LOCUS       NM_008082               2871 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus galanin receptor 1 (Galr1), mRNA.
ACCESSION   NM_008082
VERSION     NM_008082.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2871)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2871)
  AUTHORS   Sun,J., She,Y., Fang,P., Gu,X. and Zhang,Z.
  TITLE     Time-restricted feeding prevents metabolic diseases through the
            regulation of galanin/GALR1 expression in the hypothalamus of mice
  JOURNAL   Eat Weight Disord 27 (4), 1415-1425 (2022)
   PUBMED   34370270
  REMARK    GeneRIF: Time-restricted feeding prevents metabolic diseases
            through the regulation of galanin/GALR1 expression in the
            hypothalamus of mice.
REFERENCE   3  (bases 1 to 2871)
  AUTHORS   Petrescu,A.D., Grant,S., Williams,E., Frampton,G., Parks,N.,
            Blaney,H., Davies,M., John,R., Reinhart,E.H., McMillin,M. and
            DeMorrow,S.
  TITLE     Coordinated Targeting of Galanin Receptors on Cholangiocytes and
            Hepatic Stellate Cells Ameliorates Liver Fibrosis in Multidrug
            Resistance Protein 2 Knockout Mice
  JOURNAL   Am J Pathol 190 (3), 586-601 (2020)
   PUBMED   31953035
  REMARK    GeneRIF: These data demonstrate that Galanin (Gal) contributes not
            only to cholangiocyte proliferation but also to liver fibrogenesis
            via the coordinate activation of GalR1 in cholangiocytes and GalR2
            in hepatic stellate cells (HSCs).
REFERENCE   4  (bases 1 to 2871)
  AUTHORS   Hall,E.A., Nahorski,M.S., Murray,L.M., Shaheen,R., Perkins,E.,
            Dissanayake,K.N., Kristaryanto,Y., Jones,R.A., Vogt,J.,
            Rivagorda,M., Handley,M.T., Mali,G.R., Quidwai,T., Soares,D.C.,
            Keighren,M.A., McKie,L., Mort,R.L., Gammoh,N., Garcia-Munoz,A.,
            Davey,T., Vermeren,M., Walsh,D., Budd,P., Aligianis,I.A.,
            Faqeih,E., Quigley,A.J., Jackson,I.J., Kulathu,Y., Jackson,M.,
            Ribchester,R.R., von Kriegsheim,A., Alkuraya,F.S., Woods,C.G.,
            Maher,E.R. and Mill,P.
  TITLE     PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by
            Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic
            Proteins
  JOURNAL   Am J Hum Genet 100 (5), 706-724 (2017)
   PUBMED   28413018
REFERENCE   5  (bases 1 to 2871)
  AUTHORS   Kennedy,A.J., Rahn,E.J., Paulukaitis,B.S., Savell,K.E.,
            Kordasiewicz,H.B., Wang,J., Lewis,J.W., Posey,J., Strange,S.K.,
            Guzman-Karlsson,M.C., Phillips,S.E., Decker,K., Motley,S.T.,
            Swayze,E.E., Ecker,D.J., Michael,T.P., Day,J.J. and Sweatt,J.D.
  TITLE     Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory
            Function
  JOURNAL   Cell Rep 16 (10), 2666-2685 (2016)
   PUBMED   27568567
REFERENCE   6  (bases 1 to 2871)
  AUTHORS   Zachariou,V., Georgescu,D., Kansal,L., Merriam,P. and
            Picciotto,M.R.
  TITLE     Galanin receptor 1 gene expression is regulated by cyclic AMP
            through a CREB-dependent mechanism
  JOURNAL   J Neurochem 76 (1), 191-200 (2001)
   PUBMED   11145992
REFERENCE   7  (bases 1 to 2871)
  AUTHORS   Kolakowski,L.F. Jr., O'Neill,G.P., Howard,A.D., Broussard,S.R.,
            Sullivan,K.A., Feighner,S.D., Sawzdargo,M., Nguyen,T., Kargman,S.,
            Shiao,L.L., Hreniuk,D.L., Tan,C.P., Evans,J., Abramovitz,M.,
            Chateauneuf,A., Coulombe,N., Ng,G., Johnson,M.P., Tharian,A.,
            Khoshbouei,H., George,S.R., Smith,R.G. and O'Dowd,B.F.
