LOCUS       NM_001161767            5715 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus polypeptide N-acetylgalactosaminyltransferase 6
            (Galnt6), transcript variant 1, mRNA.
ACCESSION   NM_001161767
VERSION     NM_001161767.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5715)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
REFERENCE   2  (bases 1 to 5715)
  AUTHORS   Tian,E., Wang,S., Zhang,L., Zhang,Y., Malicdan,M.C., Mao,Y.,
            Christoffersen,C., Tabak,L.A., Schjoldager,K.T. and Ten Hagen,K.G.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
REFERENCE   3  (bases 1 to 5715)
  AUTHORS   Tian,E., Stevens,S.R., Guan,Y., Springer,D.A., Anderson,S.A.,
            Starost,M.F., Patel,V., Ten Hagen,K.G. and Tabak,L.A.
  TITLE     Galnt1 is required for normal heart valve development and cardiac
            function
  JOURNAL   PLoS One 10 (1), e0115861 (2015)
   PUBMED   25615642
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5715)
  AUTHORS   Yoshida,C.A., Kawane,T., Moriishi,T., Purushothaman,A.,
            Miyazaki,T., Komori,H., Mori,M., Qin,X., Hashimoto,A., Sugahara,K.,
            Yamana,K., Takada,K. and Komori,T.
  TITLE     Overexpression of Galnt3 in chondrocytes resulted in dwarfism due
            to the increase of mucin-type O-glycans and reduction of
            glycosaminoglycans
  JOURNAL   J Biol Chem 289 (38), 26584-26596 (2014)
   PUBMED   25107907
REFERENCE   5  (bases 1 to 5715)
  AUTHORS   Tian,E., Hoffman,M.P. and Ten Hagen,K.G.
  TITLE     O-glycosylation modulates integrin and FGF signalling by
            influencing the secretion of basement membrane components
  JOURNAL   Nat Commun 3, 869 (2012)
   PUBMED   22643896
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5715)
  AUTHORS   Bennett,E.P., Hassan,H., Mandel,U., Hollingsworth,M.A., Akisawa,N.,
            Ikematsu,Y., Merkx,G., van Kessel,A.G., Olofsson,S. and Clausen,H.
  TITLE     Cloning and characterization of a close homologue of human
            UDP-N-acetyl-alpha-D-galactosamine:Polypeptide
            N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6.
            Evidence for genetic but not functional redundancy
  JOURNAL   J Biol Chem 274 (36), 25362-25370 (1999)
   PUBMED   10464263
  REMARK    GeneRIF: This paper describes the identification and cloning of the
            orthologous human enzyme of mouse
            UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            N-acetylgalactosaminyltransferase 6.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY196827.1, AK159721.1, AC123724.9 and BQ175003.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155008.1, AK159721.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY196827.1         4-26
            24-2561             AK159721.1         2-2539
            2562-5558           AC123724.9         148746-151742       c
            5559-5715           BQ175003.1         1-157               c
FEATURES             Location/Qualifiers
     source          1..5715
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.39 cM"
     gene            1..5715
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /note="polypeptide N-acetylgalactosaminyltransferase 6"
                     /db_xref="GeneID:207839"
                     /db_xref="MGI:MGI:1891640"
     exon            1..74
