LOCUS       NM_008094               5906 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus glucosylceramidase beta 1 (Gba1), transcript variant
            1, mRNA.
ACCESSION   NM_008094
VERSION     NM_008094.7
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5906)
  AUTHORS   Duffy,H.B.D., Byrnes,C., Zhu,H., Tuymetova,G., Lee,Y.T., Platt,F.M.
            and Proia,R.L.
  TITLE     Deletion of Gba in neurons, but not microglia, causes
            neurodegeneration in a Gaucher mouse model
  JOURNAL   JCI Insight 9 (21), e179126 (2024)
   PUBMED   39312723
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5906)
  AUTHORS   Lin,Y., Zhao,X., Liou,B., Fannin,V., Zhang,W., Setchell,K.D.R.,
            Wang,X., Pan,D., Grabowski,G.A., Liu,C.J. and Sun,Y.
  TITLE     Intrinsic link between PGRN and Gba1 D409V mutation dosage in
            potentiating Gaucher disease
  JOURNAL   Hum Mol Genet 33 (20), 1771-1788 (2024)
   PUBMED   39101473
REFERENCE   3  (bases 1 to 5906)
  AUTHORS   Walton,S., Fenyi,A., Tittle,T., Sidransky,E., Pal,G., Choi,S.,
            Melki,R., Killinger,B.A. and Kordower,J.H.
  TITLE     Neither alpha-synuclein fibril strain nor host murine genotype
            influences seeding efficacy
  JOURNAL   NPJ Parkinsons Dis 10 (1), 105 (2024)
   PUBMED   38773124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5906)
  AUTHORS   Nam,Y., Na,J., Ma,S.X., Park,H., Park,H., Lee,E., Kim,H.,
            Jang,S.M., Ko,H.S. and Kim,S.
  TITLE     DJ-1 protects cell death from a mitochondrial oxidative stress due
            to GBA1 deficiency
  JOURNAL   Genes Genomics 46 (5), 519-529 (2024)
   PUBMED   38460098
  REMARK    GeneRIF: DJ-1 protects cell death from a mitochondrial oxidative
            stress due to GBA1 deficiency.
REFERENCE   5  (bases 1 to 5906)
  AUTHORS   Gregorio,I., Russo,L., Torretta,E., Barbacini,P., Contarini,G.,
            Pacinelli,G., Bizzotto,D., Moriggi,M., Braghetta,P., Papaleo,F.,
            Gelfi,C., Moro,E. and Cescon,M.
  TITLE     GBA1 inactivation in oligodendrocytes affects myelination and
            induces neurodegenerative hallmarks and lipid dyshomeostasis in
            mice
  JOURNAL   Mol Neurodegener 19 (1), 22 (2024)
   PUBMED   38454456
  REMARK    GeneRIF: GBA1 inactivation in oligodendrocytes affects myelination
            and induces neurodegenerative hallmarks and lipid dyshomeostasis in
            mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5906)
  AUTHORS   Tybulewicz,V.L., Tremblay,M.L., LaMarca,M.E., Willemsen,R.,
            Stubblefield,B.K., Winfield,S., Zablocka,B., Sidransky,E.,
            Martin,B.M., Huang,S.P. et al.
  TITLE     Animal model of Gaucher's disease from targeted disruption of the
            mouse glucocerebrosidase gene
  JOURNAL   Nature 357 (6377), 407-410 (1992)
   PUBMED   1594045
REFERENCE   7  (bases 1 to 5906)
  AUTHORS   Carstea,E.D., Murray,G.J. and O'Neill,R.R.
  TITLE     Molecular and functional characterization of the murine
            glucocerebrosidase gene
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1477-1483 (1992)
   PUBMED   1317175
REFERENCE   8  (bases 1 to 5906)
  AUTHORS   Osman,N., Kozak,C.A., McKenzie,I.F. and Hogarth,P.M.
  TITLE     Structure and mapping of the gene encoding mouse high affinity Fc
            gamma RI and chromosomal location of the human Fc gamma RI gene
  JOURNAL   J Immunol 148 (5), 1570-1575 (1992)
   PUBMED   1531670
REFERENCE   9  (bases 1 to 5906)
  AUTHORS   Dower,N.A., Seldin,M.F., Pugh,S. and Stone,J.C.
