LOCUS       NM_133187               6627 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus golgi associated kinase 1B (Gask1b), mRNA.
ACCESSION   NM_133187
VERSION     NM_133187.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6627)
  AUTHORS   Lachke,S.A., Ho,J.W., Kryukov,G.V., O'Connell,D.J., Aboukhalil,A.,
            Bulyk,M.L., Park,P.J. and Maas,R.L.
  TITLE     iSyTE: integrated Systems Tool for Eye gene discovery
  JOURNAL   Invest Ophthalmol Vis Sci 53 (3), 1617-1627 (2012)
   PUBMED   22323457
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6627)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   3  (bases 1 to 6627)
  AUTHORS   Meszaros,R., Strate,I., Pera,E.M. and Durbeej,M.
  TITLE     Expression of the novel gene Ened during mouse and Xenopus
            embryonic development
  JOURNAL   Int J Dev Biol 52 (8), 1119-1122 (2008)
   PUBMED   18956345
  REMARK    GeneRIF: Ened might be a novel target gene of the Fgfr signalling
            pathway during embryonic development
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119162.12 and AK143522.1.
            
            On Dec 10, 2008 this sequence version replaced NM_133187.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052367.1, AF285091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AC119162.12        84302-84571         c
            271-2896            AK143522.1         2-2627
            2897-3731           AK143522.1         2629-3463
            3732-6627           AC119162.12        24223-27118         c
FEATURES             Location/Qualifiers
     source          1..6627
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 35.13 cM"
     gene            1..6627
                     /gene="Gask1b"
                     /gene_synonym="1110032E23Rik; 2210419I08Rik; Ened;
                     Fam198b; GaskbB"
                     /note="golgi associated kinase 1B"
                     /db_xref="GeneID:68659"
                     /db_xref="MGI:MGI:1915909"
     exon            1..1201
                     /gene="Gask1b"
                     /gene_synonym="1110032E23Rik; 2210419I08Rik; Ened;
                     Fam198b; GaskbB"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1851
                     /gene="Gask1b"
                     /gene_synonym="1110032E23Rik; 2210419I08Rik; Ened;
                     Fam198b; GaskbB"
                     /note="protein ENED; protein FAM198B; expressed in nerve
                     and epithelium during development; family with sequence
                     similarity 198, member B"
                     /codon_start=1
                     /product="Golgi-associated kinase 1B"
                     /protein_id="NP_573450.2"
                     /db_xref="CCDS:CCDS17422.1"
                     /db_xref="GeneID:68659"
                     /db_xref="MGI:MGI:1915909"
                     /translation="MTCPDKPGQLVNWFVCSLCAPRVCKLWSSRRPRTRRNLLLGTAC
                     AIYLGFLVSQVGRGSFQHGQATDRGPPNGHDIFKVPFSEIPLDGTLAPPELQGNGSTL
                     QPNVVYITLRSKRSKPANIRGTVKPKRRKKYAVASAAPDQEVLVRPSLIQQEAARAAD
                     AEVPGYVQGYLTKVGERPWRVLRGPGVRTRGSNLQQPRARESNIRIYSESAPSWLSKE
                     DIRRMRLLADSEVASILPISKSGTRLLVLEGSTSGSVPGCGPSPCGLLKQPLDMSEVF
                     AFHLDRILGLNRTLPSVSRKLEFIQDGRPRPIILWDSSLASASNDSHSSVKITWGTYQ
                     RLLKQKCWLNGRVPRPEWDCTEIHHHEWSKMALFDFLLQIYNRLDTNCCGFRPRKEDA
