LOCUS       NM_008060               3915 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus alpha glucosidase 2 alpha neutral subunit (Ganab),
            transcript variant 1, mRNA.
ACCESSION   NM_008060
VERSION     NM_008060.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3915)
  AUTHORS   Geng,G., Xiao,Y., Zhang,Y., Shen,W., Liu,J., Zhu,F., Wang,X.,
            Wu,J., Liu,R., Cai,G., Bai,X., Li,Q. and Chen,X.
  TITLE     Ganab Haploinsufficiency Does Not Cause Polycystic Kidney Disease
            or Polycystic Liver Disease in Mice
  JOURNAL   Biomed Res Int 2020, 7469428 (2020)
   PUBMED   32550232
  REMARK    GeneRIF: Ganab Haploinsufficiency Does Not Cause Polycystic Kidney
            Disease or Polycystic Liver Disease in Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3915)
  AUTHORS   Rohacek,A.M., Bebee,T.W., Tilton,R.K., Radens,C.M.,
            McDermott-Roe,C., Peart,N., Kaur,M., Zaykaner,M., Cieply,B.,
            Musunuru,K., Barash,Y., Germiller,J.A., Krantz,I.D., Carstens,R.P.
            and Epstein,D.J.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   3  (bases 1 to 3915)
  AUTHORS   Caputo,A.T., Alonzi,D.S., Marti,L., Reca,I.B., Kiappes,J.L.,
            Struwe,W.B., Cross,A., Basu,S., Lowe,E.D., Darlot,B., Santino,A.,
            Roversi,P. and Zitzmann,N.
  TITLE     Structures of mammalian ER alpha-glucosidase II capture the binding
            modes of broad-spectrum iminosugar antivirals
  JOURNAL   Proc Natl Acad Sci U S A 113 (32), E4630-E4638 (2016)
   PUBMED   27462106
REFERENCE   4  (bases 1 to 3915)
  AUTHORS   Revil,T., Gaffney,D., Dias,C., Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Alternative splicing is frequent during early embryonic development
            in mouse
  JOURNAL   BMC Genomics 11, 399 (2010)
   PUBMED   20573213
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3915)
  AUTHORS   Sidman,R.L., Taksir,T., Fidler,J., Zhao,M., Dodge,J.C.,
            Passini,M.A., Raben,N., Thurberg,B.L., Cheng,S.H. and
            Shihabuddin,L.S.
  TITLE     Temporal neuropathologic and behavioral phenotype of 6neo/6neo
            Pompe disease mice
  JOURNAL   J Neuropathol Exp Neurol 67 (8), 803-818 (2008)
   PUBMED   18648322
  REMARK    GeneRIF: progression of neuropathologic and Behavioral
            abnormalities in a Pompe disease mouse model (6neo/6neo) that
            displays many features of the human disease
REFERENCE   6  (bases 1 to 3915)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (bases 1 to 3915)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3915)
  AUTHORS   Baldwin,T.A., Gogela-Spehar,M. and Ostergaard,H.L.
  TITLE     Specific isoforms of the resident endoplasmic reticulum protein
            glucosidase II associate with the CD45 protein-tyrosine phosphatase
            via a lectin-like interaction
  JOURNAL   J Biol Chem 275 (41), 32071-32076 (2000)
   PUBMED   10921916
REFERENCE   9  (bases 1 to 3915)
  AUTHORS   Arendt,C.W., Dawicki,W. and Ostergaard,H.L.
  TITLE     Alternative splicing of transcripts encoding the alpha- and
            beta-subunits of mouse glucosidase II in T lymphocytes
  JOURNAL   Glycobiology 9 (3), 277-283 (1999)
   PUBMED   10024665
REFERENCE   10 (bases 1 to 3915)
  AUTHORS   Arendt,C.W. and Ostergaard,H.L.
  TITLE     Identification of the CD45-associated 116-kDa and 80-kDa proteins
            as the alpha- and beta-subunits of alpha-glucosidase II
  JOURNAL   J Biol Chem 272 (20), 13117-13125 (1997)
   PUBMED   9148925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129217.3.
