LOCUS       NM_178930               6422 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus golgi-specific brefeldin A-resistance factor 1 (Gbf1),
            mRNA.
ACCESSION   NM_178930 XM_129295
VERSION     NM_178930.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6422)
  AUTHORS   Jia,W., Zhang,C., Luo,Y., Gao,J., Yuan,C., Zhang,D., Zhou,X.,
            Tan,Y., Wang,S., Chen,Z., Li,G. and Zhang,X.
  TITLE     GBF1 deficiency causes cataracts in human and mouse
  JOURNAL   Hum Genet 143 (11), 1281-1291 (2024)
   PUBMED   39110251
REFERENCE   2  (bases 1 to 6422)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   3  (bases 1 to 6422)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6422)
  AUTHORS   Walton,K., Leier,A. and Sztul,E.
  TITLE     Regulating the regulators: role of phosphorylation in modulating
            the function of the GBF1/BIG family of Sec7 ARF-GEFs
  JOURNAL   FEBS Lett 594 (14), 2213-2226 (2020)
   PUBMED   32333796
  REMARK    GeneRIF: Regulating the regulators: role of phosphorylation in
            modulating the function of the GBF1/BIG family of Sec7 ARF-GEFs.
            Review article
REFERENCE   5  (bases 1 to 6422)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6422)
  AUTHORS   Garcia-Mata,R. and Sztul,E.
  TITLE     The membrane-tethering protein p115 interacts with GBF1, an ARF
            guanine-nucleotide-exchange factor
  JOURNAL   EMBO Rep 4 (3), 320-325 (2003)
   PUBMED   12634853
  REMARK    GeneRIF: novel interaction between p115 and Golgi-specific
            brefeldin-A-resistant factor 1 (GBF1)
REFERENCE   7  (bases 1 to 6422)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 6422)
  AUTHORS   Lemon,W.J., Bernert,H., Sun,H., Wang,Y. and You,M.
  TITLE     Identification of candidate lung cancer susceptibility genes in
            mouse using oligonucleotide arrays
  JOURNAL   J Med Genet 39 (9), 644-655 (2002)
   PUBMED   12205107
REFERENCE   9  (bases 1 to 6422)
  AUTHORS   Rieger,D.K., Reichenberger,E., McLean,W., Sidow,A. and Olsen,B.R.
  TITLE     A double-deletion mutation in the Pitx3 gene causes arrested lens
            development in aphakia mice
  JOURNAL   Genomics 72 (1), 61-72 (2001)
   PUBMED   11247667
REFERENCE   10 (bases 1 to 6422)
  AUTHORS   Semina,E.V., Murray,J.C., Reiter,R., Hrstka,R.F. and Graw,J.
  TITLE     Deletion in the promoter region and altered expression of Pitx3
            homeobox gene in aphakia mice
  JOURNAL   Hum Mol Genet 9 (11), 1575-1585 (2000)
   PUBMED   10861284
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC076569.1.
