LOCUS       NM_008092               3405 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus GATA binding protein 4 (Gata4), transcript variant 2,
            mRNA.
ACCESSION   NM_008092
VERSION     NM_008092.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3405)
  AUTHORS   Weberling,A., Siriwardena,D., Penfold,C., Christodoulou,N.,
            Boroviak,T.E. and Zernicka-Goetz,M.
  TITLE     Primitive to visceral endoderm maturation is essential for mouse
            epiblast survival beyond implantation
  JOURNAL   iScience 28 (1), 111671 (2024)
   PUBMED   39868030
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3405)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   3  (bases 1 to 3405)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   4  (bases 1 to 3405)
  AUTHORS   Santini,L., Kowald,S., Cerron-Alvan,L.M., Huth,M., Fabing,A.P.,
            Sestini,G., Rivron,N. and Leeb,M.
  TITLE     FoxO transcription factors actuate the formative pluripotency
            specific gene expression programme
  JOURNAL   Nat Commun 15 (1), 7879 (2024)
   PUBMED   39251582
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3405)
  AUTHORS   Zhou,B.R., Feng,H., Huang,F., Zhu,I., Portillo-Ledesma,S., Shi,D.,
            Zaret,K.S., Schlick,T., Landsman,D., Wang,Q. and Bai,Y.
  TITLE     Structural insights into the cooperative nucleosome recognition and
            chromatin opening by FOXA1 and GATA4
  JOURNAL   Mol Cell 84 (16), 3061-3079 (2024)
   PUBMED   39121853
  REMARK    GeneRIF: Structural insights into the cooperative nucleosome
            recognition and chromatin opening by FOXA1 and GATA4.
REFERENCE   6  (bases 1 to 3405)
  AUTHORS   Sebastiani,G., Grepin,C., Nemer,M. and Malo,D.
  TITLE     The mouse Gata4 transcription factor maps to chromosome 14
  JOURNAL   Mamm Genome 6 (6), 442-443 (1995)
   PUBMED   7647471
REFERENCE   7  (bases 1 to 3405)
  AUTHORS   White,R.A., Dowler,L.L., Pasztor,L.M., Gatson,L.L., Adkison,L.R.,
            Angeloni,S.V. and Wilson,D.B.
  TITLE     Assignment of the transcription factor GATA4 gene to human
            chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for
            Ds (disorganization)
  JOURNAL   Genomics 27 (1), 20-26 (1995)
   PUBMED   7665171
REFERENCE   8  (bases 1 to 3405)
  AUTHORS   Bielinska,M. and Wilson,D.B.
  TITLE     Regulation of J6 gene expression by transcription factor GATA-4
  JOURNAL   Biochem J 307 (Pt 1) (Pt 1), 183-189 (1995)
   PUBMED   7717974
REFERENCE   9  (bases 1 to 3405)
  AUTHORS   Heikinheimo,M., Scandrett,J.M. and Wilson,D.B.
  TITLE     Localization of transcription factor GATA-4 to regions of the mouse
            embryo involved in cardiac development
  JOURNAL   Dev Biol 164 (2), 361-373 (1994)
   PUBMED   8045339
REFERENCE   10 (bases 1 to 3405)
  AUTHORS   Molkentin,J.D., Kalvakolanu,D.V. and Markham,B.E.
  TITLE     Transcription factor GATA-4 regulates cardiac muscle-specific
            expression of the alpha-myosin heavy-chain gene
  JOURNAL   Mol Cell Biol 14 (7), 4947-4957 (1994)
   PUBMED   8007990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090962.33, AK134639.1 and BB044491.1.
