LOCUS       NM_010255               1004 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus guanidinoacetate methyltransferase (Gamt), transcript
            variant 1, mRNA.
ACCESSION   NM_010255
VERSION     NM_010255.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1004)
  AUTHORS   Kuribayashi,S., Fukuhara,S., Kitakaze,H., Tsujimura,G., Imanaka,T.,
            Ueda,N., Takezawa,K., Ikawa,M. and Nonomura,N.
  TITLE     Intratesticular creatine maintains spermatogenesis by defining
            tight junctions
  JOURNAL   Sci Rep 14 (1), 30692 (2024)
   PUBMED   39730393
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1004)
  AUTHORS   Bejarano,E., Whitcomb,E.A., Pfeiffer,R.L., Rose,K.L., Asensio,M.J.,
            Rodriguez-Navarro,J.A., Ponce-Mora,A., Canto,A., Almansa,I.,
            Schey,K.L., Jones,B.W., Taylor,A. and Rowan,S.
  TITLE     Unbalanced redox status network as an early pathological event in
            congenital cataracts
  JOURNAL   Redox Biol 66, 102869 (2023)
   PUBMED   37677999
REFERENCE   3  (bases 1 to 1004)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1004)
  AUTHORS   Rossi,L., Nardecchia,F., Pierige,F., Ventura,R., Carducci,C.,
            Leuzzi,V., Magnani,M., Cabib,S. and Pascucci,T.
  TITLE     Intellectual Disability and Brain Creatine Deficit: Phenotyping of
            the Genetic Mouse Model for GAMT Deficiency
  JOURNAL   Genes (Basel) 12 (8), 1201 (2021)
   PUBMED   34440375
  REMARK    GeneRIF: Intellectual Disability and Brain Creatine Deficit:
            Phenotyping of the Genetic Mouse Model for GAMT Deficiency.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1004)
  AUTHORS   Branovets,J., Karro,N., Barsunova,K., Laasmaa,M., Lygate,C.A.,
            Vendelin,M. and Birkedal,R.
  TITLE     Cardiac expression and location of hexokinase changes in a mouse
            model of pure creatine deficiency
  JOURNAL   Am J Physiol Heart Circ Physiol 320 (2), H613-H629 (2021)
   PUBMED   33337958
REFERENCE   6  (bases 1 to 1004)
  AUTHORS   Schmidt,A., Marescau,B., Boehm,E.A., Renema,W.K., Peco,R., Das,A.,
            Steinfeld,R., Chan,S., Wallis,J., Davidoff,M., Ullrich,K.,
            Waldschutz,R., Heerschap,A., De Deyn,P.P., Neubauer,S. and
            Isbrandt,D.
  TITLE     Severely altered guanidino compound levels, disturbed body weight
            homeostasis and impaired fertility in a mouse model of
            guanidinoacetate N-methyltransferase (GAMT) deficiency
  JOURNAL   Hum Mol Genet 13 (9), 905-921 (2004)
   PUBMED   15028668
REFERENCE   7  (bases 1 to 1004)
  AUTHORS   Gu,G., Wells,J.M., Dombkowski,D., Preffer,F., Aronow,B. and
            Melton,D.A.
  TITLE     Global expression analysis of gene regulatory pathways during
            endocrine pancreatic development
  JOURNAL   Development 131 (1), 165-179 (2004)
   PUBMED   14660441
REFERENCE   8  (bases 1 to 1004)
  AUTHORS   Chae,Y.J., Chung,C.E., Kim,B.J., Lee,M.H. and Lee,H.
  TITLE     The gene encoding guanidinoacetate methyltransferase (GAMT) maps to
            human chromosome 19 at band p13.3 and to mouse chromosome 10
  JOURNAL   Genomics 49 (1), 162-164 (1998)
   PUBMED   9570966
REFERENCE   9  (bases 1 to 1004)
  AUTHORS   Jenne,D.E., Olsen,A.S. and Zimmer,M.
  TITLE     The human guanidinoacetate methyltransferase (GAMT) gene maps to a
            syntenic region on 19p13.3, homologous to band C of mouse
            chromosome 10, but GAMT is not mutated in jittery mice
  JOURNAL   Biochem Biophys Res Commun 238 (3), 723-727 (1997)
   PUBMED   9325156
REFERENCE   10 (bases 1 to 1004)
  AUTHORS   Lee,H., Ogawa,H., Fujioka,M. and Gerton,G.L.
