LOCUS       NM_001013759            2943 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus growth arrest-specific 2 like 2 (Gas2l2), mRNA.
ACCESSION   NM_001013759 XM_204668
VERSION     NM_001013759.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2943)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2943)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2943)
  AUTHORS   Bustamante-Marin,X.M., Yin,W.N., Sears,P.R., Werner,M.E.,
            Brotslaw,E.J., Mitchell,B.J., Jania,C.M., Zeman,K.L., Rogers,T.D.,
            Herring,L.E., Refabert,L., Thomas,L., Amselem,S., Escudier,E.,
            Legendre,M., Grubb,B.R., Knowles,M.R., Zariwala,M.A. and
            Ostrowski,L.E.
  TITLE     Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and
            Mucociliary Clearance
  JOURNAL   Am J Hum Genet 104 (2), 229-245 (2019)
   PUBMED   30665704
  REMARK    GeneRIF: results show that a pathogenic variant in GAS2L2 causes a
            genetic defect in ciliary orientation and impairs mucociliary
            clearance and results in primary ciliary dyskinesia
REFERENCE   4  (bases 1 to 2943)
  AUTHORS   Wu,Y.C., Lai,H.L., Chang,W.C., Lin,J.T., Liu,Y.J. and Chern,Y.
  TITLE     A novel Galphas-binding protein, Gas-2 like 2, facilitates the
            signaling of the A2A adenosine receptor
  JOURNAL   Biochim Biophys Acta 1833 (12), 3145-3154 (2013)
   PUBMED   23994616
  REMARK    GeneRIF: G2L2 is a new effector that controls the action of A2AR by
            modulating its ability to regulate the Galphas-mediated cAMP
            contents.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC147480.1 and BB806501.1.
            
            On Feb 15, 2013 this sequence version replaced NM_001013759.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147480.1, SRR7345562.217283.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2771              BC147480.1         1-2771
            2772-2943           BB806501.1         214-385
FEATURES             Location/Qualifiers
     source          1..2943
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.33 cM"
     gene            1..2943
                     /gene="Gas2l2"
                     /note="growth arrest-specific 2 like 2"
                     /db_xref="GeneID:237891"
                     /db_xref="MGI:MGI:3652048"
     exon            1..478
                     /gene="Gas2l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..2676
                     /gene="Gas2l2"
                     /codon_start=1
                     /product="GAS2-like protein 2"
                     /protein_id="NP_001013781.1"
                     /db_xref="CCDS:CCDS25164.1"
                     /db_xref="GeneID:237891"
                     /db_xref="MGI:MGI:3652048"
                     /translation="MSQHVGHGRRPRTPGPPVRSIRPFKSSEQYLEAMKEDLAEWLRD
                     LYGLDIDADNFLRVLETGLVLCRHANTVTEAALAFLAEAPERAQKIPMPQAGVFCNGA
                     AQPGTFQARDNISNFIQWCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWR
                     FGVAAPALVHLEEEIDEELRRDLALPSPDPPPPIPPARRPCHFHNLDQMVQSLVSHCT
                     CPVQFSMVKISEGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRCTS
                     LSHKPGSFLKPPGPPVQHEVKVQDGPSQPQPTMTISRSQSPLPPVDWKTYTSSSRKLR
                     PPTPSSPGLRSEPPVRARTLREDPLPRSQEKPTPSQRMSSPGPQFSSTCRGPDLQSTL
                     SGKRANRCPGEPPRGRTPTLWVHKEAGSRGTHTKAPTPQRLQIPEATSKRTSARGPSP
                     PPRSSSLASPHMIWVLHQGASPQLSEPMTVHSSSPGKGLTKIPIRLSPARPPTPGRSS
                     LGTEGEYSTGRGSISSRALEGNLDRSTHGHHSVEASGDHQTDIQTTSETEDPRSLGTQ
                     KWKERHTSLALGRRREQALYDNLKEEVVANMKLLEVGTAYTQGTRSQAIPRSGVYVPS
                     LGGRWPEPGGPYDKVIRELVQGPPPLLKVDLKAWKVGSECLPRPIVDPGSPKEKLGSR
                     ETGTRIKASLNAEDTTVRTVSPARGQGCSTPPVSANLEAPTRSCSDPSSDKASVCLGK
                     GKRTLRKPQKIPSIYKLKLRPRIRPRRDHRPEKRPSRIPKPLPYSCLVLARTAPGSRL
                     LKATLGGKGGVPCQVNGTGKKEEEKKKGGSNISLESSIQPAESQEPLKLGGTPLSPEE
                     ESWV"
     exon            479..720
                     /gene="Gas2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..828
