LOCUS       NM_001033331            6745 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus growth arrest-specific 2 like 3 (Gas2l3), transcript
            variant 1, mRNA.
ACCESSION   NM_001033331 XM_137276 XM_894672 XM_901795 XM_901797
VERSION     NM_001033331.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6745)
  AUTHORS   Grundl,M., Walz,S., Hauf,L., Schwab,M., Werner,K.M., Spahr,S.,
            Schulte,C., Maric,H.M., Ade,C.P. and Gaubatz,S.
  TITLE     Interaction of YAP with the Myb-MuvB (MMB) complex defines a
            transcriptional program to promote the proliferation of
            cardiomyocytes
  JOURNAL   PLoS Genet 16 (5), e1008818 (2020)
   PUBMED   32469866
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6745)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6745)
  AUTHORS   Stopp,S., Grundl,M., Fackler,M., Malkmus,J., Leone,M., Naumann,R.,
            Frantz,S., Wolf,E., von Eyss,B., Engel,F.B. and Gaubatz,S.
  TITLE     Deletion of Gas2l3 in mice leads to specific defects in
            cardiomyocyte cytokinesis during development
  JOURNAL   Proc Natl Acad Sci U S A 114 (30), 8029-8034 (2017)
   PUBMED   28698371
  REMARK    GeneRIF: Cardiomyocytes from Gas2l3-deficient mice exhibit
            increased expression of a p53-transcriptional program including the
            cell cycle inhibitor p21. Furthermore, loss of GAS2L3 results in
            premature binucleation of cardiomyocytes accompanied by unresolved
            midbody structures.
REFERENCE   4  (bases 1 to 6745)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   5  (bases 1 to 6745)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (bases 1 to 6745)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY205636.1, CF165165.1, AK136054.1 and AC152417.3.
            
            On Dec 29, 2006 this sequence version replaced NM_001033331.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136054.1, AK170634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               BY205636.1         1-120
            121-600             CF165165.1         77-556
            601-1255            AK136054.1         614-1268
            1256-6745           AC152417.3         99025-104514        c
FEATURES             Location/Qualifiers
     source          1..6745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 44.98 cM"
     gene            1..6745
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /note="growth arrest-specific 2 like 3"
                     /db_xref="GeneID:237436"
                     /db_xref="MGI:MGI:1918780"
     exon            1..113
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /inference="alignment:Splign:2.1.0"
     exon            114..220
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /inference="alignment:Splign:2.1.0"
     exon            221..289
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /inference="alignment:Splign:2.1.0"
     exon            290..337
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..2365
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GAS2-like protein 3; growth arrest-specific protein 2-like
                     3"
                     /codon_start=1
                     /product="GAS2-like protein 3 isoform 1"
                     /protein_id="NP_001028503.2"
                     /db_xref="CCDS:CCDS24115.1"
                     /db_xref="GeneID:237436"
                     /db_xref="MGI:MGI:1918780"
                     /translation="MTMQPAIQVWFGEDLPLSPRCPLTPRHGPGLADVCQYDEWIAVR
                     HEATLLPMQEDLSIWLSGLLGVDIKAERLLEELDNGVLLCQLINVLQNMVKGCHSDEP