            
            On or before Sep 17, 2004 this sequence version replaced
            XM_129295.6, NM_178930.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076569.1, BC082336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6422
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.75 cM"
     gene            1..6422
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /note="golgi-specific brefeldin A-resistance factor 1"
                     /db_xref="GeneID:107338"
                     /db_xref="MGI:MGI:1861607"
     exon            1..235
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            236..341
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..5831
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /note="BFA-resistant GEF 1"
                     /codon_start=1
                     /product="Golgi-specific brefeldin A-resistance guanine
                     nucleotide exchange factor 1"
                     /protein_id="NP_849261.2"
                     /db_xref="CCDS:CCDS29873.1"
                     /db_xref="GeneID:107338"
                     /db_xref="MGI:MGI:1861607"
                     /translation="MVDKNIYIIQGEINIVVGAIKRNARWSTHIPLDEERDPLLHSFS
                     NLKEVLNSVTELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSYALIDPTH
                     EGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGTHLTNESVCEI
                     MQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKSYVGTNMKKLKMRA
                     GGMSDSSKWKKQKRSPRPPRHTTKVTPGSELPTPNGATLPSNLTGGVPFIDAPTSISS
                     ASSEAASTVVSPCTDSGLELSSQTTSKEDLTDLEQAGSPREITTSEPGSSEMGASDQL
                     DPQEGAHVEKAQSASVESIPEVLEECTSPADHSDSASVHDMDYVNPRGVRFTQSSQKE
                     GTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQCQTLL
                     GLIKDEMCRHLFQLLSVERLNLYAASLRVCFLLFESMREHLKFQLEMYIKKLMEIITV
                     ENPKMPYEMKEMALEAVVQLWRIPSFVTELYINYDCDYYCSNLFEDLTKLLSKNAFPV
                     SGQLYTTHLLSLDALLTVIDSTESHCQAKVLNTLNQQEKKETARPGFEAVDGNPETNK
                     SERATSDGKSTGVALDARGLHFPSGGWLSTEHGKPGCRDLEEAGDSGADKKFTRKPPR
                     FSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWL
                     RENPRLDKKMIGEFVSDRKNMDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVI
                     HRLLEVFTEHWRSCNGSPFANSDACFALAYAVIMLNTDQHNHNVRKQNAPMTLEEFRK
                     NLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWSVLLHRGASPEGVF
                     LRVPPGSYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSD
                     VFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKTVFHLAHRHGDILREGWKNI
                     MEAMLQLFRAQLLPKAMVEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGP
                     EQSSVRGPSTENQEAKRVALDCIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEE
                     TYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYHLCVQAQDFCFLVERAVVGLL
                     RLAIRLLRREEISGQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDD
                     WATLFTLLECIGSGVKPPDALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDS
                     EVYTDHGRPGKIHRSATDADMVNSGWLVVGKDDIDNSKPGAGLSRPGPSPLVNQYSLT
                     VGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQD
                     KRSKSHKYDSKGNRFKKKPKEGSMLRRPRGSNQHATRGGHSDEEEDEGVPASYHTVSL
                     QVSQDLLDLMHTLHTRAASIYSSWAEEQRHLEGGGQKIEADSRTLWAHCWCPLLQGIA
                     CLCCDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPAD
                     VGGMEETRMRASTLLSKVFLQHLSPLLSLSTFAALWLTILDFMDKYMHAGSSDLLSEA
                     IPESLKNMLLVMDTAEIFHSADARGGGPSALWEITWERIDCFLPHLRDELFKQTVIQD
