LOCUS       NM_194336               4329 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus guanylate binding protein 6 (Gbp6), mRNA.
ACCESSION   NM_194336 XM_486343
VERSION     NM_194336.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4329)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4329)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 4329)
  AUTHORS   Kim,B.H., Shenoy,A.R., Kumar,P., Das,R., Tiwari,S. and
            MacMicking,J.D.
  TITLE     A family of IFN-gamma-inducible 65-kD GTPases protects against
            bacterial infection
  JOURNAL   Science 332 (6030), 717-721 (2011)
   PUBMED   21551061
  REMARK    GeneRIF: findings show that at least 4 IFN-gamma-inducible
            Gbps--Gbp1, Gbp6, Gbp7, and Gbp10--conferred cell-autonomous
            immunity to listerial or mycobacterial infection within macrophages
            and gene-deficient animals
REFERENCE   4  (bases 1 to 4329)
  AUTHORS   Burckstummer,T., Baumann,C., Bluml,S., Dixit,E., Durnberger,G.,
            Jahn,H., Planyavsky,M., Bilban,M., Colinge,J., Bennett,K.L. and
            Superti-Furga,G.
  TITLE     An orthogonal proteomic-genomic screen identifies AIM2 as a
            cytoplasmic DNA sensor for the inflammasome
  JOURNAL   Nat Immunol 10 (3), 266-272 (2009)
   PUBMED   19158679
REFERENCE   5  (bases 1 to 4329)
  AUTHORS   Degrandi,D., Konermann,C., Beuter-Gunia,C., Kresse,A., Wurthner,J.,
            Kurig,S., Beer,S. and Pfeffer,K.
  TITLE     Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10
            involved in host defense
  JOURNAL   J Immunol 179 (11), 7729-7740 (2007)
   PUBMED   18025219
REFERENCE   6  (bases 1 to 4329)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY159737.1, AK152226.1, BQ562803.1, BB657433.1, AC123697.19 and
            BX525828.1.
            
            On Mar 21, 2008 this sequence version replaced NM_194336.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128993.1, BK005759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BY159737.1         1-6
            7-837               AK152226.1         4-834
            838-1011            BQ562803.1         54-227
            1012-1547           BB657433.1         76-611
            1548-1730           AC123697.19        148925-149107       c
            1731-3850           AC123697.19        145906-148025       c
            3851-4329           BX525828.1         4-482
FEATURES             Location/Qualifiers
     source          1..4329
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.68 cM"
     gene            1..4329
                     /gene="Gbp6"
                     /gene_synonym="GBP-6; Mpa2l"
                     /note="guanylate binding protein 6"
                     /db_xref="GeneID:100702"
                     /db_xref="MGI:MGI:2140937"
     exon            1..74
                     /gene="Gbp6"
                     /gene_synonym="GBP-6; Mpa2l"
                     /inference="alignment:Splign:2.1.0"
     exon            75..264
                     /gene="Gbp6"
                     /gene_synonym="GBP-6; Mpa2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1916
                     /gene="Gbp6"
                     /gene_synonym="GBP-6; Mpa2l"
                     /note="macrophage activation 2 like; GTP-binding protein
                     6; guanine nucleotide-binding protein 6; macrophage
                     activation 2 like protein"
                     /codon_start=1
                     /product="guanylate-binding protein 6"
                     /protein_id="NP_919317.2"
                     /db_xref="CCDS:CCDS19492.1"
                     /db_xref="GeneID:100702"
                     /db_xref="MGI:MGI:2140937"
                     /translation="MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGL
                     YRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDV
                     EKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLHYVTELTELIRAKSSPNPAG
                     IKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSC
                     RECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKI
                     KTLKEGIKVTGNRLGILVTTYVNAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSE
                     QMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELF
                     LSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGV
                     KASEVFQSFLQSQAFIESSILQADTALTAGEKAIAEERAQKVAAEKEQELLRQKQKEQ
                     QEYMEAQEKSHKENLEQLRRKLEQEREQDIKDHDMMLKKLMKDQKAFLEEGFKKKAEE
                     MNKEIQQLRDVIKDKKRNTDRIKEALLNGFSTVLFHYLVRYLKHL"
     exon            265..392
                     /gene="Gbp6"
                     /gene_synonym="GBP-6; Mpa2l"
                     /inference="alignment:Splign:2.1.0"
     exon            393..502
                     /gene="Gbp6"
                     /gene_synonym="GBP-6; Mpa2l"
                     /inference="alignment:Splign:2.1.0"
     exon            503..699
                     /gene="Gbp6"
                     /gene_synonym="GBP-6; Mpa2l"
                     /inference="alignment:Splign:2.1.0"
     exon            700..945
                     /gene="Gbp6"
                     /gene_synonym="GBP-6; Mpa2l"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1226
                     /gene="Gbp6"
                     /gene_synonym="GBP-6; Mpa2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1433
                     /gene="Gbp6"
                     /gene_synonym="GBP-6; Mpa2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1536
                     /gene="Gbp6"
                     /gene_synonym="GBP-6; Mpa2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1730
                     /gene="Gbp6"
                     /gene_synonym="GBP-6; Mpa2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..4316
                     /gene="Gbp6"
                     /gene_synonym="GBP-6; Mpa2l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggagagc agaagggagc ctgaggaggc agcagcagct gagaactgca cttggacctg
       61 tgctgtggga ccaggttgct atgacccaac cacaaatggc tcccatttgc cttgtggaaa
      121 accacaatga acagctgtca gtgaaccagg aagccataga gattctggac aagatttctc
      181 agccagtggt agtcgtggct attgttggat tgtaccgtac agggaagtcc tatttgatga
      241 actgtttggc gggacagaat cacggctttc ctctgggctc caccgtgcag tctcagacca
      301 agggcatctg gatgtggtgc atgccacacc ccaccaagcc agagcacacc ctggtcctcc
      361 tggacactga gggcctgggg gatgtggaaa agggtgatcc taagaacgac ttgtggatct
      421 ttgccctcag cgtgcttctg agcagcacct tcatctacaa cagcatgatc accatcaacc
      481 accaggccct ggagcagctg cattatgtca cagaactcac agagctgatc agagcaaagt
      541 cttccccaaa tcctgctgga ataaagaatt ccacagagtt tgtgagtttc tttccagact
      601 ttgtctggac tgttcgggat ttcatgctgg agctgaagtt aaatggggaa gacatcacaa
      661 gtgatgacta cctggagaat gccttgaagc tgatcccagg tgacaaaccc agaatgcaag
      721 catccaattc atgcagggaa tgcatcagac ttttctttcc taaccggaag tgttttgtct
      781 ttgaccggcc aacgcatgac aaagaacttt tacaaaaact tgattctatc acagaagacc
      841 aactggatcc taagttccag gaagtaacaa aggcttttgt ttcttacatc ttcacttatg
      901 ccaagatcaa gaccctaaaa gagggaatta aggtcactgg gaatagacta gggattctgg
      961 tgacaaccta tgtgaatgcc atcaacagtg gagcagtgcc ttgtctggat gatgctgtga
     1021 caactctggc ccagcgtgag aactcagtag ctgtgcagaa agcagccgac cactatagtg
     1081 agcagatggc ccagcgactg aggcttccta cagaaacgct ccaggagctg ctggatgtgc
     1141 atgcagcctg cgagaaggaa gccatggctg tcttcatgga gcattccttc aaggacgaaa
     1201 atcagcaatt cctgaagaag ctggtggaat taataggaga gaacaaagag cttttcctgt
     1261 cgaagaatga agaggcatca aataaatact gtcaagaaga actggatcga ctttcaaagg
