LOCUS       NM_010257                461 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus gastrin (Gast), mRNA.
ACCESSION   NM_010257
VERSION     NM_010257.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Abarinov,V., Levine,J.A., Churchill,A.J., Hopwood,B., Deiter,C.S.,
            Guney,M.A., Wells,K.L., Schrunk,J.M., Guo,Y., Hammelman,J.,
            Gifford,D.K., Magnuson,M.A., Wichterle,H. and Sussel,L.
  TITLE     Major beta cell-specific functions of NKX2.2 are mediated via the
            NK2-specific domain
  JOURNAL   Genes Dev 37 (11-12), 490-504 (2023)
   PUBMED   37364986
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Douchi,D., Yamamura,A., Matsuo,J., Melissa Lim,Y.H.,
            Nuttonmanit,N., Shimura,M., Suda,K., Chen,S., Pang,S., Kohu,K.,
            Abe,T., Shioi,G., Kim,G., Shabbir,A., Srivastava,S., Unno,M.,
            Bok-Yan So,J., Teh,M., Yeoh,K.G., Chuang,L.S.H. and Ito,Y.
  TITLE     Induction of Gastric Cancer by Successive Oncogenic Activation in
            the Corpus
  JOURNAL   Gastroenterology 161 (6), 1907-1923 (2021)
   PUBMED   34391772
REFERENCE   3  (bases 1 to 461)
  AUTHORS   Fu,J., Tang,Y., Zhang,Z., Tong,L., Yue,R. and Cai,L.
  TITLE     Gastrin exerts a protective effect against myocardial infarction
            via promoting angiogenesis
  JOURNAL   Mol Med 27 (1), 90 (2021)
   PUBMED   34412590
  REMARK    GeneRIF: Gastrin exerts a protective effect against myocardial
            infarction via promoting angiogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 461)
  AUTHORS   Chang,W., Wang,H., Kim,W., Liu,Y., Deng,H., Liu,H., Jiang,Z.,
            Niu,Z., Sheng,W., Napoles,O.C., Sun,Y., Xu,J., Sepulveda,A.,
            Hayakawa,Y., Bass,A.J. and Wang,T.C.
  TITLE     Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division
            and Gastric Tumorigenesis
  JOURNAL   Cell Stem Cell 26 (5), 739-754 (2020)
   PUBMED   32142681
REFERENCE   5  (bases 1 to 461)
  AUTHORS   Friis-Hansen,L., Rourke,I.J., Bundgaard,J.R., Rehfeld,J.F. and
            Samuelson,L.C.
  TITLE     Molecular structure and genetic mapping of the mouse gastrin gene
  JOURNAL   FEBS Lett 386 (2-3), 128-132 (1996)
   PUBMED   8647266
REFERENCE   6  (bases 1 to 461)
  AUTHORS   Ramirez-Solis,R., Liu,P. and Bradley,A.
  TITLE     Chromosome engineering in mice
  JOURNAL   Nature 378 (6558), 720-724 (1995)
   PUBMED   7501018
REFERENCE   7  (bases 1 to 461)
  AUTHORS   Koh,T.J. and Wang,T.C.
  TITLE     Molecular cloning and sequencing of the murine gastrin gene
  JOURNAL   Biochem Biophys Res Commun 216 (1), 34-41 (1995)
   PUBMED   7488110
REFERENCE   8  (bases 1 to 461)
  AUTHORS   Noh,M.J., Kim,S.J., Kang,Y.K. and Yoo,O.J.
  TITLE     Sequences responsible for transcription termination of the mouse
            gastrin gene
  JOURNAL   Biochem Mol Biol Int 35 (6), 1205-1213 (1995)
   PUBMED   7492958
REFERENCE   9  (bases 1 to 461)
  AUTHORS   Jonsson,J., Carlsson,L., Edlund,T. and Edlund,H.
  TITLE     Insulin-promoter-factor 1 is required for pancreas development in
            mice
  JOURNAL   Nature 371 (6498), 606-609 (1994)
   PUBMED   7935793
REFERENCE   10 (bases 1 to 461)
  AUTHORS   Wang,T.C., Bonner-Weir,S., Oates,P.S., Chulak,M., Simon,B.,
            Merlino,G.T., Schmidt,E.V. and Brand,S.J.
  TITLE     Pancreatic gastrin stimulates islet differentiation of transforming
            growth factor alpha-induced ductular precursor cells
  JOURNAL   J Clin Invest 92 (3), 1349-1356 (1993)
   PUBMED   8376589
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590968.8 and AK008494.1.
            
            On Dec 1, 2015 this sequence version replaced NM_010257.3.
            
            Summary: This gene encodes the peptide hormone gastrin, which
            stimulates gastric acid secretion, proliferation, cell migration
            and angiogenesis, as well as inhibits apoptosis. The encoded
            preproprotein undergoes proteolytic processing to generate multiple
            gastrin peptides differing in size. Mice lacking the encoded
            protein exhibit a decrease in the number of parietal cells,
            achlorohydria and a decrease in the colonic proliferation.
            [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X94758.1, BY708326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL590968.8         51383-51387
            6-460               AK008494.1         2-456
            461-461             AL590968.8         53973-53973
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.46 cM"
     gene            1..461
                     /gene="Gast"
                     /gene_synonym="GAS"
                     /note="gastrin"
                     /db_xref="GeneID:14459"
                     /db_xref="MGI:MGI:104768"
     exon            1..52
                     /gene="Gast"
                     /gene_synonym="GAS"
                     /inference="alignment:Splign:2.1.0"
     exon            53..268
                     /gene="Gast"
                     /gene_synonym="GAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..363
                     /gene="Gast"
                     /gene_synonym="GAS"
                     /codon_start=1
                     /product="gastrin preproprotein"
                     /protein_id="NP_034387.3"
                     /db_xref="CCDS:CCDS25418.1"
                     /db_xref="GeneID:14459"
                     /db_xref="MGI:MGI:104768"
                     /translation="MPRLCVYMLVLVLALATFSEASWKPRSQLQDASSGPGTNEDLEQ
                     RQFNKLGSASHHRRQLGPQGPQHFIADLSKKQRPRMEEEEEAYGWMDFGRRSAEEDQ"
     exon            269..461
                     /gene="Gast"
                     /gene_synonym="GAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      441..446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gast"
                     /gene_synonym="GAS"
                     /note="hexamer: AATAAG"
     polyA_site      461
                     /gene="Gast"
                     /gene_synonym="GAS"
                     /note="major polyA site"
ORIGIN      
        1 agagcagagc tgacccagcg ccacaacagc caactattcc ccagctctgt ggacaagatg
       61 cctcgactgt gtgtgtacat gctggtctta gtgctggctc tagctacctt ctcggaagct
      121 tcttggaagc cccgctccca gctacaggat gcatcatctg gaccagggac caatgaggac
      181 ctggaacagc gccagttcaa caagctgggc tcagcctctc accatcgaag gcagctgggg
      241 ccccagggtc ctcaacactt catagcagac ctgtccaaga agcagaggcc acgaatggag
      301 gaagaagaag aggcctacgg atggatggac tttggccgcc gcagtgctga ggaagaccag
      361 taggactagc aacactcttc cagagcccag ccatctccag ccacccctcc cccagctccg
      421 tccttacaaa acatattaaa aataagctag cttccaatgt a
//
