LOCUS       NM_001167879            3832 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus GRB2 associated regulator of MAPK1 subtype 2 (Garem2),
            mRNA.
ACCESSION   NM_001167879 XM_144253 XM_908279
VERSION     NM_001167879.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3832)
  AUTHORS   Nishino,T., Tamada,K., Maeda,A., Abe,T., Kiyonari,H., Funahashi,Y.,
            Kaibuchi,K., Takumi,T. and Konishi,H.
  TITLE     Behavioral analysis in mice deficient for GAREM2 (Grb2-associated
            regulator of Erk/MAPK subtype2) that is a subtype of highly
            expressing in the brain
  JOURNAL   Mol Brain 12 (1), 94 (2019)
   PUBMED   31718706
  REMARK    GeneRIF: GAREM2 may have a common role related to the transduction
            of Erk signaling in the higher brain functions.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX237000.1, CX204487.1, BC060268.1 and CJ217704.1.
            
            On or before Nov 20, 2009 this sequence version replaced
            XM_908279.2, XM_144253.6.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               CX237000.1         1-207
            208-216             CX204487.1         191-199
            217-3827            BC060268.1         1-3611
            3828-3832           CJ217704.1         401-405
FEATURES             Location/Qualifiers
     source          1..3832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 15.92 cM"
     gene            1..3832
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml; Gm444"
                     /note="GRB2 associated regulator of MAPK1 subtype 2"
                     /db_xref="GeneID:242915"
                     /db_xref="MGI:MGI:2685290"
     exon            1..208
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml; Gm444"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2739
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml; Gm444"
                     /note="protein FAM59B; family with sequence similarity 59,
                     member B; GRB2-associated and regulator of MAPK1-like;
                     GRB2-associated and regulator of MAPK protein-like; GRB2
                     associated, regulator of MAPK1-like"
                     /codon_start=1
                     /product="GRB2-associated and regulator of MAPK protein 2"
                     /protein_id="NP_001161351.1"
                     /db_xref="CCDS:CCDS51449.1"
                     /db_xref="GeneID:242915"
                     /db_xref="MGI:MGI:2685290"
                     /translation="MEKLAAGLAGLRWSMGAFPLDLIVSRCRLPTLACLGPGEYAEGV
                     SERDILLIHSCRQWTTVTAHTLEEGHYVIGPKIDIPLQYPGKFKLLEQARDVREPVRY
                     FSSVEEVASVFPDRIFVMEAITFSVKVVSGEFSEDSEVYNFTLHAGDELTLMGQAEIL
                     CAKTTKERSRFTTLLRKLGRAGALAGIGGPGSMGATGGGGGAARPVKSKMPCLICMNH
                     RTNESLSLPFQCQGRFSTRSPLELQMQEGEHTVRAIIERVRLPVNVLVPSRPPRNPYD
                     LHPVREGHCYKLVSIISKTVVLGLALRREGPAPLHFLLLTDTPRFTLPQGLLAGDPRV
                     ERLVRDSASYCRERFDPDEYSTAVREAPAELSDDCASPRHARLCLPAPRAPGAVRAPG
                     PPGRLGPALPAPGDSDQDYVSPDWAGVSEPAGGCAEIPYEELWVHQAPESRADARARP
                     LAGPDLISFGIVGPPRHEPEAPPPPVPPKSEAVKEECRLLHAPPVPPRGGGSCSKLTG