  TITLE     Molecular characterization and expression of cloned human galanin
            receptors GALR2 and GALR3
  JOURNAL   J Neurochem 71 (6), 2239-2251 (1998)
   PUBMED   9832121
REFERENCE   8  (bases 1 to 2871)
  AUTHORS   Jacoby,A.S., Webb,G.C., Liu,M.L., Kofler,B., Hort,Y.J., Fathi,Z.,
            Bottema,C.D., Shine,J. and Iismaa,T.P.
  TITLE     Structural organization of the mouse and human GALR1 galanin
            receptor genes (Galnr and GALNR) and chromosomal localization of
            the mouse gene
  JOURNAL   Genomics 45 (3), 496-508 (1997)
   PUBMED   9367674
REFERENCE   9  (bases 1 to 2871)
  AUTHORS   Wang,S., He,C., Maguire,M.T., Clemmons,A.L., Burrier,R.E.,
            Guzzi,M.F., Strader,C.D., Parker,E.M. and Bayne,M.L.
  TITLE     Genomic organization and functional characterization of the mouse
            GalR1 galanin receptor
  JOURNAL   FEBS Lett 411 (2-3), 225-230 (1997)
   PUBMED   9271210
REFERENCE   10 (bases 1 to 2871)
  AUTHORS   Simoneaux,D.K., Leach,R.J. and O'Connell,P.
  TITLE     Galanin receptor 1 gene (Galnr1) is tightly linked to the myelin
            basic protein gene on chromosome 18 in mouse
  JOURNAL   Mamm Genome 8 (11), 875 (1997)
   PUBMED   9337411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138487.1, Y15004.1, BU609759.1 and BQ176727.1.
            
            On Jul 25, 2006 this sequence version replaced NM_008082.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138487.1, Y15004.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-606               AK138487.1         2-607
            607-2185            Y15004.1           301-1879
            2186-2794           BU609759.1         61-669
            2795-2871           BQ176727.1         134-210             c
FEATURES             Location/Qualifiers
     source          1..2871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 55.78 cM"
     gene            1..2871
                     /gene="Galr1"
                     /gene_synonym="Galnr1"
                     /note="galanin receptor 1"
                     /db_xref="GeneID:14427"
                     /db_xref="MGI:MGI:1096364"
     exon            1..1290
                     /gene="Galr1"
                     /gene_synonym="Galnr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             628..1674
                     /gene="Galr1"
                     /gene_synonym="Galnr1"
                     /note="GAL1-R; GALR-1"
                     /codon_start=1
                     /product="galanin receptor type 1"
                     /protein_id="NP_032108.1"
                     /db_xref="CCDS:CCDS29372.1"
                     /db_xref="GeneID:14427"
                     /db_xref="MGI:MGI:1096364"
                     /translation="MELAMVNLSEGNGSDPEPPAPESRPLFGIGVENFITLVVFGLIF
                     AMGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWV
                     LGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGFIW
                     ALSIAMASPVAYHQRLFHRDSNQTFCWEQWPNKLHKKAYVVCTFVFGYLLPLLLICFC
                     YAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHVVHLWAEFGAFPL
                     TPASFFFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHVCDESPRSETKENK
                     SRMDTPPSTNCTHV"
     exon            1291..1356
                     /gene="Galr1"
                     /gene_synonym="Galnr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..2871
                     /gene="Galr1"
                     /gene_synonym="Galnr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2033..2039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galr1"
                     /gene_synonym="Galnr1"