                     PMPAEPHSQKPLASTHLTSAAGDPRMPGHPPLPEIPSEMGVCDSEKPESTRAPSSSSP
                     GSPMASSPSKLSPAQEGPPPLTQPPLILQPLTSPLQVGVPPMTLPIILNPALIEATSP
                     VPLLATPRPTDPIPTSEVN"
     exon            342..408
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            409..540
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            541..659
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            660..768
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            769..829
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            830..884
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1032
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1256
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1422
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1634
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1733
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1928
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2118
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2259
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2348
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2551
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2675
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2801
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2884
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3121
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3215
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3392
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3457
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3581
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..3653
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            3654..3748
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..3902
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            3903..4128
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            4129..4289
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            4290..4536
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            4537..4742
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            4743..4893
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            4894..5024
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            5025..5126
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            5127..5240
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            5241..5421
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            5422..5550
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     exon            5551..6401
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6378..6383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /note="hexamer: AATAAA"
     polyA_site      6401
                     /gene="Gbf1"
                     /gene_synonym="1700083E03Rik; mKIAA0248"
                     /note="major polyA site"
ORIGIN      
        1 gctgacaggg aaggtagccg gcaccaccga gcgtcccggc ccacttactc cagcctgcag
       61 tgaggtctca ccctgaagtt agggttgcct tccagaagac aggatccttc ccttctctca
      121 ctcgccgccg gcgccgggag agcggccggg agacgcctcc ggggccaggc tggacatgag
      181 ctgcggctgc cgccggttct gggactaggc cccgccattt tggatccgct gacaggtttg
      241 tcaggatggt ggataagaat atttacatca ttcaaggaga aattaacatt gttgttggtg
      301 ccatcaaacg aaatgcccga tggagcaccc atataccact ggatgaagaa cgggatcccc
      361 ttctgcacag tttcagtaac ctgaaagagg tcttaaacag tgtgacagaa ctctcagaga
      421 ttgagccaaa tgtattcctt cgtccatttc tggaagtcat tcgctctgaa gacaccactg
      481 gtcctatcac cggcctggca ctcacctctg tcaacaagtt cctgtcctac gcactcatag
