LOCUS       NM_001412466            3915 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus growth arrest specific 2 (Gas2), transcript variant
            12, mRNA.
ACCESSION   NM_001412466 XM_011250797
VERSION     NM_001412466.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3915)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3915)
  AUTHORS   Chen,T., Rohacek,A.M., Caporizzo,M., Nankali,A., Smits,J.J.,
            Oostrik,J., Lanting,C.P., Kucuk,E., Gilissen,C., van de Kamp,J.M.,
            Pennings,R.J.E., Rakowiecki,S.M., Kaestner,K.H., Ohlemiller,K.K.,
            Oghalai,J.S., Kremer,H., Prosser,B.L. and Epstein,D.J.
  TITLE     Cochlear supporting cells require GAS2 for cytoskeletal
            architecture and hearing
  JOURNAL   Dev Cell 56 (10), 1526-1540 (2021)
   PUBMED   33964205
  REMARK    GeneRIF: Cochlear supporting cells require GAS2 for cytoskeletal
            architecture and hearing.
REFERENCE   3  (bases 1 to 3915)
  AUTHORS   Liu,J., Chanumolu,S.K., White,K.M., Albahrani,M., Otu,H.H. and
            Nawshad,A.
  TITLE     Transcriptional analysis of cleft palate in TGFbeta3 mutant mice
  JOURNAL   Sci Rep 10 (1), 14940 (2020)
   PUBMED   32913205
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3915)
  AUTHORS   Muthu,V., Rohacek,A.M., Yao,Y., Rakowiecki,S.M., Brown,A.S.,
            Zhao,Y.T., Meyers,J., Won,K.J., Ramdas,S., Brown,C.D.,
            Peterson,K.A. and Epstein,D.J.
  TITLE     Genomic architecture of Shh-dependent cochlear morphogenesis
  JOURNAL   Development 146 (18) (2019)
   PUBMED   31488567
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3915)
  AUTHORS   Zhang,C.L., Liu,X., He,Q.J., Zheng,H., Xu,S., Xiong,X.D., Yuan,Y.,
            Ruan,J., Li,J.B., Xing,Y., Zhou,Z. and Deng,S.
  TITLE     miR-342-5p promotes Zmpste24-deficient mouse embryonic fibroblasts
            proliferation by suppressing GAS2
  JOURNAL   Mol Med Rep 16 (6), 8944-8952 (2017)
   PUBMED   28990109
  REMARK    GeneRIF: these findings suggest that downregulated miR3425p is
            involved in regulating cell proliferation and cell cycles in
            Zmpste24/ MEFs by suppressing GAS2 in vitro.
REFERENCE   6  (bases 1 to 3915)
  AUTHORS   Brancolini,C., Benedetti,M. and Schneider,C.
  TITLE     Microfilament reorganization during apoptosis: the role of Gas2, a
            possible substrate for ICE-like proteases
  JOURNAL   EMBO J 14 (21), 5179-5190 (1995)
   PUBMED   7489707
REFERENCE   7  (bases 1 to 3915)
  AUTHORS   Brancolini,C., Bottega,S. and Schneider,C.
  TITLE     Gas2, a growth arrest-specific protein, is a component of the
            microfilament network system
  JOURNAL   J Cell Biol 117 (6), 1251-1261 (1992)
   PUBMED   1607387
REFERENCE   8  (bases 1 to 3915)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
REFERENCE   9  (bases 1 to 3915)
  AUTHORS   Colombo,M.P., Baracetti,P., Cairo,G., Schneider,C. and Parmiani,G.
  TITLE     A TaqI RFLP at the gas-2 locus
  JOURNAL   Nucleic Acids Res 17 (18), 7545 (1989)
   PUBMED   2571977
REFERENCE   10 (bases 1 to 3915)
  AUTHORS   Schneider,C., King,R.M. and Philipson,L.
  TITLE     Genes specifically expressed at growth arrest of mammalian cells
  JOURNAL   Cell 54 (6), 787-793 (1988)
   PUBMED   3409319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158345.8, AC113312.7 and AC122017.5.
