LOCUS       NM_144560               2858 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus growth arrest-specific 2 like 1 (Gas2l1), transcript
            variant beta, mRNA.
ACCESSION   NM_144560
VERSION     NM_144560.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2858)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2858)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2858)
  AUTHORS   Gamper,I., Fleck,D., Barlin,M., Spehr,M., El Sayad,S., Kleine,H.,
            Maxeiner,S., Schalla,C., Aydin,G., Hoss,M., Litchfield,D.W.,
            Luscher,B., Zenke,M. and Sechi,A.
  TITLE     GAR22beta regulates cell migration, sperm motility, and axoneme
            structure
  JOURNAL   Mol Biol Cell 27 (2), 277-294 (2016)
   PUBMED   26564797
REFERENCE   4  (bases 1 to 2858)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2858)
  AUTHORS   Gamper,I., Koh,K.R., Ruau,D., Ullrich,K., Bartunkova,J., Piroth,D.,
            Hacker,C., Bartunek,P. and Zenke,M.
  TITLE     GAR22: a novel target gene of thyroid hormone receptor causes
            growth inhibition in human erythroid cells
  JOURNAL   Exp Hematol 37 (5), 539-548 (2009)
   PUBMED   19375645
REFERENCE   6  (bases 1 to 2858)
  AUTHORS   Goriounov,D., Leung,C.L. and Liem,R.K.
  TITLE     Protein products of human Gas2-related genes on chromosomes 17 and
            22 (hGAR17 and hGAR22) associate with both microfilaments and
            microtubules
  JOURNAL   J Cell Sci 116 (Pt 6), 1045-1058 (2003)
   PUBMED   12584248
REFERENCE   7  (bases 1 to 2858)
  AUTHORS   Gordon,H.M., Kucera,G., Salvo,R. and Boss,J.M.
  TITLE     Tumor necrosis factor induces genes involved in inflammation,
            cellular and tissue repair, and metabolism in murine fibroblasts
  JOURNAL   J Immunol 148 (12), 4021-4027 (1992)
   PUBMED   1602141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052229.1, BY231632.1, AF508324.1 and AW061138.1.
            
            On Jun 19, 2010 this sequence version replaced NM_144560.2.
            
            Summary: This gene encodes a member of the Gas2 family,
            actin-associated proteins expressed at high levels in
            growth-arrested cells. The gene expression is negatively regulated
            by serum and growth factors. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (beta) differs in the 3' coding
            region and 3' UTR, compared to variant alpha, resulting in an
            isoform (beta) with a distinct and longer C-terminus, compared to
            isoform alpha. Both variants beta and delta encode the same
            isoform.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC031785.1, AF508324.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849381, SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AK052229.1         2-77
            77-287              BY231632.1         2-212
            288-695             AK052229.1         289-696
            696-2749            AF508324.1         340-2393
            2750-2858           AW061138.1         1-109               c
FEATURES             Location/Qualifiers
     source          1..2858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.21 cM"
     gene            1..2858
                     /gene="Gas2l1"
                     /gene_synonym="4930500E24Rik; D0Jmb1; Gar22; TU-71.1"
                     /note="growth arrest-specific 2 like 1"
                     /db_xref="GeneID:78926"