  TITLE     Organization and chromosomal locations of Rap1a/Krev sequences in
            the mouse
  JOURNAL   Mamm Genome 3 (3), 162-167 (1992)
   PUBMED   1617222
REFERENCE   10 (bases 1 to 5906)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161600.6.
            
            On Jul 25, 2022 this sequence version replaced NM_008094.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006663.1, SRR13948564.2167659.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AC161600.6         196720-196878
            160-328             AC161600.6         196984-197152
            329-398             AC161600.6         197264-197333
            399-590             AC161600.6         197777-197968
            591-737             AC161600.6         198067-198213
            738-871             AC161600.6         199239-199372
            872-1044            AC161600.6         199584-199756
            1045-1279           AC161600.6         199926-200160
            1280-1504           AC161600.6         201019-201243
            1505-1668           AC161600.6         201616-201779
            1669-1785           AC161600.6         202104-202220
            1786-5906           AC161600.6         202309-206429
FEATURES             Location/Qualifiers
     source          1..5906
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.01 cM"
     gene            1..5906
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /note="glucosylceramidase beta 1"
                     /db_xref="GeneID:14466"
                     /db_xref="MGI:MGI:95665"
     exon            1..159
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /inference="alignment:Splign:2.1.0"
     exon            160..328
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /inference="alignment:Splign:2.1.0"
     exon            329..398
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /inference="alignment:Splign:2.1.0"
     exon            399..590
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /inference="alignment:Splign:2.1.0"
     exon            591..737
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /inference="alignment:Splign:2.1.0"
     exon            738..871
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1044
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1279
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1504
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1668
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1785
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..5906
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1933..1938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /note="hexamer: ATTAAA"
     polyA_site      1952
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /note="major polyA site"
     polyA_site      2126
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
     regulatory      5467..5472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /note="hexamer: ATTAAA"
     polyA_site      5489
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
     regulatory      5887..5892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
                     /note="hexamer: AATAAA"
     polyA_site      5906
                     /gene="Gba1"
                     /gene_synonym="betaGC; Gba; GC; GCase; GLUC"
ORIGIN      
        1 aagccggaag gaacttgctg tgctagtcgg ttccaagagc tatgatatct gtctgtgttt
       61 tatttggtag gtcttctatc cctccaaggc acagaaactt ccacagtctt ctcattcgct
      121 ggtcctgagt agctccagtt tccaagatct tctggagagg gcatcatggc tctttgaggg
      181 cacagatgga gggagggctg aaggttgaaa tcgatggggg aaaagagtga agagagtctt