            
            On Sep 30, 2022 this sequence version replaced XM_011250797.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1077111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1836              AC158345.8         153582-155417
            1837-1924           AC158345.8         156052-156139
            1925-2089           AC158345.8         179682-179846
            2090-2211           AC113312.7         132814-132935       c
            2212-2292           AC113312.7         107581-107661       c
            2293-2434           AC113312.7         103642-103783       c
            2435-2498           AC113312.7         93569-93632         c
            2499-2640           AC113312.7         86395-86536         c
            2641-2748           AC113312.7         76885-76992         c
            2749-3915           AC122017.5         1257-2423
FEATURES             Location/Qualifiers
     source          1..3915
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 32.87 cM"
     gene            1..3915
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /note="growth arrest specific 2"
                     /db_xref="GeneID:14453"
                     /db_xref="MGI:MGI:95657"
     exon            1..1836
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1924
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2089
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1942..2967
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /note="isoform 3 is encoded by transcript variant 12;
                     growth arrest-specific protein 2"
                     /codon_start=1
                     /product="growth arrest-specific protein 2 isoform 3"
                     /protein_id="NP_001399395.1"
                     /db_xref="GeneID:14453"
                     /db_xref="MGI:MGI:95657"
                     /translation="MMCTALSPKVRSGPGLSDMHQYSQWLASRHEANLLPMKEDLALW
                     LTNLLGKEITAETFMEKLDNGALLCQLAATVQEKFKESMDANKPAKPHSPHFEAGFYL
                     TSKMTQNPTSSLSSKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFE
                     SEGLVLHKQPREVCLCLLELGRIAARYGVEPPGLIKLEKEIEQEETLSAPSPSPSPSS
                     KSSGKKSTGNLLDDAVKRISEDPPCKCPTKFCVERLSQGRYRVGEKILFIRMLHNKHV
                     MVRVGGGWETFAGYLLKHDPCRMLQISRVDGKTSPVQSKSPTLKDMNPDNYLVVSATY
                     KAKKEIK"
     exon            2090..2211
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2292
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2434
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2498
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2640
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2748
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..3915
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3895..3900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /note="hexamer: AACAAA"
     polyA_site      3915
                     /gene="Gas2"
                     /gene_synonym="Gas-2"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgctcc tgggcgcgtc cccgccgagg cggcacagca ggcgcagcgc gcttccgcgg
       61 cgcgccagga ggaccaggcg cgactgcggc acgtcgtctc ggtggtccgc ggcggggccc
      121 gggaacagca agctcggcag cgcgcgggcg gcggcgggcg cgagcgcgcg gttccgcagc
      181 aggcggaggg cgagccgcgc gtccccggac tccagcgccg cgaagctgcg cagcccgagc
      241 ggccctcccc gcgcggggag ccgcctctcg agcgcctccc gcacgcggcc gcggcccgcg
      301 aagcgtcggt acacgtggag cagataacgc gcccactgca gcgccctgcg caccttttcg
      361 gcgtcccacg tgctcaccag cgacccacac gacacggcca acagctcgga gaatcgctcg
      421 gtttgctgca caagcggctc catggcggcc gcttccgccc tgacatcccg aggcgcgagc
      481 cgattggaca tgagcgtgag cgcccgcctc agcgtgctgt gccattggac gacggccgtg
      541 tcagtctcgc accatggttt ccggggcaca ttggcgctga aaatgaacta gggcaaagtc
      601 ccaagctttt actctgggtc tgggagagga cgcgtgagtg cgagtttgag cgctaggatt
      661 ttatgtgctc ttttgtttta aaaatgccag tggtagacat ttaggcgctt ccccgaaagg
      721 ggacccatgt tcatcattat tagcagtgcg gatgtgatct gcttgcgaac tcaaagctct