            
            On Jul 16, 2015 this sequence version replaced NM_008092.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            donor splice site in the central coding region compared to variant
            1. The encoded isoform (2) is one amino acid shorter than isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U85046.1, SRR13948564.1997940.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC090962.33        93669-93789
            122-1231            AC090962.33        97295-98404
            1232-3395           AK134639.1         245-2408
            3396-3405           BB044491.1         178-187
FEATURES             Location/Qualifiers
     source          1..3405
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 33.24 cM"
     gene            1..3405
                     /gene="Gata4"
                     /gene_synonym="Gata-4"
                     /note="GATA binding protein 4"
                     /db_xref="GeneID:14463"
                     /db_xref="MGI:MGI:95664"
     exon            1..121
                     /gene="Gata4"
                     /gene_synonym="Gata-4"
                     /inference="alignment:Splign:2.1.0"
     exon            122..1231
                     /gene="Gata4"
                     /gene_synonym="Gata-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             619..1944
                     /gene="Gata4"
                     /gene_synonym="Gata-4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcription factor GATA-4; GATA-binding factor 4"
                     /codon_start=1
                     /product="transcription factor GATA-4 isoform 2"
                     /protein_id="NP_032118.2"
                     /db_xref="CCDS:CCDS49519.1"
                     /db_xref="GeneID:14463"
                     /db_xref="MGI:MGI:95664"
                     /translation="MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRV
                     PSSVLGLSYLQGGGSAAAAGTTSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPP
                     PVSPRFSFPGTTGSLAAAAAAAAAREAAAYGSGGGAAGAGLAGREQYGRPGFAGSYSS
                     PYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPGRHPNLDMFDDFSEGRECVN
                     CGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTT
                     TTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPA
                     GETLPPSSGASSGNSSNATSSSSSSEEMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHG
                     PSIHPVLSALKLSPQGYASPVTQTSQASSKQDSWNSLVLADSHGDIITA"
     exon            1232..1398
                     /gene="Gata4"
                     /gene_synonym="Gata-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1524
                     /gene="Gata4"
                     /gene_synonym="Gata-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1612
                     /gene="Gata4"
                     /gene_synonym="Gata-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1767
                     /gene="Gata4"
                     /gene_synonym="Gata-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..3405
                     /gene="Gata4"
                     /gene_synonym="Gata-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgccgggag caggggacaa gccggaggcc cgcagagtgg ccgcccgagg ctcagccgca
       61 gttgcagctc cgcggactca cggagatcgc gccggttttc tgggaaactg gagctggcca
      121 ggactgccgc ttcgcttcga agggaccggg ccctctttgt cattcttcgc tggagccgct
      181 ctggagctag cagctgcgcc tgggtgtgta gcaggcagaa agcaaggact aggcttcttt
      241 agccggtggg tgatccgaag gcctgctcag ggtgttcgag accagcctgg actgcgtctg
      301 ggcacctcca gcctctgggc cctggaatag agtccgccct cccgcacgat ttctggagca
      361 accgcaaatc caatttggga ttttcttttt cctgagcaaa ccagagccta gaggtttctg