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /inference="alignment:Splign:2.1.0"
     exon            75..295
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /inference="alignment:Splign:2.1.0"
     exon            296..882
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..2260
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /EC_number="2.4.1.41"
                     /note="N-acetylgalactosaminyltransferase T-6; Protein-UDP
                     acetylgalactosaminyltransferase 6; pp-GaNTase 6;
                     polypeptide GalNAc transferase 6;
                     UDP-N-acetyl-alpha-D-galactosamine:polypeptide
                     N-acetylgalactosaminyltransferase 6;
                     UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
                     6"
                     /codon_start=1
                     /product="polypeptide N-acetylgalactosaminyltransferase 6"
                     /protein_id="NP_001155239.1"
                     /db_xref="CCDS:CCDS27843.1"
                     /db_xref="GeneID:207839"
                     /db_xref="MGI:MGI:1891640"
                     /translation="MRLLRRRHMSLRLAMLGSVFMLFLFIRQKDVSNQEQAMEKPWLK
                     SLAGQKDQVLDFMLGAVNNIRDVMPKLQIRAPEPPQTLVSTNHSCLPGFYTPAELKPF
                     WDRPPQDPNSPGADGKAFQKKEWTNLETKEKEEGYKKHCFNAFASDRISLQRSLGPDT
                     RPPECVDQKFRRCPPLPTTSVIIVFHNEAWSTLLRTVYSVLHTSPAILLKEIILVDDA
                     STDEHLKERLEQYVQQLQIVRVVRQRERKGLITARLLGASVAQAEVLTFLDAHCECFH
                     GWLEPLLARIAEDKTAVVSPDIVTIDLNTFQFSRPVQRGKAHSRGNFDWSLTFGWEML
                     PEHEKQRRKDETYPIKSPTFAGGLFSISKAYFEHIGTYDNQMEIWGGENVEMSFRVWQ
                     CGGQLEIIPCSVVGHVFRTKSPHTFPKGTSVIARNQVRLAEVWMDDYKKIFYRRNLQA
                     AKMVQENNFGDISERLRLREQLRCHNFSWYLHNVYPEMFVPDLNPTFYGAIKNLGTNQ
                     CLDVGENNRGGKPLIMYVCHNLGGNQYFEYTSQRDLRHNIGKQLCLHASGSTLGLRSC
                     QFVGKNSRVPKDEEWELTQDQLIRNSGSGTCLTSQDKKPAMAPCNPRDPYQLWLFV"
     exon            883..1055
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1205
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1440
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1558
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1759
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1891
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1993
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2146
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..5698
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3777..3782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /note="hexamer: AATAAA"
     polyA_site      3803
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /note="major polyA site"
     regulatory      5675..5680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
                     /note="hexamer: AATAAA"
     polyA_site      5698
                     /gene="Galnt6"
                     /gene_synonym="4632410F13; GalNAc-T6"
ORIGIN      
        1 ggtcgccccg tcgggaaacc cacgagcagc tcggcggcag cggcagcggc agcggctttg
       61 cctcggcgcg gtaggatgtg gttagaacct tgaggaactg caggttccag agagaacact
      121 ttagacggcc ggattggatc cagagagcag atgctcaaga gaacttcagt ttagcccaag
      181 gtctctccgc gggaaatata aaggacaaag gtatctgcct ctacaaggga ctccaagcag
      241 tgcctggatg agagtgctgg agtgactggt gactccggag gcctttctgg aggaggttga
      301 gccccaggcg tagctacgct ggcatgtcaa gccatttcca aagtgaggca taagacttgg
