LOCUS       NM_008090               3258 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus GATA binding protein 2 (Gata2), transcript variant 1,
            mRNA.
ACCESSION   NM_008090
VERSION     NM_008090.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3258)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 3258)
  AUTHORS   Chen,X., Tober,J., Dominguez,M., Tang,A.T., Bockman,J., Yang,J.,
            Mani,S., Lee,C.N., Chen,M., Thillaikumaran,T., Mericko-Ishizuka,P.,
            Mainigi,M., Speck,N.A. and Kahn,M.L.
  TITLE     Lineage tracing studies suggest that the placenta is not a de novo
            source of hematopoietic stem cells
  JOURNAL   PLoS Biol 23 (1), e3003003 (2025)
   PUBMED   39874373
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3258)
  AUTHORS   Shen,S., Huang,Q., Liu,L., Zou,X., Kang,T. and Wu,J.
  TITLE     GATA2 downregulation contributes to pro-inflammatory phenotype and
            defective phagocytosis of pulmonary macrophages in chronic
            obstructive pulmonary disease
  JOURNAL   Aging (Albany NY) 16 (19), 12928-12951 (2024)
   PUBMED   39379099
  REMARK    GeneRIF: GATA2 downregulation contributes to pro-inflammatory
            phenotype and defective phagocytosis of pulmonary macrophages in
            chronic obstructive pulmonary disease.
REFERENCE   4  (bases 1 to 3258)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3258)
  AUTHORS   Katerndahl,C.D.S., Rogers,O.R.S., Day,R.B., Xu,Z., Helton,N.M.,
            Ramakrishnan,S.M., Miller,C.A. and Ley,T.J.
  TITLE     PML::RARA and GATA2 proteins interact via DNA templates to induce
            aberrant self-renewal in mouse and human hematopoietic cells
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2317690121 (2024)
   PUBMED   38648485
  REMARK    GeneRIF: PML::RARA and GATA2 proteins interact via DNA templates to
            induce aberrant self-renewal in mouse and human hematopoietic
            cells.
REFERENCE   6  (bases 1 to 3258)
  AUTHORS   Robb,L., Lyons,I., Li,R., Hartley,L., Kontgen,F., Harvey,R.P.,
            Metcalf,D. and Begley,C.G.
  TITLE     Absence of yolk sac hematopoiesis from mice with a targeted
            disruption of the scl gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (15), 7075-7079 (1995)
   PUBMED   7624372
REFERENCE   7  (bases 1 to 3258)
  AUTHORS   Ng,Y.K., George,K.M., Engel,J.D. and Linzer,D.I.
  TITLE     GATA factor activity is required for the trophoblast-specific
            transcriptional regulation of the mouse placental lactogen I gene
  JOURNAL   Development 120 (11), 3257-3266 (1994)
   PUBMED   7720565
REFERENCE   8  (bases 1 to 3258)
  AUTHORS   Weiss,M.J., Keller,G. and Orkin,S.H.
  TITLE     Novel insights into erythroid development revealed through in vitro
            differentiation of GATA-1 embryonic stem cells
  JOURNAL   Genes Dev 8 (10), 1184-1197 (1994)
   PUBMED   7926723
REFERENCE   9  (bases 1 to 3258)
  AUTHORS   Ryseck,R.P., Raynoschek,C., Macdonald-Bravo,H., Dorfman,K.,
            Mattei,M.G. and Bravo,R.
  TITLE     Identification of an immediate early gene, pghs-B, whose protein
            product has prostaglandin synthase/cyclooxygenase activity
  JOURNAL   Cell Growth Differ 3 (7), 443-450 (1992)
   PUBMED   1419907
REFERENCE   10 (bases 1 to 3258)
  AUTHORS   Zon,L.I., Gurish,M.F., Stevens,R.L., Mather,C., Reynolds,D.S.,
            Austen,K.F. and Orkin,S.H.
  TITLE     GATA-binding transcription factors in mast cells regulate the
            promoter of the mast cell carboxypeptidase A gene
  JOURNAL   J Biol Chem 266 (34), 22948-22953 (1991)
   PUBMED   1744088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY132907.1, BC107009.2, AB000096.2 and AW492264.1.
