LOCUS       NM_018855               1687 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus growth arrest specific 8 (Gas8), mRNA.
ACCESSION   NM_018855
VERSION     NM_018855.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1687)
  AUTHORS   Morohoshi A, Miyata H, Shimada K, Nozawa K, Matsumura T, Yanase R,
            Shiba K, Inaba K and Ikawa M.
  TITLE     Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is
            required for sperm flagellum formation and male fertility in mice
  JOURNAL   PLoS Genet 16 (1), e1008585 (2020)
   PUBMED   31961863
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1687)
  AUTHORS   Abdelhamed Z, Vuong SM, Hill L, Shula C, Timms A, Beier D, Campbell
            K, Mangano FT, Stottmann RW and Goto J.
  TITLE     A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal
            motile cilia development in mice
  JOURNAL   Development 145 (1) (2018)
   PUBMED   29317443
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1687)
  AUTHORS   Lewis WR, Malarkey EB, Tritschler D, Bower R, Pasek RC, Porath JD,
            Birket SE, Saunier S, Antignac C, Knowles MR, Leigh MW, Zariwala
            MA, Challa AK, Kesterson RA, Rowe SM, Drummond IA, Parant JM,
            Hildebrandt F, Porter ME, Yoder BK and Berbari NF.
  TITLE     Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia
            Function and Human Disease
  JOURNAL   PLoS Genet 12 (7), e1006220 (2016)
   PUBMED   27472056
  REMARK    GeneRIF: Here, we generate the first mouse with a Gas8 mutation and
            show that it causes severe Primary Ciliary Dyskinesia
            (PCD)phenotypes; however, there were no overt Hh pathway
            phenotypes. In addition, we identified two human patients with
            missense variants in Gas8
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1687)
  AUTHORS   Evron T, Philipp M, Lu J, Meloni AR, Burkhalter M, Chen W and Caron
            MG.
  TITLE     Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor
            kinase 2 (GRK2) cooperate in the control of Smoothened signaling
  JOURNAL   J Biol Chem 286 (31), 27676-27686 (2011)
   PUBMED   21659505
  REMARK    GeneRIF: results identify Gas8 as a positive regulator of Hh
            signaling that cooperates with GRK2 to control Smo signaling
REFERENCE   5  (bases 1 to 1687)
  AUTHORS   Nishimura N, Araki K, Shinahara W, Nakano Y, Nishimura K, Higashio
            H and Sasaki T.
  TITLE     Interaction of Rab3B with microtubule-binding protein Gas8 in NIH
            3T3 cells
  JOURNAL   Arch Biochem Biophys 474 (1), 136-142 (2008)
   PUBMED   18396146
  REMARK    GeneRIF: Gas8 was specifically interacted with the GTP-bound form
            of Rab3B and co-localized with Rab3B at the Golgi in NIH 3T3 cells
REFERENCE   6  (bases 1 to 1687)
  AUTHORS   Bekker JM, Colantonio JR, Stephens AD, Clarke WT, King SJ, Hill KL
            and Crosbie RH.
  TITLE     Direct interaction of Gas11 with microtubules: implications for the
            dynein regulatory complex
  JOURNAL   Cell Motil Cytoskeleton 64 (6), 461-473 (2007)
   PUBMED   17366626
  REMARK    GeneRIF: Gas11, the mammalian trypanin/PF2 homologue, associates
            with microtubules in vitro and in vivo.
REFERENCE   7  (bases 1 to 1687)
  AUTHORS   Colantonio JR, Bekker JM, Kim SJ, Morrissey KM, Crosbie RH and Hill
            KL.
  TITLE     Expanding the role of the dynein regulatory complex to non-axonemal
            functions: association of GAS11 with the Golgi apparatus
  JOURNAL   Traffic 7 (5), 538-548 (2006)
   PUBMED   16643277
REFERENCE   8  (bases 1 to 1687)
  AUTHORS   Yeh SD, Chen YJ, Chang AC, Ray R, She BR, Lee WS, Chiang HS, Cohen
            SN and Lin-Chao S.