            
            On Dec 23, 2021 this sequence version replaced NM_008060.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: U92793.1, BC128069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC129217.3         130907-130958
            53-157              AC129217.3         135063-135167
            158-266             AC129217.3         135321-135429
            267-394             AC129217.3         137734-137861
            395-574             AC129217.3         140014-140193
            575-640             AC129217.3         140650-140715
            641-710             AC129217.3         141477-141546
            711-798             AC129217.3         141720-141807
            799-895             AC129217.3         141890-141986
            896-1076            AC129217.3         142232-142412
            1077-1230           AC129217.3         143265-143418
            1231-1466           AC129217.3         143507-143742
            1467-1593           AC129217.3         143834-143960
            1594-1673           AC129217.3         144076-144155
            1674-1817           AC129217.3         144395-144538
            1818-1914           AC129217.3         144663-144759
            1915-2016           AC129217.3         145273-145374
            2017-2260           AC129217.3         145510-145753
            2261-2325           AC129217.3         147100-147164
            2326-2402           AC129217.3         147341-147417
            2403-2477           AC129217.3         147501-147575
            2478-2591           AC129217.3         147724-147837
            2592-2704           AC129217.3         147957-148069
            2705-2805           AC129217.3         148203-148303
            2806-3915           AC129217.3         148424-149533
FEATURES             Location/Qualifiers
     source          1..3915
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.96 cM"
     gene            1..3915
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /note="alpha glucosidase 2 alpha neutral subunit"
                     /db_xref="GeneID:14376"
                     /db_xref="MGI:MGI:1097667"
     exon            1..52
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            53..157
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            158..266
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            267..394
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            395..574
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            575..640
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            641..710
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            711..798
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            799..895
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1076
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1230
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1466
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1593
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1673
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1817
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1914
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2016
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2260
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2325
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2402
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2477
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2591
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2704
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2805
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..3915
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3823..3828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /note="hexamer: AATAAA"
     regulatory      3835..3840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /note="hexamer: AACAAA"
     polyA_site      3847
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /note="major polyA site"
     polyA_site      3853
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
     regulatory      3897..3902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
                     /note="hexamer: AGTAAA"
     polyA_site      3915
                     /gene="Ganab"
                     /gene_synonym="G2an; GluII; mKIAA0088"
ORIGIN      
        1 aaacccggta caagatggcg gcaatagcgg cagtggcggc gcgtaggagg cggtcttggt
       61 taagtttggt gctggcatac ttaggggtct gtctggggat tacacttgct gtggatagaa
      121 gcaactttaa gacctgtgat gagagttcct tttgcaaacg gcagcgaagc attcggccag
      181 gcctctctcc ttaccgtgcc ttgctggaca ctctgcagct tggtcctgat gctcttacag
