LOCUS       NM_010256               3329 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus phosphoribosylglycinamide formyltransferase (Gart),
            transcript variant 1, mRNA.
ACCESSION   NM_010256
VERSION     NM_010256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3329)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   2  (bases 1 to 3329)
  AUTHORS   Liu C, Morishima M, Yu T, Matsui S, Zhang L, Fu D, Pao A, Costa AC,
            Gardiner KJ, Cowell JK, Nowak NJ, Parmacek MS, Liang P, Baldini A
            and Yu YE.
  TITLE     Genetic analysis of Down syndrome-associated heart defects in mice
  JOURNAL   Hum Genet 130 (5), 623-632 (2011)
   PUBMED   21442329
  REMARK    Erratum:[Hum Genet. 2011 Nov;130(5):633. Nowak, Normal J [corrected
            to Nowak, Norma J]]
REFERENCE   3  (bases 1 to 3329)
  AUTHORS   Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P,
            Eppig JJ, Solter D and Knowles BB.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   4  (bases 1 to 3329)
  AUTHORS   Willnow T, Antignac C, Brandli A, Christensen E, Cox R, Davidson D,
            Davies J, Devuyst O, Eichele G, Hastie N, Verroust P, Schedl A and
            Meij I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   5  (bases 1 to 3329)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 3329)
  AUTHORS   Kan JL and Moran RG.
  TITLE     Analysis of a mouse gene encoding three steps of purine synthesis
            reveals use of an intronic polyadenylation signal without
            alternative exon usage
  JOURNAL   J Biol Chem 270 (4), 1823-1832 (1995)
   PUBMED   7829519
REFERENCE   7  (bases 1 to 3329)
  AUTHORS   Avraham S, Avraham H, Austen KF and Stevens RL.
  TITLE     Negative and positive cis-acting elements in the promoter of the
            mouse gene that encodes the serine/glycine-rich peptide core of
            secretory granule proteoglycans
  JOURNAL   J Biol Chem 267 (1), 610-617 (1992)
   PUBMED   1730621
REFERENCE   8  (bases 1 to 3329)
  AUTHORS   Threadgill DS and Womack JE.
  TITLE     Mapping HSA 3 loci in cattle: additional support for the ancestral
            synteny of HSA 3 and 21
  JOURNAL   Genomics 11 (4), 1143-1148 (1991)
   PUBMED   1783381
REFERENCE   9  (bases 1 to 3329)
  AUTHORS   Schild D, Brake AJ, Kiefer MC, Young D and Barr PJ.
  TITLE     Cloning of three human multifunctional de novo purine biosynthetic
            genes by functional complementation of yeast mutations
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 2916-2920 (1990)
   PUBMED   2183217
REFERENCE   10 (bases 1 to 3329)
  AUTHORS   Cox,D.R. and Epstein,C.J.
  TITLE     Comparative gene mapping of human chromosome 21 and mouse
            chromosome 16
  JOURNAL   Ann N Y Acad Sci 450, 169-177 (1985)
   PUBMED   3160288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB843046.1, AK168724.1 and DV650270.1.
            
            [WARNING] On Oct 25, 2023 this sequence was replaced by
            NM_010256.3.
            
            On Apr 21, 2006 this sequence version replaced NM_010256.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070465.1, AK168724.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BB843046.1         2-27
            27-3320             AK168724.1         2-3295
            3321-3329           DV650270.1         377-385
FEATURES             Location/Qualifiers
     source          1..3329
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 53.18 cM"
     gene            1..3329
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /note="phosphoribosylglycinamide formyltransferase"
                     /db_xref="GeneID:14450"
                     /db_xref="MGI:MGI:95654"
     exon            1..89
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            90..279
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            280..375
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            376..550
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            551..662
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            663..731
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            732..857
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            858..945
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1031
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1200
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1432
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1527
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1637
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1836
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2088
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2241
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2448