  TITLE     Guanidinoacetate methyltransferase in the mouse: extensive
            expression in Sertoli cells of testis and in microvilli of caput
            epididymis
  JOURNAL   Biol Reprod 50 (1), 152-162 (1994)
   PUBMED   8312439
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA222404.1, AC140229.3, AK140688.1, AK158087.1 and BE992264.1.
            
            On Nov 16, 2016 this sequence version replaced NM_010255.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049233.1, AK158087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AA222404.1         1-43
            44-44               AC140229.3         111122-111122       c
            45-570              AK140688.1         2-527
            571-981             AK158087.1         470-880
            982-1004            BE992264.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1004
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1004
                     /gene="Gamt"
                     /gene_synonym="Spintz1"
                     /note="guanidinoacetate methyltransferase"
                     /db_xref="GeneID:14431"
                     /db_xref="MGI:MGI:1098221"
     exon            1..292
                     /gene="Gamt"
                     /gene_synonym="Spintz1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..822
                     /gene="Gamt"
                     /gene_synonym="Spintz1"
                     /EC_number="2.1.1.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     guanidinoacetate N-methyltransferase"
                     /codon_start=1
                     /product="guanidinoacetate N-methyltransferase isoform 1"
                     /protein_id="NP_034385.1"
                     /db_xref="CCDS:CCDS35976.1"
                     /db_xref="GeneID:14431"
                     /db_xref="MGI:MGI:1098221"
                     /translation="MSSSAASPLFAPGEDCGPAWRAAPAAYDASDTHLQILGKPVMER
                     WETPYMHALAAAAASRGGRVLEVGFGMAIAASRVQQAPIEEHWIIECNDGVFQRLQDW
                     ALRQPHKVVPLKGLWEEVAPTLPDGHFDGILYDTYPLSEEAWHTHQFNFIKNHAFRLL
                     KTGGVLTYCNLTSWGELMKSKYTDITTMFEETQVPALQEAGFLKENICTEVMALVPPA
                     DCRYYAFPQMITPLVTKH"
     exon            293..438
                     /gene="Gamt"
                     /gene_synonym="Spintz1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..502
                     /gene="Gamt"
                     /gene_synonym="Spintz1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..570
                     /gene="Gamt"
                     /gene_synonym="Spintz1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..681
                     /gene="Gamt"
                     /gene_synonym="Spintz1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..988
                     /gene="Gamt"
                     /gene_synonym="Spintz1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      966..971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gamt"
                     /gene_synonym="Spintz1"
                     /note="hexamer: AATAAA"
     polyA_site      985
                     /gene="Gamt"
                     /gene_synonym="Spintz1"
                     /note="major polyA site"
ORIGIN      
        1 cccacttgag tgcaaggcta atctctgtgc agaggcaccg ccccactccg cctccaccgg
       61 ccccgcggct ccgcagccct gcgctcccgg cctggtttgc acagcctcac catgagctct
      121 tctgcagcta gcccgctctt cgcgcccggc gaggactgcg gccccgcgtg gcgcgcggcc
      181 cccgcggcct atgacgcgtc tgacacgcac ctgcaaatcc tgggcaagcc agtgatggag
      241 cgttgggaga ccccctatat gcatgcgcta gcggcggctg ctgcctccag agggggccgg
      301 gtcttggaag tgggcttcgg tatggccatt gcagcctcca gggtgcaaca ggcccccata
      361 gaggaacact ggattattga gtgcaatgat ggggtcttcc agcgtctaca agactgggcc
      421 ctgcggcagc cacataaggt tgttcccttg aaaggcctgt gggaggaggt ggcacctacc
      481 ctgcctgacg gtcactttga tgggattcta tatgacacgt acccgctgtc tgaagaggcc
      541 tggcacactc accagttcaa ctttattaag aatcatgcct tccgcttgct gaagaccggg
      601 ggcgtcctca cctactgcaa cctcacgtcc tggggggagc tcatgaagtc caaatacaca
      661 gacatcacca ccatgtttga ggagacgcag gtgcctgcac tgcaggaagc tggcttcctg
      721 aaagaaaaca tctgcacaga ggtgatggca ctggtgcccc cagccgactg ccgctactat
      781 gccttccctc agatgatcac acccctggtc accaagcact gagcagccgg cccaggtcta
      841 caaggagcct gtgtcctcct cagtaccttt gtggctggat tgtgggctcc agcctctcca
      901 ctgtccctca gtgtgacatc ctaacctctg cctggcactg ccatcttccc agagctcagg
      961 agtaaaataa atgctaacaa gaagactaaa aaaaaaaaaa aaaa
//
