LOCUS       NM_001033445            4783 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus GRB2 associated regulator of MAPK1 subtype 1 (Garem1),
            mRNA.
ACCESSION   NM_001033445 XM_355044 XM_897999 XM_904964 XM_919098
VERSION     NM_001033445.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4783)
  AUTHORS   Nishino T, Abe T, Kaneko M, Yokohira M, Yamakawa K, Imaida K and
            Konishi H.
  TITLE     GAREM1 is involved in controlling body mass in mice and humans
  JOURNAL   Biochem Biophys Res Commun 628, 91-97 (2022)
   PUBMED   36084556
  REMARK    GeneRIF: GAREM1 is involved in controlling body mass in mice and
            humans.
REFERENCE   2  (bases 1 to 4783)
  AUTHORS   Taniguchi T, Tanaka S, Ishii A, Watanabe M, Fujitani N, Sugeo A,
            Gotoh S, Ohta T, Hiyoshi M, Matsuzaki H, Sakai N and Konishi H.
  TITLE     A brain-specific Grb2-associated regulator of extracellular
            signal-regulated kinase (Erk)/mitogen-activated protein kinase
            (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of
            neuroblastoma cells by regulating Erk signaling
  JOURNAL   J Biol Chem 288 (41), 29934-29942 (2013)
   PUBMED   24003223
  REMARK    GeneRIF: Data indicate that a subtype of GAREM, GAREM2, is
            specifically expressed in the mouse, rat, and human brain.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158774.6, AK148318.1 and AC127570.4.
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_001033445.3.
            
            On Mar 30, 2007 this sequence version replaced NM_001033445.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148318.1, SRR1660817.240349.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-368               AC158774.6         85958-86325         c
            369-1338            AK148318.1         370-1339
            1339-1935           AC127570.4         96029-96625
            1936-2323           AK148318.1         1937-2324
            2324-4783           AC127570.4         114556-117015
FEATURES             Location/Qualifiers
     source          1..4783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 11.87 cM"
     gene            1..4783
                     /gene="Garem1"
                     /gene_synonym="Fam59a; Garem; Gm944; mKIAA4238"
                     /note="GRB2 associated regulator of MAPK1 subtype 1"
                     /db_xref="GeneID:381126"
                     /db_xref="MGI:MGI:2685790"
     exon            1..490
                     /gene="Garem1"
                     /gene_synonym="Fam59a; Garem; Gm944; mKIAA4238"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..3000
                     /gene="Garem1"
                     /gene_synonym="Fam59a; Garem; Gm944; mKIAA4238"
                     /note="protein FAM59A; family with sequence similarity 59,
                     member A; GRB2-associated and regulator of MAPK1; GRB2
                     associated, regulator of MAPK1"
                     /codon_start=1
                     /product="GRB2-associated and regulator of MAPK protein"
                     /protein_id="NP_001028617.2"
                     /db_xref="CCDS:CCDS29091.1"
                     /db_xref="GeneID:381126"
                     /db_xref="MGI:MGI:2685790"
                     /translation="MDPAPSLGCSLKDVKWSPVAMPLDLLVSTYRLPQIARLDSGECV
                     EGLRENDFLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGQFKLLEQDRDIKEP
                     VQYFNSVEEVAKAFPERVYVMEEITFNVKVASGECNEDTEVYNITLCTGDELTLMGQA
                     EILYAKTFKEKSRLNTIFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGR
                     FSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNI
                     QTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHQVKGDMWPETLVHHWLGICQEQF
