LOCUS       NM_001417046            3321 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus GATA binding protein 3 (Gata3), transcript variant 5,
            mRNA.
ACCESSION   NM_001417046 XM_030247533
VERSION     NM_001417046.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3321)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 3321)
  AUTHORS   Sun,Y., Ren,M., Zhang,Y., Li,S., Luo,Z., Sun,S., He,S., Wang,G.,
            Zhang,D., Mansour,S.L., Song,L. and Liu,Z.
  TITLE     Casz1 is required for both inner hair cell fate stabilization and
            outer hair cell survival
  JOURNAL   Science, eado4930 (2025) In press
   PUBMED   39883789
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 3321)
  AUTHORS   Sitko,A.A., Frank,M.M., Romero,G.E., Hunt,M. and Goodrich,L.V.
  TITLE     Lateral olivocochlear neurons modulate cochlear responses to noise
            exposure
  JOURNAL   Proc Natl Acad Sci U S A 122 (4), e2404558122 (2025)
   PUBMED   39854232
REFERENCE   4  (bases 1 to 3321)
  AUTHORS   Thiruppathy,M., Teubner,L., Roberts,R.R., Lasser,M.C.,
            Moscatello,A., Chen,Y.W., Hochstim,C., Ruffins,S., Sarkar,A.,
            Tassey,J., Evseenko,D., Lozito,T.P., Willsey,H.R., Gillis,J.A. and
            Crump,J.G.
  TITLE     Repurposing of a gill gene regulatory program for outer-ear
            evolution
  JOURNAL   Nature (2025) In press
   PUBMED   39788155
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 3321)
  AUTHORS   Gil,Y., Ryu,J., Yang,H., Ma,Y., Nam,K.H., Jang,S.W. and Shim,S.
  TITLE     Molecular Characterization of Subdomain Specification of Cochlear
            Duct Based on Foxg1 and Gata3
  JOURNAL   Int J Mol Sci 25 (23), 12700 (2024)
   PUBMED   39684410
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3321)
  AUTHORS   Pandolfi,P.P., Roth,M.E., Karis,A., Leonard,M.W., Dzierzak,E.,
            Grosveld,F.G., Engel,J.D. and Lindenbaum,M.H.
  TITLE     Targeted disruption of the GATA3 gene causes severe abnormalities
            in the nervous system and in fetal liver haematopoiesis
  JOURNAL   Nat Genet 11 (1), 40-44 (1995)
   PUBMED   7550312
REFERENCE   7  (bases 1 to 3321)
  AUTHORS   Satake,M., Nomura,S., Yamaguchi-Iwai,Y., Takahama,Y., Hashimoto,Y.,
            Niki,M., Kitamura,Y. and Ito,Y.
  TITLE     Expression of the Runt domain-encoding PEBP2 alpha genes in T cells
            during thymic development
  JOURNAL   Mol Cell Biol 15 (3), 1662-1670 (1995)
   PUBMED   7862157
REFERENCE   8  (bases 1 to 3321)
  AUTHORS   Ng,Y.K., George,K.M., Engel,J.D. and Linzer,D.I.
  TITLE     GATA factor activity is required for the trophoblast-specific
            transcriptional regulation of the mouse placental lactogen I gene
  JOURNAL   Development 120 (11), 3257-3266 (1994)
   PUBMED   7720565
REFERENCE   9  (bases 1 to 3321)
  AUTHORS   Zon,L.I., Gurish,M.F., Stevens,R.L., Mather,C., Reynolds,D.S.,
            Austen,K.F. and Orkin,S.H.
  TITLE     GATA-binding transcription factors in mast cells regulate the
            promoter of the mast cell carboxypeptidase A gene
  JOURNAL   J Biol Chem 266 (34), 22948-22953 (1991)
   PUBMED   1744088
REFERENCE   10 (bases 1 to 3321)
  AUTHORS   Ko,L.J., Yamamoto,M., Leonard,M.W., George,K.M., Ting,P. and
            Engel,J.D.
  TITLE     Murine and human T-lymphocyte GATA-3 factors mediate transcription
            through a cis-regulatory element within the human T-cell receptor
            delta gene enhancer
  JOURNAL   Mol Cell Biol 11 (5), 2778-2784 (1991)
   PUBMED   2017177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845529.10.