                     CIQNGLRSNCEDQTSVTLAHIIQRKNDPRHLVFINNKGFFDRSEDNLNFKLLEGIREF
                     PESAVSVLKSQHLRQKLLQSLFLDQVYWESQGGRQGIEKLIDVIERRARILITYINAH
                     GARVLPMNE"
     exon            1202..1416
                     /gene="Gask1b"
                     /gene_synonym="1110032E23Rik; 2210419I08Rik; Ened;
                     Fam198b; GaskbB"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1643
                     /gene="Gask1b"
                     /gene_synonym="1110032E23Rik; 2210419I08Rik; Ened;
                     Fam198b; GaskbB"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..6627
                     /gene="Gask1b"
                     /gene_synonym="1110032E23Rik; 2210419I08Rik; Ened;
                     Fam198b; GaskbB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3708..3713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gask1b"
                     /gene_synonym="1110032E23Rik; 2210419I08Rik; Ened;
                     Fam198b; GaskbB"
                     /note="hexamer: AATAAA"
     polyA_site      3734
                     /gene="Gask1b"
                     /gene_synonym="1110032E23Rik; 2210419I08Rik; Ened;
                     Fam198b; GaskbB"
                     /note="major polyA site"
     regulatory      6604..6609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gask1b"
                     /gene_synonym="1110032E23Rik; 2210419I08Rik; Ened;
                     Fam198b; GaskbB"
                     /note="hexamer: AATAAA"
     polyA_site      6627
                     /gene="Gask1b"
                     /gene_synonym="1110032E23Rik; 2210419I08Rik; Ened;
                     Fam198b; GaskbB"
ORIGIN      
        1 ggaactgaaa tgggttgagt tagtgattca gtcaactctt gtttccattc attcccagag
       61 tcagccctcc tttctcctgg gaaaggctga taggagttta aaaggcttgc ggtggccagt
      121 tcacaaagcg ttcccagaac ccgcagcagc gacccttctc ttttacctct ctgcctgttg
      181 gagaccactt agatagcgaa gcggactgga cggctggatt caggaagcca tgaatcatgt
      241 cacccggagc cagctgcaga ctttaaactc agttcagcat gtggaagcgg cagagaaatg
      301 acctgtccag acaagccggg gcagctcgta aactggtttg tctgctctct gtgcgcccca
      361 cgagtgtgta aactttggag tagtcggcgt cccaggacca gacggaacct cctgctgggc
      421 actgcctgtg ccatctacct gggctttctg gtgagccagg tgggcagagg ttcctttcag
      481 catgggcagg cgactgacag gggaccaccc aacggtcacg acatcttcaa ggtacccttc
      541 tctgagattc ccctggatgg taccctggcc cctccagagt tgcagggcaa tggaagcact
      601 ttgcagccca acgtggtgta cattactcta cgctccaagc gcagcaagcc tgcgaatatc
      661 cgtggcacgg tgaaacccaa gcgcaggaag aagtatgcgg tggcatctgc agcccctgat
      721 caggaggtgc tggttagacc atcccttata cagcaggaag ctgcacgggc agcagatgct
      781 gaagtacctg gctatgttca gggttaccta accaaggttg gtgaacgacc ctggagggtg
      841 ctgcgtggtc ctggagtcag aactagaggt tcaaacttgc agcagcctag ggcccgagag
      901 agcaacatta ggatttatag cgagagcgcc ccctcatggc tgagcaaaga agacatccgc
      961 agaatgcgcc tcctggctga tagtgaggtg gctagcatcc tacctatctc taagagtggt
     1021 acccgcttgc tggtgttgga agggagcacc tcaggctctg tgcctggctg cgggcctagc
     1081 ccctgtgggc ttctcaagca gccgctggac atgagtgaag tgttcgcctt ccacctggac
     1141 aggatcctgg gtctcaacag gaccctgcca tctgtgagca ggaaattaga gttcatccaa
     1201 gatggccgac ctcgccctat cattctctgg gactcatctc tagcatctgc aagcaatgat
     1261 agccattcct ctgttaagat cacctgggga acttatcagc ggttgctaaa acagaagtgc
