LOCUS       NM_144731               4363 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus polypeptide N-acetylgalactosaminyltransferase 7
            (Galnt7), transcript variant 1, mRNA.
ACCESSION   NM_144731
VERSION     NM_144731.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4363)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4363)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
REFERENCE   3  (bases 1 to 4363)
  AUTHORS   Tian,E., Wang,S., Zhang,L., Zhang,Y., Malicdan,M.C., Mao,Y.,
            Christoffersen,C., Tabak,L.A., Schjoldager,K.T. and Ten Hagen,K.G.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
REFERENCE   4  (bases 1 to 4363)
  AUTHORS   Guess,M.G., Barthel,K.K., Harrison,B.C. and Leinwand,L.A.
  TITLE     miR-30 family microRNAs regulate myogenic differentiation and
            provide negative feedback on the microRNA pathway
  JOURNAL   PLoS One 10 (2), e0118229 (2015)
   PUBMED   25689854
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4363)
  AUTHORS   Tian,E., Stevens,S.R., Guan,Y., Springer,D.A., Anderson,S.A.,
            Starost,M.F., Patel,V., Ten Hagen,K.G. and Tabak,L.A.
  TITLE     Galnt1 is required for normal heart valve development and cardiac
            function
  JOURNAL   PLoS One 10 (1), e0115861 (2015)
   PUBMED   25615642
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4363)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   7  (bases 1 to 4363)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 4363)
  AUTHORS   Ten Hagen,K.G., Bedi,G.S., Tetaert,D., Kingsley,P.D., Hagen,F.K.,
            Balys,M.M., Beres,T.M., Degand,P. and Tabak,L.A.
  TITLE     Cloning and characterization of a ninth member of the
            UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family,
            ppGaNTase-T9
  JOURNAL   J Biol Chem 276 (20), 17395-17404 (2001)
   PUBMED   11278534
REFERENCE   9  (bases 1 to 4363)
  AUTHORS   Kingsley,P.D., Hagen,K.G., Maltby,K.M., Zara,J. and Tabak,L.A.
  TITLE     Diverse spatial expression patterns of UDP-GalNAc:polypeptide
            N-acetylgalactosaminyl-transferase family member mRNAs during mouse
            development
  JOURNAL   Glycobiology 10 (12), 1317-1323 (2000)
   PUBMED   11159923
REFERENCE   10 (bases 1 to 4363)
  AUTHORS   Ten Hagen,K.G., Tetaert,D., Hagen,F.K., Richet,C., Beres,T.M.,
            Gagnon,J., Balys,M.M., VanWuyckhuyse,B., Bedi,G.S., Degand,P. and
            Tabak,L.A.
  TITLE     Characterization of a UDP-GalNAc:polypeptide
            N-acetylgalactosaminyltransferase that displays glycopeptide
            N-acetylgalactosaminyltransferase activity
  JOURNAL   J Biol Chem 274 (39), 27867-27874 (1999)
   PUBMED   10488133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY167413.1, AF349573.1, AK033427.1, AK152205.1 and CB524213.1.
            
            On Nov 21, 2009 this sequence version replaced NM_144731.3.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1. Variants 1 and 2 encode proteins
            of identical length but use different exons to encode aa 323-383.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.202758.1,
                                           SRR1660819.49141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                BY167413.1         2-77
            77-2104             AF349573.1         1-2028
            2105-3596           AK033427.1         2054-3545
            3597-3613           AK152205.1         2600-2616
            3614-4337           AK152205.1         2618-3341
            4338-4363           CB524213.1         385-410
FEATURES             Location/Qualifiers
     source          1..4363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 29.92 cM"
     gene            1..4363
                     /gene="Galnt7"
                     /note="polypeptide N-acetylgalactosaminyltransferase 7"
                     /db_xref="GeneID:108150"
                     /db_xref="MGI:MGI:1349449"
     exon            1..203
                     /gene="Galnt7"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2051
                     /gene="Galnt7"
                     /EC_number="2.4.1.41"
                     /note="isoform 1 is encoded by transcript variant 1;