ORIGIN      
        1 gcagaggacc cgggactaag agggagccgc agcgccagcg ccagcgaggc agggaggtgg
       61 atcttagtgc gggaagctca gcgaccctct tcaccattga aggtgtgcat cgctgggctc
      121 tgcggagctt ggcgggaaga agaggctcaa agcaacaggt gcaacctcaa ggcactgaaa
      181 gcaaggggac gcagctcaca agggccaagg gattgaaccc ataaccgctc agaagattct
      241 ccgcctgcgg agagctgcgg aggagtccca cccgtccagc ttgctgactg cgagcagtga
      301 gagtcgccta gacccgtacc tctgtgttct ggagcctgcc gcccccgcac gggaaaggct
      361 tagctcggga cttgcagcac cgcctcctct ttagccaggc caggcacgag gatagtgtga
      421 tcgggcacag ccagggtcgc tcttccaggc tttcttgcgg gttgcgggag gtactagttg
      481 gagacgcgcg cgctcgctct cgccgctctg tcctgggcca ctccgtgatc ctaggctacc
      541 tccagagcca gttttccctg gctggcacaa ctctccaggg cgctccggtc cgttgcacag
      601 cgccccaagg gggtatccca gtaagtgatg gaactggcta tggtgaacct cagtgaaggg
      661 aatgggagcg acccagagcc gccagccccg gagtccaggc cgctcttcgg cattggcgtg
      721 gagaacttca ttacgctggt agtgtttggc ctgattttcg cgatgggcgt gctgggcaac
      781 agcctggtga tcaccgtgct ggcgcgcagc aaaccaggca agccgcgcag caccaccaac
      841 ctgtttatcc tcaatctgag catcgcagac ctggcctacc tgctcttctg catccctttt
      901 caggccaccg tgtatgcact gcccacctgg gtgctgggcg ccttcatctg caagtttata
      961 cactacttct tcaccgtgtc catgctggtg agcatcttca ccctggccgc gatgtctgtg
     1021 gatcgctacg tggccattgt gcactcgcgg cgctcctcct ccctcagggt gtcccgcaac
     1081 gcactgctgg gcgtgggctt catctgggcg ctgtccatcg ccatggcctc gccggtggcc
     1141 taccaccagc gtcttttcca tcgggacagc aaccagacct tctgctggga gcagtggccc
     1201 aacaagctcc acaagaaggc ttacgtggtg tgcactttcg tctttgggta ccttctgccc
     1261 ttactgctca tctgcttttg ctatgccaag gtccttaatc atctgcataa aaagctgaaa
     1321 aacatgtcaa aaaagtctga agcatccaag aaaaagactg cacagaccgt cctggtggtc
     1381 gttgtagtat ttggcatatc ctggctgccc catcatgtcg tccacctctg ggctgagttt
     1441 ggagccttcc cactgacgcc agcttccttc ttcttcagaa tcaccgccca ttgcctggca
     1501 tacagcaact cctcagtgaa ccccatcata tatgcctttc tctcagaaaa cttccggaag
     1561 gcgtacaagc aagtgttcaa gtgtcatgtt tgcgatgaat ctccacgcag tgaaactaag
     1621 gaaaacaaga gccggatgga caccccgcca tccaccaact gcacccacgt gtgaaggttt
     1681 gcgggagcct cccgacttcc agctcccatg tgtgttagag agaggagggc ggagcgaatt
     1741 atcaagtaac atggcagctt attctccaca gcaattccta tcgatccaac tacattccac
     1801 agtggtaaaa ggacgttgat tgttcaggga actcgtgggt ctactgaaga tcattttcca
     1861 atttcatttt actctataat tgtatatatg agacaaaaga aacttctgta tagtttctag
     1921 ctctcaagga atgaaagtcc tacagcactc tgcaaatgtt ttgatctcca tggtgtaaag
     1981 taagttctgt aaagcagaga ataatatttg aaatccacat tttcaggcca gttaatatag
     2041 ggaaaaagtt ctttttaaaa aaaaatttga gaggagaggt aatagtctag tctgtgcttt
     2101 gaaatacaac tgtgggcaca gaatagtgat ttttatttta ttgaaccttt gtggaccggc
     2161 acctcatctg agtcgtgggt gtccagaggt ctgtctgggg atgtgagacc catcaagtac
     2221 atcctgggag atcagcgttg actctactac gaaacaatcc tgtgagctgg gagtttaggg
     2281 tgaactaaga aactccatgg aagtctgccg aggactgctg caaacctgtg tgtagcttta
     2341 aggatgcttt tggcaaatgc gttagctgcg tctccaaaga ggagagacgt ttgattcaga
     2401 atgaacgaag acaaaagtat cctgtgggag aatagagaca cacagagaca tgctgcctca
     2461 tgcagatttg taccaacaaa tgtctaagga ttgttttccc caaatattat tccatggagc
     2521 aatgttaatt tagaattaaa accatcacca tgtgacttac aaatgtaact ttcacaacaa
     2581 atttcatatt tacttatact tgccatagga aaatgctgtg aaattactaa attgtcctgt
     2641 cttagaagaa taatgtttag gtttaagact ttgataatat tttaggagga gggaaacaaa
     2701 gcaagacact ttaaaaaaat caaaaagggt gtatatctgt gccaaatcag cacctaattt
     2761 aggttaaaaa atgtaatgta gacttctggc tcgttaactt ttctagctca tttattttcg
     2821 tgactattcc cctgtaaata gtgtttacat ttgcaatagt ctctggatgg a
//
