LOCUS       NM_025961               2357 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus glycine amidinotransferase (L-arginine:glycine
            amidinotransferase) (Gatm), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_025961
VERSION     NM_025961.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2357)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2357)
  AUTHORS   Rashidi,A., Billingham,L.K., Zolp,A., Chia,T.Y., Silvers,C.,
            Katz,J.L., Park,C.H., Delay,S., Boland,L., Geng,Y., Markwell,S.M.,
            Dmello,C., Arrieta,V.A., Zilinger,K., Jacob,I.M., Lopez-Rosas,A.,
            Hou,D., Castro,B., Steffens,A.M., McCortney,K., Walshon,J.P.,
            Flowers,M.S., Lin,H., Wang,H., Zhao,J., Sonabend,A., Zhang,P.,
            Ahmed,A.U., Brat,D.J., Heiland,D.H., Lee-Chang,C., Lesniak,M.S.,
            Chandel,N.S. and Miska,J.
  TITLE     Myeloid cell-derived creatine in the hypoxic niche promotes
            glioblastoma growth
  JOURNAL   Cell Metab 36 (1), 62-77 (2024)
   PUBMED   38134929
REFERENCE   3  (bases 1 to 2357)
  AUTHORS   Yu,L., Wang,L., Hu,G., Ren,L., Qiu,C., Li,S., Zhou,X., Chen,S. and
            Chen,R.
  TITLE     Reprogramming alternative macrophage polarization by GATM-mediated
            endogenous creatine synthesis: A potential target for HDM-induced
            asthma treatment
  JOURNAL   Front Immunol 13, 937331 (2022)
   PUBMED   36177049
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2357)
  AUTHORS   Jensen,M., Muller,C., Hubner,N., Patone,G., Saar,K., Choe,C.U.,
            Schwedhelm,E. and Zeller,T.
  TITLE     Expression of cardiovascular-related microRNAs is altered in
            L-arginine:glycine amidinotransferase deficient mice
  JOURNAL   Sci Rep 12 (1), 5108 (2022)
   PUBMED   35332188
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2357)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   6  (bases 1 to 2357)
  AUTHORS   Garrison,W.D., Battle,M.A., Yang,C., Kaestner,K.H., Sladek,F.M. and
            Duncan,S.A.
  TITLE     Hepatocyte nuclear factor 4alpha is essential for embryonic
            development of the mouse colon
  JOURNAL   Gastroenterology 130 (4), 1207-1220 (2006)
   PUBMED   16618389
REFERENCE   7  (bases 1 to 2357)
  AUTHORS   Singh,U., Sun,T., Shi,W., Schulz,R., Nuber,U.A., Varanou,A.,
            Hemberger,M.C., Elliott,R.W., Ohta,H., Wakayama,T. and Fundele,R.
  TITLE     Expression and functional analysis of genes deregulated in mouse
            placental overgrowth models: Car2 and Ncam1
  JOURNAL   Dev Dyn 234 (4), 1034-1045 (2005)
   PUBMED   16247769
REFERENCE   8  (bases 1 to 2357)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   9  (bases 1 to 2357)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 2357)
  AUTHORS   Sandell,L.L., Guan,X.J., Ingram,R. and Tilghman,S.M.
  TITLE     Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4622-4627 (2003)
   PUBMED   12671064
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146111.1.
            
            On Oct 24, 2007 this sequence version replaced NM_025961.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145914.1, AK146111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2357              AK146111.1         2-2358
FEATURES             Location/Qualifiers
     source          1..2357
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.63 cM"
     gene            1..2357
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /note="glycine amidinotransferase (L-arginine:glycine
                     amidinotransferase)"
                     /db_xref="GeneID:67092"
                     /db_xref="MGI:MGI:1914342"
     exon            1..130
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1333
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /EC_number="2.1.4.1"
                     /note="glycine amidinotransferase, mitochondrial;
                     transamidinase; L-arginine:glycine amidinotransferase"
                     /codon_start=1
                     /product="glycine amidinotransferase, mitochondrial
                     precursor"
                     /protein_id="NP_080237.1"
                     /db_xref="CCDS:CCDS16665.1"
                     /db_xref="GeneID:67092"
                     /db_xref="MGI:MGI:1914342"
                     /translation="MLRVRCLRGGSRGAEAVHYIGSRLGGSLTGWVQRTFQSTQAATA