                     N-acetylgalactosaminyltransferase 7; galNAc-T7; pp-GaNTase
                     7; polypeptide GalNAc transferase 7; protein-UDP
                     acetylgalactosaminyltransferase 7; UDP-GalNAc:polypeptide
                     N-acetylgalactosaminyltransferase 7; ppGaNTase-T7;
                     UDP-N-acetyl-alpha-D-galactosamine: polypeptide
                     N-acetylgalactosaminyltransferase 7"
                     /codon_start=1
                     /product="N-acetylgalactosaminyltransferase 7 isoform 1"
                     /protein_id="NP_653332.3"
                     /db_xref="CCDS:CCDS22317.1"
                     /db_xref="GeneID:108150"
                     /db_xref="MGI:MGI:1349449"
                     /translation="MRLKIGFILRSLLVVGSFLGLVVLWSSLSSRPDDQSPLSRMRED
                     RDVNNPLPNRGGNGLAPGDDRFKPVVPWPHVEGVEVDLESIRRKNKAKNEQERHAGGD
                     SQRDVMQRQYLTFKPQTFTYRDPVLRPGVLGNFEPKEPEPHGVVGGPGEKAKPLVLGP
                     EYKQAVQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNE
                     GWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNER
                     REGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPIIDVIS
                     GNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTSREKRLRKTKTEPYRSPAMAGGLF
                     AIEKDFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGN
                     PPPLYVGSSPTLKNYVRVVEVWWDEYKDYFYASRPESKALPYGDISELKKFREDHNCK
                     SFKWFMEEIAYDITAHYPLPPRNVEWGEIRGLETAYCIDSMGKTNGGFVELGPCHRMG
                     GNQLFRINEANQLMQYDQCLTKGPDGSKVMITHCNLNEFKEWQYFKSLHRFTHITSGK
                     CLDRSEVLHQVFISTCDSSKMTQKWEMNNIHSV"
     exon            204..664
                     /gene="Galnt7"
                     /inference="alignment:Splign:2.1.0"
     exon            665..831
                     /gene="Galnt7"
                     /inference="alignment:Splign:2.1.0"
     exon            832..962
                     /gene="Galnt7"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1042
                     /gene="Galnt7"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1225
                     /gene="Galnt7"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1343
                     /gene="Galnt7"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1466
                     /gene="Galnt7"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1685
                     /gene="Galnt7"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1784
                     /gene="Galnt7"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1913
                     /gene="Galnt7"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..4340
                     /gene="Galnt7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4315..4320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt7"
                     /note="hexamer: AATAAA"
     polyA_site      4340
                     /gene="Galnt7"
                     /note="major polyA site"
ORIGIN      
        1 gggggagggg gaaggaggga ggggagagcg gtggcggcgg ctgcgccggg ctgtgtgtct
       61 ctcgccgccg gaggaagatg aggctgaaga tcgggttcat cttacgcagt ttgctggtgg
      121 tgggaagctt cctggggctc gtggtcctct ggtcttccct gtcctcgcgg cccgacgacc
      181 agagcccact gagcaggatg agggaagaca gagatgtcaa taaccccttg cctaaccgag
      241 gaggcaatgg actagctcct ggagatgaca gattcaaacc tgtggtacca tggcctcatg
      301 ttgaaggagt agaagtggac ttagagtcta ttagaagaaa aaacaaagcc aaaaatgaac
      361 aggagcgcca tgctggagga gattcccaga gagacgtaat gcagaggcag taccttacat
      421 ttaagcctca gaccttcacc taccgtgatc ctgtgctacg cccaggggtc ctcgggaact
      481 ttgaacccaa agaacccgag cctcacggag tggttggtgg ccctggagag aaagccaagc
      541 cattggttct gggaccagaa tacaaacaag cagttcaagc cagcattaag gagtttggat
      601 ttaacatggt ggcaagtgac atgatctcac tggaccgcag cgtcaatgac ttacgccaag
      661 aagaatgcaa gtattggcac tatgatgaaa acctgcttac ttcaagcgtt gtcattgtct
      721 tccataatga aggatggtca accctcatga ggacagtcca cagtgtaatc aaaaggacac
      781 caaggaagta cttagcagaa atcgtgttaa ttgatgactt cagcaataaa gaacacttaa
      841 aagagaaact ggatgagtat ataaagctat ggaatggcct cgtgaaggta tttcgaaatg
      901 agagaagaga gggtttgatt caagctcgga gcattggcgc acagaaggct aaactcggac
      961 aggttttgat ataccttgat gcccactgtg aggtggcagt taactggtat gctccacttg
