LOCUS       NM_008086               2961 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus growth arrest specific 1 (Gas1), mRNA.
ACCESSION   NM_008086
VERSION     NM_008086.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2961)
  AUTHORS   Franks,N.E. and Allen,B.L.
  TITLE     Hedgehog-dependent and hedgehog-independent roles for growth arrest
            specific 1 in mammalian kidney morphogenesis
  JOURNAL   Development 151 (24) (2024)
   PUBMED   39629522
REFERENCE   2  (bases 1 to 2961)
  AUTHORS   Kumari,A., Franks,N.E., Li,L., Audu,G., Liskowicz,S., Johnson,J.D.,
            Mistretta,C.M. and Allen,B.L.
  TITLE     Distinct expression patterns of Hedgehog signaling components in
            mouse gustatory system during postnatal tongue development and
            adult homeostasis
  JOURNAL   PLoS One 19 (6), e0294835 (2024)
   PUBMED   38848388
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2961)
  AUTHORS   Leung,A.O.W., Poon,A.C.H., Wang,X., Feng,C., Chen,P., Zheng,Z.,
            To,M.K., Chan,W.C.W., Cheung,M. and Chan,D.
  TITLE     Suppression of apoptosis impairs phalangeal joint formation in the
            pathogenesis of brachydactyly type A1
  JOURNAL   Nat Commun 15 (1), 2229 (2024)
   PUBMED   38472182
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2961)
  AUTHORS   Lee,J., Kim,Y., Ataliotis,P., Kim,H.G., Kim,D.W., Bennett,D.C.,
            Brown,N.A., Layman,L.C. and Kim,S.H.
  TITLE     Coordination of canonical and noncanonical Hedgehog signalling
            pathways mediated by WDR11 during primordial germ cell development
  JOURNAL   Sci Rep 13 (1), 12309 (2023)
   PUBMED   37516749
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2961)
  AUTHORS   Matsushita,Y., Liu,J., Chu,A.K.Y., Tsutsumi-Arai,C., Nagata,M.,
            Arai,Y., Ono,W., Yamamoto,K., Saunders,T.L., Welch,J.D. and Ono,N.
  TITLE     Bone marrow endosteal stem cells dictate active osteogenesis and
            aggressive tumorigenesis
  JOURNAL   Nat Commun 14 (1), 2383 (2023)
   PUBMED   37185464
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2961)
  AUTHORS   Webb,G.C., Cowled,P.A., Evdokiou,A., Ford,J.H. and Forbes,I.J.
  TITLE     Assignment, by in situ hybridization, of the growth arrest-specific
            gene, Gas-1, to mouse chromosome 13, bands B3-C2
  JOURNAL   Genomics 14 (2), 548-549 (1992)
   PUBMED   1427878
REFERENCE   7  (bases 1 to 2961)
  AUTHORS   Del Sal,G., Ruaro,M.E., Philipson,L. and Schneider,C.
  TITLE     The growth arrest-specific gene, gas1, is involved in growth
            suppression
  JOURNAL   Cell 70 (4), 595-607 (1992)
   PUBMED   1505026
REFERENCE   8  (bases 1 to 2961)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
REFERENCE   9  (bases 1 to 2961)
  AUTHORS   Colombo,M.P., Baracetti,P., Schneider,C. and Cairo,G.
  TITLE     Ava I RFLP at the gas-1 locus on mouse chromosome 12
  JOURNAL   Nucleic Acids Res 17 (13), 5415 (1989)
   PUBMED   2569712
REFERENCE   10 (bases 1 to 2961)
  AUTHORS   Schneider,C., King,R.M. and Philipson,L.
  TITLE     Genes specifically expressed at growth arrest of mammalian cells
  JOURNAL   Cell 54 (6), 787-793 (1988)
   PUBMED   3409319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124392.6.