  TITLE     Isolation and properties of Gas8, a growth arrest-specific gene
            regulated during male gametogenesis to produce a protein associated
            with the sperm motility apparatus
  JOURNAL   J Biol Chem 277 (8), 6311-6317 (2002)
   PUBMED   11751847
  REMARK    GeneRIF: a growth arrest specific gene regulated during male
            gametogensis
REFERENCE   9  (bases 1 to 1687)
  AUTHORS   Lih CJ, Cohen SN, Wang C and Lin-Chao S.
  TITLE     The platelet-derived growth factor alpha-receptor is encoded by a
            growth-arrest-specific (gas) gene
  JOURNAL   Proc Natl Acad Sci U S A 93 (10), 4617-4622 (1996)
   PUBMED   8643452
REFERENCE   10 (bases 1 to 1687)
  AUTHORS   Brenner DG, Lin-Chao S and Cohen SN.
  TITLE     Analysis of mammalian cell genetic regulation in situ by using
            retrovirus-derived 'portable exons' carrying the Escherichia coli
            lacZ gene
  JOURNAL   Proc Natl Acad Sci U S A 86 (14), 5517-5521 (1989)
   PUBMED   2501787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158362.5 and AY692443.1.
            
            [WARNING] On Dec 18, 2023 this sequence was replaced by
            NM_018855.3.
            
            On Feb 24, 2007 this sequence version replaced NM_018855.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY692443.1, U19859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC158362.5         12289-12372         c
            85-1687             AY692443.1         84-1686
FEATURES             Location/Qualifiers
     source          1..1687
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.1 cM"
     gene            1..1687
                     /gene="Gas8"
                     /gene_synonym="Gas11"
                     /note="growth arrest specific 8"
                     /db_xref="GeneID:104346"
                     /db_xref="MGI:MGI:1202386"
     exon            1..118
                     /gene="Gas8"
                     /gene_synonym="Gas11"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1552
                     /gene="Gas8"
                     /gene_synonym="Gas11"
                     /note="growth arrest-specific protein 8; growth arrest
                     specific protein 11; beta growth arrest specific protein
                     11; GAS-8; GAS-11; growth arrest specific 11"
                     /codon_start=1
                     /product="dynein regulatory complex subunit 4"
                     /protein_id="NP_061343.2"
                     /db_xref="CCDS:CCDS40512.1"
                     /db_xref="GeneID:104346"
                     /db_xref="MGI:MGI:1202386"
                     /translation="MAPKKKGKKGKAKGTAIVDGVAPEDMTKEQVEEHVARIREELDR
                     EREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKV
                     KHLLYEHQNNLAEVKAEGTVVMKLAQKEHRTQEGALRKDMRVLKVELKEQELANEVVI
                     KNLCLKQAEEITKMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTEIHEVEERKNGQ
                     ISTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEEHMEREMAEVTLQN
                     RRLADPLQKAKDEMNEMQKRLGNHERDKQILVCTKARLKVAERELKDLKWEHEVLEQR
                     FIKVQQEREELYRKFADAIQEVQQKTGFKNLLLERKLQALNAAVEKREVQFNEVLAAS
                     NLDPTALTLVSRKLEDVLESKNTTIKDLQYELARVCKAHNDLLRTYEAKLLAFGIPLD
                     NVGFKPLETAVIGQTLGQGPAGLVGAPT"
     exon            119..205
                     /gene="Gas8"
                     /gene_synonym="Gas11"