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2586
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2717
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2859
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..2975
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3329
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3304..3309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /note="putative"
     polyA_site      3320
                     /gene="Gart"
                     /gene_synonym="Gaps; Prgs"
                     /note="putative"
ORIGIN      
        1 agaggccggg gcgcgctgga ttccccgggc caacttccgg cgggtgcgag tggcgggtgc
       61 gagccggagc tgcgtggcgg ggcttgcagc aggtggttgc attttgtttc tgaatccctg
      121 cttcggagac agccatggca gcccgagttc ttgtcatcgg tagcggggga agggaacata
      181 ccctggcctg gaagctcgca cagtctcctc aggtcaagca agtgttggtt gccccaggaa
      241 acgcaggcac tgcgtgcgct gggaagatct ccaatgctgc tgtctctgtc aatgatcaca
      301 gtgccctcgc tcagttctgc aaggatgaaa agattgaact cgtagttgtc ggaccagagg
      361 cccctctggc tgcaggaatt gttggggacc tgacctctgc aggagtacga tgctttggcc
      421 ccacagcaca agcagctcaa ttagagtcca gtaagaagtt tgctaaagag tttatggacc
      481 gccatgaaat cccaactgca cagtggagag cattcaccaa ccctgaagat gcctgcagct
      541 ttattacaag cgcgaacttt cctgctttgg ttgtgaaggc cagtggcctt gcagcaggga
      601 agggagtgat tgtggccaag agccaagcgg aggcctgcag agctgtacag gagatcatgc
      661 aagaaaagtc tttcggagca gctggtgaaa cagttgttgt ggaagagttt ctggaagggg
      721 aagaagtgtc ttgcctttgc ttcactgacg ggaagacggt ggccgaaatg cccccagcac
      781 aagaccataa gcgattgctg gatggagacg aaggccccaa caccgggggg atgggagcct
      841 actgcccagc acctcaggtt tctaaggact tgttagtaaa aattaagaac actattcttc
      901 agagagcagt agacggcatg cagcaggagg gtgcgccgta cacaggaatt ctttatgctg
      961 gtataatgct gaccaaagat ggcccaaaag tgttggagtt taattgccgc tttggtgatc
     1021 cggaatgcca ggtcatcctc ccacttctta aaagtgacct ctatgaggtg atgcagtcca
     1081 ccttggatgg cctgctgagc gcgtctctgc ctgtttggct agaaaaccac agtgccgtaa
     1141 ccgtcgtcat ggcgagtaaa gggtaccctg gagcctacac caaaggcgtg gagattacag
     1201 ggtttcctga ggcccaggct ttaggactgc aggtattcca tgcaggcact gctcttaaag
     1261 atggcaaagt agtgaccagc gggggcaggg tcctcaccgt gacagctgtc caggaaaatc
     1321 tcatgtcagc ccttgctgag gccaggaaag gactcgctgc tctaaagttt gagggagcca
     1381 tctatagaaa ggacattggc ttccgtgctg tggccttcct ccagcggccc aggggcttga
     1441 cttacaagga ctccggagta gacatcgcag ctggaaatat gctggttaag aaaattcagc
     1501 ctttagcaaa agccacctcc agaccaggct gcagtgttga ccttgggggc tttgctggtc
     1561 tttttgattt gaaagcagct ggtttcaaag atcctcttct ggcctctgga acagatggtg
     1621 tgggaactaa actaaagatt gcgcagctgt gcaataagca tgattccatc gggcaggatc
     1681 tggtggccat gtgtgtgaac gacatcctcg cccagggagc agagcccctc ttcttccttg
     1741 actacttttc ctgtgggaag ctcgacctca gtacaactga agccgtcatt gctggaattg
     1801 ctgcagcttg ccagcaggct ggctgtgccc tgctgggtgg ggagacagca gagatgccca
     1861 acatgtaccc tcctggagag tatgatcttg ctgggtttgc tgttggtgct atggagagac
     1921 accagaagct ccctcagcta gaaaggatca ccgaagggga tgctgttatt ggagtggctt
     1981 catctggtct tcacagcaat gggtttagcc ttgtgaggaa aatcgtggag aggtcttcgc
     2041 tccaatactc ctccccagca cctggtggtt gtggagatca gaccttaggg gacttacttc
     2101 taactccaac caggatctac agccattcac tgctgcccat catacgttca ggacgtgtca
     2161 aagcttttgc tcatatcact ggaggcgggt tgctggaaaa catccccaga gtcctccctc
     2221 agaagtttgg agtagattta gatgccagca cctggagggt ccccaaggtc ttctcgtggc
     2281 tacagcagga aggagagctc tctgaagaag aaatggccag gacattcaac tgtgggattg
     2341 gagctgccct ggtggtgtca aaggaccagg ccgagcaggt tctgcatgac gttcggcggc
     2401 ggcaggagga agcctgggtg ataggcagtg tcgttgcgtg tcctgaagat tcccctcgtg
     2461 tcagagttaa gaatctgatt gaaaccatac aaacgaatgg gtcattggtg gcaaatggct
     2521 tcctgaaaag taatttccct gtgcaacaaa agaaggcaag agtggctgtc ttgatatctg
     2581 gaacagggtc gaacctccag gcgctcatag atagcacccg ggatcccaag agctcctcac
     2641 atattgttct tgtcatctcc aacaaagccg ccgtagccgg cttagaccga gctgagcgag
     2701 ctggtattcc caccagggta attaatcaca aattatataa aaatcgtgtt gagtttgaca
     2761 atgcagttga ccacgtcctg gaagagttct ctgtagacat cgtctgtctt gcagggttca
     2821 tgaggatcct ctctgggccc ttcgtcagaa aatgggacgg gaaaatgctc aacatccacc
     2881 catccttgct cccttccttt aagggttcaa atgcccacga gcaagtcctg gaagctggag
     2941 tcacaatcac tgggtgtacc gtacactttg tcgctgaaga tgtagatgcc ggacaaatca
     3001 tcctgcagga agctgtccct gtgcggaggg gtgacactgt ggcaacgctg tctgaacggg
     3061 tcaaagtggc agaacataag atctttcctg ccgctcttca gctggtggcc agcggggctg
     3121 tgcagctgcg agaagatggc aagatccact gggccaagga gcagtgaccg gtcctgatgc
     3181 aggagtgggc tcagtgctga gagagaggca gggccttgct gggtgccttt tcatcatgac
     3241 catggccaaa ctgaaatacc tgctggcaaa aagactttaa tccttacccg ctgccatttt
     3301 ttaaataaat aggttcattg aaaagaaaa
//
