LOCUS       NM_001289493            2743 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus guanylate binding protein 3 (Gbp3), transcript variant
            3, mRNA.
ACCESSION   NM_001289493 XM_006501722
VERSION     NM_001289493.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2743)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2743)
  AUTHORS   Zhang,Z., Song,W. and Yan,R.
  TITLE     Gbp3 is associated with the progression of lupus nephritis by
            regulating cell proliferation, inflammation and pyroptosis
  JOURNAL   Autoimmunity 56 (1), 2250095 (2023)
   PUBMED   37621179
  REMARK    GeneRIF: Gbp3 is associated with the progression of lupus nephritis
            by regulating cell proliferation, inflammation and pyroptosis.
REFERENCE   3  (bases 1 to 2743)
  AUTHORS   Feng,S., Enosi Tuipulotu,D., Pandey,A., Jing,W., Shen,C., Ngo,C.,
            Tessema,M.B., Li,F.J., Fox,D., Mathur,A., Zhao,A., Wang,R.,
            Pfeffer,K., Degrandi,D., Yamamoto,M., Reading,P.C., Burgio,G. and
            Man,S.M.
  TITLE     Pathogen-selective killing by guanylate-binding proteins as a
            molecular mechanism leading to inflammasome signaling
  JOURNAL   Nat Commun 13 (1), 4395 (2022)
   PUBMED   35906252
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2743)
  AUTHORS   Xu,H., Jin,J., Chen,Y., Wu,G., Zhu,H., Wang,Q., Wang,J., Li,S.,
            Grigore,F.N., Ma,J., Chen,C.C., Lan,Q. and Li,M.
  TITLE     GBP3 promotes glioblastoma resistance to temozolomide by enhancing
            DNA damage repair
  JOURNAL   Oncogene 41 (31), 3876-3885 (2022)
   PUBMED   35780181
  REMARK    GeneRIF: GBP3 promotes glioblastoma resistance to temozolomide by
            enhancing DNA damage repair.
REFERENCE   5  (bases 1 to 2743)
  AUTHORS   Kim,B.H., Shenoy,A.R., Kumar,P., Das,R., Tiwari,S. and
            MacMicking,J.D.
  TITLE     A family of IFN-gamma-inducible 65-kD GTPases protects against
            bacterial infection
  JOURNAL   Science 332 (6030), 717-721 (2011)
   PUBMED   21551061
REFERENCE   6  (bases 1 to 2743)
  AUTHORS   Vestal,D.J. and Jeyaratnam,J.A.
  TITLE     The guanylate-binding proteins: emerging insights into the
            biochemical properties and functions of this family of large
            interferon-induced guanosine triphosphatase
  JOURNAL   J Interferon Cytokine Res 31 (1), 89-97 (2011)
   PUBMED   21142871
  REMARK    Review article
REFERENCE   7  (bases 1 to 2743)
  AUTHORS   Degrandi,D., Konermann,C., Beuter-Gunia,C., Kresse,A., Wurthner,J.,
            Kurig,S., Beer,S. and Pfeffer,K.
  TITLE     Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10
            involved in host defense
  JOURNAL   J Immunol 179 (11), 7729-7740 (2007)
   PUBMED   18025219
REFERENCE   8  (bases 1 to 2743)
  AUTHORS   Olszewski,M.A., Gray,J. and Vestal,D.J.
  TITLE     In silico genomic analysis of the human and murine
            guanylate-binding protein (GBP) gene clusters
  JOURNAL   J Interferon Cytokine Res 26 (5), 328-352 (2006)
   PUBMED   16689661
REFERENCE   9  (bases 1 to 2743)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 2743)
  AUTHORS   Han,B.H., Park,D.J., Lim,R.W., Im,J.H. and Kim,H.D.
  TITLE     Cloning, expression, and characterization of a novel
            guanylate-binding protein, GBP3 in murine erythroid progenitor
            cells
  JOURNAL   Biochim Biophys Acta 1384 (2), 373-386 (1998)
   PUBMED   9659399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102108.12, CK389037.1 and AK132266.1.
