LOCUS       NM_008093               3302 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus GATA binding protein 5 (Gata5), mRNA.
ACCESSION   NM_008093
VERSION     NM_008093.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3302)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3302)
  AUTHORS   Ren,A., Gan,Q., Han,W., Gong,D., Cai,J. and Qu,X.
  TITLE     Endothelial GATA5 positively regulates angiogenesis via cathepsin
            S-mediated Angpt2/Flk1 and MMP2/9 signaling pathways
  JOURNAL   Biochem Biophys Res Commun 609, 111-118 (2022)
   PUBMED   35429678
  REMARK    GeneRIF: Endothelial GATA5 positively regulates angiogenesis via
            cathepsin S-mediated Angpt2/Flk1 and MMP2/9 signaling pathways.
REFERENCE   3  (bases 1 to 3302)
  AUTHORS   Moazzen,H., Wu,Y., Engineer,A., Lu,X., Aulakh,S. and Feng,Q.
  TITLE     NOX2 Is Critical to Endocardial to Mesenchymal Transition and Heart
            Development
  JOURNAL   Oxid Med Cell Longev 2020, 1679045 (2020)
   PUBMED   32655758
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3302)
  AUTHORS   Tahara,N., Akiyama,R., Theisen,J.W.M., Kawakami,H., Wong,J.,
            Garry,D.J. and Kawakami,Y.
  TITLE     Gata6 restricts Isl1 to the posterior of nascent hindlimb buds
            through Isl1 cis-regulatory modules
  JOURNAL   Dev Biol 434 (1), 74-83 (2018)
   PUBMED   29197504
REFERENCE   5  (bases 1 to 3302)
  AUTHORS   Darwich,R., Li,W., Yamak,A., Komati,H., Andelfinger,G., Sun,K. and
            Nemer,M.
  TITLE     KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5
  JOURNAL   Hum Mol Genet 26 (5), 942-954 (2017)
   PUBMED   28164238
REFERENCE   6  (bases 1 to 3302)
  AUTHORS   Komada,M. and Soriano,P.
  TITLE     Hrs, a FYVE finger protein localized to early endosomes, is
            implicated in vesicular traffic and required for ventral folding
            morphogenesis
  JOURNAL   Genes Dev 13 (11), 1475-1485 (1999)
   PUBMED   10364163
REFERENCE   7  (bases 1 to 3302)
  AUTHORS   Di Lisi,R., Millino,C., Calabria,E., Altruda,F., Schiaffino,S. and
            Ausoni,S.
  TITLE     Combinatorial cis-acting elements control tissue-specific
            activation of the cardiac troponin I gene in vitro and in vivo
  JOURNAL   J Biol Chem 273 (39), 25371-25380 (1998)
   PUBMED   9738004
REFERENCE   8  (bases 1 to 3302)
  AUTHORS   Gao,X., Sedgwick,T., Shi,Y.B. and Evans,T.
  TITLE     Distinct functions are implicated for the GATA-4, -5, and -6
            transcription factors in the regulation of intestine epithelial
            cell differentiation
  JOURNAL   Mol Cell Biol 18 (5), 2901-2911 (1998)
   PUBMED   9566909
REFERENCE   9  (bases 1 to 3302)
  AUTHORS   Molkentin,J.D., Lin,Q., Duncan,S.A. and Olson,E.N.
  TITLE     Requirement of the transcription factor GATA4 for heart tube
            formation and ventral morphogenesis
  JOURNAL   Genes Dev 11 (8), 1061-1072 (1997)
   PUBMED   9136933
REFERENCE   10 (bases 1 to 3302)
  AUTHORS   Morrisey,E.E., Ip,H.S., Tang,Z., Lu,M.M. and Parmacek,M.S.
  TITLE     GATA-5: a transcriptional activator expressed in a novel temporally
            and spatially-restricted pattern during embryonic development
  JOURNAL   Dev Biol 183 (1), 21-36 (1997)
   PUBMED   9119112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142213.1 and AL663027.9.