                     GNFPMRKVPCKKDAASGSFFARDNTANFLHWCRHIGVDETYLFESEGLVLHKDPRQVY
                     LCLLEIGRIVSRYGVEPPVLVKLEKEIELEETLLNASGLEESISIPKSCCQQEELHEA
                     VKHIAEDPPCSCSHRFSIEYLSEGRYRLGEKILFIRMLHGKHVMVRVGGGWDTLQGFL
                     LKYDPCRILQFATLEQKILAFQKGVSNESVPDSPARTPQPPEMNPLSAVNMFQKQNLR
                     PGTPVSVPKNKEKQVRLPGARLPASSVKGNLASPSTRAKRPDSPASFPHPKVTSLKDA
                     AKKTTAPSNSVSQSLASPNPGSKPSTAQCASESSRKCVTFPKTAQTKAIPAQNSRDLS
                     KSRLLPSKSPGKMEPKHLKHNHLSSRDESRINLSSKSPKLPKGAMHGRPNPSPFQPPA
                     KVTKPSSKTGAIGLGTQSQPPTRTPRSGAVSAQRLQSTLNLNSPASVCSGSSAKATQG
                     SKGKNTVSVAKKQPQSKGVCRNPGPGSSKSPGRTPLSIVTVPQSATKTETVSKSAKTA
                     MKGQYSAKGPPKSSKPPTSFRDPPSSGKGADSGDKMPTARKKEEDDHYFVMTGNKKLR
                     K"
     exon            338..506
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /inference="alignment:Splign:2.1.0"
     exon            507..622
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /inference="alignment:Splign:2.1.0"
     exon            623..764
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /inference="alignment:Splign:2.1.0"
     exon            765..828
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /inference="alignment:Splign:2.1.0"
     exon            829..967
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1075
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..6745
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6137..6142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /note="hexamer: AATAAA"
     polyA_site      6178
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /note="major polyA site"
     regulatory      6284..6289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /note="hexamer: ATTAAA"
     polyA_site      6306
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /note="major polyA site"
     regulatory      6676..6681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
                     /note="hexamer: ATTAAA"
     polyA_site      6695
                     /gene="Gas2l3"
                     /gene_synonym="8430435B07Rik; Gm240"
ORIGIN      
        1 aggcggccgc gctgggcgac gaactgcggc ggcggcggcg gttggttgca ggcttgctgg
       61 cacgcacaga ttgagcccga gtcgcccgga gaagtgatct cgctcccggg ctggttccga
      121 gaagttagca ccgttgtgcc cgtatagatg gtttacgctg gagcaggagt tgaacccaga
      181 tgaatcccgt gctttgtact accatagtgc tgttttgatg attccaagag cagagctttg
      241 gagccaacgc tgccgcctct tttgggtttt gacggattat cacggggagc atagaagttt
      301 catctcagtg tagatgacca tgcagcctgc aatccaagtg tggtttgggg aagatctgcc
      361 tctaagtccc aggtgtcccc tgactcccag acatggcccg ggactggctg acgtttgcca
      421 gtatgacgag tggatagccg tgagacatga agccaccctg ctgcctatgc aggaagatct
      481 ctctatttgg ttatctggct tactaggtgt tgacatcaag gcagaaagat tattggaaga
      541 gctcgataat ggagtgctgt tgtgtcagct aatcaatgtt cttcagaaca tggtgaaagg
      601 ctgccactct gacgagccag ggaactttcc aatgagaaag gtgccttgta agaaagatgc
      661 tgcttcgggc tcattctttg ccagagacaa caccgccaac tttcttcact ggtgccgaca
      721 catcggtgtt gacgagactt acctctttga gtcggaaggt ttagttttac ataaagatcc
      781 cagacaggtg tacctttgtc ttcttgagat tggtcggatt gtgtcaagat acggagttga
      841 gccaccagta ttagtaaaac ttgagaaaga aattgagttg gaagagacct tgcttaatgc
      901 ctcggggctt gaagagtcca tcagcatccc caaatcctgc tgtcagcaag aagaactaca
      961 tgaagctgtt aaacacattg cggaggaccc tccttgtagc tgctctcatc ggttttctat
     1021 tgaatactta tccgaagggc ggtaccggct aggggagaaa attctcttta taaggatgct