                     /db_xref="MGI:MGI:1926176"
     exon            1..113
                     /gene="Gas2l1"
                     /gene_synonym="4930500E24Rik; D0Jmb1; Gar22; TU-71.1"
                     /inference="alignment:Splign:2.1.0"
     exon            114..371
                     /gene="Gas2l1"
                     /gene_synonym="4930500E24Rik; D0Jmb1; Gar22; TU-71.1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..1024
                     /gene="Gas2l1"
                     /gene_synonym="4930500E24Rik; D0Jmb1; Gar22; TU-71.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..2428
                     /gene="Gas2l1"
                     /gene_synonym="4930500E24Rik; D0Jmb1; Gar22; TU-71.1"
                     /note="isoform beta is encoded by transcript variant beta;
                     GAS2-related protein; GAS2-like protein 1"
                     /codon_start=1
                     /product="GAS2-like protein 1 isoform beta"
                     /protein_id="NP_653146.1"
                     /db_xref="CCDS:CCDS36101.1"
                     /db_xref="GeneID:78926"
                     /db_xref="MGI:MGI:1926176"
                     /translation="MANPVAGIAGSAAKSVRPFRSSEAYVEAMKEDLADWLNALYSLG
                     LPGSGDGFLTGLATGTTLCQHANAVTEAARALAAARPTRGVAFQAHSVAPGSFMARDN
                     VASFIGWCRAELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGLLAPRLVQF
                     EQEIERELRATPQVSSVPAAEEDVTEIATVPGVPTRTPRMTPNDLRNLDELVREILGR
                     CTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC
                     SSSTHRLPQQRTGTFSPQRGSPTPSPRPGSPVPGSERRSSRPEVTPISLRGTKEGPET
                     PLRPRDQLPPLPRSRRYSGDSDSSASSAQSGPMGARSDDSATGSRRERPSHRPTSCLP
                     ASPRRPTAPRSQSRDRLDRGRPRVAPGGRGAQLSTSSPARRTRSQSREEQAVLMVRRD
                     RDGQHSWVARGRGGGGSGGSGRSTPQTPRALSPAAPRPSRGPSPGPELAATPASIFRT
                     PLQLDPQQEQQLFRRLEEEFLANARALEAAASHTPMGSAPDPPAPDSAYCSSSSSSSS
                     LSVLGGKCGQPGESGRTANGLPGPRSQALSSSSDEGSPYLAVGGALDATRSSLAGPEP
                     SLTWARGRMDTQPDRKPSRIPTPRGPRRPSGPIELGAWHAQHSVTPRTEPDSSM"
     exon            1025..1132
                     /gene="Gas2l1"
                     /gene_synonym="4930500E24Rik; D0Jmb1; Gar22; TU-71.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1229
                     /gene="Gas2l1"
                     /gene_synonym="4930500E24Rik; D0Jmb1; Gar22; TU-71.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1401
                     /gene="Gas2l1"
                     /gene_synonym="4930500E24Rik; D0Jmb1; Gar22; TU-71.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..2844
                     /gene="Gas2l1"
                     /gene_synonym="4930500E24Rik; D0Jmb1; Gar22; TU-71.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2699..2704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gas2l1"
                     /gene_synonym="4930500E24Rik; D0Jmb1; Gar22; TU-71.1"
                     /note="hexamer: AGTAAA"
     polyA_site      2720
                     /gene="Gas2l1"
                     /gene_synonym="4930500E24Rik; D0Jmb1; Gar22; TU-71.1"
                     /note="major polyA site"
ORIGIN      
        1 ggggcagagc ggacgcctgg aagcagcgat ctcgggcgac gcctgtgtgc ggcggcgcgg
       61 cccggctccg gccccgccgg ggcgatgctc cccggggcgg cggggtgagc caggcctcga
      121 gcactgcgga ggctcgcggg ggccgttcgg agtcccggcc tttcaggcac cagctcgggc