      541 atccaactca tgagggcaca gcagagggca tggagaacat ggcagatgct gtcactcacg
      601 cccgttttgt gggcacagat cctgccagtg atgaagttgt cctgatgaaa atccttcagg
      661 ttctccgaac tctgttgcta accccagtgg gtacccactt aacaaatgaa tctgtatgtg
      721 agattatgca gtcttgcttc cggatttgct ttgaaatgag actcagtgag ttattgagaa
      781 aatccgcaga gcacactctg gtagacatgg tgcagctgct cttcacaagg ttacctcagt
      841 ttaaagaaga acccaagagc tatgtgggaa ccaacatgaa gaagctgaaa atgagagcag
      901 gaggcatgag tgactcgtcc aagtggaaga aacagaaaag atctcctcga cctccacgtc
      961 atacaaccaa agtcacacca ggttcagagc tgcccacccc aaatggagcc acattaccct
     1021 ctaaccttac tggtggtgtg cccttcattg atgcacccac atccatctcc tctgcaagtt
     1081 cagaagctgc ctcgacagta gtcagtccct gtacagatag tggcctggaa ttatcctccc
     1141 agactacctc caaggaggac ctcactgacc tggagcaagc tggctcccca agggagatca
     1201 ccaccagtga gcctgggagc agtgagatgg gcgcttctga tcagcttgac cctcaggaag
     1261 gggcccatgt agagaaggcc cagtcagcat cggtggagtc catccctgaa gtgttagagg
     1321 aatgcacatc ccctgctgac cactctgact cggcctctgt ccatgatatg gactacgtca
     1381 atcctcgggg cgtgcgcttt acccagtcct cccagaaaga aggcacagct ttggttcctt
     1441 atggtcttcc ttgcatccgt gagctcttcc gcttccttat ctccctcaca aatccacacg
     1501 accgccataa ctctgaggtg atgatccaca tgggactgca tttgctgaca gtggctcttg
     1561 agtcagcgcc tgtggcccag tgccagaccc tcttgggtct cattaaggat gagatgtgcc
     1621 gacacttatt ccagctactc agcgtagagc gcctgaacct ttatgctgct tccctacgag
     1681 tgtgcttctt actcttcgag agcatgcggg aacacctcaa gttccagtta gagatgtaca
     1741 tcaaaaagct catggagatc atcactgttg aaaaccccaa gatgccttat gagatgaagg
     1801 agatggcgct ggaggccgtt gttcagctct ggcgtatccc cagcttcgtc actgagctct
     1861 acatcaacta tgattgtgac tactattgct ccaacctctt tgaagacctc accaagctgc
     1921 tgtccaagaa tgcctttcct gtgtctggtc agctttatac aacacacctg ctgtctcttg
     1981 atgccctttt gacagttatt gacagcactg agtctcattg tcaggccaaa gtcctcaaca
     2041 ccctcaacca gcaagagaag aaagagacag ccagacctgg ctttgaggca gtggatggca
     2101 acccagaaac taacaagtct gagagagcaa ccagtgatgg gaaatccaca ggtgtggcct
     2161 tagatgcccg aggccttcat tttccaagtg gaggatggtt gtcaacagaa catggaaagc
     2221 cagggtgcag agatctggag gaagctggtg actctggggc tgacaaaaag ttcaccagga
     2281 agccacctcg attttcctgt cttctgccag atccacggga actaattgaa attaaaaaca
     2341 aaaaaaagct gctgatcact ggtacagagc agttcaacca aaaaccaaag aaggggatcc
     2401 aatttctgca ggagaaaggc ctcctcacca tcccaatgga taacacggag gtagcccaat
     2461 ggctccgaga aaaccctcgg ttagacaaaa aaatgattgg agagtttgtg agtgaccgca
     2521 aaaacatgga cctgttggag agttttgtga gcaccttcag ctttcagggt ctgcggcttg
     2581 atgaagctct ccgactctac ctggaagcct tccgtttgcc tggggaagca cccgttattc
     2641 acaggttgct ggaggtattc actgagcact ggaggagttg taatggctcc ccatttgcta
     2701 atagtgatgc ctgctttgcc ctggcctatg ctgtcatcat gcttaacact gaccaacata
     2761 accacaatgt tcgaaagcag aatgcaccca tgaccctgga ggaatttcgc aaaaacctaa
     2821 aaggtgtgaa tggaggcaag gactttgagc aagacatcct ggaagacatg taccatgcca
     2881 tcaagaatga ggagattgtg atgcctgagg agcagacagg tctggtccgt gagaactatg
     2941 tgtggagcgt gctgcttcac cgaggtgcta gccctgaggg cgtgttcctt cgagtgcctc
     3001 ctggcagcta cgatcttgac ctcttcacta tgacctgggg ccccacgatc gctgctctct
     3061 cttatgtctt cgataaaagc cttgaggaga ccatcatcca gaaagccatc tcaggcttca
     3121 ggaagtgtgc catgatctcc gcccactatg gcctcagcga tgtgtttgac aatctcatca
     3181 tctctctgtg caaattcaca gctctaagta gtgagtctat tgagaacctt cccagtgtat
     3241 ttggaagcaa ccctaaagcc cacatagcag ccaagacagt attccatttg gcccatcgtc
     3301 atggtgacat ccttcgggag ggctggaaga atatcatgga ggccatgttg cagcttttcc
     3361 gagcccaact tttacccaag gctatggtgg aggtagaaga ttttgtggat cccaatggca
     3421 agatctctct acagcgggag gagacaccat ccaaccgagg agagtcaaca gttcttagct