                     /inference="alignment:Splign:2.1.0"
     exon            206..403
                     /gene="Gas8"
                     /gene_synonym="Gas11"
                     /inference="alignment:Splign:2.1.0"
     exon            404..610
                     /gene="Gas8"
                     /gene_synonym="Gas11"
                     /inference="alignment:Splign:2.1.0"
     exon            611..665
                     /gene="Gas8"
                     /gene_synonym="Gas11"
                     /inference="alignment:Splign:2.1.0"
     exon            666..871
                     /gene="Gas8"
                     /gene_synonym="Gas11"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1039
                     /gene="Gas8"
                     /gene_synonym="Gas11"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1126
                     /gene="Gas8"
                     /gene_synonym="Gas11"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1336
                     /gene="Gas8"
                     /gene_synonym="Gas11"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1402
                     /gene="Gas8"
                     /gene_synonym="Gas11"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1680
                     /gene="Gas8"
                     /gene_synonym="Gas11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctcgcgagg atttgagaac cagcacggga tctagtcgga gttgccagga gaccgcgcag
       61 cctcctctga ccagcgccca tcccggatta gtggaagtgc tggactgctg gcaccatggc
      121 acccaaaaag aaagggaaga aggggaaagc caaagggacc gcgattgttg atggcgtcgc
      181 accagaggac atgaccaagg agcaggtgga ggaacatgtc gcccgcatcc gggaggagct
      241 ggacagggag agagaggagc gtaactactt ccagctggag cgcgacaaga tccacacctt
      301 ctgggagatc acgcggaggc agctggagga gaagaaggct gagctgcgca acaaagaccg
      361 ggagatggag gaggccgagg agaggcacca ggtggagatc aaggtataca agcagaaggt
      421 gaagcacctg ctgtacgagc accagaacaa cttggctgag gtgaaggctg agggcaccgt
      481 ggtcatgaag ctggcccaga aggagcaccg cacccaggag ggcgctctgc gcaaggacat
      541 gcgggtgctg aaggtggagc tcaaggagca ggagctggct aacgaggtgg tcataaagaa
      601 cctgtgcctg aaacaagccg aggagatcac caagatgcga aatgactttg aaaggcaagt
      661 tcgagaaatt gaggccaagt atgataagaa gatgaagatg cttagagacg aacttgacct
      721 gcggaggaag actgagatcc atgaggtaga ggagaggaaa aacggccaga tcagcactct
      781 gatgcagcgc cacgaggagg ccttcacgga catcaagaac tactacaacg acatcactct
      841 caacaacctg gccctcatca actccctcaa ggagcagatg gaggacatgc gtaagaagga
      901 ggaacacatg gagagggaga tggcggaggt gactctgcag aaccggcggc tggccgaccc
      961 gctgcagaaa gccaaggacg agatgaacga gatgcagaag agactgggga accacgagag
     1021 ggacaagcag attctggtct gtacaaaggc acgtttgaag gtggctgaga gggagctaaa
     1081 ggacctgaaa tgggaacatg aggtcctgga gcagaggttc atcaaggtgc agcaggagag
     1141 ggaagagctc tatcggaagt ttgcagacgc catccaggag gtgcagcaga agacgggctt
     1201 caagaacctg ctgctggagc ggaagctgca ggccctgaac gctgctgtgg agaagagaga
     1261 ggttcagttc aatgaggtgc tggccgcctc caacctggac cccacagcat taacgcttgt
     1321 gtcccgcaaa cttgaggatg ttctagaatc gaagaatacc accatcaagg acttacagta
     1381 tgagctggcc cgggtctgca aggcccacaa tgacctgctg cgtacatatg aggcgaagtt
     1441 actggccttc gggatccccc tggacaatgt ggggttcaag cccctggaga cagcagtgat
     1501 tggacagaca ctgggacagg gccctgcagg acttgtgggt gcccctacat agccatcttc
     1561 tcagccttca acctttacag ccttcccctc tgtccaagta atacctctat gcccaacaca
     1621 ggcaagggtt tgttttctag acttacccgt cagcaatgaa agtttcccac atttacttta
     1681 aaaaaaa
//