            
            On Apr 11, 2009 this sequence version replaced NM_008090.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154981.1, AK004551.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                BY132907.1         2-97
            97-2052             BC107009.2         1-1956
            2053-3081           AB000096.2         1945-2973
            3082-3258           AW492264.1         1-177               c
FEATURES             Location/Qualifiers
     source          1..3258
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.2 cM"
     gene            1..3258
                     /gene="Gata2"
                     /gene_synonym="Gata-2"
                     /note="GATA binding protein 2"
                     /db_xref="GeneID:14461"
                     /db_xref="MGI:MGI:95662"
     exon            1..218
                     /gene="Gata2"
                     /gene_synonym="Gata-2"
                     /inference="alignment:Splign:2.1.0"
     exon            219..491
                     /gene="Gata2"
                     /gene_synonym="Gata-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1705
                     /gene="Gata2"
                     /gene_synonym="Gata-2"
                     /codon_start=1
                     /product="endothelial transcription factor GATA-2"
                     /protein_id="NP_032116.4"
                     /db_xref="CCDS:CCDS20333.1"
                     /db_xref="GeneID:14461"
                     /db_xref="MGI:MGI:95662"
                     /translation="MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDE
                     VDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGK
                     AALSAAAAHHHSPWTVSPFSKTPLHPSAAGAPGGPLSVYPGAAGGSGGGSGSSVASLT
                     PTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASSSAGGSVARGEDKDGVKYQVSLS
                     ESMKMEGGSPLRPGLATMGTQPATHHPIPTYPSYVPAAAHDYGSSLFHPGGFLGGPAS
                     SFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIK
                     PKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEG
                     IQTRNRKMSSKSKKSKKGAECFEELSKCMQEKSPPFSAAALAGHMAPVGHLPPFSHSG
                     HILPTPTPIHPSSSLSFGHPHPSSMVTAMG"
     exon            492..1133
                     /gene="Gata2"
                     /gene_synonym="Gata-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1279
                     /gene="Gata2"
                     /gene_synonym="Gata-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1405
                     /gene="Gata2"
                     /gene_synonym="Gata-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..3243
                     /gene="Gata2"
                     /gene_synonym="Gata-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3224..3229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gata2"
                     /gene_synonym="Gata-2"
                     /note="hexamer: AATAAA"
     polyA_site      3243
                     /gene="Gata2"
                     /gene_synonym="Gata-2"
                     /note="major polyA site"
ORIGIN      
        1 gtctgtgcag gagtcggcag ctggcgccag ggcggccgga ggatgcagag gggccggagc
       61 cgggcgggcc ggaggccgag acgcgcgctg tcccccaccc ctatcccgtg aatccgccgg
      121 ccctggaacg cgctgtcgct gggcccgccg tacccgggct ctcctggtgt ctcttactct
      181 ctactgctga gccctcccct tcccgcgccg ctgcgagtgg ccgccccacc ttcgcctggt
      241 tcccaagaca cagtagtgga ccatggaggt ggcgcctgag cagcctcgct ggatggcgca
      301 ccccgccgta ttgaatgcgc agcaccccga ctcgcaccat ccgggcctgg cgcataacta
      361 catggagcca gcacagctgc tgcctcccga cgaggtggat gtcttcttca accatctcga