      421 ctttgatgct ggatttaatt cgtatatatt ttgagcgagt tgggcctctc ctcgtttttt
      481 gatctccggt tgtttttttt ttgggggggg ggttagtttt tgggtttttg ttttgttttg
      541 ttttgttttg atttttggtg acagttccgc acacccgcat tctagttctt gtctgcctcg
      601 tgctcagagc ttggggcgat gtaccaaagc ctggccatgg ccgccaacca cggccccccg
      661 cccggcgcct acgaagcagg tggccctggc gccttcatgc acagcgcggg cgccgcgtcc
      721 tcgcccgtct acgtgcccac tccgcgggtg ccgtcctctg tgctgggcct gtcctacctg
      781 cagggcggtg gcagtgccgc tgcagctgga accacctcgg gtggcagctc cggggccggc
      841 ccgtcgggtg cagggcctgg gacccagcag ggtagccctg gctggagcca agctggagcc
      901 gagggagccg cctacacccc gccgcccgtg tccccgcgct tctctttccc ggggactact
      961 gggtccctgg cggccgctgc cgccgctgcc gcagcccggg aagctgcagc ctacggcagt
     1021 ggcggcgggg cggcgggcgc tggtctggct ggccgagagc agtacgggcg tccgggcttc
     1081 gccggctcct actccagccc ctacccagcc tacatggccg acgtgggagc atcctgggcc
     1141 gcagccgctg ccgcctctgc cggccccttc gacagcccag tcctgcacag cctgcctgga
     1201 cgggccaacc ctggaagaca ccccaatctc gatatgtttg atgacttctc agaaggcaga
     1261 gagtgtgtca attgtggggc catgtccacc ccactctgga ggcgagatgg gacgggacac
     1321 tacctgtgca atgcctgtgg cctctatcac aagatgaacg gcatcaaccg gcccctcatt
     1381 aagcctcagc gccgcctgtc cgcttcccgc cgggtaggcc tctcctgtgc caactgccag
     1441 actaccacca ccacgctgtg gcgtcgtaat gccgagggtg agcctgtatg taatgcctgc
     1501 ggcctctaca tgaagctcca tggggttccc aggcctcttg caatgcggaa ggaggggatt
     1561 caaaccagaa aacggaagcc caagaacctg aataaatcta agacgccagc aggtcctgct
     1621 ggtgagaccc tccctccctc cagtggtgcc tccagcggta actccagcaa tgccactagc
     1681 agcagcagca gcagtgaaga gatgcgcccc atcaagacag agcccgggct gtcatctcac
     1741 tatgggcaca gcagctccat gtcccagaca ttcagtactg tgtccggcca cgggccctcc
     1801 atccatccag tgctgtctgc tctgaagctg tccccacaag gctatgcatc tcctgtcact
     1861 cagacatcgc aggccagctc caagcaggac tcttggaaca gcctggtcct ggctgacagt
     1921 catggggaca taatcaccgc gtaatcagcg cccccccttc cctcttcaaa ttcctgctcg
     1981 gacttgggac gtgggggcca gcaaagtaaa aggctggggc acccttggcc agcccctttg
     2041 tctgggaaca actcctgaag aacaactggg tagaacttga agttgttgac aatcacttag
     2101 ggatatgggt gttccgggtt gttcaaacac ctttccaggt ggagcactgg aaaagcctgc
     2161 gttcttacag agaagcccac cttggctgca agcacagcac agtgaggcaa gagacttctt
     2221 ccttccttat tctccacctg cctgtccagg acagacacat aatctccttc accccagctc
     2281 cccacccagt tgtggtggtg ggtttttctt tgtgatccta gagtggctgt aggggcggag
     2341 gcttcaagac accatctaca gtctgagcag ggtgtctact tgttgtagac tagacataga
     2401 agccctgccc ttgtccaaca ctccccttgc ttgaggcatg gcacatctct gcatgtccca
     2461 taccagatct gactccaaag tgctgggttc aatgcagatg ttactgaatg cttcctgggg
     2521 agattaggtg aggggaaggc acatcaccca tcacacagaa tagcttcatc aaatcgcagc
     2581 ctggccatgg tgccttccct tcctctccca ggaacatcaa accccttgct ctccagcctg
     2641 aacatctacc ctctgcaaaa gtagagccca gttgtgcagc taatgccact aggtgctata
     2701 tcccagcatc cttttcaccc cttcacacac aggggttcca aggaggaaca aaacctgcta
     2761 ccaaagcagc cttggtgact atggctcatc tgcacctcag ggggtggggg agggccctct
     2821 ggaggttgtg tctacagcac aatactgttc ccaggactct agcttgcttg ccccgagcct
     2881 gccaagccaa gccctcttaa gtcagacagt tacctggctc tgggactttc tccagcacag
     2941 atcctttgtc tagaaaatac agactgtttg caaaataaat tcaaagcaga aacaactaaa
     3001 ggaaatttgt gaaaggacaa aggtgataga cgggagaaga tgtccccagg gctggcggga
     3061 cagtcatgat agcagctgtc ctaggattgg cctccctccc atctcccacc attactgggg
     3121 ctcccagaga ttcttccttg tcctcatcac ccacagagct gtagccaact gtggcattac
     3181 tttattttac ccaaaattcc cagccccacc cctaaacctt actggccgta gcagagaata
     3241 gcttcgaacc aagattctgt tgtaatcatt ttcgctgttt ctccctcaag gccgccttcc
     3301 ccatgcctgc ccctcctcca caacccgtta acattgtctt aaggtgaaat ggctgtaaaa
     3361 tcagtattta actaataaat ttatctgtat tcctgtttcc tccga
//