     1081 tcatggaaaa cacgttatgg tccgcgtcgg tggaggctgg gatactctac agggattttt
     1141 gctgaagtat gacccctgtc gaatactgca gtttgctaca ctagaacaaa aaattttagc
     1201 atttcaaaaa ggagtttcta atgaaagcgt gccagattcg cctgccagaa cgcctcagcc
     1261 tccagaaatg aaccctttgt cagcagttaa tatgtttcag aaacaaaatt taagacctgg
     1321 cacaccagtg agtgttccga agaacaagga gaaacaggta cgtctaccag gtgcacgtct
     1381 gcctgcatcg tcagtaaaag gtaatttggc ttccccgtct acccgggcta aacggccaga
     1441 ttctccagca tcatttccac atcccaaggt gacatctttg aaggacgcag caaaaaagac
     1501 gactgctcct tccaacagtg tatcgcagtc cctggcttct ccaaatccag ggtctaaacc
     1561 aagcactgca cagtgtgcct cagagtcatc gcgaaaatgt gtcaccttcc ccaagactgc
     1621 acagaccaag gctattccag cccagaattc aagagatctg tctaagtcca gacttttacc
     1681 aagtaaatct cctggaaaaa tggaaccaaa gcatttgaaa cacaatcatc tttcttctag
     1741 ggatgagtca cgtataaact tatcatccaa gtccccaaag ctacctaaag gagccatgca
     1801 cggaaggcct aacccttctc ctttccagcc acctgccaaa gtgaccaagc ccagttctaa
     1861 aaccggagcc ataggtctag ggacacagtc tcagccaccc actagaacgc cgaggtcagg
     1921 agcagtctca gcacaaagac ttcagtctac attgaattta aacagtccag cttctgtgtg
     1981 ctcagggtcc tctgcaaaag ctactcaggg atcgaaaggt aagaatacag tttcagttgc
     2041 caaaaagcaa cctcagagta agggtgtctg ccggaatccg ggacctggct cttcaaagtc
     2101 tcctggccgt accccgctgt ctattgtgac tgttccccaa tctgctacca agacagaaac
     2161 tgtctcgaag tcagccaaga ctgccatgaa gggccagtac tcagctaaag ggcctcccaa
     2221 aagcagcaag ccaccaactt ccttcaggga cccaccctca tctggtaagg gggcagacag
     2281 cggagataaa atgcccactg ccaggaagaa ggaagaagat gaccattatt ttgttatgac
     2341 cggaaataag aagcttagga aataaataca cttgtatcgt ttcagcaaat cagggtgatc
     2401 aatgaatggc gagccacaag gatcaccaaa gatcttccta tttgtgtctg tccggagagc
     2461 tgcagacatg aagtcaagat gggatgaagc tgggtcaggg aaaggaccca tgcattttgt
     2521 gtatcaatgg acaaatgtgt gagttttgac ctgtatcatc ttgctaatga tgtctgctgt
     2581 ttgagggaag tgtaaaagtc caagaacact actagaattt taactattgg tggtatattt
     2641 ttgaacacag gttaactgtg gaggttatct gctaatagca actccgatac tcttaaacac
     2701 tagttactgt gctcagccac aaagcaatgg tttgcttggc gctagtgtgt gcctgtaatc
     2761 ccagctccga aggctgaggc aggggtacac agtagaagcc agcaaggttt tgaaatgtgc
     2821 tgtaataggc acctaattta ttggtcagga atcctggtcc agcaatccta agtaccaatg
     2881 gctcctgctg tttactttga tattattctg gattaaatgg aattcttact atttaaatct
     2941 ctataatatt tccgtatcag aagggactat ttggtttttt aattaaactt ggctttttaa
     3001 tactgtatca ttttataacc aatatttttg ataaaaagaa aaaaaaactc aaccaagtaa
     3061 gttaacttat tgaatcataa gctgaaattt agtaagaatt aagtttttta aaaaaaaaaa
     3121 atatatatat atataatcta gacactttgt atcttatatt tttagatgaa gtctgtgcag
     3181 tgtgacaggg aaacatttaa tagcttttag catactaaga tattttaaat agacatttcc
     3241 tatatgtaca tataaatttt ttcattaaaa taatgtgttt tgataccaga attaggtttt
     3301 aatgatctta aaattaaaag ggatgggggg tggctcaatg gataagtcat gtctagtaca
     3361 ggcatgggga ttggagtttg tgtccccata cctacataca aatctgggtg ggcttgatgg
     3421 tctgcctgta gtcccagcac tcaggaggaa gagacaggat ttcctgggac aagctggctg
     3481 gcgagaggag ccgatggatg agaggcagct cttttgagag accaccccta ccttagtaaa
     3541 aaaggaagat tcccaaagtc aatgtctgtt ctctctatgt acagactcat acatatatcc
     3601 tgttcacata tgcacacaca cacacacaca cacacacaca cgcacacaca cctatgaatg
     3661 catatataca cacagactca catacatgca tgcacaccac atatattgac gcgtacaaaa
     3721 gattaagatg gtattaagag aacctttgtg tgatgctatg cacacatctc atcaggtgac
     3781 ttgtatttct tttgctagca cactgtcgat tttaattagt ctccagatta tgttcatctt
     3841 cattagtaag gccatgttgt gctcagtttt ccagtgccca gcagacagtg taccttctgt