            
            On Apr 10, 2008 this sequence version replaced NM_008093.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142213.1, U84725.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2112              AK142213.1         3-2114
            2113-3302           AL663027.9         196006-197195       c
FEATURES             Location/Qualifiers
     source          1..3302
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 102.85 cM"
     gene            1..3302
                     /gene="Gata5"
                     /note="GATA binding protein 5"
                     /db_xref="GeneID:14464"
                     /db_xref="MGI:MGI:109497"
     exon            1..854
                     /gene="Gata5"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1525
                     /gene="Gata5"
                     /note="GATA-binding factor 5; Transcription factor GATA-5
                     (GATA binding factor-5)"
                     /codon_start=1
                     /product="transcription factor GATA-5"
                     /protein_id="NP_032119.2"
                     /db_xref="CCDS:CCDS17175.1"
                     /db_xref="GeneID:14464"
                     /db_xref="MGI:MGI:109497"
                     /translation="MYQSLALAQSPGQGTYADSGAFLHSSGTGSPVFVAPTRMPSMLP
                     YLPSCEPGSQAPALAAHSSWTQAVAADSSAFGSGSPHPPAAHPPGATTFPFAHSPPGS
                     GSGGSAGVRDGGAFQGALLAREQYPTPLGRPMGASYPTTYPAYMSSDVAPSWTSGAFD
                     SSILHGLQARPGGLPGRRTSFVPDFLEEFPGEGRECVNCGALSTPLWRRDGTGHYLCN
                     ACGLYHKMNGVNRPLVRPQKRLSSSRRSGLCCSNCHTATTTLWRRNSEGEPVCNACGL
                     YMKLHGVPRPLAMKKESIQTRKRKPKNPAKIKGSSGSTANTTASSPTLLNSESSATTL
                     KAESSLASPVCAGPTITSQASSPADESLASSHLEFKFEPEDFAFTSSSMSPQAGLSGV
                     LRQETWCALALA"
     exon            855..1030
                     /gene="Gata5"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1156
                     /gene="Gata5"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1244
                     /gene="Gata5"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1369
                     /gene="Gata5"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..3302
                     /gene="Gata5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2094..2099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gata5"
                     /note="hexamer: AGTAAA"
     polyA_site      2116
                     /gene="Gata5"
                     /note="major polyA site"
ORIGIN      
        1 cagtctacaa cccaccggtc accctccctg ggccaacgcc gcgccttcct gtgagggctt
       61 tggctggcga tctctgcgca aggcaaggac ctcgttccta gggtcctgcg cctcatctaa
      121 ccctgtcatt ccacccagag gagcccggga cctgccctgg tgaaccgact caaaaaagtg
      181 gagtgcccaa gcggagcagc agcacctgcc ccgggcgagc gcaagagctg atggaggggg
      241 cccagtgatc ctgccctaga cgtctgcccg tctttcttct ctgcaggtca agctcgcgcg
      301 gggaaaaaaa atgtaccaaa gcttggcgtt agcccagagc cccggccagg gcacttacgc
      361 cgactccgga gcctttctgc actcttcggg aaccggctcc ccggtgttcg tggcacccac
      421 tcgcatgccc tccatgctgc cgtacctgcc ttcgtgtgag ccgggctcgc aggctcccgc
      481 gctcgccgcg cactccagct ggacacaagc agttgccgct gattcctcag ccttcggctc
      541 cggaagcccg cacccgccag ccgcacaccc accgggagcc accaccttcc cgttcgctca
      601 cagccctccg gggtcgggca gcggcggcag cgcgggggtc cgggacggcg gcgccttcca
