LOCUS       NM_153564               3021 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus guanylate binding protein 5 (Gbp5), mRNA.
ACCESSION   NM_153564 XM_001052120 XM_001052121 XM_001052122
VERSION     NM_153564.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3021)
  AUTHORS   Li,Y., Wang,W., Liu,Y., Li,S., Wang,J. and Hou,L.
  TITLE     Diminished Immune Response and Elevated Abundance in Gut Microbe
            Dubosiella in Mouse Models of Chronic Colitis with GBP5 Deficiency
  JOURNAL   Biomolecules 14 (7), 873 (2024)
   PUBMED   39062588
  REMARK    GeneRIF: Diminished Immune Response and Elevated Abundance in Gut
            Microbe Dubosiella in Mouse Models of Chronic Colitis with GBP5
            Deficiency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3021)
  AUTHORS   Luu,L.D.W., Pandey,A., Paramsothy,S., Ngo,C., Castano-Rodriguez,N.,
            Liu,C., Kamm,M.A., Borody,T.J., Man,S.M. and Kaakoush,N.O.
  TITLE     Profiling the colonic mucosal response to fecal microbiota
            transplantation identifies a role for GBP5 in colitis in humans and
            mice
  JOURNAL   Nat Commun 15 (1), 2645 (2024)
   PUBMED   38531874
  REMARK    GeneRIF: Profiling the colonic mucosal response to fecal microbiota
            transplantation identifies a role for GBP5 in colitis in humans and
            mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3021)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3021)
  AUTHORS   Marinho,F.V., Brito,C., de Araujo,A.C.V.S.C. and Oliveira,S.C.
  TITLE     Guanylate-binding protein-5 is involved in inflammasome activation
            by bacterial DNA but only the cooperation of multiple GBPs accounts
            for control of Brucella abortus infection
  JOURNAL   Front Immunol 15, 1341464 (2024)
   PUBMED   38404575
  REMARK    GeneRIF: Guanylate-binding protein-5 is involved in inflammasome
            activation by bacterial DNA but only the cooperation of multiple
            GBPs accounts for control of Brucella abortus infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3021)
  AUTHORS   Li,J., Liu,K., He,W., Zhang,W. and Li,Y.
  TITLE     Inhibition of GBP5 activates autophagy to alleviate inflammatory
            response in LPS-induced lung injury in mice
  JOURNAL   Exp Lung Res 50 (1), 106-117 (2024)
   PUBMED   38642025
  REMARK    GeneRIF: Inhibition of GBP5 activates autophagy to alleviate
            inflammatory response in LPS-induced lung injury in mice.
REFERENCE   6  (bases 1 to 3021)
  AUTHORS   Degrandi,D., Konermann,C., Beuter-Gunia,C., Kresse,A., Wurthner,J.,
            Kurig,S., Beer,S. and Pfeffer,K.
  TITLE     Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10
            involved in host defense
  JOURNAL   J Immunol 179 (11), 7729-7740 (2007)
   PUBMED   18025219
REFERENCE   7  (bases 1 to 3021)
  AUTHORS   Johansson,M.H., Taylor,M.A., Jagodic,M., Tus,K., Schatzle,J.D.,
            Wakeland,E.K. and Bennett,M.
  TITLE     Mapping of quantitative trait loci determining NK cell-mediated
            resistance to MHC class I-deficient bone marrow grafts in
            perforin-deficient mice
  JOURNAL   J Immunol 177 (11), 7923-7929 (2006)
   PUBMED   17114464
REFERENCE   8  (bases 1 to 3021)
  AUTHORS   Olszewski,M.A., Gray,J. and Vestal,D.J.
  TITLE     In silico genomic analysis of the human and murine
            guanylate-binding protein (GBP) gene clusters
  JOURNAL   J Interferon Cytokine Res 26 (5), 328-352 (2006)
   PUBMED   16689661
REFERENCE   9  (bases 1 to 3021)
  AUTHORS   Smith,J.B., Nguyen,T.T., Hughes,H.J., Herschman,H.R., Widney,D.P.,
            Bui,K.C. and Rovai,L.E.
  TITLE     Glucocorticoid-attenuated response genes induced in the lung during
            endotoxemia
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 283 (3), L636-L647 (2002)
   PUBMED   12169584
REFERENCE   10 (bases 1 to 3021)
  AUTHORS   Nguyen,T.T., Hu,Y., Widney,D.P., Mar,R.A. and Smith,J.B.