      181 ggcttttcgc agcaggaatc cggcctgcct gggtgacccg attcctccac ccactgctct
      241 gcgaccttcg gcgaatgcct gcccttactg cgcctcagtt tcctcatctg tagaatggag
      301 acgcggtcgc cgctcagcct gtggcgcggc ccttagcgga gaggagaagg gaaaggcggg
      361 acttcgtgca gtgactccac tggctctggg catggcgaac ccagtggcgg gcatcgcagg
      421 ctctgccgcc aagagtgtgc gacccttccg atccagtgag gcctatgtgg aagccatgaa
      481 ggaagacctg gccgattggc tcaatgcttt gtacagtcta ggtctccccg gcagtggcga
      541 tggcttcctc acggggctgg ccacaggcac aaccctgtgc caacatgcca acgctgtcac
      601 cgaggctgcc cgggctctgg ctgctgcccg tccaacccga ggtgtggcct tccaggcaca
      661 cagtgtggcg cctggctcct tcatggcccg agacaacgtg gcctctttca tcggctggtg
      721 ccgggctgag ctgggcgtgc ctgaagtgct catgtttgag acagaggacc tggtgctacg
      781 caagaacgag aagagtgtgg tgctctgcct gctggaggtc gcccggcgtg gggcgcgcct
      841 tggcctgctt gccccgaggc tggtacagtt cgagcaggag atcgagcggg agcttcgagc
      901 tacccctcag gtttccagcg tccctgctgc tgaagaggat gtcactgaaa ttgccactgt
      961 accaggggtt cccacccgca caccccgcat gacgcccaat gaccttcgaa accttgatga
     1021 gctggtaagg gagatcctag gcaggtgcac ctgccccgac cagtttccca tgatcaaggt
     1081 ctccgagggg aagtaccgag tgggagactc cagcttgctc atcttcgtga gggtgctgag
     1141 gagtcacgtg atggtgcgag tggggggcgg ctgggacaca ctggagcact acctagacaa
     1201 gcatgaccct tgtcgctgct cgtcttctac gcaccgtctg ccccagcaga ggaccgggac
     1261 tttctccccg cagaggggat cacccactcc tagcccccgc cccggtagcc cagtccctgg
     1321 gagtgagcgc aggagctccc ggcccgaagt aacccccatc agcctgcgag gcacaaagga
     1381 ggggcctgag accccgctca ggccccgcga tcagctgccc ccccttcccc gctcccgccg
     1441 ctactctggg gacagtgact cctcagcctc ctctgctcag agcggcccca tgggtgcccg
     1501 cagcgacgat tcagccactg gctcccggag ggagcggccc agccaccggc cgacctcctg
     1561 tcttccggcc tccccgagac ggccgaccgc gcctcgcagc cagtctcgag accggctgga
     1621 ccggggacgg ccccgcgtgg ccccaggagg ccgaggcgct cagctgtcga cctccagccc
     1681 agcaaggcgc acccgcagcc agagccgcga ggaacaggcg gtactgatgg tgcgcaggga
     1741 ccgagacggc cagcactcgt gggtggcccg gggcaggggt ggcgggggat caggaggttc
     1801 tgggaggagt accccgcaga ctccgcgtgc cctcagccct gcagcacccc ggccttccag
     1861 gggccccagc cccggcccag agctggctgc cacacctgcc agcatcttcc gcacgcccct
     1921 gcagcttgac ccacagcagg agcagcagct gttcaggcgc ctggaagagg aattcttagc
     1981 caatgcccgc gccttggagg ctgctgccag ccataccccc atgggatctg cccctgaccc
     2041 tccagctccg gactctgctt actgttcatc cagctcctcg tcttcatcac tcagtgtcct
     2101 gggtggcaaa tgtggccaac ctggggagtc aggccgcaca gccaatgggc tgcctgggcc
     2161 ccgcagccaa gctctgtcca gttcttccga tgagggcagc ccctaccttg ctgtaggagg
     2221 ggcactggat gcaaccagga gctctttggc tggcccagaa ccctcactga cctgggcaag
     2281 ggggcggatg gacacacaac cagaccgtaa accctcacgc ataccgacac ctcggggacc
     2341 ccgccgccca tcgggaccca tagaactcgg ggcttggcat gcccagcatt cggtcacccc
     2401 aaggaccgag ccagattctt cgatgtgatg gaccggctta gctacaccca caccccattc
     2461 cattttcttt gtggccttaa cctacccttt gcatcaggga ccccccttcc atctcgagca
     2521 ccagacctca tgggaccaga ccccacggga ctacatggca caatgggaca cctgttgtac
     2581 attccggttt gggggatgag cattgctatt taattactaa tattattgaa tgccttagag
     2641 gagaccgggc cagcccggtg tccagaggac ctgtggtcca gtaagcagaa cctctgacag
     2701 taaagtcttg ctccagctcc tgttttttgg ggactgagcc ttcattatat gttgggattc
     2761 tagagttaac tgcctagaag ccagacctca atgctctgaa cctgcatata ccagaacaag
     2821 aaacccttaa attgtgcatt tacaaaaaaa aaaaaaaa
//