      661 gggcgcgctg ctggctcgcg aacagtaccc gaccccgctc gggagaccca tgggcgcctc
      721 gtaccccaca acctacccag catacatgag ttccgacgta gccccttcgt ggacctccgg
      781 agccttcgac agcagcatcc tgcacggtct gcaagctcgc cctggtggcc tccctggccg
      841 caggaccagc ttcgtacctg acttcttgga ggagttccct ggtgagggcc gggagtgcgt
      901 caactgtgga gccctgtcta caccactgtg gcgcagggac ggcaccggac actatctatg
      961 caatgcctgc ggcctctatc acaagatgaa cggggtcaac cgaccgctag tgaggcccca
     1021 gaagcgtctg tcctcatccc gaagatccgg cctatgctgc tccaactgcc atactgccac
     1081 caccaccctc tggaggcgca actcggaggg cgaaccagtg tgcaacgcct gtggcctcta
     1141 catgaagctc catggggtgc caaggccact ggcaatgaaa aaggagagta tccagacaag
     1201 aaaacggaag ccaaagaacc ctgccaaaat caagggctcc tcaggatcca cagcaaacac
     1261 cacagcctct tctcccactc tcctcaactc tgagagctca gccaccactt tgaaggcaga
     1321 gtccagtctg gcatctccag tgtgtgctgg gcccactatc acctcccagg cctccagccc
     1381 agcggacgaa tccctggcct ccagccattt ggagttcaag ttcgaacctg aagactttgc
     1441 cttcacctcc tcgtccatga gcccccaggc tggtctcagt ggggtcctac gtcaggagac
     1501 ctggtgtgct ctggccttgg cctaggtgct caggaaactg tcaccacagt acatcccagg
     1561 aacagaagtt agttcctgtg tcagcagccc cagaggtccc tcaccactat gctggcgaaa
     1621 ttttctgtgc tgattgcctg gagaaagaag caggctggtg gatgaagggt tggagcctca
     1681 gccggggtag taatggactc cctagacccc ctcatggacc tctctgcagc caagatgact
     1741 ggagatatcc accaattact tgaatttagc tcttgacatc gatcgtcaaa atttacagtt
     1801 tgtagcagct ggcaaaggtt catagtatcc cacagtaaaa tctgatccaa gtgaaacaaa
     1861 catactccag gcaggcaata agaaataggg cctctgggcc ctcgtcgtct tcatttcccg
     1921 tgtttgactc tgtacgactg agagagcaca ctcttgctta cagacgcagg actgccagag
     1981 accagtgtac aggttgagca ctgtaccagg acaccgcccc aaggcaaacg catccctccg
     2041 gcccatcatc gcagacttct gtatttattt gtatgtttgt ttccaggcca ggcagtaaag
     2101 ggccttgttc tggcaatctg cgtactaagg tgtttgctag tgggcagacc tgcagagaca
     2161 ctgttggaat tgggtgatgt gtgaccttgt ggcctagctc agccattatt ccagcagttg
     2221 gcaacacagc cctatttgta gcatcttctt cacccaggtc acatcagctg gtggtgactt
     2281 tgcccaaggc ctgcaggtca gttctagggc cctggtacag ggaggtgaca ggcaacaaaa
     2341 gacaggtgtt ctatatgccg cattcccaca ggttttagct caacgggcta attcctggcc
     2401 atcccaggct tccactcccc agtgaggaaa ccaagaagca agggagtcag ggatcatcca
     2461 cccatgaagg tcacccctaa cctgtctcct gcgtggaccc tcaatccttc cttccagttc
     2521 agcttgaggg agaggcagta ggccctggtt agaaggaaat caagaggcag tagcctgcag
     2581 catttgcagg catcgcaggg gcaaaggcaa gacatgctct tgtaactagc tccaagcagg
     2641 catacctcac cacccgtgta tctgtggaag aaagccagct gcctaggtgt ctgttatcac
     2701 atcccagagg ctggagtaag gagaggaggg gactagagac ctggacacag gcaacaccgt
     2761 gtgagcatct ccaagcaccc ataccccaag tgtgcacaga tgcagacagg accacagctg
     2821 tgcacaaggt catagcacca tgttctcgat acagtgctgt tcctaggagc tctgtgtgtt
     2881 cctagtgtcc tagcctcagt ttccccttct gtgattagag aggtgtctgt gagcacatcc
     2941 gtaattcatg tacctttgag gtggttcaag gcactcacca acctaggaag gcttcctgga
     3001 gacagccaca gtgtaaggca caaggcagat ggcaccccct tgaatggaga ggaagggaac
     3061 tcgggaagag aggggcatga agacataaga tcccttccac gttggtttct ctgcctttct
     3121 ttgtttcatt cgtttgtttt ttgttgttgt tattttgttt tgttttgttt tttgagacag
     3181 ggccttacta tgtagctctg gctgtcctgg aactcattat gtagaccagg ctggcctcaa
     3241 actcacagag acctgcctgc ctctgcctcc tgagtactag gattaaaggc atgagccacc
     3301 tg
//