  TITLE     Murine GBP-5, a new member of the murine guanylate-binding protein
            family, is coordinately regulated with other GBPs in vivo and in
            vitro
  JOURNAL   J Interferon Cytokine Res 22 (8), 899-909 (2002)
   PUBMED   12396730
  REMARK    GeneRIF: Murine GBP-5, a new member of the murine guanylate-binding
            protein family, is coordinately regulated with other GBPs in vivo
            and in vitro.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK030414.1 and
            AC102108.12.
            
            On or before May 4, 2006 this sequence version replaced
            XM_001052121.1, XM_001052120.1, XM_001052122.1, NM_153564.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058555.1, AF422243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1716              AK030414.1         1-1716
            1717-3021           AC102108.12        137502-138806       c
FEATURES             Location/Qualifiers
     source          1..3021
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 66.69 cM"
     gene            1..3021
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /note="guanylate binding protein 5"
                     /db_xref="GeneID:229898"
                     /db_xref="MGI:MGI:2429943"
     exon            1..62
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /inference="alignment:Splign:2.1.0"
     exon            63..256
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1839
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /note="guanylate nucleotide binding protein 5; GBP-5;
                     muGBP-5; GTP-binding protein 5; guanine nucleotide-binding
                     protein 5"
                     /codon_start=1
                     /product="guanylate-binding protein 5"
                     /protein_id="NP_705792.2"
                     /db_xref="CCDS:CCDS17877.1"
                     /db_xref="GeneID:229898"
                     /db_xref="MGI:MGI:2429943"
                     /translation="MAPEIHMPEPLCLIGSTEGHLVTNQEALKILSAITQPVVVVAIV
                     GLYRTGKSYLMNKLAGKEKGFSVGSTVQSHTKGIWMWCVPHPQKPDHTLVLLDTEGLG
                     DVEKDDKKNDTQIFALAILLSSTFVYNTMNKIDQGAIDLLHNVTELTDLLRTRNSSDS
                     NQTEGEGPADMSFFPDLVWTLRDFFLDLQANGHAITSDEYLENSLKLKQGSDERTQTF
                     NLPRLCIQKFFPVKKCFVFDAPALGSKLSQLPTLSNEELNSDFVQDLSEFCSHIFTQS
                     KTKTLPGGIQVNGPRLESLVLTYVDAINSGALPSIENTVVTLARRENSAAVQKAIGHY
                     DQLMSEKVQLPTETLQELLDLHRTCEREAIEIFRKHSFKDEGEFFQKELESLLSAKQD
                     EICKKNADASAALCSTLLGSIFKPLEQEVAQEFYHKPGGHKLFLQRMEQLKANYRQQP
                     GKGTQAEEVLQTYLNAKETVSRTILQTDQVLTDKEIQSKAEQERAEAARLEAQRLEAI
                     RIQEEQRKAEMERQHQEQLRQIALEKARVAQEQQWILKQRAQEEADRIKAEQEAQLRA
                     LQQQLQHMREMNHHRRHHHDCVIS"
     exon            257..384
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /inference="alignment:Splign:2.1.0"
     exon            385..494
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /inference="alignment:Splign:2.1.0"
     exon            495..694
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /inference="alignment:Splign:2.1.0"
     exon            695..937
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1218
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1431
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1534
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1716
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..3021
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2984..2989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /note="hexamer: AATAAA"
     regulatory      3002..3007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /note="hexamer: TATAAA"
     polyA_site      3012
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /note="major polyA site"
     polyA_site      3021
                     /gene="Gbp5"
