgtgctgt aatgtgggaa aatatcatgt ttttcacagt ttccatcaat gtgaaataaa
     5581 atttaattct ggcaaaaaag tcta
//