     1021 tagcccccat atctaaggac agaaccattt gcactgtgcc gattatagat gtcataagcg
     1081 gcaacacata tgaaattata ccccaagggg gtggtgatga agatgggtat gcccgaggag
     1141 catgggactg gagtatgctc tggaaacggg tgcctctgac ctctcgagag aagagactga
     1201 gaaagacaaa aactgagccg tatcggtctc cagctatggc gggtggattg tttgccatag
     1261 agaaggactt cttcttcgaa ctgggtctct atgatcctgg tctccagatc tggggtggtg
     1321 aaaactttga aatttcatac aagatctggc agtgcggtgg caaattgtta tttgtgcctt
     1381 gttctcgtgt tgggcacatc taccgtcttg agggctggca aggaaacccc ccaccccttt
     1441 acgttggctc ctctccaact ctgaagaatt atgttagagt cgtggaagtc tggtgggatg
     1501 aatataaaga ctacttctat gctagccgtc ctgagtcaaa ggcgctgccc tacggggaca
     1561 tatctgagct gaagaaattt cgagaagatc acaactgcaa aagtttcaag tggtttatgg
     1621 aagaaatcgc ttatgacatc actgcccact accctttgcc ccccagaaat gtcgagtggg
     1681 gtgaaatccg aggcctcgaa actgcatact gtattgatag catggggaag acgaatggag
     1741 gcttcgtgga gctaggaccc tgccacagga tgggtgggaa ccagcttttc cgaatcaatg
     1801 aagcaaacca gctcatgcag tacgaccagt gtttgacaaa ggggcctgat ggatccaaag
     1861 tcatgatcac acactgtaac ctaaatgaat ttaaggaatg gcagtacttc aagagcctgc
     1921 acaggtttac gcacatcact tccggaaagt gcttagatcg atcggaggtc ctgcatcaag
     1981 tgttcatctc cacctgtgac tccagtaaaa tgactcagaa gtgggagatg aataacatcc
     2041 acagtgtttg acaagaacag aggaaaccaa caatctacct actgacaagt acatttatgg
     2101 aggactgaaa accgcctgga acctgctgca accattatta ctaattttgt acagctccaa
     2161 acctggaacc tctctgatca gttggaaggg gcattgataa actgtgattt tacaataaca
     2221 ttatcatctg cagtgactgt ttacaaaact gctcttacct taaactctag atgtttacat
     2281 cgttttttgt tttgttttat gatgatgttg gtaatttgtg cctttaactc ggtttcctga
     2341 accgccgagt taaagcatgt gttgtcttct ttgggaatac actcaggggt ctggaaggca
     2401 gtttggtttt ttttgttgtt gatgatgttg ttcttgtttt ttaacacact tgaaaaaaaa
     2461 aaaaggttgg agtaagcaga ctttcacatc cgacttggtg atgatcaacc tgctgtgtat
     2521 ttaattttac atctttcgga agcactgcca cgggtcgttg gccagggtgg ccttccttca
     2581 gttacgctgc tgtttgaaag gtgaatttca acacatttag tgcctctttc atttctcagt
     2641 atattgtttg agagcttcta gtgacacttc tatgatggtg acaatgaatg tcacctgggg
     2701 aacccgtctg ttactcacag gagaatttct tggctatgaa gtggaatgtt gtatggctgg
     2761 gtcgaggaca acagtgggcc caactcaagg ctgttccgtg gggcttgaag attctgtggc
     2821 attacctccc tggcctctgt tcacaccagc ttctaggcta gcaaaggagt ccttcttcta
     2881 aaaggagggg ttggtttttg cccatctaca ttttgcatct gctttcccca gtaccagtca
     2941 tagaaaacta aacataattc tcagtttgaa acttgaaggg gggttgaggg gcagggaaac
     3001 aacacaataa agccctagtg tggacgcctt aggttggtcc tgaggtaaaa atccccaagc
     3061 ccttgtgaga tggaagcctt agagaaccac ctcgaagcac aagctgtgca cagagataaa
     3121 ctgacacttt gtctacattc aaaggaaatt ccatgagcat tctttttaat ttaggaaaat
     3181 tagtatctaa ttttctattc ttagatctta ttatctaaga atacaaatca tcaacaaatg
     3241 tggacgacat tctgcgaagt tagatgctag ctctgtaggg ttccttaatt tcttttttaa
     3301 gaagtataaa ttttttttat attccccagg gaaaagaaga tttaatttga acatttatta
     3361 atacaatacc tactttaaga gaaccaaatg ttgaaaactt taatttctag gaagtctctt
     3421 attacacccc ccttccccca agataaaatg tctacattga gtgccaaaaa aagaaaaaga
     3481 aaagcaatgt ggtgagctgg ggccagttaa acatttttga tcatgtaatc atggtatcga
     3541 tgacagaaat tcacaaacta ctgccagaag gaaatatttt taaatacagc ttagggaaaa
     3601 gaagaaaaaa aaagcctgaa tttttttttg gaagaaaagc atacaattat ttttcttcca
     3661 accttagttc atcaaatttg ggcagtaaaa attcaacatc ctgaacagtt ttatttataa
     3721 tcttgaattg tcaatttgta ttttgctact gacctgtgat caactattta aactttcatc
     3781 tctagggata tttaaagaag aaatgcattt atatgcttat ataattgcaa ataaatccac
     3841 tgtagagagg aaactcggag aattggtaat tatttgtgtg ttagaaatgg acaccatttt
     3901 tcatgttaaa tagattttaa cctcgtatct atgcataggc taaggtggca catgaactgt
     3961 gcatgtcatg ttatgggtaa agtaaattgt ttttacaatt cgttaggata ctatatgaac
     4021 atgattctat atattgaaat cagaaacctt tccacacatg aaagtatcag aagctgccac
     4081 cataatgact attttgtact tcaggctgct ttggaaataa tccccatcgc cttgctttgt
     4141 aagttgataa tatcactatg catttctaca cattttataa atttgattta tgcagatttt
     4201 gatacactgt atgtttctgt agaaattgta caaatattca aaattttatt agggtaaact
     4261 caagaagctt atgtataact taattctggg ttgcttgttt tttaggtgag gaaaaataaa
     4321 atattgtatt ttaatccata aaaaaaaaaa aaaaaaaaaa aaa
//
