LOCUS       NM_010260               2471 bp    mRNA    linear   ROD 09-OCT-2024
DEFINITION  Mus musculus guanylate binding protein 2 (Gbp2), mRNA.
ACCESSION   NM_010260 XM_915830
VERSION     NM_010260.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2471)
  AUTHORS   Kubo,Y., Hans,M.B., Nakamura,T. and Hayashi,H.
  TITLE     The Furin Protease Dependence and Antiviral GBP2 Sensitivity of
            Murine Leukemia Virus Infection Are Determined by the Amino Acid
            Sequence at the Envelope Glycoprotein Cleavage Site
  JOURNAL   Int J Mol Sci 25 (18), 9987 (2024)
   PUBMED   39337476
  REMARK    GeneRIF: The Furin Protease Dependence and Antiviral GBP2
            Sensitivity of Murine Leukemia Virus Infection Are Determined by
            the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2471)
  AUTHORS   Xu,X., Ding,X., Wang,Z., Ye,S., Xu,J., Liang,Z., Luo,R., Xu,J.,
            Li,X. and Ren,Z.
  TITLE     GBP2 inhibits pathological angiogenesis in the retina via the
            AKT/mTOR/VEGFA axis
  JOURNAL   Microvasc Res 154, 104689 (2024)
   PUBMED   38636926
  REMARK    GeneRIF: GBP2 inhibits pathological angiogenesis in the retina via
            the AKT/mTOR/VEGFA axis.
REFERENCE   3  (bases 1 to 2471)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2471)
  AUTHORS   Marinho,F.V., Brito,C., de Araujo,A.C.V.S.C. and Oliveira,S.C.
  TITLE     Guanylate-binding protein-5 is involved in inflammasome activation
            by bacterial DNA but only the cooperation of multiple GBPs accounts
            for control of Brucella abortus infection
  JOURNAL   Front Immunol 15, 1341464 (2024)
   PUBMED   38404575
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2471)
  AUTHORS   Loschwitz,J., Steffens,N., Wang,X., Schaffler,M., Pfeffer,K.,
            Degrandi,D. and Strodel,B.
  TITLE     Domain motions, dimerization, and membrane interactions of the
            murine guanylate binding protein 2
  JOURNAL   Sci Rep 13 (1), 679 (2023)
   PUBMED   36639389
  REMARK    GeneRIF: Domain motions, dimerization, and membrane interactions of
            the murine guanylate binding protein 2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2471)
  AUTHORS   Vestal,D.J., Buss,J.E., McKercher,S.R., Jenkins,N.A.,
            Copeland,N.G., Kelner,G.S., Asundi,V.K. and Maki,R.A.
  TITLE     Murine GBP-2: a new IFN-gamma-induced member of the GBP family of
            GTPases isolated from macrophages
  JOURNAL   J Interferon Cytokine Res 18 (11), 977-985 (1998)
   PUBMED   9858320
REFERENCE   7  (bases 1 to 2471)
  AUTHORS   Qiu,R. and Schimmer,B.P.
  TITLE     cDNA for the beta 1 subunit of guanyl nucleotide-binding regulatory
            proteins from mouse adrenal glands
  JOURNAL   Gene 175 (1-2), 275-277 (1996)
   PUBMED   8917111
REFERENCE   8  (bases 1 to 2471)
  AUTHORS   Neun,R., Richter,M.F., Staeheli,P. and Schwemmle,M.
  TITLE     GTPase properties of the interferon-induced human guanylate-binding
            protein 2
  JOURNAL   FEBS Lett 390 (1), 69-72 (1996)
   PUBMED   8706832
REFERENCE   9  (bases 1 to 2471)
  AUTHORS   Briken,V., Ruffner,H., Schultz,U., Schwarz,A., Reis,L.F.,
            Strehlow,I., Decker,T. and Staeheli,P.