      241 ctttggagtg ggcagcaaac tccctagcag agtgaatgaa tgcaggacgc ctccagggtc
      301 tacgggcact gtctaatcac taataaagaa gtgtgctggt gtcatggctg ccaggctcat
      361 cggattcttc ctatttcagg cggtatcttg ggcatatggt gcccaaccct gcatccccaa
      421 aagctttggc tacagctcag tggtctgtgt ctgtaatgca tcgtactgtg actctcttga
      481 ccccgtgacc ttaccggctc tgggtacctt cagccgttac gagagcactc gacgtggacg
      541 tcggatggag ctgagtgtcg gggccatcca ggccaatcgc actggcacag ggttactact
      601 cactttgcag ccagaaaaga agttccagaa agtgaaagga tttggaggcg ccatgacaga
      661 cgccactgcg ctcaacatcc ttgctttgtc cccacctact cagaagctgc tactcagatc
      721 ctacttctct accaacggaa ttgaatataa catcatccgg gtacccatgg ccagttgtga
      781 cttctccatc cgtgtctata cctatgctga cacccctaac gacttccagt tatccaactt
      841 cagcctccca gaagaagaca ccaagctcaa gatacccctg attcaccaag ccctgaagat
      901 gtcctcacgc cccatttcac tctttgccag tccctggaca tcacccactt ggctcaagac
      961 caatggaaga gtgaatggga aggggtcgct caagggtcag ccaggggata tctttcacca
     1021 gacctgggcc aattactttg tcaagtttct ggatgcttat gctaagtatg gcctaagatt
     1081 ctgggcagtg acagcggaga atgaacctac agcagggctc ttcacggggt accccttcca
     1141 gtgcctgggc ttcactcctg aacaccagag agacttcatt tcccgtgacc tagggccagc
     1201 ccttgccaac agttcccatg atgtgaagct actcatgcta gatgaccaac gcttgctgct
     1261 accccgctgg gcagaggtgg tgctctctga tccagaggca gctaagtacg ttcatggcat
     1321 tgctgttcac tggtatatgg atttcctggc tccagccaaa gctactttag gagagacaca
     1381 ccgcttgttc cccaacacaa tgctctttgc ttcggaggcc tgcgtgggct ccaagttctg
     1441 ggaacagagt gttcggttgg gctcctggga tcgagggatg cagtacagtc acagcatcat
     1501 tacgaacctc ctttaccacg taactggatg gacggactgg aaccttgccc tgaatcctga
     1561 aggagggccc aactgggtcc gcaactttgt cgatagcccc attattgtcg acatccccaa
     1621 agacgcattt tacaaacagc ccatgttcta ccatcttggc cacttcagca agttcattcc
     1681 cgagggatcc cagagagtgg cgttggtggc cagtgagagc actgacttgg aaacagtagc
     1741 actgttacgc cctgacggct ctgcagttgt ggtcgtgtta aaccgatctt cggaggatgt
     1801 ccctcttacc atcagtgatc ctgacctggg cttcctggag accgtgtcac ctggctactc
     1861 cattcacact tacctgtggc gtcgccagtg atggaactga cacctgagca ggcacctggg
     1921 cttagcatgg acattaaagg gaaagagttc gctcctgtgc tatctgtgac taaaggaggc
     1981 acggcagggc ctgggggacc ttacagtgac acggggcagg gccaagggtt cggatgtctc
     2041 attctccttt ctagtatgtg ctgtgtatgg gagggaagcc ctagagtccc tccagcttcc
     2101 cagggttgta aagtgtgtgc tgtgcactgg ttgcctgtgg aagctgtgcc tacgtccagg
     2161 gtgagttcac cgtcttaaga agcacaagat ggggatgcct aggcaagctg gacctgtgtg
     2221 gaggagcaag gcagtcagtc taagggtgaa gcagcttaaa acccgagggt cagagggcag
     2281 acctgacctc tgcatcctca ttgtggcatc taagaatggc agcagccaca gaaagaaggg
     2341 attctttgat cccagttagt gtaaacaggt ttattctgag gacagcgccc catttttggc
     2401 tgctccaacc atggggagac gagggacagc tggaatgcac gagtagaaaa gtcagtcctg
     2461 ggaacaggaa cgccatcagt cctcttcatc ctcctcagcc aggcccaagg cccgggtgcc
     2521 tggggcccga gcagggcttg tccgctggat agaaacgatg ccactgagca gggcatagcc
     2581 caccatggct gccagccctg ccagcacaga gagaatctgg gtccggcgcc ggtatggctc
     2641 ctcctcggtc tcaggggctg ctggtgtctg gcgtggaagt ggcacctcat ctaggaggtg
     2701 aggaagggag gtgagcagga agccaggccc cggcggaccc cagcccgttc tcttctctcc
     2761 cactgctcct cacctccatc ccggggaaag tagaggttga ggatgtgggt gcagtaggcg
     2821 cagaggttgt gcagcccccg aaggtgggcc tgcagcttcc cactgggcag cttggcctgc
     2881 agcagcaggg ccaaatggct aaaaacaaag gcgtccaggg aggcagggct agagagagag
     2941 agagagagag aagggtggaa tggaagtgga caactgcaga gaggacaaca tgaagcaaga
     3001 ggaaaaagtc tgcttcagag gggtaggctc tgggcagcag gggtcatcca aggaagagca