      361 agccgaccct gccggggtcc cagttgagaa gatgaggttg ctacgaaggc gccacatgtc
      421 cctgcgcctc gccatgctgg gcagcgtctt catgctcttc ctcttcattc ggcagaagga
      481 tgtaagcaac caggagcagg ccatggagaa accgtggctg aagtccctgg ctggccagaa
      541 ggaccaggtc ctggacttca tgctaggtgc tgtgaacaac attagggacg tcatgcctaa
      601 gctgcagatc cgggctccag aaccgcctca gactctggtc tccacaaacc actcctgcct
      661 gcccgggttc tacacccctg ctgagctgaa acccttctgg gaccggccac ctcaagatcc
      721 caacagccct ggggcagatg gaaaagcatt tcagaagaaa gaatggacca atctagagac
      781 caaagaaaag gaagaaggct ataagaaaca ctgctttaat gcatttgcca gtgaccgcat
      841 ctccttgcag aggtccctgg ggccagacac ccggcctcct gagtgtgttg accagaagtt
      901 ccggcgctgc ccgccactgc ccaccaccag cgtgatcatt gtgttccaca acgaagcctg
      961 gtccactctg ctgcgcacag tatacagcgt cctgcacacc agccctgcca tcttgctgaa
     1021 ggaaatcatc ctcgtggatg acgccagcac agatgagcac ctgaaggaga ggctggagca
     1081 gtacgttcag cagctgcaga tcgtgcgcgt ggttcggcag cgggagcgga aggggctcat
     1141 cacagccagg ctgctggggg ccagcgtggc gcaggcagag gtgctcacgt tcctggacgc
     1201 ccactgtgag tgttttcacg gctggctgga gcccctcctg gctcgaattg ctgaagacaa
     1261 gacagcggtg gtgagcccag acatcgtcac catcgacctt aataccttcc aattctccag
     1321 accagtacag agaggcaaag cccacagccg gggcaacttc gactggagcc tgaccttcgg
     1381 ctgggaaatg cttcctgagc acgagaagca gagacgcaag gatgagacct accccatcaa
     1441 gtccccgacg tttgccggcg gcctcttctc catctccaag gcctactttg agcacatcgg
     1501 tacctatgat aaccagatgg agatctgggg aggggagaat gtggaaatgt ccttccgggt
     1561 gtggcagtgt gggggccagc tggaaataat cccctgctcg gtggtcggcc acgtgttccg
     1621 taccaagagt ccccacacct tccccaaggg caccagtgtc attgcgcgca atcaggtgcg
     1681 cctggctgag gtctggatgg acgactataa gaagattttc tacaggagaa atctgcaggc
     1741 agcaaagatg gtccaggaga acaacttcgg tgacatctcg gagcgacttc ggctcaggga
     1801 gcagctacga tgccacaact tctcctggta cctgcacaat gtctacccag agatgtttgt
     1861 ccccgacctg aaccccacct tctatggagc catcaagaat cttggcacca atcagtgttt
     1921 ggacgtgggc gagaacaacc ggggaggaaa gcctctcatc atgtatgtct gccacaacct
     1981 cggcggcaat cagtactttg agtacacatc acagagggac ctccgccaca acattggaaa
     2041 gcagctgtgt ctacatgcca gtgggagcac gctcggcctt aggagctgtc agttcgttgg
     2101 caaaaacagc agagtgccca aggacgagga gtgggaattg acccaggatc aactcatcag
     2161 aaactcagga tctggtacct gcctgacatc ccaggacaaa aagccagcca tggccccctg
     2221 taatcccagg gatccctacc agctctggct gtttgtctag gcctggggtc accctccagt
     2281 gcaggcccaa caagccctcc aggcggtagg gtcaccaggc gtctggggag tccttctccc
     2341 ccagatcctc tggaggcctg agagttggat tttgaagccc tgtggccacc aaggcaggat
     2401 gttcttcttg caacaacact ggtcccattt tctttcttcc atatcagtgg agagaccagg
     2461 aggtcacatg ctacttggcc caaggctttt gtcctctcct agagacgagc ctcgaaagca
     2521 gcctgagagt gtgtcctgca gaggaactgg aagggcagag agcctctctt gttagcagat
     2581 ctttgaagca aaccctcttg atgtgtatac acagagtgcc ttcatcctat gtcatttgca
     2641 cagttatcta tggaggagac agggagaaag gagccatcca ttgagaaggt tgagagtgag
     2701 gtggagtata tagttcaggg aaaggctctg agtttgaccc cttagcacca cagaaaacag
     2761 aaaaggagtc caggagagaa aggcaggcag agagaggcag agagggacat agggaggcag
     2821 agggcttttc tgcgattgca cagctgatag gtggctcaag ctggggttga gtccccatct
     2881 ttggtgctgt accagggttc cttccggcac ataaaaacac taaacagcga gctgccagcc
     2941 atgccatttc ctgaccccct ctctgatcat tctggctgtc tgtcctccag aaagactggt
     3001 agcgagatgg gagaccacat tgagatcctg gcctgttagt gtggaaagaa gttcatgagc