                     DIDEYSRAVRDVKTDWNEDCKSPKKGRCSGHNHLPNSLSYARDELTQSFHRLSVCVYG
                     NNLHGNSEVNLHGCRDLGGEWAPFPHDILPYQDSGDSGSDYLFPEANEESAGIPGKTE
                     VPYEELWLEEGKPSRQPLTRSLSEKSRCDTLRGSTRSTCAPSSPPTPATLGATIKSSE
                     IALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPSIPPRTVKPVRPQTRSPSP
                     TLSYYSSGLHNIITQSDTSPPNSAPVSCYPCTRVKSDSVDPKSPFGSPSAEALSSRLS
                     WPNHYSGASENQTRSDFLLDPSRSYSYPRQKTPGTPKRTCPAPFDFEGCELLGSPPST
                     TSAEFSSSGVPSCPKSASYCLENSEDNSFAAGMTKQSVSCPALPPRAPKPVEQKATPE
                     TSPLPLKIDGAEEDPTAGSLDLSEDQYFVRKGMQDIFSVSYPFSSPLHLQLAPRSCGD
                     GSPWQPPADLSGLSIEEVSKSLRFIGLSEDVIAFFVTEKIDGNLLVQLTEEILSEDFK
                     LSKLQVKKILQFINGWRPKI"
     exon            491..631
                     /gene="Garem1"
                     /gene_synonym="Fam59a; Garem; Gm944; mKIAA4238"
                     /inference="alignment:Splign:2.1.0"
     exon            632..762
                     /gene="Garem1"
                     /gene_synonym="Fam59a; Garem; Gm944; mKIAA4238"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1935
                     /gene="Garem1"
                     /gene_synonym="Fam59a; Garem; Gm944; mKIAA4238"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2102
                     /gene="Garem1"
                     /gene_synonym="Fam59a; Garem; Gm944; mKIAA4238"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..4783
                     /gene="Garem1"
                     /gene_synonym="Fam59a; Garem; Gm944; mKIAA4238"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcagtgcc gggagcgctg ctatggcgtt cctcggaccc gcggctccac ctcacactgg
       61 gctcgaggcg gaggctagga gagggccgag gaggaggagg cgggcggctg gccgccgcaa
      121 ttgcagagcc ggggccaagg gaggcggagg cggagcggga gccgccgcaa ccagcccggc
      181 cgcctgcagt gctcccctgg cttgagggcg cggggcgcca gccatgcctc ggtgtggcca
      241 ctgaagccgg gcgccggcgt ccccgccgct gtgcctcgct gtccggctgc ccgcggcggg
      301 agtacggagc cgccagccag ccagcggtgg cgcgagcgcg ggagcgcggg gcaggaggag
      361 gcggggaaga tggacccggc tccctcgttg ggttgcagcc tcaaggatgt gaagtggagc
      421 ccagtggcca tgccgctcga cctgctggtc agcacctacc ggctgcccca gatcgcgcgg
      481 ctggacagcg gagaatgcgt ggaagggctt cgggagaatg atttcctgct gatccattca
      541 tgccggcagt ggacgaccat cactgcccat agcctggaag aaggtcacta tgtcattggg
      601 ccaaagatag agatccctgt acattatgca ggacaattca agctgctgga acaagaccgg
      661 gatataaagg agccggtgca atatttcaac agcgtggagg aagtggccaa agcatttcct
      721 gaacgtgtgt acgtcatgga ggagattaca ttcaacgtga aggtggcgtc gggtgaatgc
      781 aatgaagaca ctgaagttta caacatcacc ctgtgcaccg gggatgaact caccctaatg
      841 gggcaggcag aaatccttta tgcaaagacc ttcaaggaga agtcacgtct caacaccatc
      901 ttcaaaaaga ttgggaagct caattccatc agcaagctgg ggaaaggcaa aatgccctgc
      961 ctcatttgca tgaatcaccg gaccaatgaa agcatcagcc ttccattcca gtgcaagggc
     1021 agatttagca cccgaagtcc cctggaactt cagatgcagg aaggggaaca caccatccga
     1081 aacatcgtgg agaagactcg actccccgtg aatgtgacag tgcccagtcc cccacccaga
     1141 aatccctatg acctccactt cattagagag gggcaccgct acaagtttgt gaacatccag
     1201 accaagacag tggtggtttg ttgtgtgctg cgcaacaaca agatcctccc catgcacttc
     1261 cctttgcact tgactgtccc caagttcagc ctcccggaac accaggtgaa gggagacatg
     1321 tggccagaaa cactagtcca tcactggctt ggtatctgcc aagagcagtt tgacatcgat
     1381 gagtattcac gggctgtgcg tgatgtgaaa acggactgga atgaagactg caagagcccc
     1441 aaaaagggcc gctgctctgg ccacaaccat ttacccaatt ccctcagcta tgcccgcgat
     1501 gagctcaccc agtccttcca ccgactctca gtctgtgtgt atggcaacaa tctccatggc
     1561 aatagtgagg tgaatctcca tggctgcagg gaccttgggg gagagtgggc cccttttccc
     1621 catgatatcc ttccctatca agactctggt gacagtggga gcgactacct tttcccggaa
     1681 gctaatgagg agtcagcggg catcccgggg aaaacagaag ttccctatga agagctgtgg