     3061 ggacacctag ctctgcattt ggtaagggga gttccccagg tggcgccagc ctggccctga
     3121 atggagctct atcccagggc agtataatgg acacattgag tggcgcccag cccagcagtc
     3181 tcctcctgtg cctggctcct ctcccatccc accctcctgt accaccaagg aggttctagc
     3241 cacacgcaca gcgccccgtc accagaggca gtgtctgtcc taagaacccc ttgttcccac
     3301 ctcagcccag gctttgacac ctgaacccgt atcttcttcc aacatccatt tattccccct
     3361 tggagtcaga ctcacgcatc cccaaagaag aacttctgag agcccagacg ctgagagaga
     3421 agggttaggc actcccgagc ctcttggtat agctggagga agggacacga agcatgtggt
     3481 tgtgggagct gtgacacttc ccactgtaga ttctcattcc tagccccaag ttacctcttt
     3541 ttctagttcc tcctcgttct ctgatttgtg ctcgccacac agcagctgta gccgctccat
     3601 gtactggcgc tgcatgcggc cgggcaggaa gaagttgagg ggaaagggca tagcctctgc
     3661 ataccacttt cgggtcactt ccacatagtt cttggcgtct atccaaaaag tatggatctg
     3721 gattgggcag acaggaagag aaagcctgag cccgtgcacc tgcctgtcac ggggtgggct
     3781 tctaagtctc atggctctgt agctctgctc ccttctgtgc gggctgggac tgctaggtct
     3841 gagcgtactc actagcacag gcagtagttt ctcctccagc agagacatga aggctagggt
     3901 atctgctcct tggcgagctg acagatcgta gtcggcatta tacttctgtg gaagaaatgt
     3961 tcatggggtg aatattgaag gattgcaggg acacttattt tttcagtaga gaaggaacag
     4021 taaccccaca ctagcctcaa gcatagtaga ggtagaagaa ggagtctttc ctgctgaggt
     4081 ctccttgcct cagctcagtg agtagcctgt tgctgttggc agaaagcctg ggctttggag
     4141 cccactggct gtcaaggtcc tgcacccact gcggggaggg aagaaggcct ggccacaaag
     4201 tgggagcagc tcccggactt tccacggaaa gctggcgggg tgcctgccga cagcagctct
     4261 ctaacagtaa cttcctgatc tagacaccac accacagagc tagcaacgag gcactcggct
     4321 gcaggctggg cctcagaagt cagggggcac catccttacc cttcttgaac ccagtcaatt
     4381 tacatccagc caccccaacc ccagcttgtc ccccacagca agctcttggc tatgtcttgc
     4441 acttcactcc aaacccttgt gcaccactac tgtaccttca tcgcaccggt atttccgtct
     4501 tgtcttagtg tggcccacct ttccaggctt caggctgttc cttagtaccc cctccacaga
     4561 ctaagaaagc tttgaacctg cagagcctct tgaagatgac tcttaaattt ccctgaatct
     4621 cagtttctcc tttatggaag gagacagtaa tgtttttctc tcgatgtggc tgggtttgga
     4681 aataatttag gaaaaaaccc tttggaaact gaaaaggctg tgtttatatg caagtaaccc
     4741 gggtcctgcc aggaacgctg gcttatatct ggatccggtt tctccaggcc gctaagcttc
     4801 cattacttcc ccagctccct ggaaagtaga aatgagaaag gggattctat ttctgactgt
     4861 gtgttccctc ttggaacaac gctatgaatg ccaggcctct gagagcatcc tgcctaagca
     4921 ccctagttta caagtaagga actgtagttg gtgagctgcc ttagcaggta actgtccttg
     4981 ctgtcaggct caatgacaag agttgcattg caggaggcca catagcagaa ggaaaggact
     5041 tagtctacca agctgtccaa ggacctcccc aagtgtgcca cggcatgtgc tcacacacac
     5101 acacacaccc caaagcaaga gaaataaatg cttacaaaac aaatagttca ttactttgag
     5161 aagttaaatc acctgtccaa cgtcatagtc aatgacagaa taacagagcc aaggcctcta
     5221 ctctctcgta attcttaatc atccaaacct ggcacgaagc tttgtccatc ctgagtcctg
     5281 tatctagcat aacttagcac ttgagaagag aaatagtcct tagaaatctt tgtggttttt
     5341 ttctctctct ctctctcccc cgacttttac tcctttcttt gacagttctg gcctggaact
     5401 cactctatag agcaggctga ctttcaacta cagagatctg cctgcctctg ccttctaggt
     5461 gttcagatta aagatgtgtg ccaccactgc ccagtgactt ttttcttttt tgagaggggt
     5521 tcttatgtct tccaggctgg ccccaaacac actatgtagc caaagatgat tttaaatttc
     5581 tgatcatccc acttctacca agtgctggga ttatatgcgt gtaccaccat gacggtttat
     5641 attagaaatt cctttcaggt ctacccggaa accaactgct gttctctact cttctttatt
     5701 ttccatgtgt catcagcctg tgtatttctc ttcctccctg cccatttgat ttctccgctt
     5761 atcccacccc acagcccctt aagttcacta tctggccaac tgcttgtcac agtcacactg
     5821 catcccccat gctgctcctc cctgctctgg atcacactgc tcttgcctgg cctgtgtctg
     5881 gtggccaata aataagttac acttca
//