                     SPPVLPHFPKLQPVHSPSSSLSYYSSGLQDGAGSRSGSGSPSPDAYSLYCYPCTWGDC
                     KASESSSRPPPGPLPSTTTQPSQASRGLSEPLSGRTPSLLGADTPVVKNYHSCPPLFK
                     SSRPQKSFAPFGALNPFSGPAHPSGAPAASSSGSISTSGVLATSSPTHSPGPGPGPQG
                     QGYSAAPSSSLSSSEWQEPALEPLDPFELGQASPPELELVRCQEPRAAGAPGSGPCLS
                     PLGQPKAFEPEGLVLRQVPASLSPAALQGPEAGGTLLFLTQGCLEGPPGSPREGATGA
                     GVRDASSWQPPADLSALSLEEVSRSLRFIGLSEDVVSFFARERIDGSIFVQLSEDILA
                     DDFHLTKLQVKKIMQFIKGWRPKI"
     exon            209..349
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml; Gm444"
                     /inference="alignment:Splign:2.1.0"
     exon            350..480
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml; Gm444"
                     /inference="alignment:Splign:2.1.0"
     exon            481..1542
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml; Gm444"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1712
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml; Gm444"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..3832
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml; Gm444"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3797..3802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml; Gm444"
                     /note="hexamer: AATAAA"
     polyA_site      3830
                     /gene="Garem2"
                     /gene_synonym="Fam59b; Gareml; Gm444"
                     /note="major polyA site"
ORIGIN      
        1 cttcggccca ggaggaggtg gtgggcgcgc agcccgagct gcgcgggact ggccgtcggg
       61 gtcccgggac ggcgaacccc ggggagcgcc catgccatgg agaagctggc ggccgggctg
      121 gccgggctgc gctggagcat gggcgctttc ccgctggacc tcatcgtcag ccgctgccgc
      181 ctgcccacgc tcgcctgcct cggaccagga gagtatgctg agggagtcag tgaacgagac
      241 atcctgctga tccactcctg ccgccagtgg actacagtga ctgcccacac cctggaggag
      301 ggccactatg tcattgggcc caagattgac atccccctgc agtacccagg caaattcaag
      361 ctcctggagc aggctcggga cgtgcgggag cctgtaagat acttcagcag cgtggaggag
      421 gtggccagtg tcttccctga ccgaatcttc gtgatggaag ccatcacctt cagtgtcaag
      481 gtggtgtcag gcgagttcag cgaggacagc gaggtgtaca acttcacact gcacgcaggc
      541 gacgagctca ctctcatggg ccaggcggag attctgtgcg ccaagacgac caaggagcgc
      601 tcgcgcttca ccacgctcct gcgcaagctg ggccgtgcag gggccttggc cggaatcggc
      661 ggccccggga gcatgggagc aacagggggt ggcggcgggg ccgccaggcc cgtcaaaagc
      721 aagatgccct gtctcatctg catgaaccac cgcaccaacg agagcctgag cctgcccttc
      781 cagtgccagg gccgattcag cacgcgcagc ccactggagc tgcagatgca ggagggcgag
      841 cacacggtgc gcgccatcat cgagcgcgtg cggctgccgg tgaacgtgct ggtgcccagc
      901 cggccgccgc gcaaccccta cgacctccac ccggtgcggg agggacactg ctacaagctg
      961 gtcagcatca tctccaagac ggtggtgctg gggctggcgc tgcgccgcga gggcccggcg
     1021 ccgctgcact tcctgctgct tacggacacg ccgcgcttca ctctgccgca gggtctgctg
     1081 gccggggacc cgcgcgtcga gcgcctggtg cgcgacagcg cctcctactg ccgcgagcgc
     1141 ttcgatccgg acgaatactc cactgctgtg cgcgaggcgc ccgcggagct ctccgacgac
     1201 tgcgccagcc cgcgccatgc gcgcctctgc ctgcccgcgc cgcgcgcccc cggggccgtc
     1261 cgtgcgcctg gaccgccggg tcgcctgggt cccgctttgc ccgcgcccgg cgacagcgat