            
            On Sep 20, 2017 this sequence version replaced NM_001289493.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U44731.1, SRR11927935.4112516.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               AC102108.12        99156-99490         c
            336-424             CK389037.1         210-298
            425-2732            AK132266.1         321-2628
            2733-2743           AC102108.12        86633-86643         c
FEATURES             Location/Qualifiers
     source          1..2743
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 66.69 cM"
     gene            1..2743
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /note="guanylate binding protein 3"
                     /db_xref="GeneID:55932"
                     /db_xref="MGI:MGI:1926263"
     exon            1..335
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            336..531
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..2222
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /note="guanylate nucleotide binding protein 4; putative
                     purine nucleotide binding protein; guanylate-binding
                     protein 4; GTP-binding protein 3; GTP-binding protein 4;
                     guanine nucleotide-binding protein 4; guanylate nucleotide
                     binding protein 3; guanine nucleotide-binding protein 3"
                     /codon_start=1
                     /product="guanylate-binding protein 3"
                     /protein_id="NP_001276422.1"
                     /db_xref="CCDS:CCDS17879.1"
                     /db_xref="GeneID:55932"
                     /db_xref="MGI:MGI:1926263"
                     /translation="MEAPICLVENWKNQLTVNLEAIRILEQIAQPLVVVAIVGLYRTG
                     KSYLMNRLAGRNHGFSLGSTVQSETKGIWMWCVPHPTKPTHTLVLLDTEGLGDVEKGD
                     PKNDSWIFALAVLLSSTFVYNSMSTINQQALEQLHFVTELTQLIRAKSSPREDKVKDS
                     SEFVGFFPDFIWAVRDFALELKLNGRPITEDEYLENALKLIQGDNLKVQQSNMTRECI
                     RYFFPVRKCFVFDRPTSDKRLLLQIENVPENQLERNFQVESEKFCSYIFTNGKTKTLR
                     GGVIVTGNRLGTLVQTYVNAINSGTVPCLENAVTTLAQRENSIAVQKAADHYSEQMAQ
                     RMRLPTDTLQELLTVHAACEKEAIAVFMEHSFKDDEQEFQKKLVVTIEERKEEFIRQN
                     EAASIRHCQAELERLSESLRKSISCGAFSVPGGHSLYLEARKKIELGYQQVLRKGVKA
                     KEVLKSFLQSQAIMEDSILQSDKALTDGERAIAAERTKKEVAEKELELLRQRQKEQEQ
                     VMEAQERSFRENIAKLQEKMESEKEMLLREQEKMLEHKLKVQEELLIEGFREKSDMLK
                     NEISHLREEMERTRRKPSLFGQILDTIGNAFIMILPGAGKLFGVGLKFLGSLSS"
     exon            532..659
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            660..769
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            770..966
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1212
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1493
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1706
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1809
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2003
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2743
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2714..2719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /note="hexamer: AATAAA"
     polyA_site      2739
                     /gene="Gbp3"
                     /gene_synonym="GBP-3; GBP-4; Gbp4"
                     /note="major polyA site"
ORIGIN      
        1 tcggtgatgg aacacactgt aggaaagaaa aaaagtctca atctgcaaga tgtggcgggg