     1321 tggctgaatg gccgggttcc cagacctgag tgggactgca ctgaaatcca tcaccacgag
     1381 tggtccaaga tggctctctt tgattttttg ttacagattt ataatcgctt ggatacaaat
     1441 tgctgcggat tccgacctcg aaaggaagat gcctgtatac agaatggact gcggtcgaac
     1501 tgtgaggacc aaacttctgt gacgttagca cacattatcc agagaaagaa tgacccaagg
     1561 catttggtct tcataaacaa taagggcttc tttgatagaa gcgaagataa cttaaacttt
     1621 aagttgttag aaggcatccg agagtttcct gaatctgcag tttctgtttt gaagagccaa
     1681 cacttaagac agaagctcct tcagtctctg ttccttgatc aggtttattg ggaaagtcaa
     1741 ggaggcaggc aaggcatcga gaagcttatc gacgtgatag agcggagagc cagaatcctt
     1801 atcacctaca tcaacgcaca cggggctaga gtattaccta tgaatgaatg acaaatggct
     1861 ttctgccttg agggctatac atgtgtcaca tttggttttt cttaaataaa agatatcaac
     1921 cttaagtgtt tctagaaacg aggcagcata gttgaatacg tgaaactgac gcagtttata
     1981 tcatgaactg agtttaaaaa gtttgtagag tttagaggta tgcagattca agaagtttca
     2041 gaataacata ttgcttgcag aatgcctgtt aatatatttt cctaagactc tggtatgttt
     2101 gtctcagcat tgtcattgtg taatgaccca aatgattatt cctactgatg tttaaaccat
     2161 tttcatatca tttgacggaa caatataaac cagagacact ggctcttcta ataaatcatt
     2221 cccatgccat ttgactgacc tgaccagctg ctagaaatga gttgatcggc attctctcat
     2281 tgctgatggt tgcaacagct tttccaacac tatccagagg caattctaca tcacgaaatt
     2341 gaggcgtctg atctgcaagt acaacagtct tgaaacacct tctaagtaga catggaagta
     2401 gattcgttac aaacgaccag tatattttct agagtctaag ataatcagct acctctgaac
     2461 aacaaaattc tcctatcctt ccctttttaa gaaatttatt gacagcatag acatttccat
     2521 atatgacaat tgatgtattc gatttgctgt ctcaattttg atccaattta tatcttgtgg
     2581 ttagaaaact aaaaagttat gaggcatgtt gctacctgtt tgaaaattta cttgtagaat
     2641 cccttaatat tcttattggt tgattggctt aaaaaaaagt taaggtttca catagtccag
     2701 gctggctttg aactccttac gcatcagagg atgaccttgg tcttctgatg ctttgccacc
     2761 caagtgttgg gataacagac agtatatgac accatgcccc gtagtactca ggatcaagct
     2821 gggtctctgt catgttagag agacactgta tgactaagcc cataacccca gcccactttt
     2881 aatgaatatg taacaatttg tcattttata aaggatatac tgtaatttct gaagttttct
     2941 tttttgtttt tgtttttgtt ttttgttttt cgagtcaggg tttctctgta tagccttggc
     3001 tgtcctagaa ctcactctgt agaccaggct gaccttgaac tcagaaatcc gcctgcctct
     3061 gcctcccaag tgctgggttt aaaggcatgc gccaccactg cctggctgaa gtattttttt
     3121 ttaatcatag aggacttcct tggtgcaatt aggtttcatc tgatttaact gatattatct
     3181 aggtattgac gataagttca gatattaaat atattatgta gatcagctca atacaagaag
     3241 tcctaatgaa agccaacact catgactgca tcttctcaca aagaacatgg atagagagca
     3301 tatggcaact aattaggcaa aattaagtct caactaattc tcccccaaat ccctctacca
     3361 aacctttcgt gggcttggag gaactaaggc acacaaagtt catgctctga gtctttctgt
     3421 cctgagagaa tttgccaggc catcacttat ccttcttata cggaaccttt gaatctagag
     3481 caaattctgt ctctcttgct ttcagctcta ctaccgctta tttgcaaggt cattgattag
     3541 ccaggtgtag tgatacagac ctgaaatcct agcacccagg aagccgtgga cggtttgcaa
     3601 gtctgatgtc agtctggtgt tagtgataac ctgtctgaaa tgtgcctctc ccttcataaa
     3661 aactgattta ctgacttttt cttcttttgg aaacttaaaa aaactaaaat aaaaagttac
     3721 acatttttat catacttctc atctccttgt tttcagtttt gttcttaatg cacacatctt
     3781 ccgtcttctg atgaaaaata atttgatatt gatgtgaact tttaaaaaca taccaatata
     3841 ggctacatca taggaaaaaa tacctgtgta gattataatt gatacaaata caccaacttg
     3901 tcaaactagt aagtctaagt gttaggtata agagaagaca gacgaaggga agaggcaccc