      421 ctcgcagggc aacccttact acgccaaccc ggcccacgcg cgcgcgcgcg tttcctacag
      481 cccggcgcat gcccgtctca ccggaggcca gatgtgccga ccacacttgt tgcacagccc
      541 aggcttgccg tggctggacg ggggcaaagc agctctctct gccgccgctg cccatcacca
      601 cagtccctgg accgtcagcc cgttctccaa gaccccgctg cacccctcag ctgctggagc
      661 acccggaggg cctctgtctg tttacccagg ggctgcgggt gggagcgggg gaggcagtgg
      721 gagctccgtg gcctccctca cccccactgc agcccactcg ggctcccatc tcttcggctt
      781 cccacccacg ccacccaaag aagtgtctcc agaccccagc acaacaggag ctgcttcccc
      841 ggcctcttct tctgcagggg gtagtgtagc ccggggtgag gacaaggatg gcgtcaagta
      901 ccaagtgtca ctctccgaga gcatgaagat ggaaggcggc agtcccctgc gcccgggcct
      961 agctaccatg ggcacccagc ctgcaacaca ccacccgata cccacctatc cctcctatgt
     1021 gcccgccgca gctcatgact atggcagcag tctcttccat ccaggaggct tcctgggtgg
     1081 ccccgcctcc agcttcaccc ctaagcagag aagcaaggct cgctcctgct cagaaggccg
     1141 ggagtgtgtc aactgtggtg ccacagccac ccctctctgg cgacgagatg gcacgggcca
     1201 ctacctgtgc aatgcctgtg ggctctacca caagatgaat ggacagaacc ggccgctcat
     1261 caagcccaag cggaggctgt ctgctgccag aagagcgggc acctgttgtg caaattgtca
     1321 gacgacaacc accaccttat ggcgccggaa cgccaacggg gaccctgtgt gcaacgcctg
     1381 tggcctctac tacaagctgc acaatgttaa caggccactg accatgaaga aggaagggat
     1441 ccagacccgg aatcggaaga tgtccagcaa atccaagaag agcaagaaag gggctgaatg
     1501 tttcgaggag ctctccaagt gcatgcaaga gaagtcaccg cccttcagtg cggctgccct
     1561 ggctggacac atggcacctg tgggacacct cccacctttt agtcactctg gacacatcct
     1621 acccacgccc acgcctatcc acccttcctc cagtctctct tttggccacc cccacccgtc
     1681 cagcatggtg actgccatgg gctaggcaag cctcccactg gacagacatg gacatcaagg
     1741 gtggtttggc agaaccagag cgaggctggg cactcccagg atgggtggaa catactcttg
     1801 gctcccgccc atcccaagag acccacttcc tcctgccagc ctagcctggc cgaagccacc
     1861 tctccttgga ggactcccag ccttgtgccg ccattactgt gaatatttct aactgggctg
     1921 cagctcgcgt gtgcccgggg tgctgcccag aaaagtgttt tcacggagag tgtttgtttg
     1981 gagagcaaaa tggacaggtt tacagattta tagcaagaag agactgggga tagaaaaatg
     2041 aaaccttttt ttttcttttt ctttttttct tcttctgttt tatttttttg atggagaaag
     2101 gagtaggcaa gaagaaaaat aatttatttt gctcttattt cttacaagaa cgtgaagaca
     2161 tggaggcgtg tgctatttgt gttcttgggg tccttctttg ggacctcctg ccaccagtca
     2221 gggctctcgg gggcagactt agaggtcctc agcctgagcc tccttcaccc cagcctgcct
     2281 gcagggtagc ccctgccctg acgcagccct agagggcaga gacaattgca ggcggtcctg
     2341 cgcagattcc caggccaggg ctgggtcaca ggaaggaaac attctctgga aaggggaaac
     2401 gtctcccaga tcattcccct ggcttccaga ggccaaagct ggtgtgaccc aaatgggcca
     2461 gagctgcagc ctgtgctcta ggccagtcgg acccctgtaa atacaacctt cttttctgct
     2521 aaaccctcgg ccccctcccc ctctaagata aataagaaaa tactcaaagc gaaaaccaaa
     2581 ctgcataagc ttaacccgct gatgagtggt tttattttga aactcgtttt ttgggtccag
     2641 tcaattgtac gttgccacag aagccccgct atggaaaaaa ataaataaaa cctacaaacc
     2701 aggcctgagc ttcacagtcc tttgagtggt tcttgggtcc cacagccctg gcagggggct
     2761 cgggacaagg gggaatctta tgctcttggt ttctgggaga cagggggcag gcaggcagtg
     2821 gccctgtgat cccaggcttc tgttctgctg tggctggctg aatccttcaa ggtacagttg
     2881 tacataaaaa gtgtcccaag cttcgattct gtgtgtggtg gtggcagtgg tgcagcagcc
     2941 agcaaggggg ccccgagtga gcccagggag acgattgtgc tgagtcaacc aagtgcaata
     3001 tcggtgtcca gttgctgcag agcaccctaa ccggaagtaa cttattttgt gctagtaccc
     3061 gcataagaga agaatcggca gtattttctg tttttatgtt ttgggcttgt tttattttga
     3121 attagtgacc taagttattg ttaactgtgt acaacattta aatattgtct gtaaaaattg
     3181 tatgctaccc tcttattcct ttaaagtgaa tactgttaaa aataataaaa tactttttgt
     3241 gaaaaaaaaa aaaaaaaa
//