                     SSRNSCAAEDKATHPLPKDCPVSSYNEWDPLEEVIVGRAENACVPPFTVEVKANTYEK
                     YWPFYQKNGGLYFPKDHLKKAVAEVEEMCNILSMEGVTVRRPDPIDWSLKYKTPDFES
                     TGLYSAMPRDILMVVGNEIIEAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTM
                     ADELYDQNYPIHSVEDRHKLAAQGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYL
                     GIEWMRRHLAPDYRVHIISFKDPNPMHIDATFNIIGPGLVLSNPDRPCHQIDLFKKAG
                     WTIVTPPTPVIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANEVPIQKMFEKLGISTIK
                     VNIRNANSLGGGFHCWTCDVRRRGTLQSYFD"
     exon            131..349
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /inference="alignment:Splign:2.1.0"
     exon            350..545
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /inference="alignment:Splign:2.1.0"
     exon            546..736
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /inference="alignment:Splign:2.1.0"
     exon            737..874
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1039
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1103
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1220
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..2357
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2333..2338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /note="putative"
     polyA_site      2357
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /note="putative"
ORIGIN      
        1 gggagctggc gcgagcttgg cgactaggac cttgtgcacg cggagcagca gagacggggc
       61 gatgctacgg gtgcggtgtc tgcgcggagg cagccgaggt gccgaggcgg tgcactacat
      121 cggctctcgg cttggaggat ccttaacagg atgggtgcag cgaactttcc agagcaccca
      181 ggcagctaca gcttcctccc gaaattcctg tgcagctgaa gacaaggcca cccatcctct
      241 gcccaaggac tgccctgtct cctcttacaa cgaatgggac cctttagagg aagtgatagt
      301 gggcagagct gaaaatgcct gtgtgccacc attcacagtg gaggtgaagg ccaatacata
      361 tgaaaagtac tggccatttt accaaaaaaa tggaggtctt tattttccca aagatcatct
      421 gaagaaggct gttgctgagg tcgaagagat gtgcaatatt ttatcaatgg aaggagtgac
      481 cgtgaggcgg cctgacccca tcgactggtc actcaagtat aagactcctg attttgagtc
      541 tacaggtttg tacagcgcaa tgcctcgaga catcctgatg gttgtgggaa acgagattat
      601 agaagcaccc atggcatggc gctcacgctt ctttgagtac cgagcgtaca ggtcaattat
      661 caaagactac ttccatcgtg gtgccaagtg gacaacagca cccaagccca caatggctga
      721 cgaactgtat gaccagaatt atcccatcca ttccgtggaa gacagacaca aattggccgc
      781 tcagggaaag ttcgtgacga ctgagtttga gccttgcttt gatgctgctg acttcattcg
      841 agctggaaga gatatttttg cacagagaag ccaggttaca aactacctgg gcatcgagtg
      901 gatgcgtagg catcttgctc cagactacag agtacatatc atctctttta aagaccccaa
      961 tccaatgcac atcgatgcca ccttcaacat cattggacct ggtcttgtgc tctccaaccc
     1021 cgaccgtccc tgtcatcaga ttgatctttt caagaaagca ggatggacca tagttactcc
     1081 tccaacacca gtcatccccg atgatcatcc cctctggatg tcatccaaat ggctttccat
     1141 gaacgtctta atgctagatg agaagcgcgt gatggtagat gccaatgaag ttccaattca
     1201 aaagatgttt gagaagctgg gtatcagtac cattaaggtt aacattcgaa atgccaattc
     1261 cctgggagga ggcttccact gctggacctg cgacgtccgg cgccgaggca cccttcagtc
     1321 ctactttgac tgagcaggcg tggtgtggct tggggcatag cctcagatat acctaagaag
     1381 cagcaaggcc cttctctcgc tttaacaaat gcatgaactg tagtgctttg aacaatcaca
     1441 tccttaacag ggtttccaag cctgggttac tttttgttga cgtaaggaag ataacttatg
     1501 ataggtctta ctttcttctc ctaaagttat ttacgatttg gctttaaata taaaagttca
     1561 gtaagtgtat accgaagcaa aaattagtca cttgagtaac ttggccgcta atatttaacc
     1621 atctacctct gtttttaatt ttctttccta aaggcagctt gagatgtcgg tcctaacctt
     1681 gtctttcttt ttcctctttg gtagacttat gaatgtccat attacttctt ttttcctaaa
     1741 tgggacaaag acataggcaa aaaacatgga tcctaagtag aatcagatat ttatctcttt
     1801 ttctaaaaaa ataaaataaa taaatttggg tgtttttttt taatttgctt ttatcagata
     1861 tttatctctt tttctaaaaa aaataaaata aataaatttg ggtgtttttt tttttttaat
     1921 ttgcttttaa acaacctcga ctatgcaaac actgaaaaaa aaaaaaaaaa acgaagtgac
     1981 tttccatgaa tgcctttaac attcttgtgt caacatttgg tactaaactc ttactcttac
     2041 ctcatctcaa gtgggttatc cttccttctg tccttccttc tgtccttccc tccttccttc
     2101 agagtagcgc ttagtgtaat agagtgaaac ttgtagttcc cattcctaaa ggttgatgtt
     2161 caatatctaa caggtataat ggcatcttcg gtaatctaag atttgtttac atatatgcaa
     2221 aattatttaa ggcatagagt tttaaagcat tttttttgga aaaactaatg caggtaaaac
     2281 atgtgacatg agataatttt aatgttggat attatatatg tatttttact ctaataaact
     2341 tttgtgttcc agattgg
//