     1741 ctggaggaag gcaagcccag ccgccagcct ctcactcgct cactcagtga gaagagcagg
     1801 tgcgacacct tgagaggctc cacgaggtcc acgtgtgcac cctcttctcc tcccacccct
     1861 gcgaccctgg gagccacaat taagtcttca gaaatcgccc tacctccacc tccagtgcct
     1921 cccaaatctg aagctgtcag ggaagaatgc cggctcctga acgccccacc tgtgccgccc
     1981 cgaagtgcaa agcctttgtc cacaagtccc tccatccctc ctcgaacagt caagccagtc
     2041 cggccacaga cgagatctcc aagccccacc ctgtcttact attcttcagg actgcataac
     2101 atcatcactc agagtgatac aagtcctccc aacagtgccc ctgtgtcctg ctacccctgc
     2161 acccgagtga agagtgactc tgtggacccc aagtccccat ttggaagtcc ttccgctgaa
     2221 gctctgtcct cccggctctc atggcccaac cattactcag gagcatcgga gaaccagaca
     2281 aggagtgact ttctgctcga tccgagcagg agctacagct accccagaca gaagacacct
     2341 ggcacaccaa agagaacctg cccagcccct tttgattttg agggttgcga gctcctgggc
     2401 agcccaccca gcacgacctc tgcagagttc agtagcagcg gtgtccccag ttgccccaag
     2461 tcggccagct actgtctgga gaactccgag gacaactcct ttgcagctgg catgaccaag
     2521 cagagcgtct cctgccctgc cttaccccca agggccccaa agccagtgga acagaaagcc
     2581 acccctgaaa catctccttt gcctctgaaa attgatggtg ctgaggagga ccccacagca
     2641 gggtcactgg acctctcgga ggaccagtat tttgtcagaa agggcatgca ggacatcttc
     2701 tctgtctctt accctttctc atctccgctc cacctccagc tggcccccag atcctgtggg
     2761 gatggttccc cgtggcagcc acccgctgac ctatcaggac tctctataga ggaagtgtcc
     2821 aagtctttgc ggttcattgg tttgtctgaa gacgtcatag ccttctttgt cactgaaaag
     2881 atcgatggga atttgcttgt tcaattaaca gaagagatcc tctcagagga tttcaaacta
     2941 agcaaactac aggtaaagaa aatactgcag tttattaatg gctggaggcc caagatatag
     3001 ccaaatggcc ccatccgtca tgagacagag ctaagaagcg cgtgctggaa ggggtgggct
     3061 aggacacaga ttcatgtttt tgcacttaaa acaaacaaaa caaaacaaaa ccttctctgt
     3121 atatagagat aagagaaagt cttactatgc agattccgtt tccgaatggt gaacaggcta
     3181 ttttgtacat caataaagat gctatacaga acacttagag gtgtgccttg tacgtcactc
     3241 aacattcaac agctgctaaa agaactaaag tcatatccag agaactcatt tgtaccccta
     3301 ataggtcttg gagaaggcat ggtatttatt acaaaacagc caaagctgaa acacataaac
     3361 acttgtgagc agttcgcttc ctggggagtc aacggtggac agtccattgt attctgcagc
     3421 tcgctttgct tcctgccagc tgttttcctc ctgtgcctgg tgatgtgagt ggtgtgaaat
     3481 gacactttaa tgttccatgc ttggtggaga tctttttatc aaaaggcatt ttccaaaaaa
     3541 tcatgttttg atagaggata tctggtgtcc ttaggaatga cacaaatcat gaccattaca
     3601 tttgatctgt aactgctgct agtttcatgg agcagaggaa aagaaaaaaa aaaaaaaggc
     3661 atgtgtgtgt atgcacatag atgtgtttta atgtagtttt ttaatctgat atttttagat
     3721 aatatctttt tactttataa tatccactga ggttcccagg ctttgaactg aatggattcg
     3781 ctcaaaaaca gttggcgtaa cgatcccaaa gagtctcaga acctgaactt taaagctcag
     3841 cctcctaggc tccagccctg aaaactcaga agcagtcggg aaagattctg ttgaagaatt
     3901 taatgtgctc tgtaagcccg tgggaggact gactcttgca tatctgtgct gacatttggg
     3961 gaaatgacag ctgctttgga accttcatcc tgtcctcctg tgtgcccccg tgaaaggtct
     4021 gaaaagcctt tctccaaaat gtgaggtctg ctcagcacgc ctcttgtgtt aggaaacctt
     4081 gtgactcaga cagaccacct ctctattcta gatgccatat ctctgcactg attcctaaga
     4141 taccaataag agtacttgct aattccatcg tcgacctctt tctcctcttg taaaacacag
     4201 taactatcat tcatattctg agaattccag aacatgtcca aggattttcc taaatgtggc
     4261 taaatacccc aactatacca tcactttttt tctcttgact gtttgaaggc atataacctc
     4321 aaagagttcc attttttttc tgagcaacat atcctccaca tagtccatga gtctatcccc
     4381 agattctcac cggacagaca gacatcctgg tagtgagatg cacacctgag ctgctcaggt
     4441 gagattgttt gaccaccagg agtcagtgta tcccgaacag atgaccccat tttgtcatgt
     4501 cttcctgttc cccaaaaaga agaaacaccc gccagtctgg gtttccagcc gagtgaaata
     4561 tgtcattatt tctggccatt agagatctac ttaattccat cttctgatct agaattggga
     4621 tgaattgata ctttgtctaa tttctcacct ctgatctcat tactaagaaa tggcttttat
     4681 cccttcctaa catacaatcc aaatgtaaat actacactgc aagtagcaag aatcaaacag
     4741 gcagctggaa tgcttccgga gtcagcaatg aatctgtgaa gtt
//
