LOCUS       NM_001113346            5062 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus GATA zinc finger domain containing 2A (Gatad2a),
            transcript variant 3, mRNA.
ACCESSION   NM_001113346
VERSION     NM_001113346.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5062)
  AUTHORS   Price,J.D., Lindtner,S., Ypsilanti,A., Binyameen,F., Johnson,J.R.,
            Newton,B.W., Krogan,N.J. and Rubenstein,J.L.R.
  TITLE     DLX1 and the NuRD complex cooperate in enhancer decommissioning and
            transcriptional repression
  JOURNAL   Development 149 (11) (2022)
   PUBMED   35695185
REFERENCE   2  (bases 1 to 5062)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5062)
  AUTHORS   Mor,N., Rais,Y., Sheban,D., Peles,S., Aguilera-Castrejon,A.,
            Zviran,A., Elinger,D., Viukov,S., Geula,S., Krupalnik,V.,
            Zerbib,M., Chomsky,E., Lasman,L., Shani,T., Bayerl,J., Gafni,O.,
            Hanna,S., Buenrostro,J.D., Hagai,T., Masika,H., Vainorius,G.,
            Bergman,Y., Greenleaf,W.J., Esteban,M.A., Elling,U., Levin,Y.,
            Massarwa,R., Merbl,Y., Novershtern,N. and Hanna,J.H.
  TITLE     Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates
            Deterministic Induction of Naive Pluripotency
  JOURNAL   Cell Stem Cell 23 (3), 412-425 (2018)
   PUBMED   30122475
  REMARK    GeneRIF: It validates a distinct molecular axis, Gatad2a-Chd4-Mbd3,
            within Mbd3/NuRD as being critical for blocking reestablishment of
            naive pluripotency and further highlight signaling-dependent and
            post-translational modifications of Mbd3/NuRD that influence its
            interactions and assembly.
REFERENCE   4  (bases 1 to 5062)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5062)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   6  (bases 1 to 5062)
  AUTHORS   Le Guezennec,X., Vermeulen,M., Brinkman,A.B., Hoeijmakers,W.A.,
            Cohen,A., Lasonder,E. and Stunnenberg,H.G.
  TITLE     MBD2/NuRD and MBD3/NuRD, two distinct complexes with different
            biochemical and functional properties
  JOURNAL   Mol Cell Biol 26 (3), 843-851 (2006)
   PUBMED   16428440
REFERENCE   7  (bases 1 to 5062)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 5062)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 5062)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5062)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ166913.1, CV562594.1, CN666280.1, BQ571528.1, CF726663.1,
            DV651557.1 and AC158564.7.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            an alternate in-frame splice site in the 3' coding region, compared
            to variant 1. This results in a shorter protein (isoform b),
            compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038221.1, SRR7974084.10337.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               CJ166913.1         1-345
            346-784             CV562594.1         252-690
            785-1021            CN666280.1         303-539
            1022-1542           BQ571528.1         217-737
            1543-2036           CF726663.1         82-575
            2037-2385           DV651557.1         294-642
            2386-5062           AC158564.7         101095-103771       c
FEATURES             Location/Qualifiers
     source          1..5062
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.06 cM"
     gene            1..5062
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /note="GATA zinc finger domain containing 2A"
                     /db_xref="GeneID:234366"
                     /db_xref="MGI:MGI:2384585"
     exon            1..294
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            295..396
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            397..654
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..2287
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /note="isoform b is encoded by transcript variant 3;
                     transcriptional repressor p66 alpha; GATA zinc finger
                     domain-containing protein 2A"
                     /codon_start=1
                     /product="transcriptional repressor p66 alpha isoform b"