            
            On Feb 24, 2023 this sequence version replaced XM_030247533.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.842040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AL845529.10        166159-166437       c
            280-935             AL845529.10        165421-166076       c
            936-1472            AL845529.10        162458-162994       c
            1473-1618           AL845529.10        156830-156975       c
            1619-1744           AL845529.10        151164-151289       c
            1745-3321           AL845529.10        145147-146723       c
FEATURES             Location/Qualifiers
     source          1..3321
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 6.69 cM"
     gene            1..3321
                     /gene="Gata3"
                     /gene_synonym="Gata-3; jal"
                     /note="GATA binding protein 3"
                     /db_xref="GeneID:14462"
                     /db_xref="MGI:MGI:95663"
     exon            1..279
                     /gene="Gata3"
                     /gene_synonym="Gata-3; jal"
                     /inference="alignment:Splign:2.1.0"
     exon            280..935
                     /gene="Gata3"
                     /gene_synonym="Gata-3; jal"
                     /inference="alignment:Splign:2.1.0"
     CDS             698..2029
                     /gene="Gata3"
                     /gene_synonym="Gata-3; jal"
                     /note="isoform 1 is encoded by transcript variant 5;
                     trans-acting T-cell-specific transcription factor GATA-3;
                     GATA-binding factor 3"
                     /codon_start=1
                     /product="trans-acting T-cell-specific transcription
                     factor GATA-3 isoform 1"
                     /protein_id="NP_001403975.1"
                     /db_xref="GeneID:14462"
                     /db_xref="MGI:MGI:95663"
                     /translation="MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLGHSYMEAQYPLTE
                     EVDVLFNIDGQGNHVPSYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKAL
                     SSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLAAGHSSPHLFTFPPTPPKDV
                     SPDPSLSTPGSAGSARQDEKECLKYQVQLPDSMKLETSHSRGSMTTLGGASSSAHHPI
                     TTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRR
                     DGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANG
                     DPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDALEDFPKSSSFN
                     PAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSGLSFGPHHPSSMVTAMG"
     exon            936..1472
                     /gene="Gata3"
                     /gene_synonym="Gata-3; jal"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1618
                     /gene="Gata3"
                     /gene_synonym="Gata-3; jal"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1744
                     /gene="Gata3"
                     /gene_synonym="Gata-3; jal"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..3321
                     /gene="Gata3"
                     /gene_synonym="Gata-3; jal"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3070..3075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gata3"
                     /gene_synonym="Gata-3; jal"
                     /note="hexamer: ATTAAA"
     polyA_site      3098
                     /gene="Gata3"
                     /gene_synonym="Gata-3; jal"
                     /note="major polyA site"
     regulatory      3296..3301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gata3"
                     /gene_synonym="Gata-3; jal"
                     /note="hexamer: AATAAA"
     polyA_site      3321
                     /gene="Gata3"
                     /gene_synonym="Gata-3; jal"
                     /note="major polyA site"
ORIGIN      
        1 aagtttgata tcactccctc ctcttggagg gactgtttgt gtgtgtgtgt ttgggggttt
       61 gtttgtttgg ttttttgtaa actaaaagct cagctttctc cttttggagg atttgtagtg
