LOCUS       NM_029645               1777 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glutamyl-tRNA amidotransferase subunit C (Gatc), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_029645 XM_357540
VERSION     NM_029645.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1777)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1777)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1777)
  AUTHORS   Echevarria,L., Clemente,P., Hernandez-Sierra,R., Gallardo,M.E.,
            Fernandez-Moreno,M.A. and Garesse,R.
  TITLE     Glutamyl-tRNAGln amidotransferase is essential for mammalian
            mitochondrial translation in vivo
  JOURNAL   Biochem J 460 (1), 91-101 (2014)
   PUBMED   24579914
  REMARK    GeneRIF: Glutamyl-tRNA Gln amidotransferase subunit interference
            produces a strong defect in mitochondrial translation without
            affecting the stability of the newly synthesized proteins.  .
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK034326.1.
            
            On Apr 6, 2007 this sequence version replaced NM_029645.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034326.1, SRR1660817.7464.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1777              AK034326.1         1-1777
FEATURES             Location/Qualifiers
     source          1..1777
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.05 cM"
     gene            1..1777
                     /gene="Gatc"
                     /gene_synonym="2010003O18Rik"
                     /note="glutamyl-tRNA amidotransferase subunit C"
                     /db_xref="GeneID:384281"
                     /db_xref="MGI:MGI:1923776"
     exon            1..320
                     /gene="Gatc"
                     /gene_synonym="2010003O18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..480
                     /gene="Gatc"
                     /gene_synonym="2010003O18Rik"
                     /note="gatC-like protein; glu-AdT subunit C;
                     glutamyl-tRNA(Gln) amidotransferase, subunit C homolog"
                     /codon_start=1
                     /product="glutamyl-tRNA(Gln) amidotransferase subunit C,
                     mitochondrial"
                     /protein_id="NP_083921.1"
                     /db_xref="CCDS:CCDS19588.1"
                     /db_xref="GeneID:384281"
                     /db_xref="MGI:MGI:1923776"
                     /translation="MWSRAASVRFRAPLDAGRSFASKANPQGKVQAAGLGTQAPRLVP
                     QGSGRVSPAVIEHLERLALVNFGSREAVDRLEKAIAFADQLHAVDTDGVEPLESVLED
                     RCLYLRSDNVAEGSCAEELLQNSNHVVEEYFVAPPGNISLPDMVNKIPSSTAE"
     exon            321..424
                     /gene="Gatc"
                     /gene_synonym="2010003O18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            425..1777
                     /gene="Gatc"
                     /gene_synonym="2010003O18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      913..918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gatc"
                     /gene_synonym="2010003O18Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      938
                     /gene="Gatc"
                     /gene_synonym="2010003O18Rik"
                     /note="major polyA site"
     regulatory      1562..1567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gatc"
                     /gene_synonym="2010003O18Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      1581
                     /gene="Gatc"
                     /gene_synonym="2010003O18Rik"
     regulatory      1729..1734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gatc"
                     /gene_synonym="2010003O18Rik"
                     /note="hexamer: CATAAA"
     polyA_site      1755
                     /gene="Gatc"
                     /gene_synonym="2010003O18Rik"
ORIGIN      
        1 gaagcaaaag aaatgtggtc acgggccgcg agtgtgcgat ttcgggcccc gctggacgcg
       61 ggccgaagct ttgcttccaa agcgaatcca cagggaaagg tccaggcggc ggggctgggg
      121 acccaggctc cacgtctcgt cccccagggc agcggtcgcg tgtcccccgc ggtaatcgag
      181 catctggagc gactggcgct ggtgaacttc ggcagccgcg aggcggtgga ccggctagag
      241 aaagccatcg cctttgcgga tcagctgcac gccgtggaca ctgacggtgt ggagccccta
      301 gagtcggtac tggaggacag atgtctctac ttgagatctg acaatgttgc agaaggcagc
      361 tgtgctgaag aactactaca gaattccaat cacgttgtgg aggaatactt tgtggccccc
      421 ccaggtaata tttccttgcc agacatggta aacaagattc cttcttccac agcagagtag
      481 ctattctggg gaaggggcac cctgtcaaca tggtggactc acaagggtgg tcatttgcta
      541 ctgtgaactc tatctagtat aaactggatt tacagtttct tggtaattga tccgaagaca
      601 actggacaac acccagctag cagaaaacca caagcctgct tccaaggaaa tggatcaaat
      661 actcagactc attctgtctg aaaaacaact tcctccctcc tctgccccta aaaaacacta
      721 ccttgtcaaa atatctatgt ggacttttct gtttaggtgt aagagacaga tgacctgaga
      781 tgaagagaca aatcagttct ttttagttgc tttcccactg gcttcagagc cagcacatca
      841 ccatctgttt ctgggtacct accttatgcc taccagaggg ctcgttttat ggatatgttt
      901 gagtagtatc aaagtaaact acagccggga actcctaatt cagaaccatc tttctttctc
      961 agaaggccat ccaacctcca ccttgcactc agtccatgaa caacatacac acatacacac
     1021 acacacacac acacacacac acacagtata cgtgaacacc caacccccac acacatacca
     1081 tgcaatatga acaccagcca aatagttcct ttctgaaaag agaacttgtt aaaaatagcc
     1141 ctaggcccgt cttcattctt tctcttccct ttatctgcaa tgtctgtgtc ccacacacac
     1201 acccttttct tgttgctcag ataggcctct ctgtacatca ggctggcctt gagcacacag
     1261 ctatcttcct gctacagcct cccaagcaca ggggttggag gcctgagcca cctcagtgaa
     1321 ctcctattat ggagagttca gtttacaatg ccagatctga attgtaagaa ctccgagtct
     1381 gggtcagaga tccctcagtc attcagagac cttcctatcc caggtatggt ggctccgtgt
     1441 ctttcatttc attccaacac ttgggaggca aaagccaaca gatccctgag ttcaaggcta
     1501 gcctggtcta cagagccaga attattctga gaaaccctct ctggaaaaga aaatggaaag
     1561 aaagaaaaac atcaaaccaa agaaacaaac cctcctgttc ttcatcctga gctgagtcgg
     1621 gctctggtgc ccacctcaac tcaaggtgac ccatgacctc ctgcaattcc agctccacag
     1681 gggttgatgc tgtctttctg gcctctgtag gcactaacac acacgcggca taaacatgta
     1741 aataaaaacc aacctttaaa ataaaaaaaa cagagtc
//