  TITLE     Interferon regulatory factor 1 is required for mouse Gbp gene
            activation by gamma interferon
  JOURNAL   Mol Cell Biol 15 (2), 975-982 (1995)
   PUBMED   7823961
REFERENCE   10 (bases 1 to 2471)
  AUTHORS   Cheng,Y.S., Patterson,C.E. and Staeheli,P.
  TITLE     Interferon-induced guanylate-binding proteins lack an N(T)KXD
            consensus motif and bind GMP in addition to GDP and GTP
  JOURNAL   Mol Cell Biol 11 (9), 4717-4725 (1991)
   PUBMED   1715024
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF077007.1.
            
            On Dec 7, 2005 this sequence version replaced XM_915830.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF077007.1, BC011336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2471
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 66.69 cM"
     gene            1..2471
                     /gene="Gbp2"
                     /note="guanylate binding protein 2"
                     /db_xref="GeneID:14469"
                     /db_xref="MGI:MGI:102772"
     exon            1..146
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            147..360
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1940
                     /gene="Gbp2"
                     /function="GTPase"
                     /note="interferon-induced guanylate-binding protein 2;
                     GBP-2; mGBP2; mGBP-2; GTP-binding protein 2; guanine
                     nucleotide-binding protein 2; guanylate nucleotide binding
                     protein 2; guanylate-binding protein 1"
                     /codon_start=1
                     /product="guanylate-binding protein 2"
                     /protein_id="NP_034390.1"
                     /db_xref="CCDS:CCDS17880.1"
                     /db_xref="GeneID:14469"
                     /db_xref="MGI:MGI:102772"
                     /translation="MASEIHMSEPMCLIENTEAQLVINQEALRILSAITQPVVVVAIV
                     GLYRTGKSYLMNKLAGKRTGFSLGSTVQSHTKGIWMWCVPHPKKAGQTLVLLDTEGLE
                     DVEKGDNQNDCWIFALAVLLSSTFIYNSIGTINQQAMDQLHYVTELTDLIKSKSSPDQ
                     SGVDDSANFVGFFPTFVWTLRDFSLELEVNGKPVTSDEYLEHSLTLKKGADKKTKSFN
                     EPRLCIRKFFPKRKCFIFDRPAQRKQLSKLETLREEELCGEFVEQVAEFTSYILSYSS
                     VKTLCGGIIVNGPRLKSLVQTYVGAISNGSLPCMESAVLTLAQIENSAAVQKAITHYE
                     EQMNQKIQMPTETLQELLDLHRPIESEAIEVFLKNSFKDVDQKFQTELGNLLVAKRDA
                     FIKKNMDVSSARCSDLLEDIFGPLEEEVKLGTFSKPGGYYLFLQMRQELEKKYNQAPG
                     KGLQAEAMLKNYFDSKADVVETLLQTDQSLTEAAKEVEEERTKAEAAEAANRELEKKQ
                     KEFELMMQQKEKSYQEHVKKLTEKMKDEQKQLLAEQENIIAAKLREQEKFLKEGFENE
                     SKKLIREIDTLKQNKSSGKCTIL"
     exon            361..488
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..598
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..795
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1038
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1319
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1532
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1635
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1829
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2455
                     /gene="Gbp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2431..2436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gbp2"