      241 tccatctgat ccatgaagtc accaaggtgc tgcttgtgct ggagctccag ggccttcaga
      301 agaacatgac tcggatcagg atcgatgagc tagagccccg gcggcctcga taccgagtgc
      361 cagatgtttt agtggctgac ccccccacag ctaggctttc agtctctggc cgtgatgaca
      421 acagtgtgga gctaacagtg gctgagggac cctacaaaat cattttgaca gcacagccat
      481 tccgccttga cctgctagaa gatcgaagcc tcctgctcag tgtcaatgcc cgaggactta
      541 tggcctttga gcaccagagg gcccccaggg tccctttctc ggataaagtt agtctcgcgc
      601 tcggtagcgt gtgggataag atcaagaacc ttttctctag gcaagaatca aaagacccag
      661 ctgaaggcaa tggagcccag cctgaagcaa cacctgggga tggtgacaag ccagaggaga
      721 cccaggaaaa ggctgagaag gatgagccag gagcctggga ggagacattc aaaacacatt
      781 ctgacagcaa gccttatggc cccacgtctg taggtttgga cttttctctg ccaggaatgg
      841 aacatgtgta tgggatccct gagcatgctg acagcctgag actgaaggtc actgagggcg
      901 gtgagccgta ccgcctgtac aatttggatg tgttccagta tgagctgaac aaccccatgg
      961 ctctatatgg gtctgtgcct gtgctcctgg cacacagctt tcatcgagac ctgggcatct
     1021 tctggcttaa tgctgctgag acttgggttg atatatcctc caacacggct gggaagaccc
     1081 tgtttgggaa gatgcttgat tacctgcagg gctctgggga gactccacag acagacattc
     1141 gttggatgtc agagagtggc attattgatg ttttcctaat gcttggccct tcggtttttg
     1201 atgtctttag gcagtatgct agtctcacag ggacccaggc attgccccca ctcttctccc
     1261 tcggctatca ccagagtcgc tggaactacc gggatgaggc tgatgttttg gaagtggatc
     1321 agggttttga tgatcacaac atgccttgtg atgtcatttg gttggacatt gaacatgctg
     1381 atggcaagcg gtacttcact tgggacccca cccgatttcc tcagcccctc aatatgcttg
     1441 agcacttggc ttccaagagg cggaagctgg tggccattgt ggacccccac atcaaggtag
     1501 actctggcta ccgagttcac gaagaattgc gaaaccatgg gctgtatgtt aaaactcggg
     1561 atggctctga ttacgagggc tggtgctggc caggctcagc tagttaccct gacttcacta
     1621 atccaaggat gagggcctgg tggtctaaca tgttcagctt tgacaattat gagggttcag
     1681 ctcctaatct ttatgtttgg aatgacatga atgaaccgtc tgtgttcaat ggtcctgagg
     1741 tcaccatgtt gaaggatgct gtgcattatg gaggctggga gcaccgggac atccataaca
     1801 tctatggctt atatgtgcac atggcgactg ctgatgggct aatacagcgc tctgggggca
     1861 tagagcgtcc ctttgtcctg agtagggctt tcttctcagg ctcccagcgc tttggagctg
     1921 tgtggacagg ggacaacact gccgaatggg atcatttgaa gatctctatc cctatgtgtc
     1981 tcagcctggc actggtgggg ctttccttct gtggagcgga tgtgggtggc ttcttcaaga
     2041 acccagagcc agagctgctt gtgcgctggt accaaatggg tgcctaccag ccgttctttc
     2101 gggctcatgc ccacttggac actgggcggc gagagccatg gctgttagcg tctcaatacc
     2161 aagatgcaat ccgagatgcc ttgttccagc gatattcttt gctgcccttc tggtataccc
     2221 tcttctatca agctcacaag gaagggtttc ctgtcatgag gcccctctgg gtacagtatc
     2281 ctgaggatat gtctaccttc agtatagagg atcagttcat gcttggtgat gcactcctta
     2341 ttcaccctgt atcggatgct ggggcccacg gagtgcaggt ctatttgcct ggccaagaag
     2401 aagtgtggta tgacattcag agctatcaga agcatcatgg gccccagacc ttgtatctgc
     2461 cagtaacttt gagcagtatc cccgtgttcc agcgtggcgg aaccattgtg cctcgatgga
     2521 tgcgtgtgag gcgctcttca gactgtatga aggacgatcc tatcactctc tttgttgctc
     2581 tcagtcccca gggtactgcc caaggagagc tctttctaga tgatggacac acctttaact
     2641 atcagactcg ccatgagttc ctgttgcggc ggttctcttt ctctggcagc acactggtct
     2701 ctagttcagc agaccccaaa ggccaccttg agacacctat ttggattgag cgagtagtca
     2761 tcatgggggc tggaaagcca gcagctgtgg tgctccagac caaaggatcc cctgaaagtc
     2821 gcctgtcctt ccagcatgac cctgagacct cagtgctgat attgcgtaaa cctggtgtca
     2881 gcgtggcatc cgactggagt attcatcttc gataacccaa ggaacttgtt ctgagttggg
     2941 aggaagggca tgatggtatt gagttacctt ttcttttgcc ttggagtttg accctaccta
     3001 gatttcacct tctaattcta cgacccagat tctgtcaaca tctgggcaag atgacagggc
     3061 tgtcctaggg ctctgaattc cacttgtgac ctagtctttc cttctgtgtg ttaccaagcc
     3121 cttcatactc agtatcctgt tgctgtaact ggagcacagt catttgtgaa gaccaagggg
     3181 ccttgtcgtt ctttttctct tccttagggt ccctaccttc tccttagacc ccatctattc
     3241 aagcctcttg tttgttgatg ccatttcttg gaagaagatg agggcagtga acattagggt
     3301 tccttttctt cttccctgtt ccctcctatc caaaatgccc atcctttcat tccttcccct
     3361 gaatgtcccc ttctctgttc cactgataca ctgggaccac cccttacttg gtaagggaca
     3421 aatggatcaa gattgaggtt cctggagaac gtcctcttcc ttctcatctc aaccttgtct
     3481 tcctgtttct ttccagagct gctgcatttc tcccatctta gagggagacg cttccacaca
     3541 attaggaggg caaggttatt aaacttcttt tgcccctctg gtccccttgg gacactcaag
     3601 atagagacat gagttgtggt ttcactgaat cacggtcacc tgtatttatt gctgggaaga
     3661 agactgaggg tggggggaga cgatcatgtg tacccagggg tggcttcaag ccctggtaag
     3721 cgggttgagg gaggactcag gaaccaggag aactatttgt gggaattttt tttacttcct
     3781 ctgggttccc aactgtgaca agttttgata aaaaggagaa acaataaaaa acgaaacaaa
     3841 acataaataa taattggatg tctgaattat acttgtaaac tgaacaaaat cgctccagta
     3901 aatagtggcc tacca
//
