LOCUS       NM_019521               2594 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus growth arrest specific 6 (Gas6), mRNA.
ACCESSION   NM_019521
VERSION     NM_019521.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2594)
  AUTHORS   Schott,C., Germain,A., Lacombe,J., Pata,M., Faubert,D., Boulais,J.,
            Carmeliet,P., Cote,J.F. and Ferron,M.
  TITLE     GAS6 and AXL Promote Insulin Resistance by Rewiring Insulin
            Signaling and Increasing Insulin Receptor Trafficking to Endosomes
  JOURNAL   Diabetes 73 (10), 1648-1661 (2024)
   PUBMED   39046834
  REMARK    GeneRIF: GAS6 and AXL Promote Insulin Resistance by Rewiring
            Insulin Signaling and Increasing Insulin Receptor Trafficking to
            Endosomes.
REFERENCE   2  (bases 1 to 2594)
  AUTHORS   Parinot,C., Chatagnon,J., Rieu,Q., Roux,S., Neel,D., Hamieh,F. and
            Nandrot,E.F.
  TITLE     Gas6 and Protein S Ligands Cooperate to Regulate MerTK Rhythmic
            Activity Required for Circadian Retinal Phagocytosis
  JOURNAL   Int J Mol Sci 25 (12), 6630 (2024)
   PUBMED   38928335
  REMARK    GeneRIF: Gas6 and Protein S Ligands Cooperate to Regulate MerTK
            Rhythmic Activity Required for Circadian Retinal Phagocytosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2594)
  AUTHORS   Aydin,N., Ouliass,B., Ferland,G. and Hafizi,S.
  TITLE     Modification of Gas6 Protein in the Brain by a Functional
            Endogenous Tissue Vitamin K Cycle
  JOURNAL   Cells 13 (10), 873 (2024)
   PUBMED   38786095
  REMARK    GeneRIF: Modification of Gas6 Protein in the Brain by a Functional
            Endogenous Tissue Vitamin K Cycle.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2594)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   5  (bases 1 to 2594)
  AUTHORS   Lee,Y.J., Kim,M., Kim,H.S. and Kang,J.L.
  TITLE     Administration of Gas6 attenuates lung fibrosis via inhibition of
            the epithelial-mesenchymal transition and fibroblast activation
  JOURNAL   Cell Biol Toxicol 40 (1), 20 (2024)
   PUBMED   38578518
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2594)
  AUTHORS   Ferrero,M., Desiderio,M.A., Martinotti,A., Melani,C.,
            Bernelli-Zazzera,A., Colombo,M.P. and Cairo,G.
  TITLE     Expression of a growth arrest specific gene (gas-6) during liver
            regeneration: molecular mechanisms and signalling pathways
  JOURNAL   J Cell Physiol 158 (2), 263-269 (1994)
   PUBMED   8106563
REFERENCE   7  (bases 1 to 2594)
  AUTHORS   Wenger,R.H., Rochelle,J.M., Seldin,M.F., Kohler,G. and Nielsen,P.J.
  TITLE     The heat stable antigen (mouse CD24) gene is differentially
            regulated but has a housekeeping promoter
  JOURNAL   J Biol Chem 268 (31), 23345-23352 (1993)
   PUBMED   8226859
REFERENCE   8  (bases 1 to 2594)
  AUTHORS   Manfioletti,G., Brancolini,C., Avanzi,G. and Schneider,C.
  TITLE     The protein encoded by a growth arrest-specific gene (gas6) is a
            new member of the vitamin K-dependent proteins related to protein
            S, a negative coregulator in the blood coagulation cascade
  JOURNAL   Mol Cell Biol 13 (8), 4976-4985 (1993)
   PUBMED   8336730
REFERENCE   9  (bases 1 to 2594)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
REFERENCE   10 (bases 1 to 2594)
  AUTHORS   Schneider,C., King,R.M. and Philipson,L.
  TITLE     Genes specifically expressed at growth arrest of mammalian cells
  JOURNAL   Cell 54 (6), 787-793 (1988)
   PUBMED   3409319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ062651.1, X59846.1, AK086187.1 and AI482478.1.