                     /protein_id="NP_001106817.1"
                     /db_xref="CCDS:CCDS52567.1"
                     /db_xref="GeneID:234366"
                     /db_xref="MGI:MGI:2384585"
                     /translation="MSEEACRTRSQKRTLEPDLTEDDVENKKMKMEKGSSELTVDGDS
                     RVMPEPSAGSAQGLLRTTEAMGTGSGEGLLGDGPVDMRTSHSDMKSEKRPPSPDVIVL
                     SDSEQPSSPRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKK
                     LRQSQIQKEATAQKPTASSGSTVTTPPPLVRGTQNIPAGKTSLQTSSTRIPGSIIPPP
                     LVRGGQQVSAKLGPQASSQVVMPPLVRGAQIHNIRQHSSTGPPPLLLAPRASVPSMQI
                     QGQRIIQQGLIRVANVPNTSLLVNIPQPTAASMKGTAVASAQANSTPTSVASVVASAE
                     SPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVVQNL
                     LETQAGRISATAAAAVLSREPYMCVQCKTDFTCRWREKGGAVMCENCMTSNQKKALKV
                     EHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAEPAAPHPTLKQVIKPRRKLAFR
                     SGEARVWNNGSSLQASSQLSRGSATAPRGVLHTFSQSPKLQNAASATALVSRTGRHSE
                     RVVGTGKGTASNWKKTPLSTGGTLAFVSPSLAVHKTSSAVDRQREYLLDMIPPRSIPQ
                     SATWK"
     exon            655..787
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            788..919
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1009
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1141
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1306
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1586
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1888
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1963
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2156
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..5062
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3454..3459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3475
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /note="major polyA site"
     regulatory      5040..5045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5058
                     /gene="Gatad2a"
                     /gene_synonym="1110066C11Rik"
ORIGIN      
        1 atccgggtgc gggcgggtgg cgtcgccttt aagagctccc cggtgttttg ggggccgcgg
       61 gccgggcgcg ctgacctggt gcgcatgtcc cgggcggtga cgccggcgcc gggctccatg
      121 tgtgcggccg aggggcgcat tatctggccg gcggcgcggg cgggcggagc ggcggagcga
      181 gcgccgcggg cccgggcggc ccctcaggcg cagcgagcac gcgcggccgg cgccccccgc
      241 ccccagccct gtggacacgc gcgctgcccc tgggcccggt cggcgcgcgg ccgggttggc
      301 cagcacattg agccagcaca tccacataag ttgccttttg acagaactgt ggccatggca
      361 gcatggtagg atccgtgtcc cggaccctga ggccagaatg agtgaagaag catgccgaac
      421 ccgcagtcag aagcgcaccc ttgaacctga cctaacggag gatgatgtgg agaacaagaa
      481 aatgaaaatg gagaaagggt catcagagct gacagtggac ggagacagca gggtgatgcc
      541 agagccgagt gcaggctcag cccaggggtt gctgaggaca acagaggcca tgggcacagg
      601 atctggcgag gggctgttag gagacgggcc tgtggacatg cgcacttcac acagtgacat
      661 gaagtctgag aagagacctc cctcgcctga tgtgattgtg ctctctgaca gtgagcagcc
      721 atcgagccca agggtgaatg gcctgaccac agtagccttg aaagacacca gcactgaggc
      781 gctcttgaaa agcagcccag aagaacgaga gcggatgatc aagcagctga aggaggagct
      841 gaggctagag gaagcaaaac tggtcttgtt gaagaagctg cggcagagtc agatacagaa
      901 ggaagccacc gcacagaagc ctacagcttc ctcagggagc actgtgacca cccctccccc
      961 actcgtgcgg ggtacccaga acattcctgc tggcaagacc tcacttcaga cctcctccac
     1021 tcgaataccc ggcagcatca tcccaccacc actggtccga ggtgggcagc aggtgtctgc
     1081 caaactggga ccacaggcca gctctcaagt agtcatgcca ccgcttgtca ggggggccca
     1141 gattcacaac atcagacagc attcctctac ggggccacca cccctcctcc tggccccccg
     1201 tgcctcagtg cccagcatgc agattcaggg acagaggatc atccagcagg gacttatccg
     1261 tgtcgccaat gtccccaaca ccagtctgct tgtcaacatc cctcagccta ctgcagcctc
     1321 catgaagggg acagcagttg cttctgctca ggcaaattcc actcccacca gtgtggcttc
     1381 tgtggttgca tctgctgagt ctccagctag ccgacaggcg gctgccaagc tagcactgcg
     1441 caagcagctg gagaagacac tgctggagat ccccccaccc aagccccctg ccccagagat
     1501 gaacttcttg cccagtgctg ccaataatga gtttatctac ctggtcggcc tggaggaggt
     1561 ggtgcagaac ctgctggaga cacaagcagg caggatttct gccactgcag cagctgctgt
     1621 gttatcccgg gagccctaca tgtgtgtgca gtgtaagaca gacttcacat gccgctggcg
     1681 agagaagggt ggagccgtta tgtgtgagaa ctgcatgaca tccaaccaaa agaaggcact
