LOCUS       NP_821171                117 aa            linear   ROD 30-APR-2024
DEFINITION  galanin-like peptide preproprotein [Mus musculus].
ACCESSION   NP_821171 XP_983007
VERSION     NP_821171.1
DBSOURCE    REFSEQ: accession NM_178028.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 117)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 117)
  AUTHORS   Kageyama,H., Shiba,K., Hirako,S., Wada,N., Yamanaka,S., Nogi,Y.,
            Takenoya,F., Nonaka,N., Hirano,T., Inoue,S. and Shioda,S.
  TITLE     Anti-obesity effect of intranasal administration of galanin-like
            peptide (GALP) in obese mice
  JOURNAL   Sci Rep 6, 28200 (2016)
   PUBMED   27323911
  REMARK    GeneRIF: this study demonstrates anti-obesity effect of intranasal
            administration of galanin-like peptide in obese mice
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 117)
  AUTHORS   Aziz,R., Beymer,M., Negron,A.L., Newshan,A., Yu,G., Rosati,B.,
            McKinnon,D., Fukuda,M., Lin,R.Z., Mayer,C., Boehm,U. and
            Acosta-Martinez,M.
  TITLE     Galanin-like peptide (GALP) neurone-specific phosphoinositide
            3-kinase signalling regulates GALP mRNA levels in the hypothalamus
            of males and luteinising hormone levels in both sexes
  JOURNAL   J Neuroendocrinol 26 (7), 426-438 (2014)
   PUBMED   24796383
  REMARK    GeneRIF: we investigated whether PI3K signalling in neurones
            expressing GALP plays a role in the transcriptional regulation of
            the GALP gene
REFERENCE   4  (residues 1 to 117)
  AUTHORS   Ito,K., Kageyama,H., Hirako,S., Wang,L., Takenoya,F., Ogawa,T. and
            Shioda,S.
  TITLE     Interactive effect of galanin-like peptide (GALP) and spontaneous
            exercise on energy metabolism
  JOURNAL   Peptides 49, 109-116 (2013)
   PUBMED   24055807
  REMARK    GeneRIF: results indicate the GALP ICV administration can further
            promote energy metabolism when administered to spontaneously
            exercising mice
REFERENCE   5  (residues 1 to 117)
  AUTHORS   Eberhard,N., Mayer,C., Santic,R., Navio,R.P., Wagner,A.,
            Bauer,H.C., Sperk,G., Boehm,U. and Kofler,B.
  TITLE     Distribution of alarin immunoreactivity in the mouse brain
  JOURNAL   J Mol Neurosci 46 (1), 18-32 (2012)
   PUBMED   21647713
  REMARK    GeneRIF: Distinct expression of alarin, a splice variant of GALP,
            in the adult mouse brain demonstrates potential functions in
            reproduction and metabolism.
REFERENCE   6  (residues 1 to 117)
  AUTHORS   Man,P.S. and Lawrence,C.B.
  TITLE     Interleukin-1 mediates the anorexic and febrile actions of
            galanin-like Peptide
  JOURNAL   Endocrinology 149 (11), 5791-5802 (2008)
   PUBMED   18617619
  REMARK    GeneRIF: GALP induces expression of IL-1 in the brain, and its
            anorexic and febrile actions are mediated by this cytokine acting
            via IL-1 type I receptor.
REFERENCE   7  (residues 1 to 117)
  AUTHORS   Dungan Lemko,H.M., Clifton,D.K., Steiner,R.A. and Fraley,G.S.
  TITLE     Altered response to metabolic challenges in mice with genetically
            targeted deletions of galanin-like peptide
  JOURNAL   Am J Physiol Endocrinol Metab 295 (3), E605-E612 (2008)
   PUBMED   18775887
  REMARK    GeneRIF: GALP may play a role in readjusting energy balance under
            changing nutritional circumstances
REFERENCE   8  (residues 1 to 117)
  AUTHORS   Santic,R., Schmidhuber,S.M., Lang,R., Rauch,I., Voglas,E.,
            Eberhard,N., Bauer,J.W., Brain,S.D. and Kofler,B.
  TITLE     Alarin is a vasoactive peptide
  JOURNAL   Proc Natl Acad Sci U S A 104 (24), 10217-10222 (2007)
   PUBMED   17535903
REFERENCE   9  (residues 1 to 117)
  AUTHORS   Kumano,S., Matsumoto,H., Takatsu,Y., Noguchi,J., Kitada,C. and
            Ohtaki,T.
  TITLE     Changes in hypothalamic expression levels of galanin-like peptide
            in rat and mouse models support that it is a leptin-target peptide
  JOURNAL   Endocrinology 144 (6), 2634-2643 (2003)
   PUBMED   12746327
  REMARK    GeneRIF: hypothalamic GALP gene expression is controlled by leptin
            signals
REFERENCE   10 (residues 1 to 117)
  AUTHORS   Jureus,A., Cunningham,M.J., Li,D., Johnson,L.L., Krasnow,S.M.,
            Teklemichael,D.N., Clifton,D.K. and Steiner,R.A.
  TITLE     Distribution and regulation of galanin-like peptide (GALP) in the
            hypothalamus of the mouse
  JOURNAL   Endocrinology 142 (12), 5140-5144 (2001)
   PUBMED   11713207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY163546.1.
            
            On May 4, 2006 this sequence version replaced XP_983007.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY163546.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849380,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..117
                     /organism="Mus musculus"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 3.59 cM"
     Protein         1..117
                     /product="galanin-like peptide preproprotein"
                     /calculated_mol_wt=10846
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1944
     Region          24..>44
                     /region_name="Galanin"
                     /note="smart00071"
                     /db_xref="CDD:128385"
     CDS             1..117
                     /gene="Galp"
                     /coded_by="NM_178028.2:265..618"
                     /db_xref="CCDS:CCDS20771.1"
                     /db_xref="GeneID:232836"
                     /db_xref="MGI:MGI:2663979"
ORIGIN      
        1 macsvhlvlf ltillslaet pesapahrgr ggwtlnsagy llgpvlpvss kadqgrkrds
       61 aleildlwki idglpyshsp rmtkrtmget fvkantgdmh ildknvpkee atldses
//