     1321 attttatgga aaatatttca acattttttg ttccttgtgg acacaagctt tacatggaca
     1381 agagggagaa gattgaacat gactactggc aggttcccag gaaaggggtg aaggcaagtg
     1441 aagtcttcca gagctttctg cagtcacagg ccttcatcga gagttccatc ttgcaggcag
     1501 atacagcgct cactgctggg gagaaggcca ttgcagagga gcgtgcccag aaggtggcgg
     1561 cagagaagga gcaagagctg ctaagacaga agcagaagga gcagcaggag tatatggagg
     1621 ctcaagagaa aagtcacaag gaaaacctag agcaactgag aaggaagctg gagcaggaga
     1681 gagagcagga catcaaagac catgatatga tgctgaagaa gctaatgaag gatcaaaagg
     1741 ctttccttga ggaaggattt aagaagaaag ctgaagaaat gaacaaagag atacagcaac
     1801 tgagagatgt catcaaggat aagaaaagaa acactgatcg aattaaggag gctctcttaa
     1861 atggattttc tacagttctt tttcattacc ttgtccgtta tctaaagcat ttatgattga
     1921 gtccttcaca tttgtggaaa tgatagactg tgaaatacac tttgtttcat acatgcctgc
     1981 aaagacaatg ttagccttta gaggacacat ttttgaaatg agtcctatgg aagctatgca
     2041 agtagtaatt acatgtgatt actgttggcc aatttgactg catagagaat cagcaaggag
     2101 acaaggtttt ctgtactcct atgaggacca tgtagcccag gttagcttgt gggggactgt
     2161 ctcaggttaa tattgtagga aacacatcct acgggtgggc agcactgttc ctgtggactg
     2221 aagaaacaga gaaagatgaa aacaaatggc cctaccactt gtggcttcct gactgtggat
     2281 gctatacaac aagccaggct caacttctct cagaatgcat tctccagcct tgacacaatg
     2341 tatcatcatg attcatagac cccaacaaac cctttcttaa gttggttttg tgagggtatt
     2401 tcatctcagc aagaggaaaa gtcattgata tcataatcgt gataatcctg gaaactactt
     2461 aaacatcact tgttagattg gcaatgaaat ttaatatgac ttgatcttgg cgtactatat
     2521 agtcaagaaa caaatgtcag tcaagctatc tgtaaaatga tctgaattgt actaaaatgt
     2581 acccaaaaga taaagtcaaa acaccataca actgtgtgat tattattaga aatgctacta
     2641 tcccatgcaa acatacaaga acacaaatga aatgccctct ggaagattag taaaaagcct
     2701 ggtctactgg cttcatctag agagattaag ttggagccaa aagttgaagg gatgtgtgca
     2761 ttccatgacg ttctcagtct tacacatttc atgaagagtg ctgggaaagt gacagtgata
     2821 gtgacaataa gttaaaactc accactgcat gatgaaacat ctgcttctag aaatggtata
     2881 agccactaga agtcacccaa gaacaagact tgagtaccag gaagcataac atttgcagct
     2941 taatgatgtt ttcctttaag gctttccatt tttaaaagta atttaaatag tgcatttttt
     3001 tgtaaaacca catatcaaaa tgttatttca acaggcaatc aaaataattt atgcatgctt
     3061 tttacatcaa atttatttat ttgcaaagta acagggaaac tgtattaaga gccatatgat
     3121 aatatagagt ataagagaat acatggggca catgggaggt ggagagctca gagatggctc
     3181 tgggtcaaga atgcacaatg cttatccagg gtagctcagt tcctggggca ggtaacaact
     3241 acctgtaaat ctaactccaa gggacctgac ttccttttct caaacccaag ggtcactgtt
     3301 acttccatca catatcctca gcttacacat atacatactt acaagtaaga tttaaaggaa
     3361 tatactgtta acattgataa tggaccatat gagtaaagac acaaggacac ttattagtgc
     3421 attaatgaat atgatttatt taaggtgtac ccaccccagc tcctctaaga catcctcaaa
     3481 ttaccctcgc accttcatgt cttctcttcc cccacctctt cctctttcct cataccctga
     3541 ataaattaat gctgccctca tgtccctggg cattagacac catctaccag accatggaca
     3601 attgatcatg acccaaaccc tcatagaaaa cacactccct ctcccagtca ccagatatca
     3661 actgctagta gttcctcagc taggggtggg gtctcatgag ctcactgcct ctccacactg
     3721 gatgttgact ggcttcatag tatgtatctt gtttcaacaa atatcactat tgtcgtagcc
     3781 ccatcatatc cagaaaatat tattttagaa cagtatggtc ttatttttat gcttaaatta
     3841 attatttcaa aattaaaatg tagacattct taagatttct ggaatcttgg agaagcctac
     3901 ttcgtctcta ttaatgcctg tgaaatgtca agttcaaaag aatgaactgt gtaaaggaga
     3961 gagagagatc ttggtgctgt tttattggga gccattttgt ttgcttcagt gaaagctgac
     4021 ctgccaggca caatcaagtc aggttagggt ctgctggcag atttcctggc ctactgactc
     4081 atggaactac aagaggaaat acacttgagg ctcaaggcaa gggggtgaaa gttcaattca
     4141 tcttggtggt tggaacagga aatcctctgg ataagaaaag atgtcctgtg tgtacattag
     4201 ccattatttc tgctaccttg tgacattgtt tctcatgata ctgagagata taataaagct
     4261 aagaaaaata aacttgaggt tgatgtggta ttcacctgca accttcccaa ttctaaaaaa
     4321 aaaaaaaaa
//