     1741 caaggtggag cacaccagtc gcctgaaggc cgcctttgtg aaggctctac agcaagagca
     1801 ggagatggag cagcgcctgc tgcagcaggg tgtgggtact gccagcatca aggctgagcc
     1861 tgcagctcca catcccacgc tgaagcaggt cataaagccc cgacgtaagt tggcgttccg
     1921 ctcaggagag gcccgtgtct ggaataacgg gtcctcacta caggcttcca gccagctgtc
     1981 ccgaggctca gccacagcac ctcgtggtgt tctgcacact ttcagccagt cacccaaact
     2041 gcagaatgca gcctcagcta cggccctggt aagcaggact ggcagacatt ccgagagagt
     2101 cgtgggcacc ggcaagggca ccgcctccaa ctggaaaaag acgcctctga gcacaggtgg
     2161 gaccctcgcc ttcgtcagcc caagcttggc agtacacaag acctcctcgg ctgtggatcg
     2221 acagcgagaa tacctcctgg acatgattcc tccacgctcc atcccccaat cagccacatg
     2281 gaaatagtgg gagccggccc agccgaggac aggccctctt ctctcccaag gcccttggtc
     2341 taggacacac agactgcctc ctagcgagtt gcctgagaca gctcaggcct tggctgttgc
     2401 cttgctttgg ccaggagagt gtgccaccat ggtgcccagg atcagaatga gggacctccc
     2461 aatgggcctt ctctttcctt tttgccttta gtttgcccga caccagcaga aactcggacc
     2521 ttggggccag ctctgcctgg ccagcgtggg tgggagctca ccctggacac tgtgacacac
     2581 ccgggccagg ctggcaccgg gggctcccga agttgagccg ggatttcgtt ttcttttggc
     2641 ttttcccatc ttagctcccc agtctctgcc tcttcatggc catctatagg ttgaagtttg
     2701 ggttttattg ggtttttttt tgttttgttt tgtttttttt gtttttgttt ttttataatc
     2761 acctcataat gatgatggaa ttaaaagtga actgcataga cccagagtca ctgtcataca
     2821 cagtgcactt gggcaggctc taaccccaga ggatgctcgg agtggcacca gagatggcag
     2881 gtaccaccct gactctagtt gtctgttgct gctcactgca acccctggct tccacactta
     2941 gaacgaattg cagcccatat tctgtctgaa atctagaggc tccagagaga tgctgagtcc
     3001 actgtgctgg agccagagct ggttgctggg ttactttttg tggtttattt tattaaaaat
     3061 ttctatcctt tttctctttt gatggacaca atctcatgat tcccatgcct gccaagaggc
     3121 atccatccag gtagggccca gccacagccc ttaggtctgg agtcagcaga gcttactccc
     3181 tctcaatcca cagggacgcc tgaaagggcc cagtctactt ctgttctgtt ttgtttcctt
     3241 ctccccccat tctcttaaca attggttcca tggtgaaagg cagaagtagc tgtgtgtcca
     3301 gcacgcacgg gcggccttct gctcttgtga ttggtcgccg tcgtttcccc atccaaccct
     3361 ggtttccctt gacacagtac agttagggac tttaatttaa acccttgttc tgcggaccac
     3421 cgccctctgc agacacgccc cctgcctcct cctaataaag gctcatttaa ctccatgctc
     3481 acctgtgtgg aaatcctcca tctttagaaa tcatttggac atgtgggagt tgagagtttt
     3541 ggaaaacact tttgttgtgt gatacccaag ttgctcagtg cttttgagtg tgtcacttcc
     3601 cagggtggtt ttgggggaat taacagaaat tgaagttttt taaaaggggg gtttttacac
     3661 caaaaataaa aaaaaagaga gagagaatat atgcaagcat ttcttagtcc ttgagtattt
     3721 ttgtgcctgg caagtcagtt cctgttctcc acccttccta agtggcaatg acatagacca
     3781 aaagtcttct ggctccttgg aacggcagca ccggggtggc ctctcagcca gaagtcctca
     3841 ttcctatgca gtcactgatc agaccatgtc acctagaact ggatgaagac ctccacttga
     3901 gttgagggtc tgaccaagag ggttcggttg tcctggtgca tccagacttc caagtcttgt
     3961 gacttctccc atacacctgt catccaaccc ttgtaggccc agtttatgca cctcacaagg
     4021 gacagacctc cctggctgtg gttcatactt gccaggatga caagctgtgg taaaggtctc
     4081 tctaaggagg gctagagtga ggtgccttag cttactgacc ttacttgaaa gtgctgcctg
     4141 ttcttctgca ccacactggc ctatgcagca agccctcaac atgataagga ctggggactg
     4201 aagggccatg tttgggggtg tacagagctg ccacccccac caatgctggc tttatcccta
     4261 tcctgaatgg attaaatcct gggttccttg agacccccct agagatagat tagcctctgc
     4321 ttcttgagtg ctgggattaa tggcttgtac ctccacacct ggcttaaaac tttttaaaaa
     4381 atattaatgg catggtaact ttcctgtcta tacttgggag gtgaagatgg aggtgatggt
     4441 tcctacttca ttgatttccc agaggcaaca catcagtggc tctggtcatc aaggtcacag
     4501 gtaacaccat ttcctctact aactgctagg gacaggtttg aagggaggag ccaagcacag
     4561 aacacatctg tatttgtcga accagacctt ttgacagatg tgtgacctag gtttggttgt
     4621 tgggacagtg gtcctatgaa cagcctccag acctgatcac ggtcttcccc accaccccag
     4681 ggaagccaaa gcttgcccca ggcagtagta aggattgtaa atgctggctg taacaaacac
     4741 ctccatgcac tgagtcagcc tgaatgctgt tgagggtaag agtggtcctc gccatgagtc
     4801 atgtcagcct gaagaccttg gattgtttcc aaaaagtggt cagttttctg atcctcaatg
     4861 tgtaagttac actagtgcag ggtatgggga ttggggcagt tgctacttgt atttattgtg
     4921 actgaacctt tgacagtaca tgttttttta aagtgccacc aaactggaat agatgttcca
     4981 ataaatgagc tgaaattggt agtcactgtg tcatggggaa gtctgaaacc ctgaaggaca
     5041 ataaagaaat ggaccaaatg tc
//