            
            On Jan 27, 2022 this sequence version replaced NM_008086.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: X65128.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2961              AC124392.6         31149-34109
FEATURES             Location/Qualifiers
     source          1..2961
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 31.92 cM"
     gene            1..2961
                     /gene="Gas1"
                     /gene_synonym="Gas-1"
                     /note="growth arrest specific 1"
                     /db_xref="GeneID:14451"
                     /db_xref="MGI:MGI:95655"
     exon            1..2961
                     /gene="Gas1"
                     /gene_synonym="Gas-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1579
                     /gene="Gas1"
                     /gene_synonym="Gas-1"
                     /codon_start=1
                     /product="growth arrest-specific protein 1"
                     /protein_id="NP_032112.1"
                     /db_xref="CCDS:CCDS26579.1"
                     /db_xref="GeneID:14451"
                     /db_xref="MGI:MGI:95655"
                     /translation="MDEDAHARSARNSDKLFQRPRGRHPSLVSAPHRVRRPLLPAMLA
                     ALLGGAGARTGTLPGALLCLMALLQLLCSAPRGSGLAHGRRLICWQALLQCQGEPDCS
                     YAYSQYAEACAPVLAQRGGADAPGPAGAFPASAASSPRWRCPSHCISALIQLNHTRRG
                     PALEDCDCAQDEHCRSTKRAIEPCLPRTSSVGPGAGAGSVMGCTEARRRCDRDSRCNL
                     ALSRYLAYCGKLFNGLRCTDECRAVIEDMLAVPKAALLNDCVCDGLERPICESVKENM
                     ARLCFGPDASNGPGSSGSDGGLDDYYDEEYDDEQRAGAAGGEQPLDDDDGLARPGGGA
                     AAAGGRGDLPHGPGRRSSSSGSGGHWANRSAWTPFACLLLLLLLLLGSHL"
     regulatory      2924..2929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gas1"
                     /gene_synonym="Gas-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2961
                     /gene="Gas1"
                     /gene_synonym="Gas-1"
                     /note="major polyA site"
ORIGIN      
        1 agccgggctc cgcggatccg ctccccaagc tccgggtctc ggagcagaga aacgctccga
       61 gtttcggggt cctccctgcg cctggcgccc agaacttccc ggagcgcggc ccagaccggg
      121 gtagaggggg aggggaccaa gcgtcctggc cgcgggaagg cgggatgcca gagctgcgaa
      181 gtgctacgcg ccgctgagcc gggaaccgag gagccgccgg ccgcacgact gtctgcaggc
      241 gcctagcacc atgcaccccc ggcgccgcgc gctcctgcag cttcgccgcg tccccccgga
      301 acggcactga gcgcctccaa ccgtctaccg gacccggacc tgcgtcgccg cgcttctcag
      361 ggagccccgg ccgcggtgcc ggagcgaaca cccgccttta ccagccgcgg ggccgccggc
      421 atggatggat gaggacgccc atgccagaag tgcgcggaac tcggacaaac ttttccagcg
      481 gccccgcggc cgccacccga gcctcgtctc cgctccgcac cgcgtccggc ggccgctgct
      541 gcccgcgatg ctagccgcgc tgctgggcgg cgccggggcc cgcacgggga ccttgccggg
      601 cgccttgctg tgcctgatgg cgctgctgca gctgctgtgc tcggcaccgc ggggctcggg
