LOCUS       NP_080237                423 aa            linear   ROD 10-FEB-2025
DEFINITION  glycine amidinotransferase, mitochondrial precursor [Mus musculus].
ACCESSION   NP_080237
VERSION     NP_080237.1
DBSOURCE    REFSEQ: accession NM_025961.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 423)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 423)
  AUTHORS   Rashidi,A., Billingham,L.K., Zolp,A., Chia,T.Y., Silvers,C.,
            Katz,J.L., Park,C.H., Delay,S., Boland,L., Geng,Y., Markwell,S.M.,
            Dmello,C., Arrieta,V.A., Zilinger,K., Jacob,I.M., Lopez-Rosas,A.,
            Hou,D., Castro,B., Steffens,A.M., McCortney,K., Walshon,J.P.,
            Flowers,M.S., Lin,H., Wang,H., Zhao,J., Sonabend,A., Zhang,P.,
            Ahmed,A.U., Brat,D.J., Heiland,D.H., Lee-Chang,C., Lesniak,M.S.,
            Chandel,N.S. and Miska,J.
  TITLE     Myeloid cell-derived creatine in the hypoxic niche promotes
            glioblastoma growth
  JOURNAL   Cell Metab 36 (1), 62-77 (2024)
   PUBMED   38134929
REFERENCE   3  (residues 1 to 423)
  AUTHORS   Yu,L., Wang,L., Hu,G., Ren,L., Qiu,C., Li,S., Zhou,X., Chen,S. and
            Chen,R.
  TITLE     Reprogramming alternative macrophage polarization by GATM-mediated
            endogenous creatine synthesis: A potential target for HDM-induced
            asthma treatment
  JOURNAL   Front Immunol 13, 937331 (2022)
   PUBMED   36177049
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 423)
  AUTHORS   Jensen,M., Muller,C., Hubner,N., Patone,G., Saar,K., Choe,C.U.,
            Schwedhelm,E. and Zeller,T.
  TITLE     Expression of cardiovascular-related microRNAs is altered in
            L-arginine:glycine amidinotransferase deficient mice
  JOURNAL   Sci Rep 12 (1), 5108 (2022)
   PUBMED   35332188
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 423)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   6  (residues 1 to 423)
  AUTHORS   Garrison,W.D., Battle,M.A., Yang,C., Kaestner,K.H., Sladek,F.M. and
            Duncan,S.A.
  TITLE     Hepatocyte nuclear factor 4alpha is essential for embryonic
            development of the mouse colon
  JOURNAL   Gastroenterology 130 (4), 1207-1220 (2006)
   PUBMED   16618389
REFERENCE   7  (residues 1 to 423)
  AUTHORS   Singh,U., Sun,T., Shi,W., Schulz,R., Nuber,U.A., Varanou,A.,
            Hemberger,M.C., Elliott,R.W., Ohta,H., Wakayama,T. and Fundele,R.
  TITLE     Expression and functional analysis of genes deregulated in mouse
            placental overgrowth models: Car2 and Ncam1
  JOURNAL   Dev Dyn 234 (4), 1034-1045 (2005)
   PUBMED   16247769
REFERENCE   8  (residues 1 to 423)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   9  (residues 1 to 423)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (residues 1 to 423)
  AUTHORS   Sandell,L.L., Guan,X.J., Ingram,R. and Tilghman,S.M.
  TITLE     Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4622-4627 (2003)
   PUBMED   12671064
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146111.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145914.1, AK146111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.63 cM"
     Protein         1..423
                     /product="glycine amidinotransferase, mitochondrial
                     precursor"
                     /EC_number="2.1.4.1"
                     /note="glycine amidinotransferase, mitochondrial;
                     transamidinase; L-arginine:glycine amidinotransferase"
                     /calculated_mol_wt=43679
     transit_peptide 1..43
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q9D964.1)"
                     /calculated_mol_wt=4636
     mat_peptide     44..423
                     /product="Glycine amidinotransferase, mitochondrial.
                     /id=PRO_0000001207"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D964.1)"
                     /calculated_mol_wt=43679
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P50440; propagated from
                     UniProtKB/Swiss-Prot (Q9D964.1)"
     Site            49
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P50440; propagated from
                     UniProtKB/Swiss-Prot (Q9D964.1)"
     Region          65..415
                     /region_name="amidinotransferase_AGAT-like"
                     /note="L-arginine:glycine amidinotransferase and similar
                     proteins; cd21136"
                     /db_xref="CDD:439148"
     Site            order(167,169..170,256,303,305..306,322,354..355,361,402,
                     406..407)
                     /site_type="other"
                     /note="chemical substrate binding site [chemical binding]"
                     /db_xref="CDD:439148"
     Site            385
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P50440; propagated from
                     UniProtKB/Swiss-Prot (Q9D964.1)"
     CDS             1..423
                     /gene="Gatm"
                     /gene_synonym="1810003P21Rik; AT"
                     /coded_by="NM_025961.5:62..1333"
                     /db_xref="CCDS:CCDS16665.1"
                     /db_xref="GeneID:67092"
                     /db_xref="MGI:MGI:1914342"
ORIGIN      
        1 mlrvrclrgg srgaeavhyi gsrlggsltg wvqrtfqstq aatassrnsc aaedkathpl
       61 pkdcpvssyn ewdpleeviv graenacvpp ftvevkanty ekywpfyqkn gglyfpkdhl
      121 kkavaeveem cnilsmegvt vrrpdpidws lkyktpdfes tglysamprd ilmvvgneii
      181 eapmawrsrf feyrayrsii kdyfhrgakw ttapkptmad elydqnypih svedrhklaa
      241 qgkfvttefe pcfdaadfir agrdifaqrs qvtnylgiew mrrhlapdyr vhiisfkdpn
      301 pmhidatfni igpglvlsnp drpchqidlf kkagwtivtp ptpvipddhp lwmsskwlsm
      361 nvlmldekrv mvdanevpiq kmfeklgist ikvnirnans lgggfhcwtc dvrrrgtlqs
      421 yfd
//
