LOCUS       NM_010259               2820 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus guanylate binding protein 2b (Gbp2b), mRNA.
ACCESSION   NM_010259 XM_917959
VERSION     NM_010259.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2820)
  AUTHORS   Kumar,R. and Kushawaha,P.K.
  TITLE     Interferon inducible guanylate-binding protein 1 modulates the
            lipopolysaccharide-induced cytokines/chemokines and
            mitogen-activated protein kinases in macrophages
  JOURNAL   Microbiol Immunol 68 (5), 185-195 (2024)
   PUBMED   38462687
  REMARK    GeneRIF: Interferon inducible guanylate-binding protein 1 modulates
            the lipopolysaccharide-induced cytokines/chemokines and
            mitogen-activated protein kinases in macrophages.
REFERENCE   2  (bases 1 to 2820)
  AUTHORS   Tessema,M.B., Tuipulotu,D.E., Oates,C.V., Brooks,A.G., Man,S.M.,
            Londrigan,S.L. and Reading,P.C.
  TITLE     Mouse guanylate-binding protein 1 does not mediate antiviral
            activity against influenza virus in vitro or in vivo
  JOURNAL   Immunol Cell Biol 101 (5), 383-396 (2023)
   PUBMED   36744765
  REMARK    GeneRIF: Mouse guanylate-binding protein 1 does not mediate
            antiviral activity against influenza virus in vitro or in vivo.
REFERENCE   3  (bases 1 to 2820)
  AUTHORS   Feng,S., Enosi Tuipulotu,D., Pandey,A., Jing,W., Shen,C., Ngo,C.,
            Tessema,M.B., Li,F.J., Fox,D., Mathur,A., Zhao,A., Wang,R.,
            Pfeffer,K., Degrandi,D., Yamamoto,M., Reading,P.C., Burgio,G. and
            Man,S.M.
  TITLE     Pathogen-selective killing by guanylate-binding proteins as a
            molecular mechanism leading to inflammasome signaling
  JOURNAL   Nat Commun 13 (1), 4395 (2022)
   PUBMED   35906252
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2820)
  AUTHORS   Li,G., Kryczek,I., Nam,J., Li,X., Li,S., Li,J., Wei,S., Grove,S.,
            Vatan,L., Zhou,J., Du,W., Lin,H., Wang,T., Subramanian,C.,
            Moon,J.J., Cieslik,M., Cohen,M. and Zou,W.
  TITLE     LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy
  JOURNAL   Nat Cell Biol 23 (5), 526-537 (2021)
   PUBMED   33958760
REFERENCE   5  (bases 1 to 2820)
  AUTHORS   Meng,Y., Wang,W., Chen,M., Chen,K., Xia,X., Zhou,S. and Yang,H.
  TITLE     GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular
            Secretion to Promote the Malignant Progression of Lung Cancer
  JOURNAL   Front Immunol 11, 622467 (2021)
   PUBMED   33552086
  REMARK    GeneRIF: GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular
            Secretion to Promote the Malignant Progression of Lung Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2820)
  AUTHORS   Wynn,T.A., Nicolet,C.M. and Paulnock,D.M.
  TITLE     Identification and characterization of a new gene family induced
            during macrophage activation
  JOURNAL   J Immunol 147 (12), 4384-4392 (1991)
   PUBMED   1753106
REFERENCE   7  (bases 1 to 2820)
  AUTHORS   Cheng,Y.S., Patterson,C.E. and Staeheli,P.
  TITLE     Interferon-induced guanylate-binding proteins lack an N(T)KXD
            consensus motif and bind GMP in addition to GDP and GTP
  JOURNAL   Mol Cell Biol 11 (9), 4717-4725 (1991)
   PUBMED   1715024
REFERENCE   8  (bases 1 to 2820)
  AUTHORS   Wood,L., Carter,D., Mills,M., Hatzenbuhler,N. and Vogeli,G.
  TITLE     Expression of calcyclin, a calcium-binding protein, in the
            keratogenous region of growing hair follicles
  JOURNAL   J Invest Dermatol 96 (3), 383-387 (1991)
   PUBMED   2002257
REFERENCE   9  (bases 1 to 2820)
  AUTHORS   Saris,C.J., Kristensen,T., D'Eustachio,P., Hicks,L.J., Noonan,D.J.,
            Hunter,T. and Tack,B.F.
  TITLE     cDNA sequence and tissue distribution of the mRNA for bovine and
            murine p11, the S100-related light chain of the protein-tyrosine
            kinase substrate p36 (calpactin I)
  JOURNAL   J Biol Chem 262 (22), 10663-10671 (1987)
   PUBMED   3038891
REFERENCE   10 (bases 1 to 2820)
  AUTHORS   Paul,P.R. and Elliott,R.W.
  TITLE     Analysis of the mouse Amy locus in recombinant inbred mouse strains
  JOURNAL   Biochem Genet 25 (7-8), 569-579 (1987)
   PUBMED   2451911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077796.1 and AC102108.12.