     3481 ttgtaagctg gctgacattg agtggtcctg agcagtccag tgtacggggt ccatctacag
     3541 agaaccaaga ggccaagaga gtggccttgg actgtatcaa gcaatgtgac ccagaaaaaa
     3601 tgatcacaga aagcaagttc ctccagctgg aatcactgca ggagctcatg aaggctctgg
     3661 tctcagtgac accagatgaa gagacatatg acgaagaaga tgctgctttc tgtctagaga
     3721 tgctgctaag gatcgtgtta gagaacaggg accgtgtggg ctgtgtatgg cagactgttc
     3781 gagatcatct ataccacctg tgtgttcagg cacaagattt ctgcttcctt gtggagcgag
     3841 cagtggtagg gctgctacgc ctagccatcc ggctactccg gagagaagag attagtggcc
     3901 aggtcctgct ctctctgcgc atcttgttac tgatgaagcc cagcgtgctg tccagagtca
     3961 gccaccaggt tgcatatggg ctgcatgaac tcctcaagac caatgctgcc aacatccact
     4021 cgggtgatga ctgggccacc ctcttcacat tgctggagtg cattggctca ggcgtgaagc
     4081 ctccagatgc tcttcaagcc acagccaggg ctgatgctcc tgatgcggga gcacagtcgg
     4141 acagtgagct cccatcctac catcaaaatg atgtcagcct ggaccgaggg tacacttccg
     4201 actcagaagt ctacacagac catggcaggc ctggcaagat acaccgatcg gccacagatg
     4261 ctgacatggt caacagtggt tggttagtgg tggggaagga tgacattgat aactccaaac
     4321 caggagcagg gctcagcagg ccaggccctt cacccctggt caaccagtac agccttacag
     4381 tgggcctgga tctgggccca cacgacacta agtccctgct taagtgtgtg gagtcactgt
     4441 ccttcattgt ccgagatgct gctcacatca cccctgacaa ctttgaactc tgcgtcaaga
     4501 ctctccgcat ctttgtagaa gccagtctga atggtgggtg caagtcccag gataaacgca
     4561 gcaagagtca taagtatgac agcaaaggga accgcttcaa gaaaaaaccc aaggagggct
     4621 cgatgcttcg gcggccccgg ggatccaacc agcatgctac tcggggcggg cacagtgatg
     4681 aagaggagga tgaaggtgtg cctgccagct accatacggt gtctttacag gtcagtcagg
     4741 acttgctaga cctgatgcat accctgcaca cacgggcagc ctctatctac agctcatggg
     4801 cagaggagca acgccacctg gagggaggtg gccagaagat tgaagctgac tcacgcaccc
     4861 tctgggccca ctgctggtgc cctttattac aaggaatcgc ctgcttatgc tgtgacgccc
     4921 ggcgccaggt acggatgcag gccctgacat atctgcagcg agcccttctg gtgcatgacc
     4981 tacagaagct agatgccctg gagtgggagt cctgttttaa caaggtgctg tttcctctcc
     5041 tgaccaagct tttggaaaat atcagccctg cagatgtggg cgggatggag gagacccgga
     5101 tgcgggcttc cacactgctc tcaaaggtct tcctgcagca tctgtctcca ctgctgtcac
     5161 tgtccacctt tgctgccctg tggctcacta tcctagactt catggacaag tacatgcatg
     5221 caggttccag tgatttgctg tcagaagcta tccccgagtc tctgaagaac atgctgctgg
     5281 tgatggacac agcggagatt ttccacagtg cagatgcaag aggaggaggc ccctctgctc
     5341 tctgggagat tacctgggag cgcatcgact gcttcttgcc acacttgcgt gacgagctct
     5401 tcaagcagac tgtcatccag gaccccatgc ctgcggaacc gcacagtcaa aaacctctgg
     5461 cctctactca cctgacttct gctgctggtg accccaggat gcctggccat ccacctctcc
     5521 cagagatacc ctcagaaatg ggggtttgtg actcagagaa gcccgagagt acccgagctc
     5581 ccagcagcag ctcccccgga tcgcccatgg cctctagccc cagcaaactg agtcctgccc
     5641 aagagggacc tcccccactg acccagcccc cactgatcct gcagcccttg acctccccac
     5701 tgcaggtggg ggtcccgccc atgactctgc ccatcatcct caaccctgca ctcattgagg
     5761 ccacctcccc agtgcctctc ctagccacac cccgccctac agaccccatc cccacttctg
     5821 aagtcaacta aggcaggtcc cctcagagat caggaccatt ccttcctatc aggcgttcaa
     5881 gactctgctt cagtctcagg ggctgcagaa atcttcaggc ctaaagcaag ctgctgttgc
     5941 tactatttga tggggaaatg acaactttta tagtccctgc tgggatccac tccaggctgc
     6001 gagactcttc ctctgccatt cattcctgag cttccaaact gagagtggat gcaggcagaa
     6061 cctgtagcct ctgcctccag cctggcatcc ctgggaaggc atagagccaa ccctgccgtg
     6121 ccaaccctgc agtgcctgcc atgtgccccc tgccaggttg ggcattagag ccaagcccag
     6181 ccactctgca ctttgttcct ctctatccag tcccctcagt cctgggccgc cgcctccaat
     6241 tcttcttcct tcattaaata gttggtcagc ttggagttgc ttggcaccac ggagggtgga
     6301 cagataggac tcgatggggg cctgcccaca ggagcatgta catatggaaa atgataacgg
     6361 tggacttttt atggtataat aaatgtctta gtaccaactc aaaaaaaaaa aaaaaaaaaa
     6421 aa
//
