LOCUS       NM_178028                650 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus galanin-like peptide (Galp), mRNA.
ACCESSION   NM_178028 XM_977913
VERSION     NM_178028.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 650)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 650)
  AUTHORS   Kageyama,H., Shiba,K., Hirako,S., Wada,N., Yamanaka,S., Nogi,Y.,
            Takenoya,F., Nonaka,N., Hirano,T., Inoue,S. and Shioda,S.
  TITLE     Anti-obesity effect of intranasal administration of galanin-like
            peptide (GALP) in obese mice
  JOURNAL   Sci Rep 6, 28200 (2016)
   PUBMED   27323911
  REMARK    GeneRIF: this study demonstrates anti-obesity effect of intranasal
            administration of galanin-like peptide in obese mice
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 650)
  AUTHORS   Aziz,R., Beymer,M., Negron,A.L., Newshan,A., Yu,G., Rosati,B.,
            McKinnon,D., Fukuda,M., Lin,R.Z., Mayer,C., Boehm,U. and
            Acosta-Martinez,M.
  TITLE     Galanin-like peptide (GALP) neurone-specific phosphoinositide
            3-kinase signalling regulates GALP mRNA levels in the hypothalamus
            of males and luteinising hormone levels in both sexes
  JOURNAL   J Neuroendocrinol 26 (7), 426-438 (2014)
   PUBMED   24796383
  REMARK    GeneRIF: we investigated whether PI3K signalling in neurones
            expressing GALP plays a role in the transcriptional regulation of
            the GALP gene
REFERENCE   4  (bases 1 to 650)
  AUTHORS   Ito,K., Kageyama,H., Hirako,S., Wang,L., Takenoya,F., Ogawa,T. and
            Shioda,S.
  TITLE     Interactive effect of galanin-like peptide (GALP) and spontaneous
            exercise on energy metabolism
  JOURNAL   Peptides 49, 109-116 (2013)
   PUBMED   24055807
  REMARK    GeneRIF: results indicate the GALP ICV administration can further
            promote energy metabolism when administered to spontaneously
            exercising mice
REFERENCE   5  (bases 1 to 650)
  AUTHORS   Eberhard,N., Mayer,C., Santic,R., Navio,R.P., Wagner,A.,
            Bauer,H.C., Sperk,G., Boehm,U. and Kofler,B.
  TITLE     Distribution of alarin immunoreactivity in the mouse brain
  JOURNAL   J Mol Neurosci 46 (1), 18-32 (2012)
   PUBMED   21647713
  REMARK    GeneRIF: Distinct expression of alarin, a splice variant of GALP,
            in the adult mouse brain demonstrates potential functions in
            reproduction and metabolism.
REFERENCE   6  (bases 1 to 650)
  AUTHORS   Man,P.S. and Lawrence,C.B.
  TITLE     Interleukin-1 mediates the anorexic and febrile actions of
            galanin-like Peptide
  JOURNAL   Endocrinology 149 (11), 5791-5802 (2008)
   PUBMED   18617619
  REMARK    GeneRIF: GALP induces expression of IL-1 in the brain, and its
            anorexic and febrile actions are mediated by this cytokine acting
            via IL-1 type I receptor.
REFERENCE   7  (bases 1 to 650)
  AUTHORS   Dungan Lemko,H.M., Clifton,D.K., Steiner,R.A. and Fraley,G.S.
  TITLE     Altered response to metabolic challenges in mice with genetically
            targeted deletions of galanin-like peptide
  JOURNAL   Am J Physiol Endocrinol Metab 295 (3), E605-E612 (2008)
   PUBMED   18775887
  REMARK    GeneRIF: GALP may play a role in readjusting energy balance under
            changing nutritional circumstances
REFERENCE   8  (bases 1 to 650)
  AUTHORS   Santic,R., Schmidhuber,S.M., Lang,R., Rauch,I., Voglas,E.,
            Eberhard,N., Bauer,J.W., Brain,S.D. and Kofler,B.