     1321 caggattacg tgagccccga ttgggcgggt gtgtccgagc cagcgggcgg ctgcgccgag
     1381 atcccttacg aagagctgtg ggtgcaccaa gcccccgaga gccgcgccga cgcccgtgca
     1441 cggccgctag cggggccgga cctcatctcc ttcgggatcg tggggccccc acggcatgag
     1501 ccagaggcac caccacctcc tgtccctccc aaatccgagg cggtgaagga agagtgccgc
     1561 ctgcttcacg cccctccagt gcctcctagg ggtggcggca gctgcagcaa gctcacaggc
     1621 agccctccgg tgctgcccca ctttcccaag ctgcagcctg tccactcgcc cagctccagt
     1681 ctctcctatt attcctctgg cctgcaggat ggggcaggat cccgcagtgg cagtggctcc
     1741 ccgtcaccgg atgcatactc tctctattgc tacccttgca cctggggaga ctgtaaagcc
     1801 agcgagtcct ctagtcgccc gccacctgga cccctgcctt ctaccaccac ccagcccagc
     1861 caggcctcaa gaggcctatc agagcccctg agtggtcgaa ccccctccct cttgggggct
     1921 gacaccccag tagttaagaa ctaccatagc tgcccacctc tgttcaagtc ctctcgtccc
     1981 cagaagtcct ttgctccctt tggtgcactc aaccccttct ctgggcctgc ccacccttca
     2041 ggtgctccag cggcctcctc ctctgggtcc atatccacct cgggtgtcct ggctacctct
     2101 agccccacac actccccagg cccaggccca ggcccacaag gccaaggtta ctcagctgct
     2161 ccttcctcct ccttgtcatc ctctgagtgg caggagccag ctctggagcc cctggaccca
     2221 tttgagctgg ggcaggccag tcctcctgag ctggagctag tgcgctgtca ggagcccaga
     2281 gctgcggggg cacctgggtc aggaccttgc ctttcaccac ttggtcagcc caaggccttt
     2341 gagcccgaag gtttggtgct gaggcaggtc cctgcctcac tgtcaccagc tgccttgcag
     2401 gggcctgagg caggaggaac cctactcttt ctcacccaag gatgcctgga agggcctcct
     2461 ggcagccccc gggagggagc cacaggtgct ggggtccggg atgcctcctc ctggcagcca
     2521 ccagcagact tgtctgcact ctccctggaa gaggtctccc gtagtctgcg cttcattggg
     2581 ctctcagagg acgtggtgag cttctttgcc cgagaacgca tcgacggaag catctttgtg
     2641 cagctcagtg aagacatctt ggctgacgac ttccatctca ccaagcttca ggtcaagaaa
     2701 atcatgcaat tcatcaaagg ttggagaccc aagatctgaa ccagccagcc aggtgctgca
     2761 cagcctcaac tttgggagca gaggccctgt ggggttaact tgggtctgcc agaaacagtg
     2821 cttcccgcag ggaaaatctg ggtcaagatg gaggctgctc tggaacactg agtgtttcaa
     2881 gggagaaaga gtgggaaccg tggccctttg gggccagacc ctgcaggagc ttgcctcgcc
     2941 tttgaggagg aggcactgct cttcaggtgc cctggagggg cttttagtgc catccccaca
     3001 gcagagtaaa ggtggcgcgt atgtcatcgg gtggctttgc gctggtagaa cgctgttctc
     3061 taccctgctg cagcctttca cactcacaca cacacccaaa cacacacttc tcggccctgt
     3121 atgttcaggt gagagacaag ggaagatggc tcatcatttt cagccatgtc cccaaagtgg
     3181 cctctctttc atgctctgtg ggctttggcc tgcagctgtt ccagagttag ggatgtgatt
     3241 tttgtctgtg aggtacccct tgccctagtg gatcagttac aggcctatgt ccagcaccag
     3301 agtccctgtt ccgatatcat cacagatagc ctgttgtttt ccacagagga gccagatgta
     3361 agtcagacac ctccagccta ccagtctcct gccatcagct ttggctctaa tgggctcttg
     3421 gtggcctcct tggtgtgtca ctggtacagg acagcaagtg gctcagaaag gctgcttgct
     3481 cctgagctca gccacttatt cacatggttc agagcagatc tttgtactct tcagactcaa
     3541 gtatggtgat ctgtttgaca gtagaggtct ggcctacccc tcaccctcat tctccagcac
     3601 ctctaacaag aaccacactc atgcctctgg tgtcagtttt cttgtctgcc ttccctggcc
     3661 tacctagata tttatttctt gtgttttatg aatagttaag ccctgcccat ctgtgccttt
     3721 cagacggaaa cacagaaacc taggctgtgc catttgtctt ctcacagttg tttaatgaaa
     3781 cctcaaggaa tatggaaata aaggctagac cctggagtgg tgaaagagta gg
//