       61 tgataactgc agaaagttcg gggggatctg ggaaattcct cagctcagct gaggtcacaa
      121 attctgttat tttgttcaag ccctcaacga ctgactgagt catcaagcaa ggagcatggt
      181 ttcgatttca gttcctttta tctcaatttg tgtttgggcg gctgttactt tgccacttct
      241 aacagtggct gctccaagga gcctggagca gtaggaagct cagggaaaga actaagttgg
      301 ctgaggactg tccctgttac agagccagtg cctggggttc tgcagcttcc gagtggacca
      361 tggaggcacc catttgtctg gtggaaaatt ggaaaaatca gctgacagta aatctggaag
      421 ccataaggat tcttgagcag atagcacagc ctctggtggt ggtggccatt gttggtttat
      481 atcgtacagg gaagtcctac ctcatgaatc gtcttgcagg acggaaccat ggcttctcct
      541 tgggctccac agtgcaatcc gaaaccaagg gtatctggat gtggtgtgtg ccccatccca
      601 ccaagccaac acacaccctg gtccttttgg acactgaagg ccttggtgat gtagaaaagg
      661 gtgaccctaa gaatgactcg tggatcttcg ccctggctgt gcttctgagc agcacctttg
      721 tctacaacag catgagcacc atcaaccagc aggccctgga gcagctgcat tttgtgactg
      781 aattaacaca gctaatccgg gcaaaatcga gccccagaga ggacaaagtg aaggactcca
      841 gtgagtttgt aggtttcttc ccagacttta tctgggctgt tcgagatttt gctctggagc
      901 tgaagttaaa tggtcggccc atcacagaag atgagtacct ggagaatgcc ctgaagctga
      961 tccaaggaga caatctcaaa gtccaacagt ccaacatgac cagagaatgt atcagatatt
     1021 tttttccggt acggaagtgc tttgtctttg acaggcccac aagcgacaaa cgtttattgc
     1081 tccaaattga aaatgttcca gaaaaccaac tggaacggaa tttccaggtt gaatcagaaa
     1141 aattctgttc ctacatcttc accaacggca agaccaagac tctgagaggg ggagtcattg
     1201 tcacaggaaa tcggctgggg actttggtgc agacctatgt gaatgccatc aacagtggga
     1261 ctgtgccttg tctggagaac gcagtgacaa ccctggccca gcgtgagaac tccatagctg
     1321 tgcagaaggc agctgaccac tacagtgagc agatggccca gcgaatgagg ctccccacag
     1381 acacgctcca ggagctgctg actgtgcatg cagcctgtga gaaggaagcc attgctgtct
     1441 tcatggagca ctccttcaag gatgatgagc aggagttcca gaagaagctg gtggtcacca
     1501 tagaggaaag gaaggaagag ttcatacgac agaacgaagc agcatctatt cgtcactgcc
     1561 aggctgaact ggagaggctt tcagagtccc tgaggaagag catctcctgt ggagctttct
     1621 ctgttcctgg gggtcacagc ctctacttag aagccaggaa gaagattgag ctgggctacc
     1681 agcaagtgct gaggaaggga gtgaaggcaa aagaggttct caagagtttc ctacagtcac
     1741 aggctattat ggaggactct atcttgcagt cagacaaagc tcttacagat ggagagagag
     1801 ccatagcagc tgagcggaca aagaaggaag tggctgagaa ggaactagag ctgctgaggc
     1861 agagacagaa ggagcaagag caagtgatgg aggctcagga gagaagcttc cgagaaaaca
     1921 ttgctaaact tcaggagaag atggagagcg aaaaggagat gctgctgagg gagcaggaga
     1981 agatgctgga gcacaagctg aaggtccaag aagaactgct tattgaagga ttcagagaga
     2041 aatctgatat gttaaagaat gaaataagtc acctgagaga agagatggaa agaacaagaa
     2101 ggaaaccctc actgtttggt caaatccttg acaccattgg caatgcgttc attatgattt
     2161 taccaggagc tggtaaacta tttggtgtgg ggctgaaatt cctcggctca ctaagtagtt
     2221 agtctaaaga gtttctggga aggaatttat aaaatccagg cttctgttat tttgatacca
     2281 aactttttgc tgtgattttt aagtacacat tctagtttaa taaccacggt tacaaagaaa
     2341 gtaagaactt ccattaatag ctaaattgtc agatactgct tcctcggagt ctaattctgt
     2401 gtcagttcat tacctattat atttaaggtt aaagatacaa accaatgatt gaagaatata
     2461 agggtctggc gtccataaat cctgtcaaat ttcagtgatg ttatctaaat aataaagagg
     2521 gaggccagtc agaatatagt gaaattattt ctagaaaaga tgtaagtaaa tcaaacagaa
     2581 acatggccaa atgaagacac attggcatat gtatcccagt tgtacactac agataaattg
     2641 ttaaaaagag ctcttgttaa aacgcacaag tgggttttca taagagaatg tatgaggaaa
     2701 atgtttgatt gataataaaa ggcatgcaga ttaaaataat gaa
//
