LOCUS       NM_139197               1335 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus globoside alpha-1,3-N-acetylgalactosaminyltransferase
            1 (Gbgt1), mRNA.
ACCESSION   NM_139197
VERSION     NM_139197.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1335)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   2  (bases 1 to 1335)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 1335)
  AUTHORS   Elliott SP, Yu M, Xu H and Haslam DB.
  TITLE     Forssman synthetase expression results in diminished shiga toxin
            susceptibility: a role for glycolipids in determining host-microbe
            interactions
  JOURNAL   Infect Immun 71 (11), 6543-6552 (2003)
   PUBMED   14573676
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772249.6.
            
            [WARNING] On Oct 7, 2023 this sequence was replaced by NM_139197.3.
            
            On Jul 23, 2009 this sequence version replaced NM_139197.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY749470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AL772249.6         135428-135601
            175-342             AL772249.6         136206-136373
            343-408             AL772249.6         136913-136978
            409-459             AL772249.6         140604-140654
            460-495             AL772249.6         140734-140769
            496-630             AL772249.6         141663-141797
            631-1335            AL772249.6         143248-143952
FEATURES             Location/Qualifiers
     source          1..1335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..1335
                     /gene="Gbgt1"
                     /gene_synonym="Fgs; Fs"
                     /note="globoside
                     alpha-1,3-N-acetylgalactosaminyltransferase 1"
                     /db_xref="GeneID:227671"
                     /db_xref="MGI:MGI:2449143"
     exon            1..174
                     /gene="Gbgt1"
                     /gene_synonym="Fgs; Fs"
                     /inference="alignment:Splign:2.1.0"
     exon            175..342
                     /gene="Gbgt1"
                     /gene_synonym="Fgs; Fs"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1315
                     /gene="Gbgt1"
                     /gene_synonym="Fgs; Fs"
                     /EC_number="2.4.1.88"
                     /note="forssman glycolipid synthetase; forssman glycolipid
                     synthase"
                     /codon_start=1
                     /product="globoside
                     alpha-1,3-N-acetylgalactosaminyltransferase 1"
                     /protein_id="NP_631936.2"
                     /db_xref="CCDS:CCDS15839.1"
                     /db_xref="GeneID:227671"
                     /db_xref="MGI:MGI:2449143"
                     /translation="MTRPRLAQGLAFFLLGGTGLWVLWKFIKDWLLVSYIPYYLPCPE
                     FFNMKLPFRKEKPLQPVTQLQYPQPKLLEHGPTELLTLTPWLAPIVSEGTFDPELLKS
                     MYQPLNLTIGVTVFAVGKYTCFIQRFLESAEEFFMRGYQVHYYLFTHDPTAVPRVPLG
                     PGRLLSIIPIQGYSRWEEISMRRMETINKHIAKRAHKEVDYLFCVDVDMVFRNPWGPE
                     TLGDLVAAIHPGYFAVPRRKFPYERRQVSSAFVADNEGDFYYGGALFGGRVARVYEFT
                     RACHMAILADKANSIMAAWQEESHLNRHFIWHKPSKVLSPEYLWDERKPRPRSLKMIR
                     FSSVKKNANWLRT"
     exon            343..408
                     /gene="Gbgt1"
                     /gene_synonym="Fgs; Fs"
                     /inference="alignment:Splign:2.1.0"
     exon            409..459
                     /gene="Gbgt1"
                     /gene_synonym="Fgs; Fs"
                     /inference="alignment:Splign:2.1.0"
     exon            460..495
                     /gene="Gbgt1"
                     /gene_synonym="Fgs; Fs"
                     /inference="alignment:Splign:2.1.0"
     exon            496..630
                     /gene="Gbgt1"
                     /gene_synonym="Fgs; Fs"
                     /inference="alignment:Splign:2.1.0"
     exon            631..1335
                     /gene="Gbgt1"
                     /gene_synonym="Fgs; Fs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctaaagc ttggtcagcc caaagggagt ggttctataa tcccaaagac agtctcatct
       61 gctctgccct acccgactgg gtccttgcac cgtaccccac cgcagccgct gaggaggagg
      121 aggaggaaga ggaggaggaa gtcccagtgc cagaacaagc tggacaaagt tcaggcgttt
      181 ctaagacctc aagtgaggta ggcccagagc ctgacagacc taaggcccta ggggtttctg
      241 aaagtgccca gtttctattc tgcacccagt gatgacccgc ccaagactgg cccagggcct
      301 agcgttcttc ctgctcggtg gcacaggtct ctgggtcctg tggaagttta tcaaggactg
      361 gctgctggtc tcctacatac cctattacct cccctgccca gagttcttca acatgaagct
      421 gcccttcagg aaggagaaac cgttgcagcc tgtgacacag ttacagtacc ctcagcctaa
      481 gctgctggaa cacggaccca cagagctgct gacacttacc ccgtggttgg cacccatcgt
      541 ctccgaggga acctttgacc cggagcttct gaagagcatg taccagccgt tgaacctgac
      601 cattggcgtc accgtgtttg ccgtggggaa gtacacctgc ttcattcagc gcttcctgga
      661 gtcagctgaa gagttcttta tgcgtgggta ccaagtacac tattacctct ttacccatga
      721 tcctacagcc gttcccagag ttcccctggg ccccggtcgg ctcctcagca tcatccctat
      781 ccagggttat tcccggtggg aggagatctc catgcgccga atggagacca tcaacaaaca
      841 cattgccaag agagcccaca aagaagtgga ttacctcttc tgtgtcgatg tggatatggt
      901 cttccgtaac ccatggggcc ccgagacctt gggggatcta gtggctgcca ttcacccagg
      961 ctattttgct gtacctcgcc ggaaattccc ttatgaacgc aggcaagttt cctctgcctt
     1021 tgtggcagac aatgaggggg acttctatta tggtggggca ctctttgggg gacgagtggc
     1081 cagagtgtat gagtttaccc gggcctgcca catggccatt ctggcagaca aagctaacag
     1141 cattatggca gcctggcagg aggagagcca cctgaaccgc cacttcatct ggcacaaacc
     1201 atctaaggtg ctgtccccag agtacctctg ggatgaaagg aagcctcggc cccgaagcct
     1261 gaagatgatt cgattctcct cagtgaaaaa gaatgccaac tggctgagga cctaacatcc
     1321 gggctaagac ccgcc
//