     3961 actgatgcct cttgtttctg ctttccaagg ctcatgacca aggactgcat cttccatcct
     4021 atatgtttcc tttcccttgg cgtggtgaac tttgtcgcgt tctctgcagt tctctccagt
     4081 gtgacctgag tatgactgtg ggctctggtg agtccccaca atggctgctc tctatgagtt
     4141 ttgtctcaca aatcatctta attatctttg tgagcacttt tacaccccca cttgaccttg
     4201 aattaaaaga tttctgccaa gttgtctcat gccttatcaa gacgacctac acatttatct
     4261 taatactttt ttgtttttgc agaatttacc attttaattc acattgtgat attaattaca
     4321 ggcattctgg ctttttaaaa atcttgcttt tatgctctca gttaggatgc ttctgagcaa
     4381 gctggcctcc ccaagatggg tctgacccag atgggttttt gcctagttat ttcaacatgc
     4441 ttaattctaa gcaaaaggtt cgaggacatt gcttattttt ataacttttg ttttaaagat
     4501 ttatttttac tgtttatttg tgtgtataca taggtataca cacacatgtg tatgcagtac
     4561 tcatggaagc cagaagaagg gcatcggaac ctctgaagca attgtgagct acctgacttg
     4621 gggtcttgga actcaactaa ggtcctctgg aagagcagtg catgctctca acagctgggc
     4681 atctccccag cctttacatt catttttaaa atgatttatt ttgttttgca aacagtgagt
     4741 aattgatggt gcattagttt tgactaataa cttcaggcca aactctgatt tctaacaagc
     4801 aacatttttc ttttattgaa acgatgagag tgtttttgta tttccgatgt gctaaagaaa
     4861 acctactgtg atttggtata gaatatccca ttacatggct tatttgctct aacagatgta
     4921 aatagaagat aagggcttat tctggtgtga cctgcttcct gttagctgat gtgaaaacac
     4981 acatgtgtct cagaccctgt cattaaatgc tacaaattaa attcgtgtaa ttttttctga
     5041 tacacgagtt agttttcaaa agagaataca gtgcccctcc cctttggaac agtccactcc
     5101 agtctgtctc tgctttagac agactttagt ctttgttttt atgaccaaat attctgttta
     5161 aactggaaaa cggaataaac aatgaacttc aaaaggatgt ttgtttgtta cttcaccagt
     5221 ggaaaaaaag aggcaattta gaagtcaaga tgcctgcctg ggtcgtgtgt gcaggcatgt
     5281 gtgcacgaat ttgatgtcat aattcatgat cactatgctt tctctccgtg tacatatagc
     5341 atcgtactat agggttggca aaataattag ctagcagatt tcattcctct taggaggaga
     5401 tttaattttt agttagcttt ccatggttgc tgcgagcctt acagtagctt gagctctcct
     5461 tcctcttact cctctttaat caggttgtta agtacttagg aagtgtatca tagtgtacaa
     5521 catcctagac ttattcttaa aacaatttta tctatggact tgagtaataa tgtgtttatt
     5581 ctactgtacc tttaaatatg cattacatta tatgtaacga ataaattatt tagatagaaa
     5641 gttattttca tgttgtctta tgaaatccta atgtttattt gaatgcagac tatttaagtc
     5701 acatttaatg tactagtctg aaaaacatgt tgaaatcata tatatatgaa tttgatactt
     5761 ctgtctctct ttttttctct ctccctcctt cccccttctc tcttttgtaa aataatagta
     5821 atagtagtaa tagtaataat aataataata ataataataa taataataat aataataata
     5881 ataataagta atatagccaa gaaccaggct gggggagtcc agggtattca gtagactgtg
     5941 gcaccgtgat gctttgagtt ggagcccaag cagttggagt ctcactggag aacacagcaa
     6001 gcaccttggg tgctatttac cagactgact cttctgcact gatgtgtgtt agagacactg
     6061 atggtgtgta cttgaattcc agcatgcaag agttgagtca gactgacttt aagtttgggt
     6121 cagcctggac tacagtcaga ccctgtctca aaaacaaatg aaaaccaaaa cagaactcag
     6181 aaagcaagaa ctttcacttt atgagagatt tttttttttt ggacttgtta gaacacttat
     6241 ctgaaatcag aaatagttta ctgtgacttt ggcatgttct tacaatgttg ggcctgattt
     6301 tctacagaat gactattgag caaaatttta gggaagagat tatgttgtag actcatgttt
     6361 catagaaata caagtttttc ctggttcaaa aaatgaatgt aatggttaaa atttattacc
     6421 atgttggacc cttttatatc tattccaaat attttataat atggctttta aatgtttagc
     6481 tttagaaata ttttaaaatg gacctaccac tgtagtgatg ctgcatttat tgttatgata
     6541 aaatacttca caatcatcta tttttcctaa gaatcacttt tatcttttgg aaaattttgc
     6601 tttaataaac ttctaactac tgctgta
//