      661 gctagcgcac ggccgccgcc tcatctgctg gcaggcgctg ctgcagtgtc agggcgagcc
      721 cgactgcagc tacgcctaca gccagtacgc cgaggcttgt gcgccggtgc tagcgcagcg
      781 cggcggggct gatgctccgg ggcccgccgg cgccttcccc gcctcggccg cgtcctcgcc
      841 gcgctggcgc tgcccgagcc actgcatctc ggcgcttatc cagctcaacc acacgcgccg
      901 cgggcccgcg ctggaggact gcgactgcgc gcaggacgaa cactgcaggt ccaccaagcg
      961 cgccatcgag ccctgtctgc cgcgcaccag cagcgtgggc ccgggcgcgg gagcgggctc
     1021 ggtcatgggc tgcactgagg cccggcggcg ctgcgaccgg gacagccgct gcaacctggc
     1081 gctcagccgc tacctggcct actgcggcaa gcttttcaac gggctgcgct gcacagacga
     1141 gtgccgcgcg gtcatcgagg acatgctggc cgtgcccaag gcggcgctgc tcaacgactg
     1201 cgtgtgcgat gggctggagc ggcccatctg cgaatcggtc aaagagaaca tggcccgcct
     1261 gtgcttcggc ccagatgcga gcaacggtcc gggcagcagc ggctcggacg ggggcctgga
     1321 cgactactac gacgaagaat atgacgacga gcagcgcgct ggggccgcgg gcggcgagca
     1381 acccctggac gacgacgacg gccttgcgcg cccgggcggc ggcgctgctg cggcgggcgg
     1441 ccgcggagac ttgccccacg gtcccgggcg caggagcagc agcagcggca gtggaggcca
     1501 ctgggcgaat cgaagcgcct ggaccccgtt tgcctgtttg ctgctgctgt tgctcctgct
     1561 gctcgggtca cacttgtagc tcctgcgccc ctgctgcagg ctgctccagg ccggtatgca
     1621 cgacccagct ggttcccgag cagggcacct gtggctcgga gaccggagat ggtcgggaac
     1681 actgacccac actcttcctg ggtggacagg gcccagctcg taccgcagcc aacatgttcg
     1741 gccctcttct gtgcggtttt ccaggctgca gagataaccg gctgatctat actgccagct
     1801 ctaatctgca gaattcggga caccctgcaa aagcaaagga ggcctagact cagagtgctg
     1861 aacggtgggg gtctttcaag ttccaatgga cttggagaag ggatgttgag ggaattaggt
     1921 ttgcaaaggg gccgggtttt tatttgtctg tttgttttgt ttttaaactg ttttccggtg
     1981 agggaacaca tagtactggt aacgacttaa attgcttgtg accactgaga aacacagcaa
     2041 tcgtaagtaa atagaaaagt tccccttacc gattcattcc tgtgctcttg gtgtatctat
     2101 ccatcggtaa tgctcagtgt ggagctggcg attgcctttg ggggggggag gggcttcccc
     2161 gaaattacaa ctgcattata ttcctaaccc ttcaccttta attttcctgc caccattctg
     2221 atccctctgc accacgtgtc ttagaattaa ggatccaaaa gaagaaaaaa agttaccatg
     2281 gtgttgaaca atgcatgttt tttatcctaa agctcggtac tgccatctag gaaaacctct
     2341 atgatgtttg ttctgttgtc cttttttttt tttccctcca ccaagaaatt ctaaatttga
     2401 atatgcagag attgaatatt acctctgccc ctatcagggt cttccaccct ggtacgtcgt
     2461 atataaactg tattaaaact ggggtttctt accagttgct gtactttgta tatagaattt
     2521 tttataaatt gtatgcttca gaaaataatt tatttttaaa aaaagaaatt aaaagtttta
     2581 aatctgcatc attgttgtat ctcccctatc caagaaatgt atagaataca ttggtcatga
     2641 ggaatccact cctgcagccc atccaagaaa tgtatagaat acattgctca ccaggaaccc
     2701 gctcccgcag cccattttga aatgtgccct gtgtagaaga atgtacagtg tattttacag
     2761 atttgaagta acgttcttat tttcaagaga atttatggac attgtagaaa tgtataaatg
     2821 catttccaaa ctgccttaaa cattgtattt ttatagacat cattttttta aatcccgtgt
     2881 ttaaaaaaaa aaaactatga ctttgtgtat ttttggttgt tttattaaaa atgcacacac
     2941 cagtaaagag tttaaacagt g
//