     3901 tctgtaggca gattctcgtc aggaatatcc aatgatttca tgacagcata aacaccttcc
     3961 acccacaggg atacttgtaa atgatttatg tacaggcttg tcactattta aagtttatta
     4021 atgtactttg ggaactttta agggtgttaa gtaactatgg tattaccagt tatcctaagt
     4081 tgtaggaagg aaaagcaggt ctaagaggta cacgcttgta attccattac ttggaaagtg
     4141 gaggcaggag gatcagaaat tcaaggtcat gttcagctat gcactagaga cacgcctcaa
     4201 aaaaaattgt cactttgact cctcttttat aactcagatg ccctcccttt aaaatctgct
     4261 ttccatcctc ctcctcttcc tttcttttct ttgtgagact gaggatctat ggtgtcttac
     4321 attgatagat aagcattgcg actgagcttc ctcctcggcc ccttcaaata cggtttctaa
     4381 cacaaacaaa atagttgacc cagacctgcc atcattgaat gagtgagcat cgtggctggc
     4441 tgctggcatt ctctagacct acatacagca agagaacctt gggtaaagac cactggatct
     4501 ttacccaagc agtatgcata aaatcaaaga tctactcagg atcccttaca acagaaaacc
     4561 accaaaaact tgccaaacgt tccggttctg agcatcacta atggcaatat gtacatcttt
     4621 gaaagcacct cttagcactc aaaagagatg ccaggggcat ttctgtaatc aggaatatct
     4681 aacacacctt tcagagagga aggattgtag ctttagagag gctattccct catagagagg
     4741 gccgccgaaa ctatttctag atcagtaact tctgagaatt aaaagaaaaa tataaattac
     4801 actataggca gactaaacct atgactcagt acattgtaca gttttataaa cattatcttt
     4861 tgtgctgggt aatcaagaat aaagatattc tcagacacct ggcacaaatt cccgaattaa
     4921 ctttaggatt atttatttaa gataaagatt gggttttttg tttttgtctg ctgttcagta
     4981 gcatttctcc aactgtagtc atatagggtg aatttctttg tgtgtgtacc ttgtctttcc
     5041 taagcatagg ttgtatgtga ataagtaatt cagttccatg ggaactgaga gaacactcag
     5101 caactcagaa cacttggtat tcttgcagag aacctgagtt ctatttccag cactcccggg
     5161 gtggctcaca agcatccaga actcttgttt cagggtatct gatgctcgct tctggcctcc
     5221 agaacacagg caccaggcat tcatattgca cacatacagg caaaacattc atacatgcaa
     5281 tcaatcaatt agtaaatatc tttccctccc aaattaaaaa agttaaattc tttctgatgt
     5341 attttggtat tttctaaagg agctgataaa tctttgccac aatttaaaaa acaagtataa
     5401 tgcagttgta ctcacttctt tttactacta gtgtgaaatt acataaggtc tttttgtgtt
     5461 taatatttaa taaaccaaat attaagcata aaatgctgat gtacctggaa gacacatgtg
     5521 tggtttctta aaaatagaat gtttttgttt tggaatgctt tgctaatgtg taattatata
     5581 aagctgaaca gggacgggaa gggatttttt tttttttttt ttttttaaga tttatttatt
     5641 attttatgta agtacactgt agctgtcttc agacacacca gaagagggag tcagatcttg
     5701 ttacggatgg ttgtgagcca ccatgtggtt gctgggattt gaactctgga ccttcggaag
     5761 agcagtcggg tgctcttacc cactgagcca tctcaccagc ccatgaaggg attcttttta
     5821 cactctgctt ctggggaggt gtttgaagag agcaccttcc caatgtatgg acttttagtg
     5881 cccttggcct gtcatctcca caaagtctca tcacgcagat gcagcttgcc tggcattctc
     5941 taggtagccc aggctggcct tgagctcata gcaatcctcc tgcctcagtc tcctgagtac
     6001 tgggtttgca ggtttcgggt accacatcag cttgatttca taatggataa aggaatagtt
     6061 tggagaaaat aatttcttct gcagtctttt ttatttctgt ctaatttaaa aatctgttac
     6121 ttccttaaaa ggagctaata aaggttttga tgtattctta catccaagtt tcatgccatc
     6181 tctgtgtcag tttggatttg tatatattct gttgtttttt aattgttgtt gttgtttcat
     6241 gtcagcagta tttgtatcca acttaactta tattttctca agtattaaaa tgtcagcata
     6301 aacccactct gtttgctttt ttaatgtatt ttaactgtgt tttgattatt tgacccatgt
     6361 tggaaattgc atatatgaaa ctgataaatt aagagtttta aatattatgt tattttaaac
     6421 atttttttat tgtattgttt ctcgatattg tttcagaaag accagactcg tggctaatta
     6481 tctttgagat aatggaaatg atcagttatt aaagtcaaat tttataggac acaccaacac
     6541 tgtgcttaca gaaagtcact gataatagaa tttcaaactt ccttttccca tagtcctgtt
     6601 tcagggtcac actttgatac accgtaaatg tatttgaaat ccttttttta atgttctttt
     6661 atgaccagag caattattaa aatggagtta acctactatg tatttcctgg gctgtttcta
     6721 agaataaaat cccaaatgaa gtttt
//