            
            On Mar 23, 2007 this sequence version replaced NM_010259.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077796.1, EF494422.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AK077796.1         2-69
            69-74               AC102108.12        61706-61711         c
            75-1245             AK077796.1         76-1246
            1246-1250           AC102108.12        51715-51719         c
            1251-1859           AK077796.1         1253-1861
            1860-1867           AC102108.12        41623-41630         c
            1868-2820           AK077796.1         1870-2822
FEATURES             Location/Qualifiers
     source          1..2820
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 66.69 cM"
     gene            1..2820
                     /gene="Gbp2b"
                     /gene_synonym="Gbp-1; Gbp1; LIMIT; Mag-1; Mpa-1; Mpa1"
                     /note="guanylate binding protein 2b"
                     /db_xref="GeneID:14468"
                     /db_xref="MGI:MGI:95666"
     exon            1..65
                     /gene="Gbp2b"
                     /gene_synonym="Gbp-1; Gbp1; LIMIT; Mag-1; Mpa-1; Mpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            66..269
                     /gene="Gbp2b"
                     /gene_synonym="Gbp-1; Gbp1; LIMIT; Mag-1; Mpa-1; Mpa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1849
                     /gene="Gbp2b"
                     /gene_synonym="Gbp-1; Gbp1; LIMIT; Mag-1; Mpa-1; Mpa1"
                     /note="interferon-induced guanylate-binding protein 1;
                     GTP-binding protein 1; interferon-gamma-inducible protein
                     MAG-1; guanylate nucleotide binding protein 1"
                     /codon_start=1
                     /product="guanylate-binding protein 1"
                     /protein_id="NP_034389.2"
                     /db_xref="CCDS:CCDS38658.1"
                     /db_xref="GeneID:14468"
                     /db_xref="MGI:MGI:95666"
                     /translation="MASEIHMKGPVCLIKNSGEQLEVYQEALDILSAIQNPVVVVAIV
                     GFYHTGKSYLMNKLAGKQKGFSLGSTVQSHTKGIWMWCMPHPEKPEHTLVLLDTEGLK
                     DMQKGDNQNDCWIFALAVLLSSTFIYNSIGTINQQAMDQLHYVTELTDLIKSKSSPDQ
                     SDVDNSANFVGFFPIFVWTLRDFSLDLEFDGESITPDEYLETSLALRKGTDENTKKFN
                     MPRLCIRKFFPKRKCFIFDRPGDRKQLSKLEWIQEDQLNKEFVEQVAEFTSYIFSYSG
                     VKTLSGGITVNGPRLKSLVQTYVSAICSGELPCMENAVLTLAQIENSAAVQKAITYYE
                     EQMNQKIHMPTETLQELLDLHRTCEREAIEVFMKNSFKDVDQKFQEELGAQLEAKRDA
                     FVKKNMDMSSAHCSDLLEGLFAHLEEEVKQGTFYKPGGYYLFLQRKQELEKKYIQTPG
                     KGLQAEVMLRKYFESKEDLADTLLKMDQSLTEKEKQIEMERIKAEAAEAANRALAEMQ
                     KKHEMLMEQKEQSYQEHMKQLTEKMEQERKELMAEQQRIISLKLQEQERLLKQGFQNE
                     SLQLRQEIEKIKNMPPPRSCTIL"
     exon            270..397
                     /gene="Gbp2b"
                     /gene_synonym="Gbp-1; Gbp1; LIMIT; Mag-1; Mpa-1; Mpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..507
                     /gene="Gbp2b"
                     /gene_synonym="Gbp-1; Gbp1; LIMIT; Mag-1; Mpa-1; Mpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..704
                     /gene="Gbp2b"
                     /gene_synonym="Gbp-1; Gbp1; LIMIT; Mag-1; Mpa-1; Mpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..947
                     /gene="Gbp2b"
                     /gene_synonym="Gbp-1; Gbp1; LIMIT; Mag-1; Mpa-1; Mpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1228
                     /gene="Gbp2b"
                     /gene_synonym="Gbp-1; Gbp1; LIMIT; Mag-1; Mpa-1; Mpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1441
                     /gene="Gbp2b"
                     /gene_synonym="Gbp-1; Gbp1; LIMIT; Mag-1; Mpa-1; Mpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1544
                     /gene="Gbp2b"