                     /gene_synonym="5330409J06Rik; Gbp5a"
                     /note="major polyA site"
ORIGIN      
        1 agagtcccgt ttgaagcagt gttcttactg gcccctgctc ccgctcttca gtttttctta
       61 agagacatgg ccccagagat tcacatgcca gaacccttgt gcctcattgg gagcaccgag
      121 ggacacctag taactaacca ggaagccctg aagattctgt ctgccatcac acagccagtg
      181 gtggtggtag ccattgtggg tctttatcgc acaggcaaat cctacctgat gaacaagctg
      241 gctgggaagg agaagggctt ttctgttgga tccactgtac agtctcacac caaggggatc
      301 tggatgtggt gtgtgcctca cccccaaaag ccagaccaca ctttggttct gcttgacact
      361 gaaggcctgg gagatgtgga gaaggatgat aaaaagaatg atactcagat ctttgcacta
      421 gcaatcctcc tcagtagcac ctttgtatac aacactatga acaaaattga ccagggggct
      481 atcgacctat tgcacaatgt gacagaactg acagacttgc tccggacaag aaactcctct
      541 gattctaatc aaactgaggg tgagggacct gctgacatga gcttcttccc agacttggtg
      601 tggactctga gagatttctt cctggacctg caagccaatg ggcatgccat cacatcagat
      661 gaatatctgg agaattcact gaagctgaag caaggtagcg atgaaagaac tcaaacattc
      721 aatctaccgc ggctgtgcat acagaagttc ttcccagtaa agaaatgctt tgtttttgac
      781 gctcctgcgc ttggaagtaa gctttcccag cttccaacac tcagcaacga ggagctgaac
      841 tcagattttg tgcaggacct ttcagaattc tgttcacaca tcttcaccca atctaagacc
      901 aagactcttc caggaggcat ccaggtcaac ggacctcgtc tagaaagcct ggtgctgact
      961 tatgtcgatg ccatcaacag cggggctctg ccttccatag agaacacagt agtaaccttg
     1021 gcccggaggg agaactctgc agcagttcaa aaggccattg gtcactacga tcagctgatg
     1081 agcgagaagg tgcagctgcc cacagagacc ctccaggagc tgctggacct gcaccggacc
     1141 tgtgagcgag aggccataga aatcttcagg aagcattcgt tcaaggatga gggtgaattt
     1201 ttccagaaag aattggagag cctactaagt gcaaagcagg atgagatttg taagaagaac
     1261 gcggatgctt ctgcagccct ctgctcaacc ctacttggga gtatttttaa gcctctggaa
     1321 caagaagtgg cgcaggagtt ctatcataaa ccaggaggcc acaagctctt ccttcagagg
     1381 atggaacagc tgaaggcaaa ttaccgtcag cagccaggga agggaacaca ggctgaggaa
     1441 gtgctgcaga cctatttgaa cgccaaagaa acagtgagcc gtacaattct acaaacagac
     1501 caggttctca cagacaagga gatccagagt aaagcggaac aagaaagagc agaggctgcc
     1561 cggctcgaag cacagaggtt ggaggctatt cgcatccagg aagagcaaag gaaagcagag
     1621 atggagagac agcatcaaga gcaattgagg caaatagcat tggagaaggc aagagttgca
     1681 caagagcaac agtggatcct gaagcagaga gcccaggaag aggctgatag aatcaaggca
     1741 gagcaggaag ctcaactcag agcacttcaa cagcagctcc aacacatgag ggaaatgaac
     1801 caccaccgta gacatcatca tgactgtgtt ataagctaat acgccaaaac ctgagccctc
     1861 catttcttct tgcttctcat tgaagacaca aaggaacaag agactgaagg acttcagaca
     1921 atcaaaagtt aagaagcctc agtgccccct gtcgaactgc catatttgtc tcaagatatt
     1981 ttatgttact cggggggtgt tagtggagta gaacttggcc acatctacaa ctcaaatggt
     2041 atctcttctt ctggtggaca taggaagaag gcaccaatga gaaatcagaa aagattcata
     2101 tttctcaaca gggtggagtt ccctagtccg tggcagtggg ctggctcctc agtacagtcc
     2161 gctgcccatc tgcatgttct tcttcctttc tgtttctttc ttaggagccc aaacacattg
     2221 tcacttgtca catggataac tgtcatgtca ctcacacatg gagggaggtt tgttcctcta
     2281 gaattctgct gtgtccacat tctatctctt gttgtgtcat tagtggtaaa gaaagtctct
     2341 ttaattttga tacacaaaaa tcaccatttg tctgtttcca tttttcttcc ttaaagtcta
     2401 tacttgccca ggtatattgc tcactttcta ccacaggaat tcttaaccac agtaattaca
     2461 ctgattttaa atcattttga tgatttaaaa tgtaaagttt aaaaatgatt tctcactatt
     2521 ctaagcctgt ctctgtttct gggtcgattt gctttatttc tttaaacaaa aacaaaaaca
     2581 aaaaataacc cctgttcttg ttttttctgt gtgtcttaaa attcttttaa ttgcatgctg
     2641 tacattgttg gtaacataat taagattgat agatttatgt ttggaatgtg catttccctt
     2701 ttatattgag atgtatctgg caagcattgt ctcagtgtag ttgttcacct ggaaatagcc
     2761 ttagtttgtt ctaataaagt aagtagccct tgcctttatc tatccagaag gcaatgggga
     2821 gagggagagg gagaggggga gggcgagggc gagggcgagg gcgagggcga gggcgaggga
     2881 gagggagagg gagagggaga gggagaggga gagggagagg gagagggaga gggagaggga
     2941 gagggagaga attgcctgtt tatgttagtc tcattctgtg ttcaataaaa tggaataaaa
     3001 atataaaatt cactaaattg a
//