                     /gene="Gas2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..925
                     /gene="Gas2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1175
                     /gene="Gas2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..2943
                     /gene="Gas2l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccaggac cttgactagc aggtagcaga agtaaagaga caacagtggg gggacaggag
       61 gttgttactt cctcccacac ttgagttcca gtcatgtctc agcatgtggg acatgggagg
      121 agacccagga ccccaggacc tcctgtgcgc agcatccggc ccttcaagtc cagcgagcag
      181 tacctggagg ccatgaagga agacctggct gagtggcttc gggatctgta cgggctggac
      241 atcgatgcag acaacttcct gcgggtgctg gagactggcc tggtgttgtg ccggcatgcc
      301 aacactgtca cggaggctgc tctggccttc ctggctgagg cacctgagcg agctcaaaag
      361 attcccatgc cccaggctgg agttttctgc aatggggctg ctcagccggg taccttccag
      421 gccagggaca acatctccaa cttcatccag tggtgtcgca aggagatggg gatccaagag
      481 gtgctgatgt tcgagacaga ggacctagtg ctccgcaaga acgtgaagag cgtggtactg
      541 tgtctgctgg agctgggtcg ccgcgcttgg cgcttcggtg tggcggcgcc cgccctggtg
      601 catctggaag aggaaattga tgaggagctg cggcgcgacc tggccttgcc atcgcccgac
      661 ccaccaccgc ccataccccc tgcccgcagg ccttgccact tccacaacct ggaccagatg
      721 gtgcagagcc tcgtcagcca ttgcacatgc ccagtgcaat tctccatggt caagatatct
      781 gaggggaagt acagagtggg ggactccaac actctcatct tcatccggat cctccggagc
      841 cacgtgatgg tgcgtgttgg gggtggctgg gacacgctgg gccattatct ggataaacat
      901 gacccctgcc ggtgcacgtc cctctcccac aagccaggca gcttcctgaa gcccccagga
      961 ccaccggtgc agcacgaagt gaaggtgcag gatgggccct cacaacccca gcctacaatg
     1021 accatcagcc gctcacagag cccactgcct ccagtggact ggaagacata cacctcttcc
     1081 agccgaaagc tgagacctcc cacaccttcc tctcctggac tccgtagtga acccccagtg
     1141 agggccagaa ccctcagaga ggatccactc ccaaggtccc aagagaaacc aactccatct
     1201 cagaggatgt catcacctgg tccccaattc tcatctactt gtagggggcc agacctacag
     1261 agtaccctgt ctgggaagag agcaaacaga tgcccaggtg aaccgcccag aggaaggact
     1321 cccacattgt gggttcacaa ggaagcaggc agtcgaggaa cacacaccaa ggcccccaca
     1381 ccacagaggc tccaaatccc tgaggccacc agcaaaagga cgtcagcaag gggaccatcg
     1441 cccccacctc gttcctccag cctagccagt cctcacatga tctgggtcct gcaccagggt
     1501 gcctccccac agctcagtga acccatgact gttcattcct catcccctgg caaagggctc
     1561 accaaaatcc ctatccggtt gtcccctgcc cggcccccaa ctccaggaag aagctctttg
     1621 ggtactgaag gtgaatactc cacggggaga ggctccatct catcaagggc cctcgaaggg
     1681 aacctggata gatccacaca tgggcatcac tctgtggaag caagtgggga ccaccagaca
     1741 gacatccaga ctacttcaga gactgaggat cccaggagct tgggtacaca gaagtggaaa
     1801 gagagacaca cctctttggc cctgggcagg cgcagagagc aagccctcta tgataacctt
     1861 aaagaggagg ttgtggccaa catgaagctg ctggaggtgg ggactgccta cactcagggt
     1921 acaaggtctc aagccatccc tcgaagtggg gtctatgttc ctagcctggg tgggaggtgg
     1981 cctgagcctg ggggtcctta tgataaagtc atccgggaac tggttcaggg tcccccaccc
     2041 ctccttaaag tggatctgaa agcctggaag gttggatctg aatgccttcc taggccaatt
     2101 gtggacccag gaagccccaa agagaagcta ggttccagag aaacggggac aaggataaag
     2161 gcaagcctga atgctgagga taccacagtg aggactgtat cacctgcaag agggcagggg
     2221 tgctcaaccc cgcctgtatc tgccaacctg gaggctccca cacgttcatg ctcagacccc
     2281 agttctgaca aagccagtgt atgtctgggc aagggcaaga gaactctccg gaagccccag
     2341 aagatcccat ccatttacaa gctgaagctg agacccagaa tccggcctcg tagagaccat
     2401 agacctgaga agagaccttc cagaattccc aagccactgc cttactcctg cctggttcta
     2461 gccaggacag ctcctggaag caggctatta aaagctacat tgggtggcaa gggaggggtc
     2521 ccctgccagg tgaatggaac aggtaagaag gaggaagaga aaaagaaagg aggcagcaac
     2581 atctccttgg agagcagcat ccagcccgca gagagccagg agcctctgaa gcttggtgga
     2641 accccacttt cacccgagga ggaatcttgg gtctgaagag ccctcagata gggaagagta
     2701 cagcaaaatt tatgcagtgc agagtatgtg tgagaaagta cagtccctca ctcagcacag
     2761 tgtcttggcc aggaatcggc ctgaagagcc caccagttgc gtgaatgggc agcccatagc
     2821 tccattgcaa gccagcatca agccaggggt gatagagagc ccattaagaa caccaagaac
     2881 agctcctcag cctctggaca ttgccacagc tgtaagttat taaacacatg tgggtgtgct
     2941 ttg
//