            
            On Apr 17, 2007 this sequence version replaced NM_019521.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X59846.1, AK086187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                CJ062651.1         2-52
            52-1664             X59846.1           23-1635
            1665-2585           AK086187.1         1660-2580
            2586-2594           AI482478.1         1-9                 c
FEATURES             Location/Qualifiers
     source          1..2594
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 6.06 cM"
     gene            1..2594
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /note="growth arrest specific 6"
                     /db_xref="GeneID:14456"
                     /db_xref="MGI:MGI:95660"
     exon            1..275
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..2221
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /note="growth arrest-specific protein 6; AXL receptor
                     tyrosine kinase ligand"
                     /codon_start=1
                     /product="growth arrest-specific protein 6 precursor"
                     /protein_id="NP_062394.2"
                     /db_xref="CCDS:CCDS40232.1"
                     /db_xref="GeneID:14456"
                     /db_xref="MGI:MGI:95660"
                     /translation="MPPPPGPAAALGTALLLLLLASESSHTVLLRAREAAQFLRPRQR
                     RAYQVFEEAKQGHLERECVEEVCSKEEAREVFENDPETEYFYPRYQECMRKYGRPEEK
                     NPDFAKCVQNLPDQCTPNPCDKKGTHICQDLMGNFFCVCTDGWGGRLCDKDVNECVQK
                     NGGCSQVCHNKPGSFQCACHSGFSLASDGQTCQDIDECTDSDTCGDARCKNLPGSYSC
                     LCDEGYTYSSKEKTCQDVDECQQDRCEQTCVNSPGSYTCHCDGRGGLKLSPDMDTCED
                     ILPCVPFSMAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFA
                     GGRSDSTWIVLGLRAGRLELQLRYNGVGRITSSGPTINHGMWQTISVEELERNLVIKV
                     NKDAVMKIAVAGELFQLERGLYHLNLTVGGIPFKESELVQPINPRLDGCMRSWNWLNG
                     EDSAIQETVKANTKMQCFSVTERGSFFPGNGFATYRLNYTRTSLDVGTETTWEVKVVA
                     RIRPATDTGVLLALVGDDDVVPISVALVDYHSTKKLKKQLVVLAVEDVALALMEIKVC
                     DSQEHTVTVSLREGEATLEVDGTKGQSEVSTAQLQERLDTLKTHLQGSVHTYVGGLPE
                     VSVISAPVTAFYRGCMTLEVNGKILDLDTASYKHSDITSHSCPPVEHATP"
     exon            276..442
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     exon            443..467
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     exon            468..530
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     exon            531..653
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     exon            654..776
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     exon            777..899
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1021
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1140
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1330
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1495
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1664
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1837
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2066
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2593
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2566..2571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /note="hexamer: AATAAA"
     polyA_site      2593
                     /gene="Gas6"