  TITLE     Alarin is a vasoactive peptide
  JOURNAL   Proc Natl Acad Sci U S A 104 (24), 10217-10222 (2007)
   PUBMED   17535903
REFERENCE   9  (bases 1 to 650)
  AUTHORS   Kumano,S., Matsumoto,H., Takatsu,Y., Noguchi,J., Kitada,C. and
            Ohtaki,T.
  TITLE     Changes in hypothalamic expression levels of galanin-like peptide
            in rat and mouse models support that it is a leptin-target peptide
  JOURNAL   Endocrinology 144 (6), 2634-2643 (2003)
   PUBMED   12746327
  REMARK    GeneRIF: hypothalamic GALP gene expression is controlled by leptin
            signals
REFERENCE   10 (bases 1 to 650)
  AUTHORS   Jureus,A., Cunningham,M.J., Li,D., Johnson,L.L., Krasnow,S.M.,
            Teklemichael,D.N., Clifton,D.K. and Steiner,R.A.
  TITLE     Distribution and regulation of galanin-like peptide (GALP) in the
            hypothalamus of the mouse
  JOURNAL   Endocrinology 142 (12), 5140-5144 (2001)
   PUBMED   11713207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY163546.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_977913.1, NM_178028.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY163546.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849380,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..650
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 3.59 cM"
     gene            1..650
                     /gene="Galp"
                     /note="galanin-like peptide"
                     /db_xref="GeneID:232836"
                     /db_xref="MGI:MGI:2663979"
     exon            1..263
                     /gene="Galp"
                     /inference="alignment:Splign:2.1.0"
     exon            264..348
                     /gene="Galp"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..618
                     /gene="Galp"
                     /codon_start=1
                     /product="galanin-like peptide preproprotein"
                     /protein_id="NP_821171.1"
                     /db_xref="CCDS:CCDS20771.1"
                     /db_xref="GeneID:232836"
                     /db_xref="MGI:MGI:2663979"
                     /translation="MACSVHLVLFLTILLSLAETPESAPAHRGRGGWTLNSAGYLLGP
                     VLPVSSKADQGRKRDSALEILDLWKIIDGLPYSHSPRMTKRTMGETFVKANTGDMHIL
                     DKNVPKEEATLDSES"
     exon            349..397
                     /gene="Galp"
                     /inference="alignment:Splign:2.1.0"
     exon            398..478
                     /gene="Galp"
                     /inference="alignment:Splign:2.1.0"
     exon            479..556
                     /gene="Galp"
                     /inference="alignment:Splign:2.1.0"
     exon            557..650
                     /gene="Galp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaagacagt ctcaaatcaa ggacctgcca gcaatggctg tggcagagaa atgttttctg
       61 ccacaaggca cctttgtctg acctcacact ccagttaagg aactctgaag tggatgagtc
      121 gtcctctctg cctccatcct cactagcccg cccacccttg tctctctccc taacctcctc
      181 attctcctca gaagctcaca aaccaggatc cccgctgctg ctgagagccg cccagcccag
      241 ccggtgctgc cagctccaca caggatggcc tgctccgtac atctggtcct cttcctcacc
      301 atcttgctga gcctggcaga aacaccggaa tctgcacctg ctcacagggg acgaggaggc
      361 tggaccctca atagtgctgg ttacctcctg ggtcctgtcc tccccgtttc ctccaaggcc
      421 gaccagggca ggaagagaga ctcagctctt gagatcctag acctgtggaa gatcattgat
      481 ggacttcctt attcccactc tccaaggatg accaaaagga caatgggaga aacgtttgtc
      541 aaagcgaata ctggagatat gcacatactg gacaagaatg ttcccaagga agaagccacc
      601 ctggactcag agagttagcc atacctcact cctccttcgt ttccagctca
//