      121 gttggaaaga tcctggggcc ggtgtcctcc agggaggact tgtccccaag ttttaattgc
      181 ttagtcagtc ctgggctcct gcgagcctgg ctgtcggagg tgtgctgcgg agcttggctt
      241 ctttccctcc gggtcttcgc gtgcgtgtgc acgtcccggg tctctctttc tctcccttgc
      301 aggtgatcgg aagagcaacc gtctctgagc gccaaggaat cagtgtgcag tgtggtcaca
      361 ctcggattcc tctctccctc cttttttttt tttttttttt gaccccttta ttcctccgtg
      421 tctgcttttt ttttgggggg ggggatcgcc ctcattcttt tctttttctt ctttcccttc
      481 ctttcttttg ctaaactatc ccgcaaagat ttttctttcc tccctaaacc ctcctttttg
      541 ctctcctttt ctataccctt aactgcaaac aaaccattaa acgacccctc tcctgggcct
      601 ccgacggcag gagtccgcgg acctcccagg ccgacagccc tccctctacc cgcgagggtt
      661 ccgggccggg cgagagggcg cgagcacagc cgaggacatg gaggtgactg cggaccagcc
      721 gcgctgggtg agccaccatc accccgcggt cctcaacggt cagcacccag acacgcacca
      781 cccgggcctc ggccattcgt acatggaagc tcagtatccg ctgacggaag aggtggacgt
      841 actttttaac atcgatggtc aaggcaacca cgtcccgtcc tactacggaa actccgtcag
      901 ggctacggtg cagaggtatc ctccgaccca ccacgggagc caggtatgcc gcccgcctct
      961 gctgcacgga tctctgccct ggctggatgg cggcaaagcc ctgagcagcc accacaccgc
     1021 ctcgccctgg aacctcagcc ccttctccaa gacgtccatc caccacggct ctccggggcc
     1081 tctgtccgtt taccctccgg cttcatcctc ttctctggcg gccggccact ccagtcctca
     1141 tctcttcacc ttcccgccca ccccgccgaa agacgtctcc ccagacccgt cgctgtccac
     1201 cccgggatcc gccgggtcgg ccaggcaaga tgagaaagag tgcctcaagt atcaggtgca
     1261 gctgccagat agcatgaagc tggagacgtc tcactctcga ggcagcatga ccaccctggg
     1321 tggggcctca tcctcagccc accaccccat taccacctat ccgccctatg tgcccgagta
     1381 cagctctgga ctcttcccac ccagcagcct gctgggagga tcccctaccg ggttcggatg
     1441 taagtcgagg cccaaggcac gatccagcac agaaggcagg gagtgtgtga actgcggggc
     1501 aacctctacc ccactgtggc ggcgagatgg taccgggcac tacctttgca atgcctgcgg
     1561 actctaccat aaaatgaatg ggcagaaccg gccccttatc aagcccaagc gaaggctgtc
     1621 ggcagcaagg agagcaggga catcctgcgc gaactgtcag accaccacca ccaccctctg
     1681 gaggaggaac gctaatgggg acccggtctg caatgcctgt gggctgtact acaagcttca
     1741 taatattaac agacccctga ctatgaagaa agaaggcatc cagacccgaa accggaagat
     1801 gtctagcaaa tcgaaaaagt gcaaaaaggt gcatgacgcg ctggaggact tccccaagag
     1861 cagctccttc aacccggccg ctctctccag acacatgtca tccctgagcc acatctctcc
     1921 cttcagccac tccagccaca tgctgaccac accgacgccc atgcatccgc cctccggcct
     1981 ctccttcgga cctcaccacc cttccagcat ggtcaccgcc atgggttaga gaggcagagc
     2041 cctgctccac atgcgtgagg agtctccaag tgtgcgaaga gttcctccga ccccttctac
     2101 ttgcgttttt cgcaggagca gtatcatgaa gcccgaaagc gacagatctg tgtttttgaa
     2161 ggcagaaagc aaaatgtttg cttctttttt caaaggagct cgaggtggtg tctgcattcc
     2221 aaccactgaa tccggatccc atttgtgaat aagccattca gactcatatt ccctatttaa
     2281 cagggtctct agtgctgtga aaaaaatatt gctgaacatt gcatataact tatattgtaa
     2341 gaaatactgt acatttgagg aagactttat tgtacctgga tagctgtaag aaaggcatga
     2401 aggacgccaa gagttttaag gaatataggg ggattaaagt atggagatac agaagaaacc
     2461 actaagtctg atgtccaaat gggcacactg tcagttttgt ttcccttcag ttgtttgatg
     2521 catttaaaaa aaaaaaaaag aaagaaaaag aaaaaaaggg ggggggggga gaaaaaaata
     2581 aattaaaaaa aaaaaaaaaa aaagaaaaga aagaaaaatc taagaaaaaa aaaaaaaagg
     2641 ttgtaggcaa atcatttgtt ccaggctgtg agcctgtgca aaagagattt cagatctggg
     2701 caatgggtgt gtgatctcac ccactgaaga tctgagaatg tcatggctag gcctacatgc
     2761 tctgtgaatc agtccctgta attgttgttt gtatgtataa ttcagaagca ccaaaataag
     2821 aaaagatgta gatttatttc atcatattat acagactgaa ttgttgtata aatttattta
     2881 ctgctagtgt taggaactgc tttttttttt ttttttggtt ttaatgtttt tttttttttt
     2941 gttttttgtt tttttttttc tttctctctg gatttttggt tgaataaact agattgcttt
     3001 cagttgactt aaggtggatg tactctggag ggtttatttt tccttttatt attatttttg
     3061 atggtattta ttaaatagct tctatgggcc cggcggtacc tgtctttttc gtcacttttc
     3121 ttgcagccta aactatgaag gtagcagcgt accagctacc aacatgcatg tcagagaccc
     3181 ggccactcac aggcctggtc ctgagagcca cctggctgac tgttagcccc tgtgtgttct
     3241 gtattagtga tcactgcctt taaacagtct gttggaataa tactataaaa ataataataa
     3301 agttaaaata ttttaaaaca a
//