     3061 tgagacagct ggtgagcctc aagcccaggt cccctttgtt ctaagctata gacaaggaga
     3121 gtaataggct gaagcaggag ctaggcatga aggcacaggt ctgcagcctc ggtgctcaga
     3181 gactaaagca gcaaggtctt aagctccaag gacagcctgg gcttcaaaat ttgacctttc
     3241 ctcaaaggca attaaaaaac agcatggaga atatgcaggg gactgccttg cagcccctga
     3301 actaaggcag cccccctccc cttttacact tactcctcag cagaaactag ataggtgttt
     3361 tgtccaaggt cacctggcaa gatgtttagc agttccaagc ttagacccaa gataaggcta
     3421 atcagagtcg tggcaagtct gaggggtcag ggacagcgtg cagttgcctg gagggctgat
     3481 ctcatctgct tgcctgagtg ccctgtgcag agctgacccg aggatgccag cctttctaca
     3541 atcaacttgg accccactgt cactctgcct ggaagaaaat agaaatgtcc aggaaggctt
     3601 taggggactt cagcatggga ccatggctgc ctcctgctcc atgcaagggc acattgcagg
     3661 aagcctccct tgtcccctgg gtgacaatca gaggtagccc agccaaggga aagagtctga
     3721 ccgagttgtg atccaaggtg ggagagggaa gagaggctga ttgggaacct ggtggaaata
     3781 aaggttttat ggtattggtc aaagatgttg gatttgagtt cctctctccc tgctttagcc
     3841 ataactgaaa cagatgggac tagcaaggac cctgtggcta ctgtcacacc tgcaaacact
     3901 ctccagccag tgtgtattgg gtgtgtagtg tgtgcaagtg tgagatggga cccttacccc
     3961 gtgaagtcta aagacgagtc ccagaatgct tgaggaaagg agttaaaaca agtcaggaga
     4021 ggcctgacaa cggtggctga agggagaagc tgatggtggt gggtcctaag gcagaggcag
     4081 gcaggcaggc agacattagt ttgaggccag gctggtctac atagcaagtt ccatgctagc
     4141 cagggctaca gagtgagacc ttgtctcaaa aagagaaaga aggtgggaag gaaagctgga
     4201 gagatgactt tgtgaccagg agctctttct gcttttccag aggacctgga ttcaatcccc
     4261 agcagccata tgtaacgaca tgtaaccatc agttctgaaa ggttgtgtca tcttctggct
     4321 tctaagcaca tcaggcacat gagtggtaca tagacataca tgcagcaaaa acactcatac
     4381 ctgtaaagtg taaataagta ttcttaattt taaaacaaaa atgaaaagct gggcagtgtt
     4441 cagttggtaa catgagcctg acatgctcaa ggcccggggt ttgatccatt aagccaggta
     4501 cactaggtat ggtgacccag gttagcccag gctagtaatt ccagcagtta ggagatagaa
     4561 gcaagaagat gtgaggttca cgtgagctag actgggagct ggagaccaac atgggctatg
     4621 atgctaagtt cagatcacat tggcataaag ataacaatat agatcctatt catttcttca
     4681 gatcttaagt tgaaacactt tttataggcc cctaaatata ttctgggccc taagcactgt
     4741 tcctactgac tagatctgcc ccataggaga gcaggttgac ctgtaggtga gaaagactgt
     4801 gtgaactatg ttaacaatga gttaattata gggagtcaaa atcttgaccc taatgttggt
     4861 tccatcaaac atctaaatgt ttatcagcca taaactattt cccctctatc ccagaatttt
     4921 tatattacct cctcagccca attctgttat acccagctaa ggtatccact ctagtgctga
     4981 caggctttct catgtatccc agaatttgta tattacctct tcagcccaat tctattatac
     5041 ccagctaagg tgtccactct ggtggcttcc tcacacccac cccggaacag agctgttcct
     5101 ttttcttcct cccttcttcc caggcaggat catgctgtgt agcccaaact ggccttcctt
     5161 gccccatgct gggggggggg ggggggtcac aggcttgcac tatttctcat tttcatgagc
     5221 tatactattg cttcaggaat ctttctggaa taagtgcttt gacaccagtg gaagtggaag
     5281 agaggagctg ccaccggtgt tctgaaacca ggacagctct tgaaaggcct ctgtcctggt
     5341 gcagtttgtg tgctcatttt tagattctaa aaccacaagg tggatcaggc aagcaagtga
     5401 ggttttacca aagcctccct ggcagccaac aggttgttag agcaaagaca ccattccatt
     5461 ccaggtacca agtgaagcat acttgacaaa taggcagtct aagcagtgtt ttaaataaac
     5521 cactaaataa agcaacaaat cagtatcttt ttttttttct accaaattgc tctttttcta
     5581 ccttaaacta cttcaccatt tgatctaata tattcaaact tcctctgtac aagcttggat
     5641 ttttccaaag ttcatgggaa attttatgag cagaaataaa attttgtcat aaactgtaaa
     5701 aaaaaaaaaa aaaaa
//