                     /note="hexamer: AATAAA"
     polyA_site      2455
                     /gene="Gbp2"
                     /note="major polyA site"
ORIGIN      
        1 aaaatctgga acttcccggg ttactacagg gtctatgtca cagtgcctgt gagagaggac
       61 agagcactct gcagccagcc tcagaggcaa agctgaccag cattgaaaag ctgcttcttc
      121 ttcttctcta aaggatttct cttcagagac aaaaagaaac caccctggac atggcctcag
      181 agatccacat gtcggaaccc atgtgcctca ttgagaacac tgaggctcaa ctagtgatca
      241 accaggaggc tctgaggatc ctgtctgcca ttacacagcc tgtggtggtg gtggcaatcg
      301 tgggcctcta ccgcacaggc aaatcctacc tgatgaacaa gctagctggg aagaggacag
      361 gcttttccct gggctccact gtgcagtctc acaccaaggg catctggatg tggtgtgtgc
      421 ctcaccccaa gaaggcaggg caaaccctgg ttctgcttga cactgagggc cttgaagatg
      481 ttgagaaggg tgacaaccag aatgactgct ggatctttgc tttggcagtc ctcctcagca
      541 gcaccttcat ctacaacagc ataggaacca tcaaccagca ggccatggac cagctgcact
      601 atgtgacgga gctaactgat cttatcaagt caaagtcatc acctgaccag agtggggtag
      661 acgattccgc taactttgtg ggcttctttc caacctttgt gtggactctg agagatttct
      721 ccctcgagct ggaggttaac ggaaaacccg tcacttctga tgagtacctg gaacattccc
      781 tgaccctgaa aaaaggagct gataagaaaa ctaaaagctt taatgagccg cgactgtgca
      841 tcaggaaatt ctttccaaag aggaagtgct tcatctttga caggcctgct cagaggaagc
      901 aacttagcaa actggagact ctgcgggagg aggagctgtg tggtgaattt gtagaacaag
      961 ttgcagaatt cacctcatac atcttgagct actcttctgt caagactctg tgtggtggca
     1021 tcatagtcaa tgggccacgt ctaaagagcc tggtgcagac ctatgttggt gccatcagca
     1081 atgggtctct cccctgcatg gagagtgctg tgctgacttt ggcccagata gagaactcag
     1141 cagcagtgca aaaggccatc acccactatg aagaacagat gaatcagaag attcagatgc
     1201 ccacagaaac cctccaggag ctcctggatc tgcacaggcc aattgagagt gaggccattg
     1261 aggtcttcct gaagaattct ttcaaggatg tagaccaaaa gttccagaca gaattaggga
     1321 acctgctggt agccaagcga gatgccttta tcaagaagaa catggatgtc tcatcagctc
     1381 gttgctcaga cttgctggag gatatttttg gacccctgga agaagaagta aaattaggga
     1441 cattttctaa accaggaggt tactacctct tccttcaaat gagacaagag ctagagaaaa
     1501 agtataacca ggctcctggg aaggggctcc aggcagaagc gatgctgaaa aactactttg
     1561 attccaaggc agatgttgtt gaaacacttc tacagacgga tcagtcactc acagaggcag
     1621 caaaggaggt agaagaggaa cgtacgaagg ctgaagctgc tgaagctgca aacagagagt
     1681 tagaaaagaa gcagaaggag ttcgagctga tgatgcagca gaaggaaaag agttaccagg
     1741 agcatgtgaa gaagctgact gagaagatga aagacgaaca gaaacagtta ttagcagaac
     1801 aggaaaacat catagctgct aaacttcggg aacaggaaaa atttcttaag gaaggattcg
     1861 agaatgagag caaaaaactt attcgagaga ttgataccct gaagcaaaac aaatcgtctg
     1921 ggaagtgcac tatactctga aggcccaagg cccaaacctc tctgccaagc tctctccatc
     1981 acacactatg ttgactgagc atcttcaggc tttgaaacaa ctgctatgaa actcaattca
     2041 cctcagctca aaatcaatca tatgcgactc cattttgggg tcactgtctg accactgggc
     2101 actgtcagag gaagtccctc tgtgtgcaga atgcatgtat gagcagaggt tcagtcacct
     2161 gtgttatagg tactctcggc cttcatcatg cccagccata cgtttctcct gtataatctt
     2221 aagtgttcct ctttcctaca gatagcttct gtaatcacag aacaggcaac ttttaactaa
     2281 cttgcaaaat gaattccctt tcatttctct gaggactttt tctactgtta ttccaaacct
     2341 aaatctcatc ccaggtttcc cttttatctc cccactgtga caacatgtct tgaaattact
     2401 caagacaaat gtcttgcaag agcacaagtt aataaaaatg attagcccac tgtaaaaaaa
     2461 aaaaaaaaaa a
//