                     /gene_synonym="Gbp-1; Gbp1; LIMIT; Mag-1; Mpa-1; Mpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1738
                     /gene="Gbp2b"
                     /gene_synonym="Gbp-1; Gbp1; LIMIT; Mag-1; Mpa-1; Mpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..2820
                     /gene="Gbp2b"
                     /gene_synonym="Gbp-1; Gbp1; LIMIT; Mag-1; Mpa-1; Mpa1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcatcct gattcaagag ggaagaagcc accagctcct cttcacttcc taattttatc
       61 caaagagtac tctctggaaa tggcctcaga aatccacatg aaaggcccag tgtgcctcat
      121 caagaactcc ggtgagcagt tggaggtcta ccaggaagca ctggacatcc tgtctgctat
      181 ccaaaatcct gtggtggtcg tagcaatagt gggcttctac cacacaggca aatcctatct
      241 gatgaataag ctggctggaa agcagaaggg cttctccctg ggctccactg tgcagtctca
      301 cacaaagggc atctggatgt ggtgcatgcc tcatcccgag aagccagaac ataccctggt
      361 tctgcttgac actgagggcc tgaaagacat gcagaagggt gacaaccaga atgactgttg
      421 gatctttgct ttggcagtcc tcctcagcag caccttcatc tacaacagca taggaaccat
      481 caaccagcag gccatggacc agctgcacta tgtgacagaa ctgactgatc tcatcaaatc
      541 aaagtcatca cctgatcaga gtgatgtaga caactcagct aactttgtgg gcttttttcc
      601 tatctttgtg tggactctga gggatttctc cctggatctg gaatttgatg gagaatccat
      661 cactcctgat gagtacctgg agacttcact ggctctgaga aaaggaactg atgagaacac
      721 taaaaaattt aatatgcctc gcctgtgtat caggaagttc ttcccaaaga ggaagtgctt
      781 catctttgac aggcctggag acaggaagca actttccaaa ctagagtgga tacaggagga
      841 ccagctgaat aaagaatttg tagaacaagt tgcagaattc acctcataca tcttcagcta
      901 ttctggtgtc aagactctat ctggaggcat cacagtcaat gggccacgtc taaaaagcct
      961 ggtgcagacc tatgtcagtg ccatctgcag tggagaacta ccctgtatgg agaacgcagt
     1021 cctgactttg gcccagatag agaactcagc agcagtgcaa aaggccatca cctactacga
     1081 agaacagatg aatcagaaga tccacatgcc cacagaaacc ctccaggagc tcctggatct
     1141 gcacaggacc tgtgagaggg aggccattga ggtcttcatg aagaattctt tcaaggatgt
     1201 agaccagaag ttccaggaag aattaggggc ccagctggaa gccaaacgag atgcctttgt
     1261 taagaagaac atggacatgt catctgctca ttgctcagac ttactggagg gcctctttgc
     1321 tcatctggaa gaagaagtga agcaggggac attttataaa ccaggaggct actacctttt
     1381 tcttcaaagg aaacaagagc tggagaaaaa gtatatccag actcctggaa agggactcca
     1441 ggctgaagtg atgctgagaa aatactttga atccaaggag gatttggctg atacacttct
     1501 aaagatggac cagtcactca cagaaaagga aaagcagatt gaaatggaac gtataaaagc
     1561 agaagccgca gaagcagcaa atagagcatt ggcagaaatg caaaagaagc atgagatgct
     1621 gatggaacag aaggaacaga gttatcaaga gcacatgaaa cagctgactg agaagatgga
     1681 gcaggaacgg aaagagttaa tggcagagca acaaagaatc atatccctta aacttcagga
     1741 acaggaaaga cttctcaagc aaggattcca gaatgagagc ttgcaactac gtcaagagat
     1801 agagaaaatc aagaacatgc ctccacctcg atcatgcacc atactttaaa atctgaacag
     1861 actaaagctc tctaccctgt ttccactcat caaggaaaaa acttcgggga cagctttgga
     1921 ttgtgacaca gcatggcatt gaatgagact tgaagacaat gacactttac taggaagaag
     1981 ggagaaataa agttcacaaa gtggagttta tatgtgaaaa aaatgtttgg cttatgaggt
     2041 gactcagttc atgtttgtgt tagaagtgaa aattcatgtg atttttaatc gggtcttata
     2101 tttgatactg caaacatgga ctctgtagac atactaaatt gtattgttgg gatttgtttt
     2161 tacaacacag tgatagggca gctgtctttg ggtagacatt ttgtatcaca tacatcccct
     2221 actggatatt cttagttgtg tgctcataag taattcaaag atgtagcttg ctctaagctg
     2281 ggattggcat gttataaaca tgataaaaat ctgaacatat ccatggaaca cagctcctag
     2341 ggcctcatgc tatctgcaga cattggttcc cagggtagac aatgggcagt gcccaatgtg
     2401 ggaaggctct gtggttgctg gatgagcaga gtatttcatt ggagaggaga agaaaattcc
     2461 cctccaggca gaatgcatag gcgagtgggc gttgcacctc ccccattgag agaacttctt
     2521 gttttctttc atgctccagc ctactgtgtt tcctttctaa tctctctttt tatttttcaa
     2581 aaacactttc tccttctaag agttttagaa tgacttctac acagaatgga gaactcaaaa
     2641 taaatttcgt tctattcctc tgaggctcat aatcacagtg ccaactcttg tgaaaccaac
     2701 cttcattttt atctttcttt tgctgctatg acatgatttg catatctctg aagataaatg
     2761 ccttttacaa tgtggcagaa gcactgttta agtgaaaact gttaataaaa atgattaagc
//