                     /gene_synonym="Gas-6"
                     /note="major polyA site"
ORIGIN      
        1 acccgctgcc tccttcacgg cccagaaccg cagcgagcgc cgggtgcggc gctgccgccg
       61 cagggatgtg accttcaccg tcgcttagcc aggatgaccg gagcccgtgt ctcgcggcgt
      121 ccgcgcctcg cttcagcctc ccgggtgctc tgaccgcacg ctcccggctg ctaggctccc
      181 cggcaccggc ctcgccatgc cgccaccgcc cgggcccgcc gccgccctgg gcactgcgct
      241 tctgctgctc ctgctggctt ccgagtcttc tcacactgtg ctgttgcggg cgcgtgaggc
      301 ggcgcagttt ctgcggccca ggcagcgccg cgcctaccaa gtcttcgagg aggccaagca
      361 gggccacctg gaacgggagt gcgtggagga ggtgtgcagc aaagaggagg ccagagaggt
      421 gttcgagaac gaccccgaga cggagtattt ctatccacga tatcaagagt gcatgagaaa
      481 atatggcagg cctgaagaaa aaaacccaga tttcgccaaa tgtgttcaga acttgcctga
      541 ccagtgcacc ccaaaccctt gtgataagaa gggtactcat atctgccaag acctcatggg
      601 caacttcttc tgcgtgtgca cagatggctg gggaggccgg ctctgtgaca aagatgtcaa
      661 tgagtgtgtc cagaagaatg ggggctgcag ccaggtctgc cacaacaaac caggaagctt
      721 ccaatgtgcc tgccatagtg gcttctcgct tgcatcagac ggccagacct gccaagatat
      781 cgatgaatgc acagactcag acacctgtgg ggacgcgcga tgcaagaact tgccaggctc
      841 ctactcttgc ctctgcgatg agggatatac atacagctcc aaggagaaga cctgccaaga
      901 tgtggacgag tgccagcagg atcgctgtga gcagacctgt gtcaactccc caggcagcta
      961 tacctgccac tgtgatgggc gagggggcct aaaactatcc ccagacatgg atacttgtga
     1021 ggacatctta ccatgtgtgc ccttcagcat ggccaagagc gtgaagtcct tgtacctggg
     1081 ccgcatgttc agcgggaccc ccgtgattag actacgcttc aagaggcttc agcctaccag
     1141 gctgctggct gaatttgact tccgcacttt tgaccctgaa ggagtcctct tcttcgctgg
     1201 aggccgttca gacagcacct ggattgtcct gggcctaaga gctgggcggc ttgagctgca
     1261 gcttcggtac aatggcgttg ggcgcatcac cagcagcggg ccaaccatca accacggcat
     1321 gtggcaaact atctccgtgg aagagctgga acgtaacctt gtcatcaagg tcaacaaaga
     1381 tgctgtaatg aagatcgcgg tagctgggga gctgtttcag ctggagaggg gcctctatca
     1441 cctgaatctc accgtgggcg gcattccctt caaggagagt gagctcgtcc agccgattaa
     1501 ccctcgcctg gatgggtgca tgaggagttg gaactggctg aacggggaag acagcgccat
     1561 ccaggagaca gtcaaggcaa acacaaaaat gcagtgcttc tctgtgacag aaaggggctc
     1621 cttcttcccg gggaatggat ttgctaccta caggctcaac tacacccgaa catcgctgga
     1681 tgtcggcacg gaaaccacct gggaagttaa agttgtggct cggatccgcc ctgccacgga
     1741 cacgggggtg ctgctggcgc tggtggggga cgacgatgtc gtccccatct ctgtggccct
     1801 agtcgactac cactctacaa agaagctcaa gaagcagttg gtggtcctgg cagttgagga
     1861 tgttgccctg gcactgatgg aaatcaaggt gtgcgacagc caggaacaca cggtcactgt
     1921 ctccctgcgg gagggtgagg ccaccctaga agtggatggc acaaagggcc agagtgaagt
     1981 gagcactgcc cagctgcagg agcgactgga cacacttaag acacatctgc aaggctctgt
     2041 gcacacctat gttggaggcc tgccagaagt atcggtgatt tctgcacccg tcactgcgtt
     2101 ctaccgcgga tgcatgactc tggaggtaaa cgggaaaatc ctggacctgg atacggcctc
     2161 gtacaagcac agtgacatca cctcccactc ctgcccgcct gtggagcatg ccacccccta
     2221 gaccgagctg caagagggct ccacacctaa agacaaaaat gaagcagggt ttggacacac
     2281 agcactggct cctctcgcat ggtcctgcaa cactggagca ggtgggctac cgcccttgtg
     2341 gttttttttt cttgagatct ttctttttgc cttgtaacat atctgtacat aatgggacgg
     2401 gtgtcgggtc accggctgct cagagagagc cacgtgacct ggtgggagct ggctggaagg
     2461 ggctgggcta gaggggctgg cagtttgcag cagaacggat gtgaagaaaa taattctcta
     2521 ttatttttat tactacatgc ttctttctga ctctaaaata tggaaaataa aatatttaca
     2581 gaaacctttt taaa
//