      781 taaatggccc gtttccctgg tacttgtgga accaggaccc tcacacgctg tgctgtgagt
      841 tcccgggctt ttttcctttt tccttattta tattgtttac tgattctgag gaaacctatc
      901 actgaattgt gcaagcagcc tttcagtttg cagtcctgcc tcgactaacc tagtgactgg
      961 cagcactatc ctgaggctta ctagccatgc aataaatgaa agtttaagct caaaattaat
     1021 ctacacattt atgctagact ctgaatagtt ctgggcattc ttatcagaac atatagttaa
     1081 gccagttttg tttagttttt agccattagc ccagactata gtgtttggcc ttgtgatttt
     1141 attttagtct gtgtgatggg ttttaaagtt tcaggtggta gctattagga attacagagg
     1201 tcactggttc atccacttac taaatactaa gtcacgtgat gtgatagcca gtgaaggaca
     1261 ggactggcgc agttgagata aatgtagtta aagcttccct gtcccacagg aaacactaat
     1321 gttccttaga gagacttcaa cttcataatg cggtagacaa aaataagagt cactagatct
     1381 tagatgttag ggaaagcccc attaaacctt cctttcaact gaatgcccaa agaatacacc
     1441 tggaaatgct tcaaggccat gggaaccgtt aataagtctt aagccaccag agtgaaaacc
     1501 agatctaatc cagggtgaga aagaagtcca aaacagcttc atttccaagt ggctgggaca
     1561 gttcagagaa acttcaccag tgctcacctt ttcaaaacca atattatgtt aaatctcagt
     1621 accacagtga gtaattattt gtttcacagt agccatcttt tattaagtag ctatgcatcc
     1681 ctccgacagt ttcccatcag aagaatgcac tttggatttc gaaccagttt tccatttaat
     1741 ttggaacaat ctatgtagag gctgaaagat gataaacact ttaatttcaa gaaacctatg
     1801 cacttgaggc agacattggg aggattccca acccatgtga gcatgccaac tcttagcttc
     1861 cttcctctgc tgccttgccc agcccctgct gtgatggact cttgctctcc tagaaccctc
     1921 aaccgtgtta ggagtggata aatgatgtgc actgccctga gccccaaggt tcgcagcgga
     1981 cctggcctgt ctgatatgca tcagtacagc cagtggctgg ccagcagaca tgaagctaat
     2041 ttgctgccga tgaaagaaga cttggccttg tggttaacca atctattagg gaaagagata
     2101 acagcagaaa ccttcatgga gaagttggat aatggtgcct tgctctgtca gcttgcagca
     2161 actgtgcagg agaaattcaa agagagtatg gatgccaaca agcctgccaa gccccattca
     2221 ccgcattttg aagctggatt ttatctgaca tcaaaaatga ctcaaaatcc tacttcatcc
     2281 ctttcttcaa agaccctacc actgaagaag attccttgca aagccagtgc accctcgggc
     2341 tccttttttg cccgagacaa cacagccaat ttcctatcct ggtgccgaga tttgggagtt
     2401 gatgaaacat gtctttttga atctgaaggc ctggttctgc ataagcagcc ccgagaagtg
     2461 tgtctctgtt tgctagagct tggtcggatt gcagccaggt atggtgtgga gcctcctggt
     2521 ctgataaagc tggaaaaaga aattgaacaa gaagagacac tttctgcccc atctccttcg
     2581 ccttctcctt catcaaagtc ttcaggaaag aagagtactg gaaacttact ggatgatgca
     2641 gtaaaaagaa tctctgaaga tcctccctgc aagtgcccaa ccaagttctg tgtggagcgg
     2701 ctctctcaag gtcgataccg agtgggagag aagatcctct tcatcaggat gctgcacaac
     2761 aagcatgtga tggtccgagt gggaggaggc tgggagacct tcgctggcta tctgctcaag
     2821 catgacccct gccgcatgct gcagatctcc cgtgtggacg gcaagacatc ccctgtccag
     2881 agcaaatccc caaccctgaa ggacatgaat cctgataatt acctggtggt ctctgccacc
     2941 tacaaggcta agaaggagat taaatgaaac tgatctctga aagaggactc atgcaatggc
     3001 ctgtgtccat tcttcagtgt agtcaatgta gttcacatgc tctgaaaaac cacacagcag
     3061 acaggaaaat actcaaatgg tagcactatt tatttgtaat gcatctgtag aactttgcct
     3121 atggagaaaa aaatctaaac tcaatgaaat cagacaaatt gtaagcaaat cattatttct
     3181 caatatgtga acatagtata tagaacaaac cttgttagga actaagttct aggtacagtc
     3241 attgaaggtg atcatgacta ggagactgta tttacttaaa tgggtaggtc aacagaaagt
     3301 gcctgctgta tgtctatgag ctaaagcacc ccagaaactt ttataatggc ggggatttta
     3361 tacctatttt ttacaaagtg acaatgtgat aatgtgctac taaaatttgt ctgagagcac
     3421 tatatagtag agagttttct cagccataat acttaactgg aaaggacact tcagagatgt
     3481 ttacattaac ttggaagatt gccttaaagt tcatctctga tccctgacca aaccaacctc
     3541 tggggtactt ttggatgttg cctgtgcagc cccttaggaa tagcaggtac cttttacaca
     3601 cagagaagct gtgtttagga tgatcactta gtgaaataca catgcctaag ctagcagtca
     3661 ttcacattct gatgtgtgga ctgcacagtc aaatgttcat caaccttgtg attttgttta
     3721 tttcaagcat tttcttatta aaattatgta gctttagtta gtcctattct gctatgctgt
     3781 ctcatgaagt aaaattcatg tagtgaatta tgttacagac ttgtataccc aggacagagc
     3841 tgttttgtat caataaacag caagatattg tccacactga tttaaaaaat taaaaacaaa
     3901 gtttaaaaaa accca
//
